protein cereblon isoform 1 [Mus musculus]
Protein Classification
LON peptidase substrate-binding domain-containing protein; cereblon family protein( domain architecture ID 12032068)
LON peptidase substrate-binding domain-containing protein similar to the N-terminal polypeptide interaction domain of ATP-dependent protease La (LON) that degrades polypeptides processively to yield small peptide fragments| cereblon family protein such as protein cereblon, a substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| CRBN_C_like | cd15777 | Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains; Cereblon ... |
323-424 | 1.71e-52 | |||||
Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains; Cereblon is part of an E3 ubiquitin ligase complex, together with damaged DNA-binding protein 1 (DDB1), CUL4A and ROC1. Cereblon interacts directly with DDB1, although the C-terminal domain characterized here does not contribute to that interaction. Ubiquination of cellular targets by this complex increases levels of FGF8 and FGF10, which was shown to affect the development of limbs and auditory vesicles in embryogenesis. The C-terminal domain of Cereblon was shown to contain the binding site for thalidomide and its analogs, a class of teratogenic drugs that exhibit an antiproliferative effect on myelomas. Mutations in CRBN, some of which map onto the C-terminal domain, were associated with autosomal recessive mental retardation, which may have to do with interactions between CRBN and ion channels in the brain. : Pssm-ID: 276940 Cd Length: 101 Bit Score: 171.27 E-value: 1.71e-52
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| LON_substr_bdg | pfam02190 | ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be ... |
82-319 | 1.59e-32 | |||||
ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organizms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. : Pssm-ID: 426647 [Multi-domain] Cd Length: 195 Bit Score: 122.06 E-value: 1.59e-32
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| Name | Accession | Description | Interval | E-value | |||||
| CRBN_C_like | cd15777 | Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains; Cereblon ... |
323-424 | 1.71e-52 | |||||
Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains; Cereblon is part of an E3 ubiquitin ligase complex, together with damaged DNA-binding protein 1 (DDB1), CUL4A and ROC1. Cereblon interacts directly with DDB1, although the C-terminal domain characterized here does not contribute to that interaction. Ubiquination of cellular targets by this complex increases levels of FGF8 and FGF10, which was shown to affect the development of limbs and auditory vesicles in embryogenesis. The C-terminal domain of Cereblon was shown to contain the binding site for thalidomide and its analogs, a class of teratogenic drugs that exhibit an antiproliferative effect on myelomas. Mutations in CRBN, some of which map onto the C-terminal domain, were associated with autosomal recessive mental retardation, which may have to do with interactions between CRBN and ion channels in the brain. Pssm-ID: 276940 Cd Length: 101 Bit Score: 171.27 E-value: 1.71e-52
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| LON_substr_bdg | pfam02190 | ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be ... |
82-319 | 1.59e-32 | |||||
ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organizms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. Pssm-ID: 426647 [Multi-domain] Cd Length: 195 Bit Score: 122.06 E-value: 1.59e-32
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| Yippee-Mis18 | pfam03226 | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both ... |
323-428 | 5.27e-11 | |||||
Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon. Pssm-ID: 427204 Cd Length: 99 Bit Score: 58.87 E-value: 5.27e-11
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| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
81-189 | 3.06e-04 | |||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 43.08 E-value: 3.06e-04
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| Name | Accession | Description | Interval | E-value | |||||
| CRBN_C_like | cd15777 | Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains; Cereblon ... |
323-424 | 1.71e-52 | |||||
Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains; Cereblon is part of an E3 ubiquitin ligase complex, together with damaged DNA-binding protein 1 (DDB1), CUL4A and ROC1. Cereblon interacts directly with DDB1, although the C-terminal domain characterized here does not contribute to that interaction. Ubiquination of cellular targets by this complex increases levels of FGF8 and FGF10, which was shown to affect the development of limbs and auditory vesicles in embryogenesis. The C-terminal domain of Cereblon was shown to contain the binding site for thalidomide and its analogs, a class of teratogenic drugs that exhibit an antiproliferative effect on myelomas. Mutations in CRBN, some of which map onto the C-terminal domain, were associated with autosomal recessive mental retardation, which may have to do with interactions between CRBN and ion channels in the brain. Pssm-ID: 276940 Cd Length: 101 Bit Score: 171.27 E-value: 1.71e-52
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| LON_substr_bdg | pfam02190 | ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be ... |
82-319 | 1.59e-32 | |||||
ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organizms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. Pssm-ID: 426647 [Multi-domain] Cd Length: 195 Bit Score: 122.06 E-value: 1.59e-32
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| RLR_C_like | cd15803 | C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and ... |
323-424 | 4.43e-26 | |||||
C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains; Retinoic acid-inducible gene (RIG)-I-like Receptors (RLRs) are cytoplasmic RNA receptors that recognize non-self RNA and act as molecular sensors to detect viral pathogens. They play crucial roles in innate antiviral responses, including the production of proinflammatory cytokines and type I interferon. There are three RLRs in vertebrates, RIG-I, LGP2, and MDA5. They are characterized by a central DExD/H-box helicase domain and a C-terminal domain, both of which are responsible for binding viral RNA. Cereblon is part of an E3 ubiquitin ligase complex, together with damaged DNA binding protein 1 (DDB1), CUL4A and ROC1. Cereblon interacts directly with DDB1, although the C-terminal domain characterized here does not contribute to that interaction. The C-terminal domain of Cereblon was shown to contain the binding site for thalidomide and its analogs, a class of teratogenic drugs that exhibit an antiproliferative effect on myelomas. Mutations in CRBN, some of which map onto the C-terminal domain, were associated with autosomal recessive mental retardation, which may have to do with interactions between CRBN and ion channels in the brain. RLRs and Cereblon contain a common conserved zinc binding site in their C-terminal domains. Pssm-ID: 276941 Cd Length: 84 Bit Score: 100.67 E-value: 4.43e-26
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| Yippee-Mis18 | pfam03226 | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both ... |
323-428 | 5.27e-11 | |||||
Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon. Pssm-ID: 427204 Cd Length: 99 Bit Score: 58.87 E-value: 5.27e-11
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| Lon | COG0466 | ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ... |
81-189 | 3.06e-04 | |||||
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440234 [Multi-domain] Cd Length: 785 Bit Score: 43.08 E-value: 3.06e-04
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