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Conserved domains on  [gi|2000186002|ref|NP_062168|]
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T-cell surface glycoprotein CD5 precursor [Rattus norvegicus]

Protein Classification

SR and SRCR domain-containing protein( domain architecture ID 12193634)

SR and SRCR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 46-143 3.02e-13

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 65.83  E-value: 3.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002   46 VMLSGSNSKCQGLVEVQMNGM-KTVCSSSWrlsqdlwkNANEASTVCQQLGCGNPLALGHLTLWNRPKNQIL-----CQG 119
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQwGTVCDDGW--------DLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWldnvrCSG 72

                           90       100
                   ....*....|....*....|....*....
gi 2000186002  120 PPWSFSNCSTSSLGQ--CL---PLSLVCL 143
Cdd:smart00202  73 TEASLSDCPHSGWGShnCShgeDAGVVCS 101
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 287-368 4.16e-04

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 39.63  E-value: 4.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002  287 RLVGGSSVCEGIAEVRQRSQWAALCDSSaargpgrWEE-----LCQEQQCGNLISF--HVMDADRTSP----GVLCT-QE 354
Cdd:smart00202   2 RLVGGGSPCEGRVEVYHNGQWGTVCDDG-------WDLrdanvVCRQLGFGGAVSAsgSAYFGPGSGPiwldNVRCSgTE 74

                           90
                   ....*....|....*
gi 2000186002  355 K-LSQCYQLQKKTHC 368
Cdd:smart00202  75 AsLSDCPHSGWGSHN 89
SRCR super family cl27545
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 177-278 8.44e-03

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


The actual alignment was detected with superfamily member pfam00530:

Pssm-ID: 459844  Cd Length: 98  Bit Score: 35.81  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002 177 GLRCTGVVEFYNGSRGGTILykakARPVDL--GNLICKSLQCGSFLTHLSRIETAGTpapaelrdPRPLPIrWeAQNGSC 254
Cdd:pfam00530   2 SSPCEGRVEVYHNGSWGTVC----DDGWDLrdAHVVCRQLGCGGAVSAPSGCSYFGP--------GSTGPI-W-LDDVRC 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2000186002 255 ----TSLQQCFQKTTVQEG---SQALAVVCS 278
Cdd:pfam00530  68 sgneTSLWQCPHRPWGNHNcshSEDAGVICS 98
 
Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 46-143 3.02e-13

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 65.83  E-value: 3.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002   46 VMLSGSNSKCQGLVEVQMNGM-KTVCSSSWrlsqdlwkNANEASTVCQQLGCGNPLALGHLTLWNRPKNQIL-----CQG 119
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQwGTVCDDGW--------DLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWldnvrCSG 72

                           90       100
                   ....*....|....*....|....*....
gi 2000186002  120 PPWSFSNCSTSSLGQ--CL---PLSLVCL 143
Cdd:smart00202  73 TEASLSDCPHSGWGShnCShgeDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 51-134 3.62e-08

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 51.22  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002  51 SNSKCQGLVEVQMNGM-KTVCSSSWRLsqdlwknaNEASTVCQQLGCGNPL-ALGHLTLWNRPKNQ------ILCQGPPW 122
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSwGTVCDDGWDL--------RDAHVVCRQLGCGGAVsAPSGCSYFGPGSTGpiwlddVRCSGNET 72

                          90
                  ....*....|..
gi 2000186002 123 SFSNCSTSSLGQ 134
Cdd:pfam00530  73 SLWQCPHRPWGN 84
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 287-368 4.16e-04

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 39.63  E-value: 4.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002  287 RLVGGSSVCEGIAEVRQRSQWAALCDSSaargpgrWEE-----LCQEQQCGNLISF--HVMDADRTSP----GVLCT-QE 354
Cdd:smart00202   2 RLVGGGSPCEGRVEVYHNGQWGTVCDDG-------WDLrdanvVCRQLGFGGAVSAsgSAYFGPGSGPiwldNVRCSgTE 74

                           90
                   ....*....|....*
gi 2000186002  355 K-LSQCYQLQKKTHC 368
Cdd:smart00202  75 AsLSDCPHSGWGSHN 89
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 177-278 8.44e-03

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 35.81  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002 177 GLRCTGVVEFYNGSRGGTILykakARPVDL--GNLICKSLQCGSFLTHLSRIETAGTpapaelrdPRPLPIrWeAQNGSC 254
Cdd:pfam00530   2 SSPCEGRVEVYHNGSWGTVC----DDGWDLrdAHVVCRQLGCGGAVSAPSGCSYFGP--------GSTGPI-W-LDDVRC 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2000186002 255 ----TSLQQCFQKTTVQEG---SQALAVVCS 278
Cdd:pfam00530  68 sgneTSLWQCPHRPWGNHNcshSEDAGVICS 98
 
Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 46-143 3.02e-13

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 65.83  E-value: 3.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002   46 VMLSGSNSKCQGLVEVQMNGM-KTVCSSSWrlsqdlwkNANEASTVCQQLGCGNPLALGHLTLWNRPKNQIL-----CQG 119
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQwGTVCDDGW--------DLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWldnvrCSG 72

                           90       100
                   ....*....|....*....|....*....
gi 2000186002  120 PPWSFSNCSTSSLGQ--CL---PLSLVCL 143
Cdd:smart00202  73 TEASLSDCPHSGWGShnCShgeDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 51-134 3.62e-08

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 51.22  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002  51 SNSKCQGLVEVQMNGM-KTVCSSSWRLsqdlwknaNEASTVCQQLGCGNPL-ALGHLTLWNRPKNQ------ILCQGPPW 122
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSwGTVCDDGWDL--------RDAHVVCRQLGCGGAVsAPSGCSYFGPGSTGpiwlddVRCSGNET 72

                          90
                  ....*....|..
gi 2000186002 123 SFSNCSTSSLGQ 134
Cdd:pfam00530  73 SLWQCPHRPWGN 84
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 287-368 4.16e-04

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 39.63  E-value: 4.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002  287 RLVGGSSVCEGIAEVRQRSQWAALCDSSaargpgrWEE-----LCQEQQCGNLISF--HVMDADRTSP----GVLCT-QE 354
Cdd:smart00202   2 RLVGGGSPCEGRVEVYHNGQWGTVCDDG-------WDLrdanvVCRQLGFGGAVSAsgSAYFGPGSGPiwldNVRCSgTE 74

                           90
                   ....*....|....*
gi 2000186002  355 K-LSQCYQLQKKTHC 368
Cdd:smart00202  75 AsLSDCPHSGWGSHN 89
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 177-278 8.44e-03

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 35.81  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186002 177 GLRCTGVVEFYNGSRGGTILykakARPVDL--GNLICKSLQCGSFLTHLSRIETAGTpapaelrdPRPLPIrWeAQNGSC 254
Cdd:pfam00530   2 SSPCEGRVEVYHNGSWGTVC----DDGWDLrdAHVVCRQLGCGGAVSAPSGCSYFGP--------GSTGPI-W-LDDVRC 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2000186002 255 ----TSLQQCFQKTTVQEG---SQALAVVCS 278
Cdd:pfam00530  68 sgneTSLWQCPHRPWGNHNcshSEDAGVICS 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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