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Conserved domains on  [gi|117606355|ref|NP_075463|]
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protein furry homolog isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2319-3013 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1188.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2319 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSTSSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2398
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2399 HVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDN 2478
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGEGESMDN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2479 FNWGVRRRSLDSLDKCDMQILEERQLSGSTPSLNKMHHEDSDESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTA 2558
Cdd:pfam19421  161 FNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSLSQS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2559 CDSTPAEPHSFNTRMSSFDASLPDMNNLQisegskaeavreeedttvheddlsssinelpaafecsdsfsldmtegeekg 2638
Cdd:pfam19421  241 QDSSSADEESLRAETPSLEVSLPEDASAR--------------------------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2639 nraldqftlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRF 2718
Cdd:pfam19421  270 ------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKF 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2719 CFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLA 2798
Cdd:pfam19421  338 CSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLD 417

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2799 NCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSMPELLNMSRELSDLKKHLKEA 2878
Cdd:pfam19421  418 NCKATFPRGSGDGVITCQPADQEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEA 497

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2879 SAVIAADPLYS-DGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTL 2957
Cdd:pfam19421  498 EASVTSDELAQeESASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTL 577

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 117606355  2958 GQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTTFLPDSSVSGTSL 3013
Cdd:pfam19421  578 GQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 165-671 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 618.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   165 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 244
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   245 KKFMAELKELRHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 324
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   325 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHIFLNNCLSNLKNKdpKMARVAL 404
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   405 ESLYRLLWVYMIRIKcESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 484
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   485 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 560
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   561 KAVDNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 626
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 117606355   627 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 671
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2042-2295 3.17e-61

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 211.18  E-value: 3.17e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2042 ATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQlKW-ADFSGLQQLLLKGFTSLTTTDLTLQL 2120
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2121 FSLLTPVSKISMVDASHAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2198
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2199 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQS 2277
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 117606355  2278 VHWREALNILKLVVSRSA 2295
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 734-1898 6.54e-24

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 111.27  E-value: 6.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   734 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALFIAL----------GQPEDDDRP--MIDVMDQLSSSILESfih 801
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYNDLrdmsskersdVSWKNNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   802 vAVSDSAtlpltHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 878
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   879 yaftRLQSVMPLVDPNSPINAKKTSTAGSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 958
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   959 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 1035
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1036 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1112
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1113 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1164
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1165 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1206
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1207 VLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYP-FDIVTLLNLVLFKASDTNREIYEISMQLMQILE 1285
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1286 AKLFVYSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1364
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1365 HNIELVdsrlllpgsspsspedevkdregdvtashGLRGNGWgspeaTSLVLNNLMYMTAKYGDEVPGpEMENAWNALAN 1444
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1445 NEKwsnNLRITLQFLISLCGVSSDT--------VLLPYI---KKVAIYLCRNNTIQTMEELLFELQQ------TEPVNPI 1507
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRPS 768

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1508 VQHCDnppfyrftasskasaaasgttSSSNTVVAGQENfPDAEENKILKESDERFSNVIrAHTRLESRYSNSSGG----- 1582
Cdd:pfam14228  769 DGAFD---------------------LESSAVLEFSQG-PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1583 SYDEDKNDPISPYTGWLLTITETKQ-----PQPLPMPCTGGcwaPLV-------------------DYLPET-------- 1630
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1631 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLlia 1696
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNL--- 977

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1697 lscnsnFHSIASVLLQtremgeaktltvqpayqpeyLYtggfdflredqsspvpdsglsssstsssislggssgnlpqmt 1776
Cdd:pfam14228  978 ------LYSLAGRHLE--------------------LY------------------------------------------ 989

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1777 qEVEDVDtaAETDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVS--VFKDSksgfhLEHQLSEVA 1854
Cdd:pfam14228  990 -DVEHGD--GEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWGEEA 1061

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 117606355  1855 LQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1898
Cdd:pfam14228 1062 LKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2319-3013 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1188.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2319 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSTSSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2398
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2399 HVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDN 2478
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGEGESMDN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2479 FNWGVRRRSLDSLDKCDMQILEERQLSGSTPSLNKMHHEDSDESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTA 2558
Cdd:pfam19421  161 FNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSLSQS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2559 CDSTPAEPHSFNTRMSSFDASLPDMNNLQisegskaeavreeedttvheddlsssinelpaafecsdsfsldmtegeekg 2638
Cdd:pfam19421  241 QDSSSADEESLRAETPSLEVSLPEDASAR--------------------------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2639 nraldqftlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRF 2718
Cdd:pfam19421  270 ------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKF 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2719 CFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLA 2798
Cdd:pfam19421  338 CSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLD 417

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2799 NCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSMPELLNMSRELSDLKKHLKEA 2878
Cdd:pfam19421  418 NCKATFPRGSGDGVITCQPADQEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEA 497

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2879 SAVIAADPLYS-DGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTL 2957
Cdd:pfam19421  498 EASVTSDELAQeESASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTL 577

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 117606355  2958 GQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTTFLPDSSVSGTSL 3013
Cdd:pfam19421  578 GQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 165-671 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 618.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   165 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 244
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   245 KKFMAELKELRHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 324
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   325 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHIFLNNCLSNLKNKdpKMARVAL 404
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   405 ESLYRLLWVYMIRIKcESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 484
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   485 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 560
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   561 KAVDNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 626
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 117606355   627 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 671
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2042-2295 3.17e-61

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 211.18  E-value: 3.17e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2042 ATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQlKW-ADFSGLQQLLLKGFTSLTTTDLTLQL 2120
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2121 FSLLTPVSKISMVDASHAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2198
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2199 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQS 2277
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 117606355  2278 VHWREALNILKLVVSRSA 2295
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 734-1898 6.54e-24

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 111.27  E-value: 6.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   734 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALFIAL----------GQPEDDDRP--MIDVMDQLSSSILESfih 801
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYNDLrdmsskersdVSWKNNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   802 vAVSDSAtlpltHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 878
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   879 yaftRLQSVMPLVDPNSPINAKKTSTAGSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 958
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   959 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 1035
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1036 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1112
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1113 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1164
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1165 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1206
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1207 VLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYP-FDIVTLLNLVLFKASDTNREIYEISMQLMQILE 1285
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1286 AKLFVYSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1364
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1365 HNIELVdsrlllpgsspsspedevkdregdvtashGLRGNGWgspeaTSLVLNNLMYMTAKYGDEVPGpEMENAWNALAN 1444
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1445 NEKwsnNLRITLQFLISLCGVSSDT--------VLLPYI---KKVAIYLCRNNTIQTMEELLFELQQ------TEPVNPI 1507
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRPS 768

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1508 VQHCDnppfyrftasskasaaasgttSSSNTVVAGQENfPDAEENKILKESDERFSNVIrAHTRLESRYSNSSGG----- 1582
Cdd:pfam14228  769 DGAFD---------------------LESSAVLEFSQG-PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1583 SYDEDKNDPISPYTGWLLTITETKQ-----PQPLPMPCTGGcwaPLV-------------------DYLPET-------- 1630
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1631 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLlia 1696
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNL--- 977

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1697 lscnsnFHSIASVLLQtremgeaktltvqpayqpeyLYtggfdflredqsspvpdsglsssstsssislggssgnlpqmt 1776
Cdd:pfam14228  978 ------LYSLAGRHLE--------------------LY------------------------------------------ 989

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1777 qEVEDVDtaAETDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVS--VFKDSksgfhLEHQLSEVA 1854
Cdd:pfam14228  990 -DVEHGD--GEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWGEEA 1061

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 117606355  1855 LQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1898
Cdd:pfam14228 1062 LKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2319-3013 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1188.02  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2319 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSTSSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2398
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2399 HVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDN 2478
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGEGESMDN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2479 FNWGVRRRSLDSLDKCDMQILEERQLSGSTPSLNKMHHEDSDESSEEEDLTASQILEHSDLIMTLSPSEETNPMELLTTA 2558
Cdd:pfam19421  161 FNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSLSQS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2559 CDSTPAEPHSFNTRMSSFDASLPDMNNLQisegskaeavreeedttvheddlsssinelpaafecsdsfsldmtegeekg 2638
Cdd:pfam19421  241 QDSSSADEESLRAETPSLEVSLPEDASAR--------------------------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2639 nraldqftlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRF 2718
Cdd:pfam19421  270 ------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKF 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2719 CFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLA 2798
Cdd:pfam19421  338 CSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLD 417

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2799 NCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSMPELLNMSRELSDLKKHLKEA 2878
Cdd:pfam19421  418 NCKATFPRGSGDGVITCQPADQEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEA 497

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2879 SAVIAADPLYS-DGAWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTL 2957
Cdd:pfam19421  498 EASVTSDELAQeESASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTL 577

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 117606355  2958 GQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTTFLPDSSVSGTSL 3013
Cdd:pfam19421  578 GQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 165-671 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 618.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   165 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 244
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   245 KKFMAELKELRHKEQNPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 324
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   325 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHIFLNNCLSNLKNKdpKMARVAL 404
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   405 ESLYRLLWVYMIRIKcESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 484
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   485 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 560
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   561 KAVDNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 626
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 117606355   627 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 671
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2042-2295 3.17e-61

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 211.18  E-value: 3.17e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2042 ATIFWVTVALMESDFEFEYLMALRLLSRLLAHMPLDKAENREKLEKLQAQlKW-ADFSGLQQLLLKGFTSLTTTDLTLQL 2120
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2121 FSLLTPVSKISMVDASHAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2198
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  2199 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSVQQPLLQVIYSLLSYMDLSVVPVKQFNVEVLKTIEKYVQS 2277
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 117606355  2278 VHWREALNILKLVVSRSA 2295
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 734-1898 6.54e-24

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 111.27  E-value: 6.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   734 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALFIAL----------GQPEDDDRP--MIDVMDQLSSSILESfih 801
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYNDLrdmsskersdVSWKNNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   802 vAVSDSAtlpltHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 878
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   879 yaftRLQSVMPLVDPNSPINAKKTSTAGSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 958
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355   959 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 1035
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1036 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1112
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1113 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1164
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1165 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1206
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1207 VLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYP-FDIVTLLNLVLFKASDTNREIYEISMQLMQILE 1285
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1286 AKLFVYSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1364
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1365 HNIELVdsrlllpgsspsspedevkdregdvtashGLRGNGWgspeaTSLVLNNLMYMTAKYGDEVPGpEMENAWNALAN 1444
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1445 NEKwsnNLRITLQFLISLCGVSSDT--------VLLPYI---KKVAIYLCRNNTIQTMEELLFELQQ------TEPVNPI 1507
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRPS 768

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1508 VQHCDnppfyrftasskasaaasgttSSSNTVVAGQENfPDAEENKILKESDERFSNVIrAHTRLESRYSNSSGG----- 1582
Cdd:pfam14228  769 DGAFD---------------------LESSAVLEFSQG-PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1583 SYDEDKNDPISPYTGWLLTITETKQ-----PQPLPMPCTGGcwaPLV-------------------DYLPET-------- 1630
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1631 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLlia 1696
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNL--- 977

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1697 lscnsnFHSIASVLLQtremgeaktltvqpayqpeyLYtggfdflredqsspvpdsglsssstsssislggssgnlpqmt 1776
Cdd:pfam14228  978 ------LYSLAGRHLE--------------------LY------------------------------------------ 989

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117606355  1777 qEVEDVDtaAETDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVS--VFKDSksgfhLEHQLSEVA 1854
Cdd:pfam14228  990 -DVEHGD--GEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWGEEA 1061

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 117606355  1855 LQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1898
Cdd:pfam14228 1062 LKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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