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Conserved domains on  [gi|21914829|ref|NP_071601|]
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programmed cell death protein 4 [Rattus norvegicus]

Protein Classification

MA3 domain-containing protein( domain architecture ID 10650530)

MA3 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
327-440 5.56e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


:

Pssm-ID: 214714  Cd Length: 113  Bit Score: 128.90  E-value: 5.56e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829    327 LVKEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLEStGESAFKMMLDLLKSLWKSSTITIDQMKRGYE 406
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEE-KRTYREMYSVLLSRLCQANVISTKQFEKGFW 79
                           90       100       110
                   ....*....|....*....|....*....|....
gi 21914829    407 RIYNEIPDINLDVPHSYSVLERFVEECFQAGIIS 440
Cdd:smart00544  80 RLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
164-275 4.35e-34

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


:

Pssm-ID: 214714  Cd Length: 113  Bit Score: 123.89  E-value: 4.35e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829    164 FEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLC-GTVMSTNDVEKSFDK 242
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCqANVISTKQFEKGFWR 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 21914829    243 LLKDLPELALDTPRAPQLVGQFIARAVGDGILC 275
Cdd:smart00544  81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
 
Name Accession Description Interval E-value
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
327-440 5.56e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 128.90  E-value: 5.56e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829    327 LVKEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLEStGESAFKMMLDLLKSLWKSSTITIDQMKRGYE 406
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEE-KRTYREMYSVLLSRLCQANVISTKQFEKGFW 79
                           90       100       110
                   ....*....|....*....|....*....|....
gi 21914829    407 RIYNEIPDINLDVPHSYSVLERFVEECFQAGIIS 440
Cdd:smart00544  80 RLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
164-275 4.35e-34

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 123.89  E-value: 4.35e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829    164 FEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLC-GTVMSTNDVEKSFDK 242
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCqANVISTKQFEKGFWR 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 21914829    243 LLKDLPELALDTPRAPQLVGQFIARAVGDGILC 275
Cdd:smart00544  81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
329-440 4.63e-26

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 101.97  E-value: 4.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829   329 KEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLEStGESAFKMMLDLLKSLWKSSTITIDQMKRGYERI 408
Cdd:pfam02847   3 RKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEE-SKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81
                          90       100       110
                  ....*....|....*....|....*....|..
gi 21914829   409 YNEIPDINLDVPHSYSVLERFVEECFQAGIIS 440
Cdd:pfam02847  82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
164-274 2.84e-21

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 88.49  E-value: 2.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829   164 FEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGT-VMSTNDVEKSFDK 242
Cdd:pfam02847   1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFnLISTKQFEKGFWR 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 21914829   243 LLKDLPELALDTPRAPQLVGQFIARAVGDGIL 274
Cdd:pfam02847  81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGL 112
 
Name Accession Description Interval E-value
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
327-440 5.56e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 128.90  E-value: 5.56e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829    327 LVKEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLEStGESAFKMMLDLLKSLWKSSTITIDQMKRGYE 406
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEE-KRTYREMYSVLLSRLCQANVISTKQFEKGFW 79
                           90       100       110
                   ....*....|....*....|....*....|....
gi 21914829    407 RIYNEIPDINLDVPHSYSVLERFVEECFQAGIIS 440
Cdd:smart00544  80 RLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
164-275 4.35e-34

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 123.89  E-value: 4.35e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829    164 FEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLC-GTVMSTNDVEKSFDK 242
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCqANVISTKQFEKGFWR 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 21914829    243 LLKDLPELALDTPRAPQLVGQFIARAVGDGILC 275
Cdd:smart00544  81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
329-440 4.63e-26

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 101.97  E-value: 4.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829   329 KEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLEStGESAFKMMLDLLKSLWKSSTITIDQMKRGYERI 408
Cdd:pfam02847   3 RKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEE-SKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81
                          90       100       110
                  ....*....|....*....|....*....|..
gi 21914829   409 YNEIPDINLDVPHSYSVLERFVEECFQAGIIS 440
Cdd:pfam02847  82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
164-274 2.84e-21

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 88.49  E-value: 2.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21914829   164 FEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGT-VMSTNDVEKSFDK 242
Cdd:pfam02847   1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFnLISTKQFEKGFWR 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 21914829   243 LLKDLPELALDTPRAPQLVGQFIARAVGDGIL 274
Cdd:pfam02847  81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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