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Conserved domains on  [gi|110625701|ref|NP_075546|]
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single Ig IL-1-related receptor isoform 1 [Mus musculus]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 12161571)

toll/interleukin-1 receptor (TIR) domain-containing protein; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
164-309 2.74e-14

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 69.66  E-value: 2.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   164 YDAYVSYSDCPEdrkFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFRE 243
Cdd:smart00255   2 YDVFISYSGKED---VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   244 GL-CRLLELTRRPIFITFEGQRREPIHpalrllrQHRHLvTLVLWKPG---SVTPSSDFWKELQLALPRK 309
Cdd:smart00255  79 ALeNALEEGGLRVIPIFYEVIPSDVRK-------QPGKF-RKVFKKNYlkwPEDEKEQFWKKALYAVPSK 140
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 9-101 6.49e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.49  E-value: 6.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701    9 PNFLSPSEDQALglALGREVALNCTAWVFsrpqcPQPSVQWLKDGLALGNGSHfslhedfwvSANFSEIVSSVLVLNLTN 88
Cdd:pfam13927   2 PVITVSPSSVTV--REGETVTLTCEATGS-----PPPTITWYKNGEPISSGST---------RSRSLSGSNSTLTISNVT 65

                          90
                  ....*....|...
gi 110625701   89 AEDYGTFTCSVWN 101
Cdd:pfam13927  66 RSDAGTYTCVASN 78
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
164-309 2.74e-14

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 69.66  E-value: 2.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   164 YDAYVSYSDCPEdrkFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFRE 243
Cdd:smart00255   2 YDVFISYSGKED---VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   244 GL-CRLLELTRRPIFITFEGQRREPIHpalrllrQHRHLvTLVLWKPG---SVTPSSDFWKELQLALPRK 309
Cdd:smart00255  79 ALeNALEEGGLRVIPIFYEVIPSDVRK-------QPGKF-RKVFKKNYlkwPEDEKEQFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 167-310 1.06e-13

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 68.55  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701  167 YVSYSDCPE--DRK-FVNFILKpQLeRRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFRE 243
Cdd:pfam01582   1 YDVFLSFRGsdTREwFVSHLLK-EL-KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701  244 GLCRLLELTRRPIFITFE-------GQRREPIHpALRLLRQHRHLVTLVLWKPG-----------SVTPSSDFWKELQLA 305
Cdd:pfam01582  79 ILECALDLGQKVIPIFYEvdpsdvrKQTGSFGK-AFKKHKKVLTEEKVLKWRGAlnevaniwhskSVSDESKFWKKIAYD 157


                  ....*
gi 110625701  306 LPRKV 310
Cdd:pfam01582 158 ISNKL 162
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 9-101 6.49e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.49  E-value: 6.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701    9 PNFLSPSEDQALglALGREVALNCTAWVFsrpqcPQPSVQWLKDGLALGNGSHfslhedfwvSANFSEIVSSVLVLNLTN 88
Cdd:pfam13927   2 PVITVSPSSVTV--REGETVTLTCEATGS-----PPPTITWYKNGEPISSGST---------RSRSLSGSNSTLTISNVT 65

                          90
                  ....*....|...
gi 110625701   89 AEDYGTFTCSVWN 101
Cdd:pfam13927  66 RSDAGTYTCVASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-101 1.97e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.57  E-value: 1.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701    24 LGREVALNCTAWVFsrpqcPQPSVQWLKDGL-ALGNGSHFSLHEDfwvsanfseivSSVLVLNLTNA--EDYGTFTCSVW 100
Cdd:smart00410   8 EGESVTLSCEASGS-----PPPEVTWYKQGGkLLAESGRFSVSRS-----------GSTSTLTISNVtpEDSGTYTCAAT 71


                   .
gi 110625701   101 N 101
Cdd:smart00410  72 N 72
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 28-101 2.00e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 45.01  E-value: 2.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625701  28 VALNCTAWVFsrpqcPQPSVQWLKDGLALGNGSHFSlhedfwvsaNFSEIVSSVLVLNLTNAEDYGTFTCSVWN 101
Cdd:cd00096    1 VTLTCSASGN-----PPPTITWYKNGKPLPPSSRDS---------RRSELGNGTLTISNVTLEDSGTYTCVASN 60
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
164-309 2.74e-14

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 69.66  E-value: 2.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   164 YDAYVSYSDCPEdrkFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFRE 243
Cdd:smart00255   2 YDVFISYSGKED---VRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   244 GL-CRLLELTRRPIFITFEGQRREPIHpalrllrQHRHLvTLVLWKPG---SVTPSSDFWKELQLALPRK 309
Cdd:smart00255  79 ALeNALEEGGLRVIPIFYEVIPSDVRK-------QPGKF-RKVFKKNYlkwPEDEKEQFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 167-310 1.06e-13

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 68.55  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701  167 YVSYSDCPE--DRK-FVNFILKpQLeRRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFRE 243
Cdd:pfam01582   1 YDVFLSFRGsdTREwFVSHLLK-EL-KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701  244 GLCRLLELTRRPIFITFE-------GQRREPIHpALRLLRQHRHLVTLVLWKPG-----------SVTPSSDFWKELQLA 305
Cdd:pfam01582  79 ILECALDLGQKVIPIFYEvdpsdvrKQTGSFGK-AFKKHKKVLTEEKVLKWRGAlnevaniwhskSVSDESKFWKKIAYD 157


                  ....*
gi 110625701  306 LPRKV 310
Cdd:pfam01582 158 ISNKL 162
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 9-101 6.49e-08

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 49.49  E-value: 6.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701    9 PNFLSPSEDQALglALGREVALNCTAWVFsrpqcPQPSVQWLKDGLALGNGSHfslhedfwvSANFSEIVSSVLVLNLTN 88
Cdd:pfam13927   2 PVITVSPSSVTV--REGETVTLTCEATGS-----PPPTITWYKNGEPISSGST---------RSRSLSGSNSTLTISNVT 65

                          90
                  ....*....|...
gi 110625701   89 AEDYGTFTCSVWN 101
Cdd:pfam13927  66 RSDAGTYTCVASN 78
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 167-267 5.23e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 48.08  E-value: 5.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701  167 YVSYSdcPEDRKFVNfILKPQLERRrGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFREGLc 246
Cdd:pfam13676   2 FISYA--GEDRAWAE-WLADALEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAAL- 76

                          90       100
                  ....*....|....*....|.
gi 110625701  247 RLLELTRRPIFITFEGQRREP 267
Cdd:pfam13676  77 ADPEGRKRLIPVRLECDLELP 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-101 1.97e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.57  E-value: 1.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701    24 LGREVALNCTAWVFsrpqcPQPSVQWLKDGL-ALGNGSHFSLHEDfwvsanfseivSSVLVLNLTNA--EDYGTFTCSVW 100
Cdd:smart00410   8 EGESVTLSCEASGS-----PPPEVTWYKQGGkLLAESGRFSVSRS-----------GSTSTLTISNVtpEDSGTYTCAAT 71


                   .
gi 110625701   101 N 101
Cdd:smart00410  72 N 72
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 28-101 2.00e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 45.01  E-value: 2.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625701  28 VALNCTAWVFsrpqcPQPSVQWLKDGLALGNGSHFSlhedfwvsaNFSEIVSSVLVLNLTNAEDYGTFTCSVWN 101
Cdd:cd00096    1 VTLTCSASGN-----PPPTITWYKNGKPLPPSSRDS---------RRSELGNGTLTISNVTLEDSGTYTCVASN 60
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 25-110 6.31e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 43.92  E-value: 6.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   25 GREVALNCTAWVfsrpqCPQPSVQWLKDGLALGNGSHFSlhedfwvsanfseivssvlvLNLTNAEDYGTFTCSVWN--- 101
Cdd:pfam13895  14 GEPVTLTCSAPG-----NPPPSYTWYKDGSAISSSPNFF--------------------TLSVSAEDSGTYTCVARNgrg 68

                          90
                  ....*....|
gi 110625701  102 -VSSHSFTLW 110
Cdd:pfam13895  69 gKVSNPVELT 78
I-set pfam07679
Immunoglobulin I-set domain;
9-101 3.24e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 42.24  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701    9 PNFLSPSEDQALglALGREVALNCTAWvfsrpQCPQPSVQWLKDGLALGNGSHFSLHEDfwvSANFSEIVSSVlvlnltN 88
Cdd:pfam07679   1 PKFTQKPKDVEV--QEGESARFTCTVT-----GTPDPEVSWFKDGQPLRSSDRFKVTYE---GGTYTLTISNV------Q 64

                          90
                  ....*....|...
gi 110625701   89 AEDYGTFTCSVWN 101
Cdd:pfam07679  65 PDDSGKYTCVATN 77
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 22-106 9.12e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 41.03  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   22 LALGREVALNCTAwvfsRPQCPQPSVQWLKDGLALGNGSHFSLHEDfwvsanfSEIVSSVLVLNLTnAEDYGTFTCSVWN 101
Cdd:pfam00047   8 VLEGDSATLTCSA----STGSPGPDVTWSKEGGTLIESLKVKHDNG-------RTTQSSLLISNVT-KEDAGTYTCVVNN 75


                  ....*
gi 110625701  102 VSSHS 106
Cdd:pfam00047  76 PGGSA 80
IgI_4_Dscam cd20956
Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 8-106 5.32e-03

Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409548 [Multi-domain]  Cd Length: 96  Bit Score: 36.00  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701   8 APNFLSPSEDQALglALGREVALNCTAwVFSrpqcPQPSVQWLKDGLALGNGSHFSLHEdfWVSANfSEIVSSVlvlNLT 87
Cdd:cd20956    1 APVLLETFSEQTL--QPGPSVSLKCVA-SGN----PLPQITWTLDGFPIPESPRFRVGD--YVTSD-GDVVSYV---NIS 67

                         90       100
                 ....*....|....*....|....
gi 110625701  88 NA--EDYGTFTCSVWN---VSSHS 106
Cdd:cd20956   68 SVrvEDGGEYTCTATNdvgSVSHS 91
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 11-106 5.46e-03

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 35.90  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625701  11 FLSPSEDQALGlalGREVALNCTAWVFSRPQcpqPSVQWLKDGLALGNGSHfslhEDFWVSAN---FSeiVSSVLVLNLT 87
Cdd:cd00098    3 TLLPPSPEEKG---GGKVTLVCLVSGFYPKD---ITVTWLKNGVPLTSGVS----TSSPVEPNdgtYS--VTSSLTVPPS 70

                         90
                 ....*....|....*....
gi 110625701  88 NAEDYGTFTCSVWNVSSHS 106
Cdd:cd00098   71 DWDEGATYTCVVTHESLKS 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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