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Conserved domains on  [gi|12545378|ref|NP_072102|]
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chorionic somatomammotropin hormone-like 1 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
growth_hormone_like super family cl07831
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 4-137 1.82e-54

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


The actual alignment was detected with superfamily member cd10285:

Pssm-ID: 324147  Cd Length: 180  Bit Score: 168.78  E-value: 1.82e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378   4 DSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDsDDYHLLKDLEEGIQMLMGRLEDGSHLT 83
Cdd:cd10285  47 ESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLSSVFTNQLHFGSSD-RIYEKLKDLEEGIQTLIRELEDGSPRG 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12545378  84 GQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRS-VEGSC 137
Cdd:cd10285 126 GQLLKQTYSKFDVNLRSDEALLKNYGLLSCFKKDMHKVETYLRVMKCRRfPESNC 180
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 4-137 1.82e-54

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 168.78  E-value: 1.82e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378   4 DSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDsDDYHLLKDLEEGIQMLMGRLEDGSHLT 83
Cdd:cd10285  47 ESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLSSVFTNQLHFGSSD-RIYEKLKDLEEGIQTLIRELEDGSPRG 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12545378  84 GQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRS-VEGSC 137
Cdd:cd10285 126 GQLLKQTYSKFDVNLRSDEALLKNYGLLSCFKKDMHKVETYLRVMKCRRfPESNC 180
Hormone_1 pfam00103
Somatotropin hormone family;
4-137 1.33e-33

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 116.71  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378     4 DSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLR----STFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDg 79
Cdd:pfam00103  75 NSIHTPENREKAQQTSNEELLKWSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVID- 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12545378    80 SHLTGQTLKQTYSKFD--TNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCR-SVEGSC 137
Cdd:pfam00103 154 PERTENEAYPAWSGLSslTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRlIYKDSC 214
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 4-137 1.82e-54

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 168.78  E-value: 1.82e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378   4 DSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDsDDYHLLKDLEEGIQMLMGRLEDGSHLT 83
Cdd:cd10285  47 ESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLSSVFTNQLHFGSSD-RIYEKLKDLEEGIQTLIRELEDGSPRG 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12545378  84 GQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRS-VEGSC 137
Cdd:cd10285 126 GQLLKQTYSKFDVNLRSDEALLKNYGLLSCFKKDMHKVETYLRVMKCRRfPESNC 180
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 5-137 3.37e-36

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 122.22  E-value: 3.37e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378   5 SIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNN----LVYDTSDSDDYHLLKDLEEGIQMLMGRLEDgS 80
Cdd:cd10284  45 SIPTPSSKEEAQQKSDKELLRISLELLQSWSEPLLHLHTVLANSkgtsLALLPKAKQVSEMLKLLEDGVETLSERIKD-L 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12545378  81 HLTGQTLKQTYSKFDTnsHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSC 137
Cdd:cd10284 124 PLEFNSVGALWSVDET--HNSLRRMHDYDLLSCFKKDAHKVETYLKILKCRRFEHSC 178
Hormone_1 pfam00103
Somatotropin hormone family;
4-137 1.33e-33

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 116.71  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378     4 DSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLR----STFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDg 79
Cdd:pfam00103  75 NSIHTPENREKAQQTSNEELLKWSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVID- 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12545378    80 SHLTGQTLKQTYSKFD--TNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCR-SVEGSC 137
Cdd:pfam00103 154 PERTENEAYPAWSGLSslTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRlIYKDSC 214
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
 5-137 1.40e-09

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 53.71  E-value: 1.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12545378   5 SIPTSSNmeETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNnlvYDTSDSDDYHLLK-------DLEEGIQMLMGR-L 76
Cdd:cd10286  71 SIPTSKT--EIQQISDKWLLHSVLILVQFWIDPLVDLQTSLDR---YDNAPSALLNKTKwmstklmNLEQGVLVLIRKmL 145

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12545378  77 EDGSHLTGQTLKQTYSKFDTnSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEG-SC 137
Cdd:cd10286 146 GEGMLLNNESPADTLDHFVM-SDMLESVLRDYTLLSCFKKDAHKVETFLKLLKCRQTDRlNC 206
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
 100-137 5.67e-05

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 41.01  E-value: 5.67e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 12545378 100 NHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSV-EGSC 137
Cdd:cd10287 146 GHLDAMSDYDLLHCFRRDSNKVQNYLKILKCRIFpESSC 184
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
 95-136 4.98e-04

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 38.40  E-value: 4.98e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 12545378  95 DTNSHnHDALlknYGLLHCFRKDMDKVETFLRMVQCRSVEGS 136
Cdd:cd10288 160 DEDSR-LFAF---YNLFHCLRRDSHKIDTYLKLLKCRIIHGN 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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