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Conserved domains on  [gi|158517890|ref|NP_071299|]
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interphotoreceptor matrix proteoglycan 1 precursor [Mus musculus]

Protein Classification

SEA domain-containing protein( domain architecture ID 10475853)

SEA (found in Sea urchin sperm protein, Enterokinase, Agrin) domain-containing protein similar to vertebrate interphotoreceptor matrix proteoglycan 1 and human membrane mucins (mucin-12, -16 and -17)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 578-668 4.94e-12

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 62.64  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158517890  578 VVFFSLRVANMPFSYDLFNKSSLEYQALEQRFTDLLVPYLR-SNL-TGFKQLEILSFR--NGSVIVNSKVRFAK---AVP 650
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRnSSLrKQYIKSHVLRLRpdGGSVVVDVVLVFRFpstEPA 81

                          90
                  ....*....|....*...
gi 158517890  651 YNLTQAVRGVLEDLRSTA 668
Cdd:pfam01390  82 LDREKLIEEILRQTLNNT 99
SEA super family cl02507
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 239-295 4.83e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


The actual alignment was detected with superfamily member pfam01390:

Pssm-ID: 470595  Cd Length: 100  Bit Score: 39.91  E-value: 4.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 158517890  239 VEFSISLPNHRFKAELTNSGSPYYQELVGQSQLQLQKIFKK---LPGFGEIRVLGFRPKK 295
Cdd:pfam01390   3 YTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslRKQYIKSHVLRLRPDG 62
 
Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 578-668 4.94e-12

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 62.64  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158517890  578 VVFFSLRVANMPFSYDLFNKSSLEYQALEQRFTDLLVPYLR-SNL-TGFKQLEILSFR--NGSVIVNSKVRFAK---AVP 650
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRnSSLrKQYIKSHVLRLRpdGGSVVVDVVLVFRFpstEPA 81

                          90
                  ....*....|....*...
gi 158517890  651 YNLTQAVRGVLEDLRSTA 668
Cdd:pfam01390  82 LDREKLIEEILRQTLNNT 99
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 577-646 1.02e-10

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 59.73  E-value: 1.02e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 158517890   577 LVVFFSLRVANMPFSYDLFNKSSLEYQALEQRFTDLLVPYLRSNLT--GFKQLEILSFRNGSVIVNSKVRFA 646
Cdd:smart00200   8 SLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLkpDFVGTEVIEFRNGSVVVDLGLLFN 79
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 239-295 4.83e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 39.91  E-value: 4.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 158517890  239 VEFSISLPNHRFKAELTNSGSPYYQELVGQSQLQLQKIFKK---LPGFGEIRVLGFRPKK 295
Cdd:pfam01390   3 YTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslRKQYIKSHVLRLRPDG 62
 
Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 578-668 4.94e-12

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 62.64  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158517890  578 VVFFSLRVANMPFSYDLFNKSSLEYQALEQRFTDLLVPYLR-SNL-TGFKQLEILSFR--NGSVIVNSKVRFAK---AVP 650
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRnSSLrKQYIKSHVLRLRpdGGSVVVDVVLVFRFpstEPA 81

                          90
                  ....*....|....*...
gi 158517890  651 YNLTQAVRGVLEDLRSTA 668
Cdd:pfam01390  82 LDREKLIEEILRQTLNNT 99
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 577-646 1.02e-10

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 59.73  E-value: 1.02e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 158517890   577 LVVFFSLRVANMPFSYDLFNKSSLEYQALEQRFTDLLVPYLRSNLT--GFKQLEILSFRNGSVIVNSKVRFA 646
Cdd:smart00200   8 SLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLkpDFVGTEVIEFRNGSVVVDLGLLFN 79
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 239-295 4.83e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 39.91  E-value: 4.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 158517890  239 VEFSISLPNHRFKAELTNSGSPYYQELVGQSQLQLQKIFKK---LPGFGEIRVLGFRPKK 295
Cdd:pfam01390   3 YTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslRKQYIKSHVLRLRPDG 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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