|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
672-813 |
3.30e-33 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 124.74 E-value: 3.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255 2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594 752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 813
Cdd:smart00255 79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
675-814 |
1.88e-29 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 114.77 E-value: 1.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 675 FVIYSS----QNEDWVRNELVKNLeeGVPRFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750
Cdd:pfam01582 1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 751 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNPLGRHIFWRRLKN 811
Cdd:pfam01582 78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156
|
...
gi 10946594 812 ALL 814
Cdd:pfam01582 157 DIS 159
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-298 |
3.32e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.82 E-value: 3.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 53 SSTKNIDLSFNPLKILkSYSFSNFSELQWLDLSRCEIETIeDKAWHGLHHLSNLILTGNPIQSFsPGSFSGLTSLENLVA 132
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 133 VETKLASLeSFPIGQLITLKKLNVAHNFIHSckLPAYFSNLTNLVHVDLSYNYIQTI-TVNDLQFLREnpqvnlsLDMSL 211
Cdd:COG4886 190 SNNQITDL-PEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLpELGNLTNLEE-------LDLSN 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 212 NPIDFIqDQAFQGIKLHELTLRGNfnssNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTY 291
Cdd:COG4886 260 NQLTDL-PPLANLTNLKTLDLSNN----QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
|
....*..
gi 10946594 292 TNDFSDD 298
Cdd:COG4886 335 VTLTTLA 341
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
347-580 |
1.15e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.90 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 347 DLPFLKSLTLTMNKGSISFKKvalpsLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLEE 421
Cdd:COG4886 94 DLTNLTELDLSGNEELSNLTN-----LESLDLSGNQLT--------DLPEElanltNLKELDLSNNQLTDLPEPLGNLTN 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 422 LQHLDFQHSTLKRVTEfsAFLSLEKLLYLDISytNTKI-DFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTFLD 500
Cdd:COG4886 161 LKSLDLSNNQLTDLPE--ELGNLTNLKELDLS--NNQItDLPEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLD 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 501 LSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLDSSHynQLYSLSTLDCSFNRIETSKgiLQHFPKSLAFFNLTNNSVAC 580
Cdd:COG4886 235 LSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLL 308
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
46-456 |
1.17e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 65.25 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 46 KVPDDI---PSSTKNIDLSFNPLKilKSYSFSNFSELQWLDLSRceiETIEDKAWHGLHHLSNLI---LTGNPIQSFSPG 119
Cdd:PLN00113 108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSN---NMLSGEIPNDIGSFSSLKvldLGGNVLVGKIPN 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 120 SFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRE 199
Cdd:PLN00113 183 SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKN 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 200 NPQVNLSLDMSLNPIdfiQDQAFQGIKLHELTLRGNFNSSNI--MKTCLQNLAGLHVhrlilgeFKDErnleiFEPSIME 277
Cdd:PLN00113 262 LQYLFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQNLEILHL-------FSNN-----FTGKIPV 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 278 GLCDVTIDEFRLTYTNDFSDDIVK-------FHCLaNVSAMSLAGVSIKYLEDVPKHFKW------------------QS 332
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFSGEIPKnlgkhnnLTVL-DLSTNNLTGEIPEGLCSSGNLFKLilfsnslegeipkslgacRS 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 333 LSIIRCQLKQFPT------LDLPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDL 404
Cdd:PLN00113 406 LRRVRLQDNSFSGelpsefTKLPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDL 482
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594 405 S---FNGAIIMSanFMGLEELQHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 456
Cdd:PLN00113 483 SrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
53-113 |
3.29e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 3.29e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594 53 SSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPI 113
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
369-555 |
3.38e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 53.13 E-value: 3.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 369 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 447
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 448 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 518
Cdd:cd00116 143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 10946594 519 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 555
Cdd:cd00116 222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
494-554 |
5.04e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.74 E-value: 5.04e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594 494 TNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRI 554
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
73-214 |
1.36e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 73 FSNFSELQWLDLSRCEIETIEDkaWHGLHHLSNLILTGNPIQSFSpgsfsGLTSLENL---------VAVETKLASLESF 143
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLeelhienqrLPPGEKLTFDPRS 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594 144 PIGQLITLKKLNVAHNFIHScklPAYFSNLTNLVHVDLSYNYIQTI-----TVNDLQFLREnpqvnlsLDMSLNPI 214
Cdd:cd21340 115 LAALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDLeelldLLSSWPSLRE-------LDLTGNPV 180
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
672-813 |
3.30e-33 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 124.74 E-value: 3.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255 2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594 752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 813
Cdd:smart00255 79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
675-814 |
1.88e-29 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 114.77 E-value: 1.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 675 FVIYSS----QNEDWVRNELVKNLeeGVPRFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750
Cdd:pfam01582 1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 751 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNPLGRHIFWRRLKN 811
Cdd:pfam01582 78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156
|
...
gi 10946594 812 ALL 814
Cdd:pfam01582 157 DIS 159
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-298 |
3.32e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.82 E-value: 3.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 53 SSTKNIDLSFNPLKILkSYSFSNFSELQWLDLSRCEIETIeDKAWHGLHHLSNLILTGNPIQSFsPGSFSGLTSLENLVA 132
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 133 VETKLASLeSFPIGQLITLKKLNVAHNFIHSckLPAYFSNLTNLVHVDLSYNYIQTI-TVNDLQFLREnpqvnlsLDMSL 211
Cdd:COG4886 190 SNNQITDL-PEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLpELGNLTNLEE-------LDLSN 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 212 NPIDFIqDQAFQGIKLHELTLRGNfnssNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTY 291
Cdd:COG4886 260 NQLTDL-PPLANLTNLKTLDLSNN----QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
|
....*..
gi 10946594 292 TNDFSDD 298
Cdd:COG4886 335 VTLTTLA 341
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
347-580 |
1.15e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.90 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 347 DLPFLKSLTLTMNKGSISFKKvalpsLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLEE 421
Cdd:COG4886 94 DLTNLTELDLSGNEELSNLTN-----LESLDLSGNQLT--------DLPEElanltNLKELDLSNNQLTDLPEPLGNLTN 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 422 LQHLDFQHSTLKRVTEfsAFLSLEKLLYLDISytNTKI-DFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTFLD 500
Cdd:COG4886 161 LKSLDLSNNQLTDLPE--ELGNLTNLKELDLS--NNQItDLPEPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLD 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 501 LSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLDSSHynQLYSLSTLDCSFNRIETSKgiLQHFPKSLAFFNLTNNSVAC 580
Cdd:COG4886 235 LSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK--LKELELLLGLNSLLLLLLLL 308
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
675-770 |
5.56e-12 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 63.49 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 675 FVIYSSQNEDWVRnELVKNLEE-GvprFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAq 753
Cdd:pfam13676 2 FISYAGEDRAWAE-WLADALEAaG---YRVWLDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75
|
90
....*....|....*..
gi 10946594 754 tWQFLSSRSGIIFIVLE 770
Cdd:pfam13676 76 -LADPEGRKRLIPVRLE 91
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
46-456 |
1.17e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 65.25 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 46 KVPDDI---PSSTKNIDLSFNPLKilKSYSFSNFSELQWLDLSRceiETIEDKAWHGLHHLSNLI---LTGNPIQSFSPG 119
Cdd:PLN00113 108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSN---NMLSGEIPNDIGSFSSLKvldLGGNVLVGKIPN 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 120 SFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRE 199
Cdd:PLN00113 183 SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKN 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 200 NPQVNLSLDMSLNPIdfiQDQAFQGIKLHELTLRGNFNSSNI--MKTCLQNLAGLHVhrlilgeFKDErnleiFEPSIME 277
Cdd:PLN00113 262 LQYLFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQNLEILHL-------FSNN-----FTGKIPV 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 278 GLCDVTIDEFRLTYTNDFSDDIVK-------FHCLaNVSAMSLAGVSIKYLEDVPKHFKW------------------QS 332
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFSGEIPKnlgkhnnLTVL-DLSTNNLTGEIPEGLCSSGNLFKLilfsnslegeipkslgacRS 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 333 LSIIRCQLKQFPT------LDLPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDL 404
Cdd:PLN00113 406 LRRVRLQDNSFSGelpsefTKLPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDL 482
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594 405 S---FNGAIIMSanFMGLEELQHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 456
Cdd:PLN00113 483 SrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
347-600 |
1.95e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 63.80 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 347 DLPFLKSLTLTMNK-GSISFKKVALPSLSYLDLSRNALSfsgccsysDLGTN-----SLRHLDLSFNGAIIMSANFMGLE 420
Cdd:COG4886 111 NLTNLESLDLSGNQlTDLPEELANLTNLKELDLSNNQLT--------DLPEPlgnltNLKSLDLSNNQLTDLPEELGNLT 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 421 ELQHLDFQHStlkRVTEFSAFLS-LEKLLYLDISYTNTKiDFDGIFLGLTSLNTLKMAGNSFKDntLSNvFANTTNLTFL 499
Cdd:COG4886 183 NLKELDLSNN---QITDLPEPLGnLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLTD--LPE-LGNLTNLEEL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 500 DLSKCQLEQISwgVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVA 579
Cdd:COG4886 256 DLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
|
250 260
....*....|....*....|.
gi 10946594 580 CICEHQKFLQWVKEQKQFLVN 600
Cdd:COG4886 334 LVTLTTLALSLSLLALLTLLL 354
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
331-579 |
1.60e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 331 QSLSIIRCQLKQFPTL--DLPFLKSLTLTMNK-GSISFKKVALPSLSYLDLSRNALSfsgCCSYSDLGTNSLRHLDLSFN 407
Cdd:COG4886 116 ESLDLSGNQLTDLPEElaNLTNLKELDLSNNQlTDLPEPLGNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 408 GAIIMSANFMGLEELQHLDFQHStlkRVTEFSAFLS-LEKLLYLDISYTN-TKIDFdgiFLGLTSLNTLKMAGNSFKDNT 485
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGN---QLTDLPEPLAnLTNLETLDLSNNQlTDLPE---LGNLTNLEELDLSNNQLTDLP 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 486 LSnvfANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFP 565
Cdd:COG4886 267 PL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343
|
250
....*....|....
gi 10946594 566 KSLAFFNLTNNSVA 579
Cdd:COG4886 344 LSLLALLTLLLLLN 357
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
43-275 |
2.12e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 2.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 43 KLSKVPDDIPSST--KNIDLSFNPLKILkSYSFSNFSELQWLDLSRCEIETIEDkAWHGLHHLSNLILTGNPIQSFSpgS 120
Cdd:COG4886 170 QLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--E 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 121 FSGLTSLENLVAVETKLASLEsfPIGQLITLKKLNVAHNFIHSCKLPA-YFSNLTNLVHVDLSYNYIQTITVNDLQFLRE 199
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKElELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594 200 NPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSI 275
Cdd:COG4886 324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
53-113 |
3.29e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 3.29e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594 53 SSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPI 113
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
369-555 |
3.38e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 53.13 E-value: 3.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 369 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 447
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 448 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 518
Cdd:cd00116 143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 10946594 519 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 555
Cdd:cd00116 222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
77-130 |
1.27e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 46.36 E-value: 1.27e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 10946594 77 SELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENL 130
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
42-235 |
1.00e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.78 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 42 QKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSF 121
Cdd:COG4886 10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 122 SGLTSLENLvaveTKLASLESFPIGQLITLKKLNVAHNFIHSckLPAYFSNLTNLVHVDLSYNYIQTITvNDLQFLRenp 201
Cdd:COG4886 90 TDLGDLTNL----TELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLP-EPLGNLT--- 159
|
170 180 190
....*....|....*....|....*....|....*
gi 10946594 202 qvNL-SLDMSLNPIDFIQDQAFQGIKLHELTLRGN 235
Cdd:COG4886 160 --NLkSLDLSNNQLTDLPEELGNLTNLKELDLSNN 192
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
494-554 |
5.04e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.74 E-value: 5.04e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594 494 TNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRI 554
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
97-168 |
8.38e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 46.35 E-value: 8.38e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594 97 WHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPA 168
Cdd:PLN03150 438 ISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL-SGRVPA 508
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
430-576 |
4.55e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.38 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 430 STLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNsfkdntlsNVFANTTNLTFLDLSKCQLEQI 509
Cdd:COG4886 57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDL 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594 510 SWGVFDtLHRLQLLNMSHNNLLFLDSShYNQLYSLSTLDCSFNRIETSKGILQHFPKsLAFFNLTNN 576
Cdd:COG4886 129 PEELAN-LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNN 192
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
490-530 |
9.83e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 9.83e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 10946594 490 FANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNL 530
Cdd:pfam13855 21 FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
73-214 |
1.36e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 73 FSNFSELQWLDLSRCEIETIEDkaWHGLHHLSNLILTGNPIQSFSpgsfsGLTSLENL---------VAVETKLASLESF 143
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLeelhienqrLPPGEKLTFDPRS 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594 144 PIGQLITLKKLNVAHNFIHScklPAYFSNLTNLVHVDLSYNYIQTI-----TVNDLQFLREnpqvnlsLDMSLNPI 214
Cdd:cd21340 115 LAALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDLeelldLLSSWPSLRE-------LDLTGNPV 180
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
47-162 |
1.64e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 42.14 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 47 VPDDIPSST-KNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLT 125
Cdd:PLN00113 468 LPDSFGSKRlENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMP 547
|
90 100 110
....*....|....*....|....*....|....*..
gi 10946594 126 SLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIH 162
Cdd:PLN00113 548 VLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
150-214 |
4.80e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.96 E-value: 4.80e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594 150 TLKKLNVAHNFIHSCKlPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRenpqvNL-SLDMSLNPI 214
Cdd:pfam13855 2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-----SLrYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
422-554 |
9.02e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 38.61 E-value: 9.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 422 LQHLDFQHSTLKRVTEFSAFLSLEKLlYLDisytNTKI----DFDGiflgLTSLNTLKMAGNS--------FKDNTLSNV 489
Cdd:cd21340 48 LTHLYLQNNQIEKIENLENLVNLKKL-YLG----GNRIsvveGLEN----LTNLEELHIENQRlppgekltFDPRSLAAL 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594 490 fANTtnLTFLDLSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLD--SSHYNQLYSLSTLDCSFNRI 554
Cdd:cd21340 119 -SNS--LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
|
|
| |
