|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
203-552 |
6.65e-122 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 367.72 E-value: 6.65e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWQKRNAapppsnteappgetrteag 282
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNG------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenld 362
Cdd:cd17946 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatcKAYPKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVV 442
Cdd:cd17946 62 ------------------VGGKQKPLRALILTPTRELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVV 123
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 443 ATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQ--YNPKRQTLVFSATLTLVHQAPARI 520
Cdd:cd17946 124 ATPGRLWELIQEGNEHLANLKSLRFLVLDEADRMLEKGHFAELEKILELLNKDRagKKRKRQTFVFSATLTLDHQLPLKL 203
|
330 340 350
....*....|....*....|....*....|..
gi 9966805 521 LHKKHTKKMDKTAKLDLLMQKIGMRGKPKVID 552
Cdd:cd17946 204 NSKKKKKKKEKKQKLELLIEKVGFRKKPKVID 235
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
195-730 |
9.87e-96 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 306.30 E-value: 9.87e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 195 KDLFVPRPVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLqwqkrnaapppsntEAPP 274
Cdd:COG0513 5 ADLGLSPPLLKALAELGYTTPTPIQAQAI-PLILAGRDVLGQAQTGTGKTAAFLLPLLQRLD--------------PSRP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 275 GETRteagaetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqn 354
Cdd:COG0513 70 RAPQ---------------------------------------------------------------------------- 73
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 355 eneeenldkeqtgnlkqelddksatckaypkrpllGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRML 434
Cdd:COG0513 74 -----------------------------------ALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRAL 118
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 435 NRRPEIVVATPGRLWELIKEKHYhlrNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNdsqynPKRQTLVFSATLtlvh 514
Cdd:COG0513 119 KRGVDIVVATPGRLLDLIERGAL---DLSGVETLVLDEADRMLDMGFIEDIERILKLLP-----KERQTLLFSATM---- 186
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 515 qaPARILHkkhtkkmdktakldlLMQKIgMRgKPKVIDLTRNEATVETLTETKIHCETDEKDFYLYYFLMQY-PGRSLVF 593
Cdd:COG0513 187 --PPEIRK---------------LAKRY-LK-NPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEdPERAIVF 247
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 594 ANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVH 673
Cdd:COG0513 248 CNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVH 327
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9966805 674 RSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKD---EDIPLF-PVQTKYMDVVKERIR 730
Cdd:COG0513 328 RIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKieeEELPGFePVEEKRLERLKPKIK 388
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
203-511 |
3.08e-52 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 180.72 E-value: 3.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWQKRNAAPPpsnteappgetrteag 282
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAI-PLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRGP---------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdQALlfgdddagegpsslirekpvpkqneneeenld 362
Cdd:cd00268 64 ---------------------------------------------QAL-------------------------------- 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrpllglVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVV 442
Cdd:cd00268 67 -----------------------------VLAPTRELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVV 117
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9966805 443 ATPGRLWELIKEKHyhlRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:cd00268 118 GTPGRLLDLIERGK---LDLSNVKYLVLDEADRMLDMGFEEDVEKILSAL-----PKDRQTLLFSATLP 178
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
204-702 |
1.86e-49 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 180.91 E-value: 1.86e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 204 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAVLQWQKRNAAPPpsnteappgetRTeaga 283
Cdd:PRK11192 13 LEALQDKGYTRPTAIQAEAIPPALDGR-DVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPP-----------RI---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 284 etrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenldk 363
Cdd:PRK11192 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 364 eqtgnlkqelddksatckaypkrpllgLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVA 443
Cdd:PRK11192 77 ---------------------------LILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVA 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 444 TPGRLWELIKEKHYhlrNLRQLRCLVVDEADRMVEKGhFAELSQllEMLNDSQYnpKRQTLVFSATL--TLVHQAPARIL 521
Cdd:PRK11192 130 TPGRLLQYIKEENF---DCRAVETLILDEADRMLDMG-FAQDIE--TIAAETRW--RKQTLLFSATLegDAVQDFAERLL 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 522 hkkhtkkmDKTAKLDllmqkigmrgkpkvIDLTRNEatvetltETKIH-----CETDEKDFYLYYFLMQYP--GRSLVFA 594
Cdd:PRK11192 202 --------NDPVEVE--------------AEPSRRE-------RKKIHqwyyrADDLEHKTALLCHLLKQPevTRSIVFV 252
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 595 NSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHR 674
Cdd:PRK11192 253 RTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHR 332
|
490 500
....*....|....*....|....*...
gi 9966805 675 SGRTARATNEGLSLMLIGPEDVINFKKI 702
Cdd:PRK11192 333 IGRTGRAGRKGTAISLVEAHDHLLLGKI 360
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
391-695 |
4.28e-49 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 180.38 E-value: 4.28e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFT-GIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWElikekhyHLR----NLRQL 465
Cdd:PRK11776 76 LVLCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILD-------HLRkgtlDLDAL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 466 RCLVVDEADRMVEKGHFAELSQLLemlndSQYNPKRQTLVFSATLtlvhqaPARILHkkhtkkmdktakldlLMQKIgMR 545
Cdd:PRK11776 149 NTLVLDEADRMLDMGFQDAIDAII-----RQAPARRQTLLFSATY------PEGIAA---------------ISQRF-QR 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 546 gKPKVIdltrneaTVETLTE-TKI-----HCETDEKDFYLYYFLMQY-PGRSLVFANSISCIKRLSGLLKVLDIMPLTLH 618
Cdd:PRK11776 202 -DPVEV-------KVESTHDlPAIeqrfyEVSPDERLPALQRLLLHHqPESCVVFCNTKKECQEVADALNAQGFSALALH 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9966805 619 ACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPED 695
Cdd:PRK11776 274 GDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEE 350
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
563-691 |
1.18e-45 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 159.98 E-value: 1.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 563 LTETKIHCETDEKDFYLYYFLMQ--YPGRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCV 640
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEklKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 9966805 641 LLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLI 691
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
172-708 |
6.80e-41 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 157.00 E-value: 6.80e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 172 KVPKKAKTWIPE--VHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAI 249
Cdd:PRK01297 65 RKPKPASLWKLEdfVVEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGH-DAIGRAQTGTGKTAAFLI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 250 PMIHAVLQwqkrnaAPPPsnteappgetrteagaETRSPGkaeaesdalpddtviesealpsdiaaEARAktggtvsdqa 329
Cdd:PRK01297 144 SIINQLLQ------TPPP----------------KERYMG--------------------------EPRA---------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 330 llfgdddagegpsslirekpvpkqneneeenldkeqtgnlkqelddksatckaypkrpllgLVLTPTRELAVQVKQHIDA 409
Cdd:PRK01297 166 -------------------------------------------------------------LIIAPTRELVVQIAKDAAA 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 410 VARFTGIKTAILVGGMSTQKQQRMLNRR-PEIVVATPGRLWELIKEKHYHlrnLRQLRCLVVDEADRMVEKGHFAELSQL 488
Cdd:PRK01297 185 LTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVH---LDMVEVMVLDEADRMLDMGFIPQVRQI 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 489 LEMlndSQYNPKRQTLVFSATLTlvhqaparilhkkhtkkmdktakLDLLMQKIGMRGKPKVIDLTRNEATVETLTETKI 568
Cdd:PRK01297 262 IRQ---TPRKEERQTLLFSATFT-----------------------DDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVY 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 569 HCETDEKDFYLYYFLMQYP-GRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVA 647
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPwERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVA 395
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9966805 648 ARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKK 708
Cdd:PRK01297 396 GRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGR 456
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
196-702 |
8.27e-41 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 155.51 E-value: 8.27e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 196 DLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAVLQwqkrNAAPPPSNTEAPpg 275
Cdd:PRK04837 12 DFALHPQVVEALEKKGFHNCTPIQALALPLTLAGR-DVAGQAQTGTGKTMAFLTATFHYLLS----HPAPEDRKVNQP-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 276 etrteagaetrspgkaeaesdalpddtviesealpsdiaaeaRAktggtvsdqallfgdddagegpsslirekpvpkqne 355
Cdd:PRK04837 85 ------------------------------------------RA------------------------------------ 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 356 neeenldkeqtgnlkqelddksatckaypkrpllgLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLN 435
Cdd:PRK04837 87 -----------------------------------LIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLE 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 436 RRPEIVVATPGRLWELIKEKHYhlrNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQynpKRQTLVFSATLTLvhq 515
Cdd:PRK04837 132 SGVDILIGTTGRLIDYAKQNHI---NLGAIQVVVLDEADRMFDLGFIKDIRWLFRRMPPAN---QRLNMLFSATLSY--- 202
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 516 aPARILHKKHtkkMDKtakldllmqkigmrgkPKVIDLTRNEATVETLTETKIHCETDEKdFYLYYFLMQ--YPGRSLVF 593
Cdd:PRK04837 203 -RVRELAFEH---MNN----------------PEYVEVEPEQKTGHRIKEELFYPSNEEK-MRLLQTLIEeeWPDRAIIF 261
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 594 ANSI-SCIKRLS---------GLLKVlDIMpltlhacmhQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQ 663
Cdd:PRK04837 262 ANTKhRCEEIWGhlaadghrvGLLTG-DVA---------QKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYD 331
|
490 500 510
....*....|....*....|....*....|....*....
gi 9966805 664 VPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKI 702
Cdd:PRK04837 332 LPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAI 370
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
166-713 |
9.14e-41 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 158.01 E-value: 9.14e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 166 SQSTAAKVPKKAKTWIPEVHDQKADVSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTL 245
Cdd:PTZ00110 104 SSKEVDEIRKEKEITIIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGR-DMIGIAETGSGKTL 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 246 AFAIP-MIHavlqwqkrnaapppsnteappgetrteagaetrspgkaeaesdalpddtviesealpsdiaaearaktggt 324
Cdd:PTZ00110 183 AFLLPaIVH----------------------------------------------------------------------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 325 VSDQALLfgddDAGEGPsslirekpvpkqneneeenldkeqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVK 404
Cdd:PTZ00110 192 INAQPLL----RYGDGP-----------------------------------------------IVLVLAPTRELAEQIR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 405 QHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKhyhLRNLRQLRCLVVDEADRMVEKGHFAE 484
Cdd:PTZ00110 221 EQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESN---VTNLRRVTYLVLDEADRMLDMGFEPQ 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 485 LSQLLemlndSQYNPKRQTLVFSATLTLVHQAPARILHKK---------------HTKKM--------DKTAKLDLLMQK 541
Cdd:PTZ00110 298 IRKIV-----SQIRPDRQTLMWSATWPKEVQSLARDLCKEepvhvnvgsldltacHNIKQevfvveehEKRGKLKMLLQR 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 542 IgMRGKPKVIdltrneatvetltetkIHCETDEKdfylyyflmqypgrslvfANSISCIKRLSGllkvldiMP-LTLHAC 620
Cdd:PTZ00110 373 I-MRDGDKIL----------------IFVETKKG------------------ADFLTKELRLDG-------WPaLCIHGD 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 621 MHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFK 700
Cdd:PTZ00110 411 KKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLAR 490
|
570
....*....|....
gi 9966805 701 KIYKTLKK-DEDIP 713
Cdd:PTZ00110 491 DLVKVLREaKQPVP 504
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
194-511 |
9.56e-40 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 145.92 E-value: 9.56e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 194 WKDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAVLqwqkrnaapppsntEAP 273
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGR-DIIGLAETGSGKTAAFALPILQALL--------------ENP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 274 pgetrteagaetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkq 353
Cdd:cd17954 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 354 neneeenldkeqtgnlkqelddksatckaypkRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRM 433
Cdd:cd17954 67 --------------------------------QRFFALVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIA 114
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 434 LNRRPEIVVATPGRLWelikekhYHLRN-----LRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPK-RQTLVFS 507
Cdd:cd17954 115 LAKKPHVIVATPGRLV-------DHLENtkgfsLKSLKFLVMDEADRLLNMDFEPEIDKILKVI------PReRTTYLFS 181
|
....
gi 9966805 508 ATLT 511
Cdd:cd17954 182 ATMT 185
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
203-511 |
1.13e-38 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 142.39 E-value: 1.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAVLqwqkrnaapppsnteappgeTRTEAG 282
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGK-DICASAVTGSGKTAAFLLPILERLL--------------------YRPKKK 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 AETRspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenld 362
Cdd:cd17947 60 AATR---------------------------------------------------------------------------- 63
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrpllGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVV 442
Cdd:cd17947 64 ---------------------------VLVLVPTRELAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVI 116
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9966805 443 ATPGRLWElikekhyHLRN-----LRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPK-RQTLVFSATLT 511
Cdd:cd17947 117 ATPGRLID-------HLRNspsfdLDSIEILVLDEADRMLEEGFADELKEILRLC------PRtRQTMLFSATMT 178
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
369-713 |
1.34e-37 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 146.88 E-value: 1.34e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 369 LKQELDDKSATCKAypKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRL 448
Cdd:PRK10590 59 LLQHLITRQPHAKG--RRPVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 449 WELikeKHYHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLTLVHQAPA-RILHK---- 523
Cdd:PRK10590 137 LDL---EHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLAKL-----PAKRQNLLFSATFSDDIKALAeKLLHNplei 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 524 -------------KHTKKMDKTAKLDLLMQKIGMRGKPKVIDLTRNEATVETLTETKihcetdEKDfylyyflmqypgrs 590
Cdd:PRK10590 209 evarrntaseqvtQHVHFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQL------NKD-------------- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 591 lvfansiscikrlsgllkvlDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEI 670
Cdd:PRK10590 269 --------------------GIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPED 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 9966805 671 YVHRSGRTARA--TNEGLSLMLIGPEDVInfKKIYKTLKKdeDIP 713
Cdd:PRK10590 329 YVHRIGRTGRAaaTGEALSLVCVDEHKLL--RDIEKLLKK--EIP 369
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
195-511 |
9.06e-36 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 134.27 E-value: 9.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 195 KDLFVPRPVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAvlqwqkrnaapppsnteapp 274
Cdd:cd17955 2 EDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGR-DVIGGAKTGSGKTAAFALPILQR-------------------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 275 getrteagaetrspgkaeaesdaLPDDtviesealPSDIAAearaktggtvsdqallfgdddagegpsslirekpvpkqn 354
Cdd:cd17955 61 -----------------------LSED--------PYGIFA--------------------------------------- 70
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 355 eneeenldkeqtgnlkqelddksatckaypkrpllgLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRML 434
Cdd:cd17955 71 ------------------------------------LVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALEL 114
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9966805 435 NRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:cd17955 115 SKRPHIVVATPGRLADHLRSSDDTTKVLSRVKFLVLDEADRLLTGSFEDDLATILSAL-----PPKRQTLLFSATLT 186
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
202-510 |
6.36e-34 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 129.35 E-value: 6.36e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 202 PVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVlqwqkrnaapppsnteappgetrtea 281
Cdd:cd17959 11 PLLRAIKKKGYKVPTPIQRKTI-PLILDGRDVVAMARTGSGKTAAFLIPMIEKL-------------------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 282 gaetrspgkaeaesdalpddtviesealpsdiaaEARAKTGGtvsdqallfgdddagegpsslIRekpvpkqneneeenl 361
Cdd:cd17959 64 ----------------------------------KAHSPTVG---------------------AR--------------- 73
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 362 dkeqtgnlkqelddksatckaypkrpllGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIV 441
Cdd:cd17959 74 ----------------------------ALILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDII 125
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9966805 442 VATPGRLWELIKEKHYhlrNLRQLRCLVVDEADRMVEKGhFAElsQLLEMLndSQYNPKRQTLVFSATL 510
Cdd:cd17959 126 IATPGRLLHLLVEMNL---KLSSVEYVVFDEADRLFEMG-FAE--QLHEIL--SRLPENRQTLLFSATL 186
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
384-685 |
7.34e-34 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 137.77 E-value: 7.34e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 384 PKRPLlGLVLTPTRELAVQVkqHIDAVaRF---TGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEkhYHLR 460
Cdd:PRK04537 82 PEDPR-ALILAPTRELAIQI--HKDAV-KFgadLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQ--HKVV 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 461 NLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDsqyNPKRQTLVFSATLTlvHqapaRILHKKHtKKMDKTAKLdllmq 540
Cdd:PRK04537 156 SLHACEICVLDEADRMFDLGFIKDIRFLLRRMPE---RGTRQTLLFSATLS--H----RVLELAY-EHMNEPEKL----- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 541 kigmrgkpkvidltrnEATVETLTETKIHCET-----DEKDFYLYYFLMQYPG-RSLVFANSISCIKRLSGLLKVLDIMP 614
Cdd:PRK04537 221 ----------------VVETETITAARVRQRIyfpadEEKQTLLLGLLSRSEGaRTMVFVNTKAFVERVARTLERHGYRV 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9966805 615 LTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEG 685
Cdd:PRK04537 285 GVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEG 355
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
196-762 |
3.93e-33 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 136.13 E-value: 3.93e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 196 DLFVPRPVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHavlqwqkrnaapppsnteappg 275
Cdd:PRK11634 10 DLGLKAPILEALNDLGYEKPSPIQAECI-PHLLNGRDVLGMAQTGSGKTAAFSLPLLH---------------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 276 etrteagaetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqne 355
Cdd:PRK11634 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 356 neeenldkeqtgNLKQELddksatckaypKRPLLgLVLTPTRELAVQVKQhidAVARFT----GIKTAILVGGMSTQKQQ 431
Cdd:PRK11634 67 ------------NLDPEL-----------KAPQI-LVLAPTRELAVQVAE---AMTDFSkhmrGVNVVALYGGQRYDVQL 119
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 432 RMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQlrcLVVDEADRMVEKGHFAELSQLLemlndSQYNPKRQTLVFSATLT 511
Cdd:PRK11634 120 RALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSG---LVLDEADEMLRMGFIEDVETIM-----AQIPEGHQTALFSATMP 191
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 512 lvhQAPARIlhkkhTKKMDKTAKlDLLMQKiGMRGKP-------KVIDLTRNEATVETLtetkihcetDEKDFylyyflm 584
Cdd:PRK11634 192 ---EAIRRI-----TRRFMKEPQ-EVRIQS-SVTTRPdisqsywTVWGMRKNEALVRFL---------EAEDF------- 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 585 qypGRSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEqfaRLEDC---VLLATDVAARGLDIPKVQHVIH 661
Cdd:PRK11634 246 ---DAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLE---RLKDGrldILIATDVAARGLDVERISLVVN 319
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 662 YQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKIYKTLKKdeDIPlfPVQTKYMDVVKERiRLAR-------Q 734
Cdd:PRK11634 320 YDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKL--TIP--EVELPNAELLGKR-RLEKfaakvqqQ 394
|
570 580
....*....|....*....|....*...
gi 9966805 735 IEKSEYRNFQACLHNSWIEQAAAALEIE 762
Cdd:PRK11634 395 LESSDLDQYRALLAKIQPTAEGEELDLE 422
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
203-510 |
1.17e-30 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 120.00 E-value: 1.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLqwqKRNAAPPPSNTEAppgetrteag 282
Cdd:cd17964 5 LLKALTRMGFETMTPVQQKTLKPILSTGDDVLARAKTGTGKTLAFLLPAIQSLL---NTKPAGRRSGVSA---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenld 362
Cdd:cd17964 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrpllgLVLTPTRELAVQVKQHIDAVARF-TGIKTAILVGGMSTQKQ-QRMLNRRPEI 440
Cdd:cd17964 72 ----------------------------LIISPTRELALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAElNRLRRGRPDI 123
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 441 VVATPGRLWELIKEKHYhLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQYNPkRQTLVFSATL 510
Cdd:cd17964 124 LVATPGRLIDHLENPGV-AKAFTDLDYLVLDEADRLLDMGFRPDLEQILRHLPEKNADP-RQTLLFSATV 191
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
391-702 |
1.18e-30 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 125.32 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRqlrCLVV 470
Cdd:PTZ00424 100 LILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLK---LFIL 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 471 DEADRMVEKGHFAELSQLLEMLNdsqynPKRQTLVFSATLtlvhqaPARILHKkhtkkmdkTAKLdllmqkigMRgKPKV 550
Cdd:PTZ00424 177 DEADEMLSRGFKGQIYDVFKKLP-----PDVQVALFSATM------PNEILEL--------TTKF--------MR-DPKR 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 551 IDLTRNEATVETLTETKIHCETDE------KDFYLYYFLMQypgrSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQK 624
Cdd:PTZ00424 229 ILVKKDELTLEGIRQFYVAVEKEEwkfdtlCDLYETLTITQ----AIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQK 304
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9966805 625 QRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFKKI 702
Cdd:PTZ00424 305 DRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI 382
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
216-511 |
7.60e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 116.19 E-value: 7.60e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 216 TPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIhavlqwqkrnaapppsnteappgetrteagaetrspgkaeaes 295
Cdd:pfam00270 1 TPIQAEAIPAILEGR-DVLVQAPTGSGKTLAFLLPAL------------------------------------------- 36
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 296 dalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenldkeqtgnlkQELDD 375
Cdd:pfam00270 37 ---------------------------------------------------------------------------EALDK 41
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 376 KSATCKAypkrpllgLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLnRRPEIVVATPGRLWELIKEK 455
Cdd:pfam00270 42 LDNGPQA--------LVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER 112
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 9966805 456 hyhlRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:pfam00270 113 ----KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL-----PKKRQILLLSATLP 159
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
191-523 |
2.08e-29 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 116.71 E-value: 2.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 191 VSAWKDLFVPRPVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLqwqkrnAAPPPSnt 270
Cdd:cd17953 11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQAL-PAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIK------DQRPVK-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 271 eappgetrteagaetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddAGEGPsslirekpv 350
Cdd:cd17953 82 ------------------------------------------------------------------PGEGP--------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 351 pkqneneeenldkeqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQ 430
Cdd:cd17953 87 --------------------------------------IGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQ 128
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 431 QRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEmlndsQYNPKRQTLVFSATL 510
Cdd:cd17953 129 IAELKRGAEIVVCTPGRMIDILTANNGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVN-----NIRPDRQTVLFSATF 203
|
330
....*....|....
gi 9966805 511 -TLVHQAPARILHK 523
Cdd:cd17953 204 pRKVEALARKVLHK 217
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
385-707 |
4.02e-29 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 122.59 E-value: 4.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 385 KRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEkhyHLRNLRQ 464
Cdd:PLN00206 194 QRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSK---HDIELDN 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 465 LRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPKRQTLVFSATLTlvhqaparilhkKHTKKMDKTAKLDLLMQKIGM 544
Cdd:PLN00206 271 VSVLVLDEVDCMLERGFRDQVMQIFQAL------SQPQVLLFSATVS------------PEVEKFASSLAKDIILISIGN 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 545 RGKPkvidltrNEAtvetLTETKIHCETDEKDFYLYYFLM---QYPGRSLVFANSISCIKRLS-GLLKVLDIMPLTLHAC 620
Cdd:PLN00206 333 PNRP-------NKA----VKQLAIWVETKQKKQKLFDILKskqHFKPPAVVFVSSRLGADLLAnAITVVTGLKALSIHGE 401
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 621 MHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVINFK 700
Cdd:PLN00206 402 KSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFP 481
|
....*..
gi 9966805 701 KIYKTLK 707
Cdd:PLN00206 482 ELVALLK 488
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
203-509 |
8.78e-28 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 111.31 E-value: 8.78e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIP-MIHavlqwqkrnaapppsnteappgetrtea 281
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGR-DMVGIAQTGSGKTLAFLLPaIVH---------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 282 gaetrspgkaeaesdalpddtviesealpsdiaaearaktggtVSDQALLfgddDAGEGPsslirekpvpkqneneeenl 361
Cdd:cd17966 52 -------------------------------------------INAQPPL----ERGDGP-------------------- 64
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 362 dkeqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIV 441
Cdd:cd17966 65 ---------------------------IVLVLAPTRELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEIC 117
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9966805 442 VATPGRLWELIKEKHyhlRNLRQLRCLVVDEADRMVEKGHFAELSQLLemlndSQYNPKRQTLVFSAT 509
Cdd:cd17966 118 IATPGRLIDFLDQGK---TNLRRVTYLVLDEADRMLDMGFEPQIRKIV-----DQIRPDRQTLMWSAT 177
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
211-510 |
1.87e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 111.04 E-value: 1.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 211 GFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQwqkrnaAPPPSNTEAPPgetrteagaetrspgk 290
Cdd:cd17967 19 GYTKPTPVQKYAI-PIILAGRDLMACAQTGSGKTAAFLLPIISKLLE------DGPPSVGRGRR---------------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 291 aeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenldkeqtgnlk 370
Cdd:cd17967 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 371 qelddksatcKAYPKrpllGLVLTPTRELAVQvkqhIDAVAR-F---TGIKTAILVGGMSTQKQQRMLNRRPEIVVATPG 446
Cdd:cd17967 76 ----------KAYPS----ALILAPTRELAIQ----IYEEARkFsyrSGVRSVVVYGGADVVHQQLQLLRGCDILVATPG 137
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9966805 447 RLWELIkEKHYhlRNLRQLRCLVVDEADRMVEKGhFaeLSQLLEMLNDSQYNPK--RQTLVFSATL 510
Cdd:cd17967 138 RLVDFI-ERGR--ISLSSIKFLVLDEADRMLDMG-F--EPQIRKIVEHPDMPPKgeRQTLMFSATF 197
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
203-511 |
7.06e-27 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 109.33 E-value: 7.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAVlqwqkrnaapppsnTEAPPgetrteag 282
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNR-DIIGIAETGSGKTAAFLIPLLVYI--------------SRLPP-------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aetrspgkaeaesdaLPDDTVIEsealpsdiaaearaktggtvsdqallfgdddageGPsslirekpvpkqneneeenld 362
Cdd:cd17945 58 ---------------LDEETKDD----------------------------------GP--------------------- 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVV 442
Cdd:cd17945 68 --------------------------YALILAPTRELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILI 121
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 443 ATPGRLWELIkEKHYHLrnLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQYNPK---------------RQTLVFS 507
Cdd:cd17945 122 ATPGRLLDCL-ERRLLV--LNQCTYVVLDEADRMIDMGFEPQVTKILDAMPVSNKKPDteeaeklaasgkhryRQTMMFT 198
|
....
gi 9966805 508 ATLT 511
Cdd:cd17945 199 ATMP 202
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
200-511 |
2.91e-26 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 107.28 E-value: 2.91e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 200 PRpVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAVLQwqkrnaapppsnteappgetrt 279
Cdd:cd17961 3 PR-LLKAIAKLGWEKPTLIQSKAIPLALEGK-DILARARTGSGKTAAYALPIIQKILK---------------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 280 eagaetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneee 359
Cdd:cd17961 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 360 nldkeqtgnLKQELDDKSATckaypkrplLGLVLTPTRELAVQVKQHIDAVARFTG--IKTAILVGGMSTQKQQRMLNRR 437
Cdd:cd17961 59 ---------AKAESGEEQGT---------RALILVPTRELAQQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEK 120
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9966805 438 PEIVVATPGRLWELIKEKhyHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPKR-QTLVFSATLT 511
Cdd:cd17961 121 PDIVVSTPARLLSHLESG--SLLLLSTLKYLVIDEADLVLSYGYEEDLKSLLSYL------PKNyQTFLMSATLS 187
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
203-510 |
3.50e-26 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 106.73 E-value: 3.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMI-Havlqwqkrnaapppsnteappgetrtea 281
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGR-DMIGIAKTGSGKTAAFIWPMLvH---------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 282 gaetrspgkaeaesdalpddtviesealpsdiaaearaktggtVSDQALLfgddDAGEGPsslirekpvpkqneneeenl 361
Cdd:cd17952 52 -------------------------------------------IMDQREL----EKGEGP-------------------- 64
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 362 dkeqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIV 441
Cdd:cd17952 65 ---------------------------IAVIVAPTRELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIV 117
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9966805 442 VATPGRLWELIKEKhyhLRNLRQLRCLVVDEADRMVEKGhFAelSQLLEMLNdsQYNPKRQTLVFSATL 510
Cdd:cd17952 118 VATPGRLIDMVKKK---ATNLQRVTYLVLDEADRMFDMG-FE--YQVRSIVG--HVRPDRQTLLFSATF 178
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
574-681 |
2.25e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 101.13 E-value: 2.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 574 EKDFYLYYFLMQYPG-RSLVFANSISCIKrLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLD 652
Cdd:pfam00271 1 EKLEALLELLKKERGgKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100
....*....|....*....|....*....
gi 9966805 653 IPKVQHVIHYQVPRTSEIYVHRSGRTARA 681
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRA 108
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
390-511 |
5.11e-24 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 100.48 E-value: 5.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 390 GLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQlrcLV 469
Cdd:cd17939 68 ALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKM---FV 144
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 9966805 470 VDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:cd17939 145 LDEADEMLSRGFKDQIYDIFQFL-----PPETQVVLFSATMP 181
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
381-511 |
3.28e-23 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 98.42 E-value: 3.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 381 KAYPKRP-LLGLVLTPTRELAVQvkqhIDAVAR------FTGIKTAILVGGMSTQKQQRMLNR-RPEIVVATPGRLWELI 452
Cdd:cd17960 56 KANLKKGqVGALIISPTRELATQ----IYEVLQsflehhLPKLKCQLLIGGTNVEEDVKKFKRnGPNILVGTPGRLEELL 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 453 KEKHyHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPK-RQTLVFSATLT 511
Cdd:cd17960 132 SRKA-DKVKVKSLEVLVLDEADRLLDLGFEADLNRILSKL------PKqRRTGLFSATQT 184
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
204-511 |
3.56e-23 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 98.13 E-value: 3.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 204 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIhavlqwqkrnaapppsnteappgetrteaga 283
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGR-DILGAAKTGSGKTLAFLVPLL------------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 284 etrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeENLDK 363
Cdd:cd17941 50 ---------------------------------------------------------------------------EKLYR 54
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 364 EQTGnlkqELDDKSAtckaypkrpllgLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRpEIVVA 443
Cdd:cd17941 55 ERWT----PEDGLGA------------LIISPTRELAMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINRM-NILVC 117
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9966805 444 TPGRLWELIKEKHYHlrNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:cd17941 118 TPGRLLQHMDETPGF--DTSNLQMLVLDEADRILDMGFKETLDAIVENL-----PKSRQTLLFSATQT 178
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
391-510 |
5.94e-23 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 97.39 E-value: 5.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFT---GIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKhyhLRNLRQLRC 467
Cdd:cd17938 64 LILEPSRELAEQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTG---KLDLSSVRF 140
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 9966805 468 LVVDEADRMVEKGHFAELSQLLEMLNDSQYNPKR-QTLVFSATL 510
Cdd:cd17938 141 FVLDEADRLLSQGNLETINRIYNRIPKITSDGKRlQVIVCSATL 184
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
601-681 |
7.22e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 93.05 E-value: 7.22e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 601 KRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTAR 680
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
.
gi 9966805 681 A 681
Cdd:smart00490 81 A 81
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
391-511 |
2.44e-22 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 95.64 E-value: 2.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQ-QRMLNRRPEIVVATPGRLWELIKEKHYHLRNlrqLRCLV 469
Cdd:smart00487 58 LVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLENDKLSLSN---VDLVI 134
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 9966805 470 VDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:smart00487 135 LDEAHRLLDGGFGDQLEKLLKLL-----PKNVQLLLLSATPP 171
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
384-511 |
3.85e-22 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 96.16 E-value: 3.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 384 PKRPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRML--------NRRPEIVVATPGRLWElikek 455
Cdd:cd17956 65 VVPRLRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLlvdtsgryLSRVDILVATPGRLVD----- 139
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9966805 456 hyHLRN-----LRQLRCLVVDEADRMVEKGHFAELSQLLE-----------------MLNDSQYNPkrQTLVFSATLT 511
Cdd:cd17956 140 --HLNStpgftLKHLRFLVIDEADRLLNQSFQDWLETVMKalgrptapdlgsfgdanLLERSVRPL--QKLLFSATLT 213
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
203-510 |
5.34e-22 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 94.71 E-value: 5.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWQKRnaapppsnteappgetrteag 282
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGL-PTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKK--------------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aetrspgkaeaesdalpddtvieseaLPSDiaaearaktggtvsdqallfgdddAGEGPsslirekpvpkqneneeenld 362
Cdd:cd17951 59 --------------------------LPFI------------------------KGEGP--------------------- 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVKQHIDAVAR------FTGIKTAILVGGMSTQKQQRMLNR 436
Cdd:cd17951 68 --------------------------YGLIVCPSRELARQTHEVIEYYCKalqeggYPQLRCLLCIGGMSVKEQLEVIRK 121
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9966805 437 RPEIVVATPGRLWELIKEKHYhlrNLRQLRCLVVDEADRMVEKGHFAELSQLLemlndSQYNPKRQTLVFSATL 510
Cdd:cd17951 122 GVHIVVATPGRLMDMLNKKKI---NLDICRYLCLDEADRMIDMGFEEDIRTIF-----SYFKGQRQTLLFSATM 187
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
204-520 |
9.79e-22 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 93.96 E-value: 9.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 204 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHAV--LQWQKRNAapppsnteappgetrtea 281
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGR-DVLGAAKTGSGKTLAFLIPAIELLykLKFKPRNG------------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 282 gaetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenl 361
Cdd:cd17942 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 362 dkeqTGnlkqelddksatckaypkrpllGLVLTPTRELAVQvkqhIDAVAR---FTGIKT-AILVGGMSTQKQQRMLNRR 437
Cdd:cd17942 63 ----TG----------------------VIIISPTRELALQ----IYGVAKellKYHSQTfGIVIGGANRKAEAEKLGKG 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 438 PEIVVATPGRLWElikekhyHLRN-----LRQLRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPK-RQTLVFSATLT 511
Cdd:cd17942 113 VNILVATPGRLLD-------HLQNtkgflYKNLQCLIIDEADRILEIGFEEEMRQIIKLL------PKrRQTMLFSATQT 179
|
....*....
gi 9966805 512 LVHQAPARI 520
Cdd:cd17942 180 RKVEDLARI 188
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
389-509 |
3.27e-21 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 94.26 E-value: 3.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 389 LGLVLTPTRELAVQVkqHIDAV--ARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELI-KEKhyhlRNLRQL 465
Cdd:cd18052 122 QALIVAPTRELANQI--FLEARkfSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIgRGK----ISLSKL 195
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 9966805 466 RCLVVDEADRMVEKGHFAELSQLLEMLNDSQYNpKRQTLVFSAT 509
Cdd:cd18052 196 KYLILDEADRMLDMGFGPEIRKLVSEPGMPSKE-DRQTLMFSAT 238
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
203-511 |
3.42e-20 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 89.57 E-value: 3.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVlqwqkrnaapppsnteappGETRTEAG 282
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAI-PILLHGRDLLACAPTGSGKTLAFLIPILQKL-------------------GKPRKKKG 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aetrspgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenld 362
Cdd:cd17957 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrpLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMS-TQKQQRMLNRRPEIV 441
Cdd:cd17957 61 -------------------------LRALILAPTRELASQIYRELLKLSKGTGLRIVLLSKSLEaKAKDGPKSITKYDIL 115
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 442 VATPGRLWELIKEKHYHLRNLRQlrcLVVDEADRMVEKGhFAElsQLLEMLNDSQyNPKRQTLVFSATLT 511
Cdd:cd17957 116 VSTPLRLVFLLKQGPIDLSSVEY---LVLDEADKLFEPG-FRE--QTDEILAACT-NPNLQRSLFSATIP 178
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
210-511 |
5.39e-20 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 89.18 E-value: 5.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 210 LGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWQKRnaapppsnteappgetrteagaETRSPG 289
Cdd:cd17949 9 MGIEKPTAIQKLAI-PVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPR----------------------VDRSDG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 290 kaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenldkeqtgnl 369
Cdd:cd17949 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 370 kqelddksatckaypkrpLLGLVLTPTRELAVQVKQHIDAVAR-FTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRL 448
Cdd:cd17949 66 ------------------TLALVLVPTRELALQIYEVLEKLLKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRL 127
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9966805 449 WelikekhYHLRN-----LRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQYN--------PKRQTLVFSATLT 511
Cdd:cd17949 128 L-------DHLKNtqsfdVSNLRWLVLDEADRLLDMGFEKDITKILELLDDKRSKaggekskpSRRQTVLVSATLT 196
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
391-511 |
7.05e-20 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 88.94 E-value: 7.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARF-TGIKTAILVGGMSTQKQQRML-NRRPEIVVATPGRLWELIKEKHYhlrNLRQLRCL 468
Cdd:cd17950 74 LVICHTRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLkNKCPHIVVGTPGRILALVREKKL---KLSHVKHF 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 9966805 469 VVDEADRMVEKghfaelsqlLEMLNDSQ-----YNPKRQTLVFSATLT 511
Cdd:cd17950 151 VLDECDKMLEQ---------LDMRRDVQeifraTPHDKQVMMFSATLS 189
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
386-509 |
1.32e-19 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 87.70 E-value: 1.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 386 RPLLGLVLTPTRELAVQVKQHIDAVA-RFTGIKTAILVGGMSTQKQQRMLNrRPEIVVATPGRLWELIKEkhyHLRNLRQ 464
Cdd:cd17943 57 RHPQVLILAPTREIAVQIHDVFKKIGkKLEGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIEL---GALNVSH 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 9966805 465 LRCLVVDEADRMVEKGHFAELSQLLEMLndsqynPK-RQTLVFSAT 509
Cdd:cd17943 133 VRLFVLDEADKLMEGSFQKDVNWIFSSL------PKnKQVIAFSAT 172
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
390-509 |
7.45e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 85.32 E-value: 7.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 390 GLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMlnrRPEIVVATPGRLWELIKEKHYhlrNLRQLRCLV 469
Cdd:cd17963 67 ALCLAPTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPRGKKI---TAQIVIGTPGTVLDWLKKRQL---DLKKIKILV 140
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 9966805 470 VDEADRMVEKGHFAELSQ-LLEMLNDSQynpkrQTLVFSAT 509
Cdd:cd17963 141 LDEADVMLDTQGHGDQSIrIKRMLPRNC-----QILLFSAT 176
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
203-510 |
2.30e-18 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 85.11 E-value: 2.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 203 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQWqkrnaappPSNTEAPpgetrteag 282
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGI-PSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRY--------KLLAEGP--------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 283 aeTRSPgkaeaesdalpddtviesealpsdiaaearaktggtvsdqallfgdddagegpsslirekpvpkqneneeenld 362
Cdd:cd17948 63 --FNAP-------------------------------------------------------------------------- 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 363 keqtgnlkqelddksatckaypkrplLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMStqKQQRMLNRRPE--I 440
Cdd:cd17948 67 --------------------------RGLVITPSRELAEQIGSVAQSLTEGLGLKVKVITGGRT--KRQIRNPHFEEvdI 118
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9966805 441 VVATPGRLWELIKEkhyHLRNLRQLRCLVVDEADRMVEKGHFAELSQLLE--------MLNDSQYNPKRQTLVFSATL 510
Cdd:cd17948 119 LVATPGALSKLLTS---RIYSLEQLRHLVLDEADTLLDDSFNEKLSHFLRrfplasrrSENTDGLDPGTQLVLVSATM 193
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
391-509 |
2.32e-18 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 85.06 E-value: 2.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHyhlRNLRQLRCLVV 470
Cdd:cd18049 101 LVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVL 177
|
90 100 110
....*....|....*....|....*....|....*....
gi 9966805 471 DEADRMVEKGHFAELSQLLEmlndsQYNPKRQTLVFSAT 509
Cdd:cd18049 178 DEADRMLDMGFEPQIRKIVD-----QIRPDRQTLMWSAT 211
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
380-522 |
2.39e-18 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 84.14 E-value: 2.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 380 CKAYPKRPLlGLVLTPTRELAVQVKQHIDAVAR-FTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEkhyH 458
Cdd:cd17962 52 CLTEHRNPS-ALILTPTRELAVQIEDQAKELMKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQ---S 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9966805 459 LRNLRQLRCLVVDEADRMVEKGHFAELSQLLEMLNDSQynpkrQTLVFSATL-TLVHQAPARILH 522
Cdd:cd17962 128 SVELDNIKIVVVDEADTMLKMGFQQQVLDILENISHDH-----QTILVSATIpRGIEQLAGQLLQ 187
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
391-509 |
1.73e-17 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 83.52 E-value: 1.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHyhlRNLRQLRCLVV 470
Cdd:cd18050 139 LVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVL 215
|
90 100 110
....*....|....*....|....*....|....*....
gi 9966805 471 DEADRMVEKGHFAELSQLLEmlndsQYNPKRQTLVFSAT 509
Cdd:cd18050 216 DEADRMLDMGFEPQIRKIVD-----QIRPDRQTLMWSAT 249
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
386-511 |
3.00e-17 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 80.97 E-value: 3.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 386 RPLLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQl 465
Cdd:cd18045 66 RETQALILSPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKM- 144
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 9966805 466 rcLVVDEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLT 511
Cdd:cd18045 145 --LVLDEADEMLNKGFKEQIYDVYRYL-----PPATQVVLVSATLP 183
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
381-519 |
6.03e-17 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 81.24 E-value: 6.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 381 KAYPkrplLGLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLR 460
Cdd:cd18051 103 KQYP----LALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGLD 178
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9966805 461 NLRQlrcLVVDEADRMVEKGHFAELSQLLEMLNdsqyNPK---RQTLVFSATLTLVHQAPAR 519
Cdd:cd18051 179 YCKY---LVLDEADRMLDMGFEPQIRRIVEQDT----MPPtgeRQTLMFSATFPKEIQMLAR 233
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
391-509 |
3.93e-16 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 77.50 E-value: 3.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVArFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEkhyHLRNLRQLRCLVV 470
Cdd:cd17958 68 LVLTPTRELALQIEAECSKYS-YKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMN---NVINLKSITYLVL 143
|
90 100 110
....*....|....*....|....*....|....*....
gi 9966805 471 DEADRMVEKGhFAelSQLLEMLNDSQynPKRQTLVFSAT 509
Cdd:cd17958 144 DEADRMLDMG-FE--PQIRKILLDIR--PDRQTIMTSAT 177
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
390-509 |
1.90e-15 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 75.80 E-value: 1.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 390 GLVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHyhlRNLRQLRCLV 469
Cdd:cd17940 70 ALILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGV---ADLSHCKTLV 146
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 9966805 470 VDEADRMVEKghfaELSQLLEMLNDSqYNPKRQTLVFSAT 509
Cdd:cd17940 147 LDEADKLLSQ----DFQPIIEKILNF-LPKERQILLFSAT 181
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
391-522 |
2.59e-15 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 75.56 E-value: 2.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKEKHYHLRNLRQlrcLVV 470
Cdd:cd18046 71 LVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKM---FVL 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 9966805 471 DEADRMVEKGHFAELSQLLEMLndsqyNPKRQTLVFSATLtlvhqaPARILH 522
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKL-----PPDTQVVLLSATM------PNDVLE 188
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
391-509 |
5.28e-14 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 71.80 E-value: 5.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARftGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIKekHYHLrNLRQLRCLVV 470
Cdd:cd17944 68 LVLAPTRELANQVTKDFKDITR--KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQ--NGRL-DLTKLKHVVL 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 9966805 471 DEADRMVEKGhFAElsQLLEMLN-----DSQYNPkrQTLVFSAT 509
Cdd:cd17944 143 DEVDQMLDMG-FAE--QVEEILSvsykkDSEDNP--QTLLFSAT 181
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
391-809 |
1.43e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 64.66 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQvkqhidAVARFTGIKTAILVGGmstqkqqRMLNRRPEIVVATPGRLWelikeKHYHLRNLRQLRCLVV 470
Cdd:COG1061 131 LVLVPRRELLEQ------WAEELRRFLGDPLAGG-------GKKDSDAPITVATYQSLA-----RRAHLDELGDRFGLVI 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 471 -DEAdrmvekgHFAELSQLLEMLNdsqYNPKRQTLVFSAT---LTLVHQAPARILHKKHTKKMDKTAKLDLLmqkigmrG 546
Cdd:COG1061 193 iDEA-------HHAGAPSYRRILE---AFPAAYRLGLTATpfrSDGREILLFLFDGIVYEYSLKEAIEDGYL-------A 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 547 KPKVI----DLTRNEATVETLTET---KIHCETDEKDFYLYYFLMQYPG--RSLVFANSISCIKRLSGLLKVLDIMPLTL 617
Cdd:COG1061 256 PPEYYgirvDLTDERAEYDALSERlreALAADAERKDKILRELLREHPDdrKTLVFCSSVDHAEALAELLNEAGIRAAVV 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 618 HACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQvPRTSE-IYVHRSGRTARATNEG--LSLMLIGPE 694
Cdd:COG1061 336 TGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLR-PTGSPrEFIQRLGRGLRPAPGKedALVYDFVGN 414
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 695 DVINFKKIYKTLKKDE------------DIPLFPVQTKYMDVVKERIRLARQIEKSEYRNFQACLHNSWIEQAAAALEIE 762
Cdd:COG1061 415 DVPVLEELAKDLRDLAgyrvefldeeesEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALE 494
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 9966805 763 LEEDMYKGGKADQQEERRRQKQMKVLKKELRHLLSQPLFTESQKTKY 809
Cdd:COG1061 495 LLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLEL 541
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
391-509 |
4.11e-10 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 58.95 E-value: 4.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARfTGIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWELIkeKHYHLRNLRQLRCLVV 470
Cdd:cd00046 34 LVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEEREKNKLGDADIIIATPDMLLNLL--LREDRLFLKDLKLIIV 110
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 9966805 471 DEADRMVEKGHFAELSQLLEMlndsQYNPKR-QTLVFSAT 509
Cdd:cd00046 111 DEAHALLIDSRGALILDLAVR----KAGLKNaQVILLSAT 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
621-680 |
6.75e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 59.74 E-value: 6.75e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9966805 621 MHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQ-VPrtSEI-YVHRSGRTAR 680
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVP--SEIrSIQRKGRTGR 454
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
621-682 |
5.27e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 56.81 E-value: 5.27e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9966805 621 MHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQ-VPrtSEI-YVHRSGRTARAT 682
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEpVP--SEIrSIQRKGRTGRQE 468
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
621-680 |
1.19e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 51.59 E-value: 1.19e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9966805 621 MHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQvPRTSEI-YVHRSGRTAR 680
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYD-ASPSPIrMIQRMGRTGR 133
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
568-697 |
2.34e-07 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 54.38 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 568 IHCETDEKDFYLYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATdV 646
Cdd:COG0514 210 VPKPPDDKLAQLLDFLKEHPGGSgIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-I 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 9966805 647 A-ARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTARATNEGLSLMLIGPEDVI 697
Cdd:COG0514 289 AfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVA 340
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
589-662 |
3.58e-07 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 50.17 E-value: 3.58e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9966805 589 RSLVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDC--VLLATDVAARGLDIPKVQHVIHY 662
Cdd:cd18793 29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNLTAANRVILY 104
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
621-690 |
8.49e-07 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 49.13 E-value: 8.49e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 621 MHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRtARATNEGLSLML 690
Cdd:cd18802 74 MTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNSKYILMV 142
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
370-479 |
1.46e-06 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 50.45 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 370 KQELDDKSATCKAYPKRPLLG----LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQRMLN--RRPEIVVA 443
Cdd:cd17965 88 RQEQEPFEEAEEEYESAKDTGrprsVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLAfkGRIDILVT 167
|
90 100 110
....*....|....*....|....*....|....*.
gi 9966805 444 TPGRLWELIKEKhyhLRNLRQLRCLVVDEADRMVEK 479
Cdd:cd17965 168 TPGKLASLAKSR---PKILSRVTHLVVDEADTLFDR 200
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
640-691 |
2.19e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 46.16 E-value: 2.19e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 9966805 640 VLLATDVAARGLDIPKVQHVIHYQVPRTSEIYVHRSGRTAR-ATNEGLSLMLI 691
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
572-680 |
3.23e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 47.20 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 572 TDEKDFYLYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATdVA-AR 649
Cdd:cd18794 14 KDEKLDLLKRIKVEHLGGSgIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGM 92
|
90 100 110
....*....|....*....|....*....|.
gi 9966805 650 GLDIPKVQHVIHYQVPRTSEIYVHRSGRTAR 680
Cdd:cd18794 93 GIDKPDVRFVIHYSLPKSMESYYQESGRAGR 123
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
181-257 |
5.94e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 50.22 E-value: 5.94e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9966805 181 IPEVHDQKADVSAWkdlfVPRPVLRALSFLGFSAPTPIQALTLApAIRDKLDILGAAETGSGKTLAFAIPMIHAVLQ 257
Cdd:COG1205 27 IPAREARYAPWPDW----LPPELRAALKKRGIERLYSHQAEAIE-AARAGKNVVIATPTASGKSLAYLLPVLEALLE 98
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
391-510 |
1.39e-05 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 46.49 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQQrmlNRRPEIVVATPGRL-WELIKEKHyhlRNLRQLRCLV 469
Cdd:cd17921 50 VYIAPTRALVNQKEADLRERFGPLGKNVGLLTGDPSVNKLL---LAEADILVATPEKLdLLLRNGGE---RLIQDVRLVV 123
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 9966805 470 VDEAdRMVEKGHFAE-LSQLLEMLNdsQYNPKRQTLVFSATL 510
Cdd:cd17921 124 VDEA-HLIGDGERGVvLELLLSRLL--RINKNARFVGLSATL 162
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
628-738 |
1.95e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 45.76 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 628 RNLEQFARLEDCVLLAT----DVAARGLDIPK-VQHVIHYQVPRTSeiYVHRSGRTARATN----EGLSLMLIGPEDVIN 698
Cdd:cd18798 63 KNLEKFEEGEIDVLIGVasyyGVLVRGIDLPErIKYAIFYGVPVTT--YIQASGRTSRLYAggltKGLSVVLVDDPELFE 140
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 9966805 699 FKKiYKTLKKDEDIPLFPVQTKYMDVVKerirlaRQIEKS 738
Cdd:cd18798 141 ALK-KRLKLILDEFIFKELEEVDLEELL------SEIDES 173
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
343-510 |
3.80e-05 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 45.78 E-value: 3.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 343 SLIREKPVPKQNENEEENL-DKEQTGNLKQE-----LDDKSATCKAYPKrpllGLVLTPTRELAVQVKQHIDAVARF-TG 415
Cdd:cd18048 42 SKIQENALPMMLADPPQNLiAQSQSGTGKTAafvlaMLSRVDALKLYPQ----CLCLSPTFELALQTGKVVEEMGKFcVG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 416 IKTAILVGGMSTQKQQRMlnrRPEIVVATPGRLWELIkekhYHLR--NLRQLRCLVVDEADRMVEKGHFAELSQLLEmln 493
Cdd:cd18048 118 IQVIYAIRGNRPGKGTDI---EAQIVIGTPGTVLDWC----FKLRliDVTNISVFVLDEADVMINVQGHSDHSVRVK--- 187
|
170
....*....|....*...
gi 9966805 494 dsQYNPKR-QTLVFSATL 510
Cdd:cd18048 188 --RSMPKEcQMLLFSATF 203
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
579-696 |
7.91e-05 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 46.24 E-value: 7.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 579 LYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDIMPLTLHACMHQKQRLRNLEQFARLEDCVLLATDVAARGLDIPKVQ 657
Cdd:PRK11057 227 LMRYVQEQRGKSgIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVR 306
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 9966805 658 HVIHYQVPRTSEIYVHRSGRTARatnEGL---SLMLIGPEDV 696
Cdd:PRK11057 307 FVVHFDIPRNIESYYQETGRAGR---DGLpaeAMLFYDPADM 345
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
391-510 |
2.56e-04 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 43.17 E-value: 2.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFtgIKTAILVGGMSTQKQQRMLNRRPEIVVATPGRLWE-LIKEKhyhLRNLRQLRCLV 469
Cdd:cd18047 75 LCLSPTYELALQTGKVIEQMGKF--YPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDwCSKLK---FIDPKKIKVFV 149
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 9966805 470 VDEADRMV-EKGHFAELSQLLEMLndsqynPKR-QTLVFSATL 510
Cdd:cd18047 150 LDEADVMIaTQGHQDQSIRIQRML------PRNcQMLLFSATF 186
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
393-500 |
6.70e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 41.87 E-value: 6.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 393 LTPTRELavqVKQHIDAVARFTGIKTAILVGGMST--QKQQRMLN--RRPEIVVATPGRLWELIkeKHYHLRnLRQLRCL 468
Cdd:cd18034 57 LVPTVPL---VAQQAEAIRSHTDLKVGEYSGEMGVdkWTKERWKEelEKYDVLVMTAQILLDAL--RHGFLS-LSDINLL 130
|
90 100 110
....*....|....*....|....*....|...
gi 9966805 469 VVDEADRMVeKGH-FAELSQLLEMLNDSQYNPK 500
Cdd:cd18034 131 IFDECHHAT-GDHpYARIMKEFYHLEGRTSRPR 162
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
212-246 |
1.10e-03 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 42.78 E-value: 1.10e-03
10 20 30
....*....|....*....|....*....|....*
gi 9966805 212 FSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLA 246
Cdd:COG1201 22 FGAPTPPQREAW-PAIAAGESTLLIAPTGSGKTLA 55
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
391-510 |
1.49e-03 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 42.19 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 391 LVLTPTRELAVQVKQHIDAVARFTGIKTAILVGGMSTQKQqrmLNRRPEIVVATPgrlwelikEK-HYHLRN----LRQL 465
Cdd:COG1204 70 LYIVPLRALASEKYREFKRDFEELGIKVGVSTGDYDSDDE---WLGRYDILVATP--------EKlDSLLRNgpswLRDV 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 9966805 466 RCLVVDEA----DRmvEKGHFAE--LSQLLEMlndsqyNPKRQTLVFSATL 510
Cdd:COG1204 139 DLVVVDEAhlidDE--SRGPTLEvlLARLRRL------NPEAQIVALSATI 181
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
415-511 |
1.65e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 40.60 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966805 415 GIKTAILVGGMSTQKQQRMLNRRPE----IVVATPGRLW-ELIKEKHYHLRNLRQLRCLVVDEADRMVEKGH-----FAE 484
Cdd:cd17920 76 GIRAAALNSTLSPEEKREVLLRIKNgqykLLYVTPERLLsPDFLELLQRLPERKRLALIVVDEAHCVSQWGHdfrpdYLR 155
|
90 100
....*....|....*....|....*..
gi 9966805 485 LSQLLEMLNDSqynpkrQTLVFSATLT 511
Cdd:cd17920 156 LGRLRRALPGV------PILALTATAT 176
|
|
| |
