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Conserved domains on  [gi|12083617|ref|NP_073168|]
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zinc finger protein ZIC 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 219-264 1.27e-25

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


:

Pssm-ID: 436441  Cd Length: 45  Bit Score: 98.23  E-value: 1.27e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12083617   219 QPIKQELICKWIEPEQLAnPKKSCNKTFSTMHELVTHVTVEHVGGP 264
Cdd:pfam18366   1 QPIKQELSCKWIDPEQPA-PKKPCNKTFSTMHEIVTHLTVEHVGGP 45
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 298-382 5.35e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 5.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617 298 GEKPFPCPFPGCGKVFARSENLKIHKRthtgekpfkcefEG-CDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSS 376
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML------------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413


                ....*.
gi 12083617 377 LRKHMK 382
Cdd:COG5189 414 LKYHRK 419
 
Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 219-264 1.27e-25

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


Pssm-ID: 436441  Cd Length: 45  Bit Score: 98.23  E-value: 1.27e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12083617   219 QPIKQELICKWIEPEQLAnPKKSCNKTFSTMHELVTHVTVEHVGGP 264
Cdd:pfam18366   1 QPIKQELSCKWIDPEQPA-PKKPCNKTFSTMHEIVTHLTVEHVGGP 45
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 298-382 5.35e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 5.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617 298 GEKPFPCPFPGCGKVFARSENLKIHKRthtgekpfkcefEG-CDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSS 376
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML------------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413


                ....*.
gi 12083617 377 LRKHMK 382
Cdd:COG5189 414 LKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-345 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*...
gi 12083617   318 NLKIHKRTHTGEKPFKCEFegCDRRFAN 345
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 219-264 1.27e-25

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


Pssm-ID: 436441  Cd Length: 45  Bit Score: 98.23  E-value: 1.27e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12083617   219 QPIKQELICKWIEPEQLAnPKKSCNKTFSTMHELVTHVTVEHVGGP 264
Cdd:pfam18366   1 QPIKQELSCKWIDPEQPA-PKKPCNKTFSTMHEIVTHLTVEHVGGP 45
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 298-382 5.35e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 5.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617 298 GEKPFPCPFPGCGKVFARSENLKIHKRthtgekpfkcefEG-CDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSS 376
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML------------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413


                ....*.
gi 12083617 377 LRKHMK 382
Cdd:COG5189 414 LKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-385 5.48e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617 238 PKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPregKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSE 317
Cdd:COG5048 291 KSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG---KLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12083617 318 NLKIHKRTH-----TGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCK--MCDKSYTHPSSLRKHMKVHE 385
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-376 1.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.09e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12083617 299 EKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSS 376
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-443 8.31e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 8.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617 289 LVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDrKKHMHVHTSDKPYLCKMCD 368
Cdd:COG5048  49 LTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS-SLSSSSSNSNDNNLLSSHS 127

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12083617 369 KSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPTTDNPTTSSMSPSSSAVHHTAGHSALSSNFN 443
Cdd:COG5048 128 LPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSEN 202
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-345 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*...
gi 12083617   318 NLKIHKRTHTGEKPFKCEFegCDRRFAN 345
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-361 4.36e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617 246 FSTMHELVTHVTVEHVGGPEQSNHICfWEECPREGKPFKAKYKLVNHIRVhtGEKPFPCPFPGCGKVFARSENLKIHKRT 325
Cdd:COG5048 269 SSQSSSPNESDSSSEKGFSLPIKSKQ-CNISFSRSSPLTRHLRSVNHSGE--SLKPFSCPYSLCGKLFSRNDALKRHILL 345

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 12083617 326 HTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKP 361
Cdd:COG5048 346 HTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDL 381
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 362-384 6.39e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.39e-04
                          10        20
                  ....*....|....*....|...
gi 12083617   362 YLCKMCDKSYTHPSSLRKHMKVH 384
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-315 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*..
gi 12083617   289 LVNHIRVHTGEKPFPCPFpgCGKVFAR 315
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 303-383 7.82e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 35.86  E-value: 7.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12083617   303 PCPFPGCGKVFARSENLKIHKRTHTGE------KPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYL-CKMCDKSYTHPS 375
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFkCENCLLRFRTHR 80


                  ....*...
gi 12083617   376 SLRKHMKV 383
Cdd:pfam15909  81 SLFKHLHV 88
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-373 9.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.08e-03
                          10        20
                  ....*....|....*....|....
gi 12083617   350 KKHMHVHTSDKPYLCKMCDKSYTH 373
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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