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Conserved domains on  [gi|13194201|ref|NP_075380|]
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reticulon-4 receptor precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-260 1.98e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.57  E-value: 1.98e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  60 QRIFLHGNRISHVPAaSFRACRNLTILWLHSNVLARIDAAaFTGLALLEQLDLSDNaQLRSVdPATFHGLGRLHTLHLDR 139
Cdd:COG4886 116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 140 CGLQELgPGLFRGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLLLHQNRVAHVHP 219
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 13194201 220 HAfrDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Cdd:COG4886 268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
260-296 9.82e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 9.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 13194201    260 NPWVCDCRARPLWAWLQKFRGSSSEVP--CSLPQRLAGR 296
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-260 1.98e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.57  E-value: 1.98e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  60 QRIFLHGNRISHVPAaSFRACRNLTILWLHSNVLARIDAAaFTGLALLEQLDLSDNaQLRSVdPATFHGLGRLHTLHLDR 139
Cdd:COG4886 116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 140 CGLQELgPGLFRGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLLLHQNRVAHVHP 219
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 13194201 220 HAfrDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Cdd:COG4886 268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.05e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.05e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13194201   156 LQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRV 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-264 1.44e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 1.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  62 IFLHGNRISHVPAasFRACRNLTILWLHSNVLARIDaaAFTGLALLEQLDLSDNaQLRSVDPatFHGLGRLHTLHLDR-- 139
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNN-QIEKIEN--LENLVNLKKLYLGGnr 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 140 ----CGLQelgpglfrGLAALQYLYLQDnalQALPDD---TFRD------LGNLTHLFLHGNRISSVpeRAFRGLHSLDR 206
Cdd:cd21340  80 isvvEGLE--------NLTNLEELHIEN---QRLPPGeklTFDPrslaalSNSLRVLNISGNNIDSL--EPLAPLRNLEQ 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13194201 207 LLLHQNRVahvhphafrdlgrlmtlylfaNNLSALpTEALAPLRALQYLRLNDNPwVC 264
Cdd:cd21340 147 LDASNNQI---------------------SDLEEL-LDLLSSWPSLRELDLTGNP-VC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-260 2.14e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   82 NLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNaQLRSVDPatfHGLGRLHTLHLDRCGLQELG---PGLFRGLAALQY 158
Cdd:PLN00113 165 SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN-QLVGQIP---RELGQMKSLKWIYLGYNNLSgeiPYEIGGLTSLNH 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  159 LYLQDNALQALPDDTFRDLGNLTHLFLHGNRIS-SVPERAFrGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANN 237
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                        170       180
                 ....*....|....*....|...
gi 13194201  238 LSALPTEALAPLRALQYLRLNDN 260
Cdd:PLN00113 320 FTGKIPVALTSLPRLQVLQLWSN 342
LRR smart00370
Leucine-rich repeats, outliers;
177-200 3.13e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.72  E-value: 3.13e-04
                           10        20
                   ....*....|....*....|....
gi 13194201    177 LGNLTHLFLHGNRISSVPERAFRG 200
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRRCT smart00082
Leucine rich repeat C-terminal domain;
260-296 9.82e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 9.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 13194201    260 NPWVCDCRARPLWAWLQKFRGSSSEVP--CSLPQRLAGR 296
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-260 1.98e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.57  E-value: 1.98e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  60 QRIFLHGNRISHVPAaSFRACRNLTILWLHSNVLARIDAAaFTGLALLEQLDLSDNaQLRSVdPATFHGLGRLHTLHLDR 139
Cdd:COG4886 116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 140 CGLQELgPGLFRGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLLLHQNRVAHVHP 219
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 13194201 220 HAfrDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Cdd:COG4886 268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-260 4.71e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 4.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  82 NLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLqelgpglFRGLAALQYLYL 161
Cdd:COG4886  48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 162 QDNALQALPDDtFRDLGNLTHLFLHGNRISSVPErAFRGLHSLDRLLLHQNRVAHVhPHAFRDLGRLMTLYLFANNLSAL 241
Cdd:COG4886 121 SGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                       170
                ....*....|....*....
gi 13194201 242 PtEALAPLRALQYLRLNDN 260
Cdd:COG4886 198 P-EPLGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.05e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.05e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13194201   156 LQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRV 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
131-190 1.95e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 1.95e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   131 RLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-264 1.44e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 1.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  62 IFLHGNRISHVPAasFRACRNLTILWLHSNVLARIDaaAFTGLALLEQLDLSDNaQLRSVDPatFHGLGRLHTLHLDR-- 139
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNN-QIEKIEN--LENLVNLKKLYLGGnr 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 140 ----CGLQelgpglfrGLAALQYLYLQDnalQALPDD---TFRD------LGNLTHLFLHGNRISSVpeRAFRGLHSLDR 206
Cdd:cd21340  80 isvvEGLE--------NLTNLEELHIEN---QRLPPGeklTFDPrslaalSNSLRVLNISGNNIDSL--EPLAPLRNLEQ 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13194201 207 LLLHQNRVahvhphafrdlgrlmtlylfaNNLSALpTEALAPLRALQYLRLNDNPwVC 264
Cdd:cd21340 147 LDASNNQI---------------------SDLEEL-LDLLSSWPSLRELDLTGNP-VC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-260 1.88e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 1.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 129 LGRLHTLHLDRCGLQELGpgLFRGLAALQYLYLQDNALQALPDdtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLL 208
Cdd:cd21340   1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 209 LHQNRVAHV------------H---------------PHAFRDLGR-LMTLYLFANNLSALptEALAPLRALQYLRLNDN 260
Cdd:cd21340  75 LGGNRISVVeglenltnleelHienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN 152
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-194 2.54e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 2.54e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  62 IFLHGNRISHVPAASFraCRNLTILWLHSNVLARIDAaaFTGLALLEQLDLSDNA-----------QLR----------- 119
Cdd:cd21340  29 LYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenltNLEelhienqrlpp 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 120 ----SVDPATFHGLGR-LHTLHLDRCGLQELGPglFRGLAALQYLYLQDNALQALPD--DTFRDLGNLTHLFLHGNRISS 192
Cdd:cd21340 105 geklTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK 182


                ..
gi 13194201 193 VP 194
Cdd:cd21340 183 KP 184
LRR_8 pfam13855
Leucine rich repeat;
179-238 2.90e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 2.90e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   179 NLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL 238
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
60-115 8.50e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 8.50e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 13194201    60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDN 115
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
203-261 9.65e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.65e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13194201   203 SLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNP 261
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-260 2.14e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   82 NLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNaQLRSVDPatfHGLGRLHTLHLDRCGLQELG---PGLFRGLAALQY 158
Cdd:PLN00113 165 SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN-QLVGQIP---RELGQMKSLKWIYLGYNNLSgeiPYEIGGLTSLNH 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  159 LYLQDNALQALPDDTFRDLGNLTHLFLHGNRIS-SVPERAFrGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANN 237
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                        170       180
                 ....*....|....*....|...
gi 13194201  238 LSALPTEALAPLRALQYLRLNDN 260
Cdd:PLN00113 320 FTGKIPVALTSLPRLQVLQLWSN 342
LRR_8 pfam13855
Leucine rich repeat;
81-166 4.95e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 4.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201    81 RNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAqlrsvdpatfhglgrlhtlhldrcgLQELGPGLFRGLAALQYLY 160
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-------------------------LTTLSPGAFSGLPSLRYLD 55


                  ....*.
gi 13194201   161 LQDNAL 166
Cdd:pfam13855  56 LSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
4-260 2.05e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201    4 ASAGGSR--LLAWVLWLQaWQVAAPCPGA------------CVCYNEPKVTTScpQQGLQAVPVGIPAASQRIFLHGNRI 69
Cdd:PRK15370 135 SSASGSKdaVNYELIWSE-WVKEAPAKEAanreeavqrmrdCLKNNKTELRLK--ILGLTTIPACIPEQITTLILDNNEL 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   70 SHVPAaSFRAcrNLTILWLHSNVLARIDAaafTGLALLEQLDLSDN--AQLRSVDPATfhglgrLHTLHLDRCGLQELGP 147
Cdd:PRK15370 212 KSLPE-NLQG--NIKTLYANSNQLTSIPA---TLPDTIQEMELSINriTELPERLPSA------LQSLDLFHNKISCLPE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  148 GLFRGLaalQYLYLQDNALQALPDDTfrdLGNLTHLFLHGNRISSVPERAFRGLHSLD------------------RLLL 209
Cdd:PRK15370 280 NLPEEL---RYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPGLKTLEagenaltslpaslppelqVLDV 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 13194201  210 HQNRVAhVHPHAFRDlgRLMTLYLFANNLSALPTEALAplrALQYLRLNDN 260
Cdd:PRK15370 354 SKNQIT-VLPETLPP--TITTLDVSRNALTNLPENLPA---ALQIMQASRN 398
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 51-260 2.35e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   51 VPVGIPAAS--QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAqLRSVDPATFHG 128
Cdd:PLN00113 324 IPVALTSLPrlQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNS-LEGEIPKSLGA 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  129 LGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRIS-SVPEraFRGLHSLDRL 207
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD--SFGSKRLENL 480

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 13194201  208 LLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Cdd:PLN00113 481 DLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR smart00370
Leucine-rich repeats, outliers;
177-200 3.13e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.72  E-value: 3.13e-04
                           10        20
                   ....*....|....*....|....
gi 13194201    177 LGNLTHLFLHGNRISSVPERAFRG 200
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
177-200 3.13e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 37.72  E-value: 3.13e-04
                           10        20
                   ....*....|....*....|....
gi 13194201    177 LGNLTHLFLHGNRISSVPERAFRG 200
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 82-123 3.32e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 3.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 13194201    82 NLTILWLHSNVLARIDAaaFTGLALLEQLDLSDNAQLRSVDP 123
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-269 1.00e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201  60 QRIFLHGNRISHVPAASF----RACRNLTILWLHSNVL----ARIDAAAFTGLALLEQLDLSDNaqlrSVDPATFHGLG- 130
Cdd:COG5238 183 ETVYLGCNQIGDEGIEELaealTQNTTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNN----QIGDEGVIALAe 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 131 ------RLHTL-----HLDRCGLQELGPGLfRGLAALQYLYLQDN--------ALQalpdDTFRDLGNLTHLFLHGNRIS 191
Cdd:COG5238 259 alknntTVETLylsgnQIGAEGAIALAKAL-QGNTTLTSLDLSVNrigdegaiALA----EGLQGNKTLHTLNLAYNGIG 333

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 192 SVPERAF-------RGLHSLDrllLHQNRV----AHVHPHAFRDLGRLMTLYLFANNLSALPTEALAplRALQ-----YL 255
Cdd:COG5238 334 AQGAIALakalqenTTLHSLD---LSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI--DALQtnrlhTL 408

                       250
                ....*....|....
gi 13194201 256 RLNDNPWVCDCRAR 269
Cdd:COG5238 409 ILDGNLIGAEAQQR 422
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-261 1.05e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 107 LEQLDLSDNaQLRSVDPAT---FHGLG---RLHTLHLDRCGLQELGPGLFRGL---AALQYLYLQDNALQALPDDT---- 173
Cdd:cd00116  53 LKELCLSLN-ETGRIPRGLqslLQGLTkgcGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLlakg 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 174 FRDLG-NLTHLFLHGNRISSVPER----AFRGLHSLDRLLLHQNRV----AHVHPHAFRDLGRLMTLYLFANNL-----S 239
Cdd:cd00116 132 LKDLPpALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLtdegaS 211

                       170       180
                ....*....|....*....|..
gi 13194201 240 ALpTEALAPLRALQYLRLNDNP 261
Cdd:cd00116 212 AL-AETLASLKSLEVLNLGDNN 232
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-261 2.02e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 155 ALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRvahvhphAFRDLGRLMTLYLF 234
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLS 121

                        90       100
                ....*....|....*....|....*..
gi 13194201 235 ANNLSALPtEALAPLRALQYLRLNDNP 261
Cdd:COG4886 122 GNQLTDLP-EELANLTNLKELDLSNNQ 147
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 152-255 2.62e-03

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 38.84  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   152 GLAALQYL--YLQDNALQALPDDTfrdlgnlthLFL--HGNRISSvpeRAFRglHSLDRLLLHQNRVAHVHPHAFRdlgr 227
Cdd:pfam00589  71 SDAALELLkeWLSKRLLEAPKSDY---------LFAskRGKPLSR---QTVR--KIFKRAGKEAGLELPLHPHMLR---- 132

                          90       100
                  ....*....|....*....|....*...
gi 13194201   228 lmtlYLFANNLSalptEALAPLRALQYL 255
Cdd:pfam00589 133 ----HSFATHLL----EAGVDLRVVQKL 152
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-260 2.67e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201 122 DPATFHGLGRLHTLHLDRCGLQELGPGLfRGLAALQYLYLQDNALQALPDDTFRDL---GNLTHLFLHGNRISSVPERAF 198
Cdd:cd00116  50 QPSLKELCLSLNETGRIPRGLQSLLQGL-TKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLL 128

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13194201 199 -RGL----HSLDRLLLHQNRVAHVH----PHAFRDLGRLMTLYLFANNLSALPTEALAP----LRALQYLRLNDN 260
Cdd:cd00116 129 aKGLkdlpPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNN 203
LRR_9 pfam14580
Leucine-rich repeat;
169-261 2.94e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13194201   169 LPDDTFRDLGNLTHLflhgNRISSvperafrglhsldrLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPT-EALA 247
Cdd:pfam14580  49 FSDNEIRKLDGFPLL----RRLKT--------------LLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLA 110

                          90
                  ....*....|....
gi 13194201   248 PLRALQYLRLNDNP 261
Cdd:pfam14580 111 SLKKLTFLSLLRNP 124
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 179-212 6.64e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 6.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 13194201   179 NLTHLFLHGNRISSVPerAFRGLHSLDRLLLHQN 212
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
260-296 9.82e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 9.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 13194201    260 NPWVCDCRARPLWAWLQKFRGSSSEVP--CSLPQRLAGR 296
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRGP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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