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Conserved domains on  [gi|19923572|ref|NP_067004|]
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SLAM family member 7 isoform a precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 27-125 2.23e-28

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16842:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 105.87  E-value: 2.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923572  27 KELVGSVGGAVTFPLK-SKVKQVDSIVWTFNTTPLVtIQPEGGT---IIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI 102
Cdd:cd16842   1 KEVNGILGGSVTFPLNiSDGQEIENITWSFKTSLAV-IAPGEGGapeIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                        90       100
                ....*....|....*....|...
gi 19923572 103 YYVGIYSSSLQQPSTQEYVLHVY 125
Cdd:cd16842  80 YRARINTKNSRVTITKEFTLHIY 102
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-125 2.23e-28

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 105.87  E-value: 2.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923572  27 KELVGSVGGAVTFPLK-SKVKQVDSIVWTFNTTPLVtIQPEGGT---IIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI 102
Cdd:cd16842   1 KEVNGILGGSVTFPLNiSDGQEIENITWSFKTSLAV-IAPGEGGapeIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                        90       100
                ....*....|....*....|...
gi 19923572 103 YYVGIYSSSLQQPSTQEYVLHVY 125
Cdd:cd16842  80 YRARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-122 4.72e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.06  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923572    27 KELVGSVGGAVTFP---LKSKVKQVDSIVWTF-----NTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKN 98
Cdd:pfam07686   4 REVTVALGGSVTLPctySSSMSEASTSVYWYRqppgkGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*.
gi 19923572    99 DSGIYYVGIYSSSLQ--QPSTQEYVL 122
Cdd:pfam07686  84 DSGTYTCAVIPSGEGvfGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 27-104 1.50e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19923572     27 KELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPeggtiivtqnrnRERVDFPDGGYSLKLSKLKKNDSGIYY 104
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESG------------RFSVSRSGSTSTLTISNVTPEDSGTYT 67
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 27-125 2.23e-28

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 105.87  E-value: 2.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923572  27 KELVGSVGGAVTFPLK-SKVKQVDSIVWTFNTTPLVtIQPEGGT---IIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGI 102
Cdd:cd16842   1 KEVNGILGGSVTFPLNiSDGQEIENITWSFKTSLAV-IAPGEGGapeIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                        90       100
                ....*....|....*....|...
gi 19923572 103 YYVGIYSSSLQQPSTQEYVLHVY 125
Cdd:cd16842  80 YRARINTKNSRVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 27-111 2.90e-12

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 61.98  E-value: 2.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923572  27 KELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGgySLKLSKLKKNDSGIYYVG 106
Cdd:cd05775   3 GEVYGALGGNVTLTISSLQDDIDEIKWKKTKDKIVEWENNIGPTYFGSFKDRVLLDKESG--SLTIKNLTKEDSGTYELE 80


                ....*
gi 19923572 107 IYSSS 111
Cdd:cd05775  81 ITSTN 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-122 4.72e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.06  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923572    27 KELVGSVGGAVTFP---LKSKVKQVDSIVWTF-----NTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKN 98
Cdd:pfam07686   4 REVTVALGGSVTLPctySSSMSEASTSVYWYRqppgkGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*.
gi 19923572    99 DSGIYYVGIYSSSLQ--QPSTQEYVL 122
Cdd:pfam07686  84 DSGTYTCAVIPSGEGvfGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 27-104 1.50e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19923572     27 KELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPeggtiivtqnrnRERVDFPDGGYSLKLSKLKKNDSGIYY 104
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESG------------RFSVSRSGSTSTLTISNVTPEDSGTYT 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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