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Conserved domains on  [gi|31981500|ref|NP_067261|]
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seizure protein 6 isoform 1 precursor [Mus musculus]

Protein Classification

CUB domain-containing protein; beta-2-glycoprotein 1( domain architecture ID 12869276)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein| beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 413-523 3.27e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.95  E-value: 3.27e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 413 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNVEApPVYDSYEVE 488
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981500 489 YLPIEgLLSSGRHFFVEFSTDSSGAAAGMALRYEA 523
Cdd:cd00041  80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 590-699 3.45e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 590 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSG-----DVLTFYDGDDLTARVLGQYSGPR 663
Cdd:cd00041   1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 31981500 664 GHFKLFTSMADVTIQFQSDPGTSAlgyqQGFVIHFF 699
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTG----RGFKATYS 112
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 707-763 1.54e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 68.64  E-value: 1.54e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31981500 707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSCQ 763
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 707-892 3.40e-14

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.92  E-value: 3.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELvhGTVVTYQCYPGYQVVGSSILMCQW----DLSWSEDLPSCQRVtSCHDPGDVEHSRRLIS 782
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  783 SPKFPVGATVQYVCDQGFVLTGSAILTChdrqaGSPKWSDrAPKClleQFKPCHGLSAPENGARSPEKRLHPAGATIHFS 862
Cdd:PHA02927 163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 31981500  863 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 892
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
Sushi pfam00084
Sushi repeat (SCR repeat);
529-586 8.73e-11

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 8.73e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500   529 CYEPF-VKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECVDlhDPQWNETEPAC 586
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 241-349 1.47e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 50.87  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 241 CSWNFSGP-EGSLDSPTAPSSPSDvGLDCFYYISVYPGYGVEIKVENISLQEGET-----ITVEGLGGPDPLPLANQSFL 314
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPN-NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981500 315 LRGQVIRSPTHQAALRFQSLPLPAGPGtFHFRYQA 349
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 354-410 2.49e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.53  E-value: 2.49e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500 354 CHFPRRPAYGDVTV--TSLHPGGSAHFHCATGYQLKGARFLTCLNATQpfWDSQEPVCI 410
Cdd:cd00033   1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 78-182 3.66e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    78 QEGLEREEAPQPALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPELSITSSLPPG 157
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981

                          90       100
                  ....*....|....*....|....*
gi 31981500   158 PSMAVPTllPEdrPSTTPPSQAWTP 182
Cdd:PHA03247 2982 PAPSREA--PA--SSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 413-523 3.27e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.95  E-value: 3.27e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 413 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNVEApPVYDSYEVE 488
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981500 489 YLPIEgLLSSGRHFFVEFSTDSSGAAAGMALRYEA 523
Cdd:cd00041  80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 590-699 3.45e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 590 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSG-----DVLTFYDGDDLTARVLGQYSGPR 663
Cdd:cd00041   1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 31981500 664 GHFKLFTSMADVTIQFQSDPGTSAlgyqQGFVIHFF 699
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTG----RGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 423-521 5.82e-20

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 85.90  E-value: 5.82e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    423 GRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNVEApPVYDSYEVEYLPIEGLLSS 498
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASS-PLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 31981500    499 GRHFFVEFSTDSSGAAAGMALRY 521
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 599-698 4.00e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.51  E-value: 4.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    599 GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSG-----DVLTFYDGDDLTARVLGQYSGPRGHFKLFTSMA 673
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|....*.
gi 31981500    674 D-VTIQFQSDPGTSAlgyqQGFVIHF 698
Cdd:smart00042  81 NsLTLTFVSDSSVQK----RGFSARY 102
CUB pfam00431
CUB domain;
413-521 6.78e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 74.25  E-value: 6.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   413 CGGVIRNATtGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNvEAPPVYDSYEVE 488
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGPS-ASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 31981500   489 YLPiEGLLSSGRHFFVEFSTDSSGAAAGMALRY 521
Cdd:pfam00431  79 GIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
590-698 6.46e-15

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 71.56  E-value: 6.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   590 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML-----DIRVLRIGSGDVLTFYDGDDLTARVLGQYSGPRG 664
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLtfqdfELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 31981500   665 HFKLFTSMADVTIQFQSDPGTSAlgyqQGFVIHF 698
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQK----RGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 707-763 1.54e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 68.64  E-value: 1.54e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31981500 707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSCQ 763
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 707-762 1.82e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 68.71  E-value: 1.82e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500    707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSC 762
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 707-892 3.40e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.92  E-value: 3.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELvhGTVVTYQCYPGYQVVGSSILMCQW----DLSWSEDLPSCQRVtSCHDPGDVEHSRRLIS 782
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  783 SPKFPVGATVQYVCDQGFVLTGSAILTChdrqaGSPKWSDrAPKClleQFKPCHGLSAPENGARSPEKRLHPAGATIHFS 862
Cdd:PHA02927 163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 31981500  863 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 892
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 835-893 1.21e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.55  E-value: 1.21e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500 835 CHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPICR 893
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 768-827 3.66e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 59.08  E-value: 3.66e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    768 CHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagSPKWSDRAPKC 827
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE----NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
707-762 6.84e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 6.84e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500   707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSC 762
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
529-586 8.73e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 8.73e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500   529 CYEPF-VKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECVDlhDPQWNETEPAC 586
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 532-587 2.25e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 2.25e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500 532 PFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECVDlhDPQWNETEPACR 587
Cdd:cd00033   5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTE--NGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 532-586 9.58e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 9.58e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 31981500    532 PFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECvdLHDPQWNETEPAC 586
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITC--LENGTWSPPPPTC 56
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 241-349 1.47e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 50.87  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 241 CSWNFSGP-EGSLDSPTAPSSPSDvGLDCFYYISVYPGYGVEIKVENISLQEGET-----ITVEGLGGPDPLPLANQSFL 314
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPN-NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981500 315 LRGQVIRSPTHQAALRFQSLPLPAGPGtFHFRYQA 349
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
768-827 4.29e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 4.29e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   768 CHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagSPKWSDRAPKC 827
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE----DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 354-410 2.49e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.53  E-value: 2.49e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500 354 CHFPRRPAYGDVTV--TSLHPGGSAHFHCATGYQLKGARFLTCLNATQpfWDSQEPVCI 410
Cdd:cd00033   1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 354-409 2.99e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.21  E-value: 2.99e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981500    354 CHFPRRPAYGDVTVTS--LHPGGSAHFHCATGYQLKGARFLTCLNATQpfWDSQEPVC 409
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA03247 PHA03247
large tegument protein UL36; Provisional
 78-182 3.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    78 QEGLEREEAPQPALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPELSITSSLPPG 157
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981

                          90       100
                  ....*....|....*....|....*
gi 31981500   158 PSMAVPTllPEdrPSTTPPSQAWTP 182
Cdd:PHA03247 2982 PAPSREA--PA--SSTPPLTGHSLS 3002
PHA02831 PHA02831
EEV host range protein; Provisional
 701-762 5.44e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 43.06  E-value: 5.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500  701 VPRNDTCP----ELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSC 762
Cdd:PHA02831 130 VPKYPVCKlircKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 42-199 5.54e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    42 LTAAPTPEQSDRGVHFVTTAPTLKLLNHHPLLEEflqeglEREEAPQPALP--FQPDSPTHFTPSPLPRLTNQDNRPvfT 119
Cdd:pfam03154 206 VPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP------QRLPSPHPPLQpmTQPPPPSQVSPQPLPQPSLHGQMP--P 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   120 SPTPAVAAAPTQPHS-REKPWNLeskpPELSITSSLPPGPSMAVPTllPEDRPSTTPPSQAWTPTQEGPGDMDRPWVPEV 198
Cdd:pfam03154 278 MPHSLQTGPSHMQHPvPPQPFPL----TPQSSQSQVPPGPSPAAPG--QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLS 351


                  .
gi 31981500   199 M 199
Cdd:pfam03154 352 M 352
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 78-198 2.18e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 41.68  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   78 QEGLEREEAPQPALPFQPDSPTHfTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPwNLESKPPELSitsslpPG 157
Cdd:NF033839 286 EPGNKKPSAPKPGMQPSPQPEKK-EVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKP-QLETPKPEVK------PQ 357

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 31981500  158 PSMAVPTLLPE-DRPSTTPPSQAWTPTQEGPGDMDRPwVPEV 198
Cdd:NF033839 358 PEKPKPEVKPQpEKPKPEVKPQPETPKPEVKPQPEKP-KPEV 398
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 413-523 3.27e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.95  E-value: 3.27e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 413 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNVEApPVYDSYEVE 488
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981500 489 YLPIEgLLSSGRHFFVEFSTDSSGAAAGMALRYEA 523
Cdd:cd00041  80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 590-699 3.45e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.78  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 590 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSG-----DVLTFYDGDDLTARVLGQYSGPR 663
Cdd:cd00041   1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 31981500 664 GHFKLFTSMADVTIQFQSDPGTSAlgyqQGFVIHFF 699
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTG----RGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 423-521 5.82e-20

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 85.90  E-value: 5.82e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    423 GRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNVEApPVYDSYEVEYLPIEGLLSS 498
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASS-PLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 31981500    499 GRHFFVEFSTDSSGAAAGMALRY 521
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 599-698 4.00e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 80.51  E-value: 4.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    599 GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSG-----DVLTFYDGDDLTARVLGQYSGPRGHFKLFTSMA 673
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|....*.
gi 31981500    674 D-VTIQFQSDPGTSAlgyqQGFVIHF 698
Cdd:smart00042  81 NsLTLTFVSDSSVQK----RGFSARY 102
CUB pfam00431
CUB domain;
413-521 6.78e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 74.25  E-value: 6.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   413 CGGVIRNATtGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDD----DRLIIRNGNNvEAPPVYDSYEVE 488
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGPS-ASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 31981500   489 YLPiEGLLSSGRHFFVEFSTDSSGAAAGMALRY 521
Cdd:pfam00431  79 GIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
590-698 6.46e-15

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 71.56  E-value: 6.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   590 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML-----DIRVLRIGSGDVLTFYDGDDLTARVLGQYSGPRG 664
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLtfqdfELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 31981500   665 HFKLFTSMADVTIQFQSDPGTSAlgyqQGFVIHF 698
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQK----RGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 707-763 1.54e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 68.64  E-value: 1.54e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31981500 707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSCQ 763
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 707-762 1.82e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 68.71  E-value: 1.82e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500    707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSC 762
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 707-892 3.40e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.92  E-value: 3.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELvhGTVVTYQCYPGYQVVGSSILMCQW----DLSWSEDLPSCQRVtSCHDPGDVEHSRRLIS 782
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  783 SPKFPVGATVQYVCDQGFVLTGSAILTChdrqaGSPKWSDrAPKClleQFKPCHGLSAPENGARSPEKRLHPAGATIHFS 862
Cdd:PHA02927 163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 31981500  863 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 892
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 728-889 1.04e-12

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.30  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  728 GTVVTYQCYPGY--QVVGSSILMCQ---WDLswsedLPSCQRvTSCHDPGDVEHSRRLISSPKFpvGATVQYVCDQGFVL 802
Cdd:PHA02927  47 GDTIEYLCLPGYrkQKMGPIYAKCTgtgWTL-----FNQCIK-RRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  803 TGSAILTCHDRQAGSPKWSDRAPKCllEQFKpCHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGhp 882
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPIC--ESVK-CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG-- 193


                 ....*..
gi 31981500  883 sHWSDPP 889
Cdd:PHA02927 194 -EWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 835-893 1.21e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.55  E-value: 1.21e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500 835 CHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPICR 893
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 768-827 3.66e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 59.08  E-value: 3.66e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    768 CHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagSPKWSDRAPKC 827
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE----NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
707-762 6.84e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 6.84e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500   707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSC 762
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 768-827 7.86e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 7.86e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 768 CHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagSPKWSDRAPKC 827
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTE----NGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
529-586 8.73e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 8.73e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500   529 CYEPF-VKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECVDlhDPQWNETEPAC 586
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 835-892 3.09e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 3.09e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981500    835 CHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPIC 892
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 706-834 9.11e-10

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 61.26  E-value: 9.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  706 TCPELP----EIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDlSWSEdLPSCQRvtSCHDPgdvEHSRRLI 781
Cdd:PHA02954 124 TCPNAEcqplQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGASYISCTAN-SWNV-IPSCQQ--KCDIP---SLSNGLI 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 31981500  782 SSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagsPKWSDRAPKCLL--EQFKP 834
Cdd:PHA02954 197 SGSTFSIGGVIHLSCKSGFTLTGSPSSTCID-----GKWNPVLPICVRsnEEFDP 246
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 707-828 1.34e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 60.05  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDlSWSeDLPSCQrVTSCHDPGDVEHSRRLISSPKF 786
Cdd:PHA02927 148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG-EWS-DPPTCQ-IVKCPHPTISNGYLSSGFKRSY 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 31981500  787 PVGATVQYVCDQGFVLTGSAILTChdrqagSP--KWSDRAPKCL 828
Cdd:PHA02927 225 SYNDNVDFKCKYGYKLSGSSSSTC------SPgnTWQPELPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 532-587 2.25e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 2.25e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500 532 PFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECVDlhDPQWNETEPACR 587
Cdd:cd00033   5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTE--NGGWSPPPPTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 768-903 6.26e-09

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 58.52  E-value: 6.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  768 CHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTChDRQAGSPKWSDRAPKCLLeqfKPCHGLSAPENGARS 847
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTC-IKDKNNAIWSNKAPFCML---KECNDPPSIINGKIY 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500  848 PEKRLHPAGATIHFSC----APGYVLKGQASIKCVpgHPSHWSDPPPICR------AASLDGFYNG 903
Cdd:PHA02639  98 NKREMYKVGDEIYYVCnehkGVQYSLVGNEKITCI--QDKSWKPDPPICKmincrfPALQNGYING 161
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 532-586 9.58e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 9.58e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 31981500    532 PFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLeQGSIIIECvdLHDPQWNETEPAC 586
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITC--LENGTWSPPPPTC 56
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 241-349 1.47e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 50.87  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500 241 CSWNFSGP-EGSLDSPTAPSSPSDvGLDCFYYISVYPGYGVEIKVENISLQEGET-----ITVEGLGGPDPLPLANQSFL 314
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPN-NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981500 315 LRGQVIRSPTHQAALRFQSLPLPAGPGtFHFRYQA 349
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
768-827 4.29e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 4.29e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   768 CHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagSPKWSDRAPKC 827
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE----DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 354-410 2.49e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.53  E-value: 2.49e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31981500 354 CHFPRRPAYGDVTV--TSLHPGGSAHFHCATGYQLKGARFLTCLNATQpfWDSQEPVCI 410
Cdd:cd00033   1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 354-409 2.99e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.21  E-value: 2.99e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981500    354 CHFPRRPAYGDVTVTS--LHPGGSAHFHCATGYQLKGARFLTCLNATQpfWDSQEPVC 409
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 707-892 3.48e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.05  E-value: 3.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLS---WSEDLPSCQrVTSCHDPGDVEHSRRLISS 783
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCM-LKECNDPPSIINGKIYNKR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  784 PKFPVGATVQYVCDQ----GFVLTGSAILTCHDRQAgspkWSDRAPKCLLEQFKpchgLSAPENGARS--PEKRLHPAGA 857
Cdd:PHA02639 101 EMYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKS----WKPDPPICKMINCR----FPALQNGYINgiPSNKKFYYKT 172

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 31981500  858 TIHFSCAPGYVLKGQASIKCvpGHPSHWSDPPPIC 892
Cdd:PHA02639 173 RVGFSCKSGFDLVGEKYSTC--NINATWFPSIPTC 205
PHA02831 PHA02831
EEV host range protein; Provisional
 707-828 3.95e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELVHGTVVTYQC----YPGYQVVGSSILMCqWDLSWSEDLPSCqRVTSCHDPGdVEHSRRLIS 782
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKC-INKQWVPKYPVC-KLIRCKYPA-LQNGFLNVF 154

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 31981500  783 SPKFPVGATVQYVCDQGFVLTGSAILTCHDRQAgspkWSDRAPKCL 828
Cdd:PHA02831 155 EKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI----WYPGIPKCV 196
Sushi pfam00084
Sushi repeat (SCR repeat);
835-892 4.00e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.10  E-value: 4.00e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31981500   835 CHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPIC 892
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 705-827 8.35e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.93  E-value: 8.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  705 DTCPELPEIPNGWKNPSQPELVHGTVVTYQCYPG-----YQVVGSSILMCQWDLSWSEDLPSCQrVTSCHDPG-DVEHSR 778
Cdd:PHA02817  22 NKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCK-IIRCRFPAlQNGFVN 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 31981500  779 RLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDRQAgspkWSDRAPKC 827
Cdd:PHA02817 101 GIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPIC 145
PHA03247 PHA03247
large tegument protein UL36; Provisional
 78-182 3.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    78 QEGLEREEAPQPALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPELSITSSLPPG 157
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981

                          90       100
                  ....*....|....*....|....*
gi 31981500   158 PSMAVPTllPEdrPSTTPPSQAWTP 182
Cdd:PHA03247 2982 PAPSREA--PA--SSTPPLTGHSLS 3002
PHA02831 PHA02831
EEV host range protein; Provisional
 701-762 5.44e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 43.06  E-value: 5.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31981500  701 VPRNDTCP----ELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSC 762
Cdd:PHA02831 130 VPKYPVCKlircKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 42-199 5.54e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    42 LTAAPTPEQSDRGVHFVTTAPTLKLLNHHPLLEEflqeglEREEAPQPALP--FQPDSPTHFTPSPLPRLTNQDNRPvfT 119
Cdd:pfam03154 206 VPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP------QRLPSPHPPLQpmTQPPPPSQVSPQPLPQPSLHGQMP--P 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   120 SPTPAVAAAPTQPHS-REKPWNLeskpPELSITSSLPPGPSMAVPTllPEDRPSTTPPSQAWTPTQEGPGDMDRPWVPEV 198
Cdd:pfam03154 278 MPHSLQTGPSHMQHPvPPQPFPL----TPQSSQSQVPPGPSPAAPG--QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLS 351


                  .
gi 31981500   199 M 199
Cdd:pfam03154 352 M 352
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 86-178 9.50e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 42.16  E-value: 9.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   86 APQPALPfqpdSPTHFTPSPLPRLTNqdnrPVFTSPTPAVA----AAPTQPHSREKPWNLESKPPELSITSSLPPGPSMA 161
Cdd:PHA02682  83 APSPACA----APAPACPACAPAAPA----PAVTCPAPAPAcppaTAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLP 154

                         90       100
                 ....*....|....*....|.
gi 31981500  162 VPTLLPEDRPS----TTPPSQ 178
Cdd:PHA02682 155 TPKPAPAAKPIflhnQLPPPD 175
PHA02639 PHA02639
EEV host range protein; Provisional
 707-828 1.39e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.96  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  707 CPELPEIPNGWKNPSQPELVHGTVVTYQC--YPG--YQVVGSSILMCQWDLSWSEDLPSCQRVtSCHDPG-DVEHSRRLI 781
Cdd:PHA02639  85 CNDPPSIINGKIYNKREMYKVGDEIYYVCneHKGvqYSLVGNEKITCIQDKSWKPDPPICKMI-NCRFPAlQNGYINGIP 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 31981500  782 SSPKFPVGATVQYVCDQGFVLTGSAILTCHDrqagSPKWSDRAPKCL 828
Cdd:PHA02639 164 SNKKFYYKTRVGFSCKSGFDLVGEKYSTCNI----NATWFPSIPTCV 206
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 78-198 2.18e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 41.68  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   78 QEGLEREEAPQPALPFQPDSPTHfTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPwNLESKPPELSitsslpPG 157
Cdd:NF033839 286 EPGNKKPSAPKPGMQPSPQPEKK-EVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKP-QLETPKPEVK------PQ 357

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 31981500  158 PSMAVPTLLPE-DRPSTTPPSQAWTPTQEGPGDMDRPwVPEV 198
Cdd:NF033839 358 PEKPKPEVKPQpEKPKPEVKPQPETPKPEVKPQPEKP-KPEV 398
PHA03379 PHA03379
EBNA-3A; Provisional
 89-197 3.14e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 41.58  E-value: 3.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   89 PALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHS--------REKPWNleSKPPELSITSSLPPGPSM 160
Cdd:PHA03379 517 PGVAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQGPGETSGivrvrerwRPAPWT--PNPPRSPSQMSVRDRLAR 594

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 31981500  161 AVPTLLPEDRPSTTPPSQAWTPTQEGPgdMDRPWVPE 197
Cdd:PHA03379 595 LRAEAQPYQASVEVQPPQLTQVSPQQP--MEYPLEPE 629
PHA02831 PHA02831
EEV host range protein; Provisional
 733-882 3.79e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 40.36  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  733 YQCYPGYQVVgssILMCQwDLSWSEDlPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYVCD----QGFVLTGSAIL 808
Cdd:PHA02831  48 YKCNNNFDKV---FVTCN-NGSWSTK-NMCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACKvnklEKYSIVGNETV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500  809 TCHDRQagspkWSDRAPKCLLEQFKpchgLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKC------VPGHP 882
Cdd:PHA02831 123 KCINKQ-----WVPKYPVCKLIRCK----YPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCdinsiwYPGIP 193
PHA03247 PHA03247
large tegument protein UL36; Provisional
 87-197 6.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 6.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    87 PQPALPFQPDSPTHFTPSPLP-----RLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPElsiTSSLPPGPSMA 161
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPlggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE---SFALPPDQPER 2907

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 31981500   162 VPTLLPEDRPSTTPPSQAW---TPTQEGPGDMDRPWVPE 197
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPpqpQPPPPPPPRPQPPLAPT 2946
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 82-265 6.54e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500    82 EREEAPQPALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAaptqPHSREKPWNLeSKPPELSITSSLPPGPSMA 161
Cdd:pfam03154 323 QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPN----PQSHKHPPHL-SGPSPFQMNSNLPPPPALK 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981500   162 VPTLLPEDRPSTT--PPSQAWTPTQEGPGDmdrPWVPEVMSKTTGLGVEGTIATSTASgddeettttiitTTVTTVQPPG 239
Cdd:pfam03154 398 PLSSLSTHHPPSAhpPPLQLMPQSQQLPPP---PAQPPVLTQSQSLPPPAASHPPTSG------------LHQVPSQSPF 462

                         170       180
                  ....*....|....*....|....*..
gi 31981500   240 PC-SWNFSGPEGSLDSPTAPSSPSDVG 265
Cdd:pfam03154 463 PQhPFVPGGPPPITPPSGPPTSTSSAM 489
PHA02639 PHA02639
EEV host range protein; Provisional
 710-764 7.83e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 39.65  E-value: 7.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 31981500  710 LPEIPNGWKN--PSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSCQR 764
Cdd:PHA02639 151 FPALQNGYINgiPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVR 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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