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Conserved domains on  [gi|31543969|ref|NP_065595|]
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DNA repair protein XRCC2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-242 1.01e-81

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


:

Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 245.34  E-value: 1.01e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSE-----GGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQS------------ 103
Cdd:cd19490   1 GDVIEITGPSGSGKTELLYHLAARCILPSSWggvplGGLEAAVVFIDTDGRFDILRLRSILEARIRAAiqaanssddeed 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 104 SEEAMKLCLARLFLAYCSSSMQLLLTLHSLEALLCSR---PSLCLLIVDSLSSFYWIDRVSGGES---VALQESTLQKCS 177
Cdd:cd19490  81 VEEIARECLQRLHIFRCHSSLQLLATLLSLENYLLSLsanPELGLLLIDSISAFYWQDRFSAELAraaPLLQEAALRAIL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543969 178 QLLERLVTEYRLLLFATTQSLMQKGSDSADGPSS-SKHPCDGDMGYRAYLCKAWQRVVKHRVIFSR 242
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAAnNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
 
Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-242 1.01e-81

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 245.34  E-value: 1.01e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSE-----GGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQS------------ 103
Cdd:cd19490   1 GDVIEITGPSGSGKTELLYHLAARCILPSSWggvplGGLEAAVVFIDTDGRFDILRLRSILEARIRAAiqaanssddeed 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 104 SEEAMKLCLARLFLAYCSSSMQLLLTLHSLEALLCSR---PSLCLLIVDSLSSFYWIDRVSGGES---VALQESTLQKCS 177
Cdd:cd19490  81 VEEIARECLQRLHIFRCHSSLQLLATLLSLENYLLSLsanPELGLLLIDSISAFYWQDRFSAELAraaPLLQEAALRAIL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543969 178 QLLERLVTEYRLLLFATTQSLMQKGSDSADGPSS-SKHPCDGDMGYRAYLCKAWQRVVKHRVIFSR 242
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAAnNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 41-235 3.04e-12

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 65.02  E-value: 3.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAM-KLCLARlflAY 119
Cdd:pfam08423  37 GSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVAIAE-RYGLDPEDVLdNVAYAR---AY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   120 -CSSSMQLLLTLhsleALLCSRPSLCLLIVDSLSSFYWIDrVSGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQSL 198
Cdd:pfam08423 113 nSEHQMQLLQQA----AAMMSESRFALLIVDSATALYRTD-FSGRGELAERQQHLAKFLRTLQRLADEFGVAVVITNQVV 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 31543969   199 MQKGSDSADGPSSSKHPCDGD-MGY----RAYLCKAW--QRVVK 235
Cdd:pfam08423 188 AQVDGAAGMFSGDPKKPIGGHiMAHasttRLSLRKGRgeQRICK 231
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 43-196 1.98e-11

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 63.22  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQSSEEAMKLCLARLFlaycSS 122
Cdd:TIGR02236  97 ITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEARGLDPDEVLKNIYVARAY----NS 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31543969   123 SMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVsGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQ 196
Cdd:TIGR02236 173 NHQMLLVEKAEDLIKELNNPVKLLIVDSLTSHFRAEYV-GRGALAERQQKLNKHLHDLLRLADLYNAAVVVTNQ 245
PTZ00035 PTZ00035
Rad51 protein; Provisional
 41-235 4.75e-10

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 59.24  E-value: 4.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEamklCLARLFLAYC 120
Cdd:PTZ00035 118 GSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQIAE-RFGLDPED----VLDNIAYARA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  121 SSSMQLLLTLHSLEALLCSRPsLCLLIVDSLSSFYWIDRVSGGEsVALQESTLQKCSQLLERLVTEYRLLLFATTQsLMQ 200
Cdd:PTZ00035 193 YNHEHQMQLLSQAAAKMAEER-FALLIVDSATALFRVDYSGRGE-LAERQQHLGKFLRALQKLADEFNVAVVITNQ-VMA 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 31543969  201 KGSDSADGPSSSKHPCDGD-MGY----RAYLCKAW--QRVVK 235
Cdd:PTZ00035 270 DVDGASMFVADPKKPIGGHiIAHasttRLSLRKGRgeQRICK 311
 
Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-242 1.01e-81

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 245.34  E-value: 1.01e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSE-----GGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQS------------ 103
Cdd:cd19490   1 GDVIEITGPSGSGKTELLYHLAARCILPSSWggvplGGLEAAVVFIDTDGRFDILRLRSILEARIRAAiqaanssddeed 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 104 SEEAMKLCLARLFLAYCSSSMQLLLTLHSLEALLCSR---PSLCLLIVDSLSSFYWIDRVSGGES---VALQESTLQKCS 177
Cdd:cd19490  81 VEEIARECLQRLHIFRCHSSLQLLATLLSLENYLLSLsanPELGLLLIDSISAFYWQDRFSAELAraaPLLQEAALRAIL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543969 178 QLLERLVTEYRLLLFATTQSLMQKGSDSADGPSS-SKHPCDGDMGYRAYLCKAWQRVVKHRVIFSR 242
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAAnNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 41-242 1.85e-46

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 154.05  E-value: 1.85e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILpkseggLQIEVLFIDTDYHFDMLRLVTVLEHrlSQSSEEAMKLCLARLFLAYC 120
Cdd:cd01393   1 GKITEIYGPPGSGKTQLALQLAANALL------LGGGVVWIDTEGAFPPSRLVQILEA--SPSSELELAEALSRLLYFRP 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 121 SSSMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVSGGE---SVALQESTLQKCSQLLERLVTEYRLLLFATTQS 197
Cdd:cd01393  73 PDTLAHLLALDSLPESLFPPPNTSLVVVDSVSALFRKAFPRGGDgdsSSSLRARLLSQLARALQKLAAQFNLAVVVTNQV 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 31543969 198 LMQKGSDSADGPssskhpcdgdmgYRAYLCKAWQRVVKHRVIFSR 242
Cdd:cd01393 153 TTKIRGGSGASL------------VPPALGNTWEHSVSTRLLLYR 185
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 41-249 1.92e-17

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 78.90  E-value: 1.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHR------LSQSSEEAMKLCLAR 114
Cdd:cd19493  11 GAITEITGASGSGKTQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIAEARfpeafsGFMEENERAEEMLKR 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 115 LFLAYCSSSMQLLLTLHSL-EALLCSRPSlcLLIVDSLSSFYwiDRVSGGESVALQE--STLQKCSQLLERLVTEYRLLL 191
Cdd:cd19493  91 VAVVRVTTLAQLLERLPNLeEHILSSGVR--LVVIDSIAALV--RREFGGSDGEVTErhNALAREASSLKRLAEEFRIAV 166

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543969 192 FATTQSLMQKGsDSADGPSSSKhpcdgdmgyrAYLCKAWQRVVKHRVIFSRDDE--------AKSS 249
Cdd:cd19493 167 LVTNQATTHFG-DAGDGSSGVT----------AALGDAWAHAVNTRLRLERCLLqlrrvleiVKSP 221
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 43-196 9.05e-15

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 71.63  E-value: 9.05e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRlSQSSEEAMK-LCLARLFlaycS 121
Cdd:cd19515  21 ITEVFGEFGSGKTQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKAL-GLDPDEVLDnIYVARAY----N 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31543969 122 SSMQLLLtLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVsGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQ 196
Cdd:cd19515  96 SNHQMLL-VEKAEDLIKEGNNIKLLIVDSLTSHFRAEYV-GRGTLAERQQKLNKHLHDLHRLADLYNIAVLVTNQ 168
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
 41-213 9.50e-15

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 71.79  E-value: 9.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQSSEEAMKLCLARLFlayc 120
Cdd:cd01123  19 GSITEMFGEFRTGKTQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIAQRFGLDPDDVLDNVAYARAF---- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 121 SSSMQLLLtLHSLEALLCSRPsLCLLIVDSLSSFYWIDRVSGGESVALQEStLQKCSQLLERLVTEYRLLLFATTQSLMQ 200
Cdd:cd01123  95 NSDHQTQL-LDQAAAMMVESR-FKLLIVDSATALYRTDYSGRGELSARQMH-LAKFLRMLQRLADEFGVAVVVTNQVVAQ 171

                       170
                ....*....|...
gi 31543969 201 KGSDSADGPSSSK 213
Cdd:cd01123 172 VDGAMMFAADPKK 184
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 41-196 4.07e-13

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 65.71  E-value: 4.07e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFdmlrlvtvlehrlsqsseeamklclaRLFLAYC 120
Cdd:cd19492   1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------NIHYFRV 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 121 SSSMQLLLTLHSLEALLCSRPSLCLLIVDSLS-----SFywidrvsggESVALQESTLQKCSQLLERLVTEYRLLLFATT 195
Cdd:cd19492  55 HDYVELLALINSLPKFLEDHPKVKLIVVDSIAfpfrhDF---------DDLAQRTRLLNGLAQLLHSLARQHNLAVVLTN 125


                .
gi 31543969 196 Q 196
Cdd:cd19492 126 Q 126
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 41-235 3.04e-12

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 65.02  E-value: 3.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAM-KLCLARlflAY 119
Cdd:pfam08423  37 GSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVAIAE-RYGLDPEDVLdNVAYAR---AY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   120 -CSSSMQLLLTLhsleALLCSRPSLCLLIVDSLSSFYWIDrVSGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQSL 198
Cdd:pfam08423 113 nSEHQMQLLQQA----AAMMSESRFALLIVDSATALYRTD-FSGRGELAERQQHLAKFLRTLQRLADEFGVAVVITNQVV 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 31543969   199 MQKGSDSADGPSSSKHPCDGD-MGY----RAYLCKAW--QRVVK 235
Cdd:pfam08423 188 AQVDGAAGMFSGDPKKPIGGHiMAHasttRLSLRKGRgeQRICK 231
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 41-249 1.29e-11

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 62.27  E-value: 1.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILpksegGLQIEVLFIDTDYHFDMLRLVTVLEHRlsQSSEEAMKLCLARLFLAYC 120
Cdd:cd19489   7 GEITELVGESSSGKTQLCLTAAANVAS-----RSGQNVLYIDTKSSFSARRLAQILKSR--AQDAEEIDKALQRIRVVRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 121 SSSMQLLLTLHSLEALL-----CSRPSLCLLIVDSLSSFywIDRVSGGESVALQESTLQKCSQLLERLVTEYRLLLFATt 195
Cdd:cd19489  80 FDPYELLDLLEELRNTLsqqqeNLYSRLKLVIIDSLSAL--ISPLLGGSKHSEGHALLASLARLLKKLAAEYQIAVLVT- 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 31543969 196 qSLMQKGSDSADGPSSskhpcdgdmgyRAYLCKAWQRVVKHRVIFSRDDEAKSS 249
Cdd:cd19489 157 -NLTVRGGDGGQQGST-----------KPALGEYWESVPSTRLLLSRDENDPEE 198
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 43-196 1.98e-11

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 63.22  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQSSEEAMKLCLARLFlaycSS 122
Cdd:TIGR02236  97 ITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEARGLDPDEVLKNIYVARAY----NS 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31543969   123 SMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVsGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQ 196
Cdd:TIGR02236 173 NHQMLLVEKAEDLIKELNNPVKLLIVDSLTSHFRAEYV-GRGALAERQQKLNKHLHDLLRLADLYNAAVVVTNQ 245
Rad51 cd19513
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ...
 41-235 5.22e-11

RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.


Pssm-ID: 410921 [Multi-domain]  Cd Length: 235  Bit Score: 61.18  E-value: 5.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAM-KLCLARlflAY 119
Cdd:cd19513  19 GSITELFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAE-RYGLNGEDVLdNVAYAR---AY 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 120 -CSSSMQLLLTLHSLEALlcSRPSlcLLIVDSLSSFYWIDRVSGGESVALQeSTLQKCSQLLERLVTEYRLLLFATTQSL 198
Cdd:cd19513  95 nTDHQMQLLIQASAMMAE--SRYA--LLIVDSATALYRTDYSGRGELSARQ-MHLAKFLRMLQRLADEFGVAVVITNQVV 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 31543969 199 MQ-KGSDSADGPssSKHPCDGD-MGY----RAYLCKAW--QRVVK 235
Cdd:cd19513 170 AQvDGAAMFAGD--PKKPIGGNiMAHasttRLYLRKGRgeTRICK 212
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
 41-235 6.79e-11

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 61.66  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAM-KLCLARlflAY 119
Cdd:TIGR02239  96 GSITEIFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAE-RYGLNPEDVLdNVAYAR---AY 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   120 -CSSSMQLLLTLHSLEALlcSRPSlcLLIVDSLSSFYWIDRVSGGESVALQEStLQKCSQLLERLVTEYRLLLFATTQSL 198
Cdd:TIGR02239 172 nTDHQLQLLQQAAAMMSE--SRFA--LLIVDSATALYRTDFSGRGELSARQMH-LARFLRSLQRLADEFGVAVVITNQVV 246

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 31543969   199 MQKGSDSADGPSSSKHPCDGD-MGY----RAYLCKAW--QRVVK 235
Cdd:TIGR02239 247 AQVDGAGSMFAGDPKKPIGGNiMAHasttRLSLRKGRgeQRICK 290
PTZ00035 PTZ00035
Rad51 protein; Provisional
 41-235 4.75e-10

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 59.24  E-value: 4.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEamklCLARLFLAYC 120
Cdd:PTZ00035 118 GSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQIAE-RFGLDPED----VLDNIAYARA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  121 SSSMQLLLTLHSLEALLCSRPsLCLLIVDSLSSFYWIDRVSGGEsVALQESTLQKCSQLLERLVTEYRLLLFATTQsLMQ 200
Cdd:PTZ00035 193 YNHEHQMQLLSQAAAKMAEER-FALLIVDSATALFRVDYSGRGE-LAERQQHLGKFLRALQKLADEFNVAVVITNQ-VMA 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 31543969  201 KGSDSADGPSSSKHPCDGD-MGY----RAYLCKAW--QRVVK 235
Cdd:PTZ00035 270 DVDGASMFVADPKKPIGGHiIAHasttRLSLRKGRgeQRICK 311
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 43-196 9.10e-10

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 57.37  E-value: 9.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAMKLCL-ARlflAYCS 121
Cdd:cd19514  21 ITEVFGEFRTGKTQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRIRPIAE-RFGVDHDAVLDNILyAR---AYTS 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31543969 122 S-SMQLLLtlhSLEALLCSRPSLCLLIVDSLSSFYWIDRVSGGESVALQestlQKCSQLLERLV---TEYRLLLFATTQ 196
Cdd:cd19514  97 EhQMELLD---YVAAKFHEEAVFRLLIIDSIMALFRVDFSGRGELAERQ----QKLAQMLSRLQkisEEYNVAVFITNQ 168
radA PRK04301
DNA repair and recombination protein RadA; Validated
 43-196 5.47e-09

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 56.04  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAMK-LCLARlflAYcS 121
Cdd:PRK04301 104 ITEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAE-ALGLDPDEVLDnIHVAR---AY-N 178

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31543969  122 SSMQLLLtLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVsGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQ 196
Cdd:PRK04301 179 SDHQMLL-AEKAEELIKEGENIKLVIVDSLTAHFRAEYV-GRGNLAERQQKLNKHLHDLLRLADLYNAAVVVTNQ 251
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 43-196 3.73e-08

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 53.63  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAMKLCL-ARlflAYCS 121
Cdd:TIGR02238  98 ITEVFGEFRCGKTQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRIRAIAE-RFGVDPDAVLDNILyAR---AYTS 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31543969   122 S-SMQLLLtlhSLEALLCSRPsLCLLIVDSLSSFYWIDRVSGGESVALQestlQKCSQLLERLV---TEYRLLLFATTQ 196
Cdd:TIGR02238 174 EhQMELLD---YLAAKFSEEP-FRLLIVDSIMALFRVDFSGRGELSERQ----QKLAQMLSRLNkisEEFNVAVFVTNQ 244
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 41-220 5.62e-08

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 53.20  E-value: 5.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAMK-LCLARlflAY 119
Cdd:PLN03186 123 GSITEIYGEFRTGKTQLCHTLCVTCQLPLDQGGGEGKAMYIDTEGTFRPQRLIQIAE-RFGLNGADVLEnVAYAR---AY 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  120 -CSSSMQLLLTLHSLEALlcSRpsLCLLIVDSLSSFYWIDRVSGGESVALQEStLQKCSQLLERLVTEYRLLLFATTQSL 198
Cdd:PLN03186 199 nTDHQSELLLEAASMMAE--TR--FALMIVDSATALYRTEFSGRGELSARQMH-LGKFLRSLQRLADEFGVAVVITNQVV 273

                        170       180
                 ....*....|....*....|...
gi 31543969  199 MQ-KGSDSADGPSSSkhPCDGDM 220
Cdd:PLN03186 274 AQvDGSAFFAGPQLK--PIGGNI 294
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-189 2.01e-07

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 50.75  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQSSEEAMKLCLARLFLAYC 120
Cdd:cd19491  12 GGITEIAGESGAGKTQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQLASSLPKRYHLEKAKNFLDNIFVEHV 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31543969 121 SSSMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVSGGESVALQESTLQKCSQLLERLVTEYRL 189
Cdd:cd19491  92 ADLETLEHCLNYQLPALLERGPIRLVVIDSIAALFRSEFDTSRSDLVERAKYLRRLADHLKRLADKYNL 160
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 43-196 1.05e-06

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 49.01  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969   43 IFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEhRLSQSSEEAM-KLCLARlflAYCS 121
Cdd:PLN03187 128 ITEAFGEFRSGKTQLAHTLCVTTQLPTEMGGGNGKVAYIDTEGTFRPDRIVPIAE-RFGMDADAVLdNIIYAR---AYTY 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31543969  122 SSMQLLLTlhSLEALLCSRPsLCLLIVDSLSSFYWIDRVSGGESVALQestlQKCSQLLERLVT---EYRLLLFATTQ 196
Cdd:PLN03187 204 EHQYNLLL--GLAAKMAEEP-FRLLIVDSVIALFRVDFTGRGELAERQ----QKLAQMLSRLTKiaeEFNVAVYMTNQ 274
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 41-257 2.08e-04

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 41.53  E-value: 2.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969  41 GDIFEFHGPEGTGKTEMLyhLTARCILPKSEGGlqieVLFIDTdyhfDMLRLvtvleHRLSQSSEEAMKLCLARLFLAYC 120
Cdd:cd01394  19 GTITQIYGPPGSGKTNIC--LQLAVEAAKQGKK----VVYIDT----EGLSP-----ERFQQIAGERFESIASNIIVFEP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969 121 SSSMQLLLTLHSLEAlLCSRPSLCLLIVDSLSSFYWIDRvsGGESVALQEstLQKCSQLLERLVTEYRLLLFATTQSLMQ 200
Cdd:cd01394  84 YSFDEQGVAIQEAEK-LLKSDKVDLVVVDSATALYRLEL--GDDSEANRE--LSRQMSKLLSIARKYDIPVVITNQVYSD 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31543969 201 KGSDSADgpssskhPCDGDMgyRAYLCKAWQRVVKHRvifsrddeaKSSRFSLVSRH 257
Cdd:cd01394 159 IDDDRLK-------PVGGTL--LEHWSKAIIRLEKSP---------PGLRRATLEKH 197
AAA_25 pfam13481
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
 21-158 1.48e-03

AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.


Pssm-ID: 463892 [Multi-domain]  Cd Length: 193  Bit Score: 38.90  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    21 RSSLKELEPNLFADEDSP----VHGDIFE-----FHGPEGTGKTEMLYHLTARCILPKSEGGL-----QIEVLFIDTDYH 86
Cdd:pfam13481   4 PLELLDVLADGLAAPPPPrrwlIKGLLPAgglglLAGAPGTGKTTLALDLAAAVATGKPWLGGprvpeQGKVLYVSAEGP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543969    87 FDMLRLvtvlehRLSQsSEEAMKLClARLFLAYCSSSMQLLLT----------LHSLEALLCSRPSLCLLIVDSLSSFYW 156
Cdd:pfam13481  84 ADELRR------RLRA-AGADLDLP-ARLLFLSLVESLPLFFLdrggplldadVDALEAALEEVEDPDLVVIDPLARALG 155


                  ..
gi 31543969   157 ID 158
Cdd:pfam13481 156 GD 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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