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Conserved domains on  [gi|13385312|ref|NP_080112|]
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perilipin-3 [Mus musculus]

Protein Classification

perilipin family protein( domain architecture ID 10503492)

perilipin family protein similar to human perilipin-1 that functions as a modulator of adipocyte lipid metabolism

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Perilipin pfam03036
Perilipin family; The perilipin family includes lipid droplet-associated protein (perilipin), ...
18-429 0e+00

Perilipin family; The perilipin family includes lipid droplet-associated protein (perilipin), adipose differentiation-related protein (adipophilin) and TIP47, also known as perilin-3, altogether form the PAT family of proteins. They predominantly localize to the surface of intracellular neutral lipid droplets. Perilipin is a modulator of adipocyte lipid metabolism and adipophilinis and are involved in the development and maintenance of adipose tissue. This family appears to share some similarity with pfam08618.


:

Pssm-ID: 460784  Cd Length: 400  Bit Score: 580.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312    18 EPVVQPSVVDRVAGLPLISSTYGMVSAAYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAH 97
Cdd:pfam03036   1 EEPEQQSVVSRVANLPLVSSTCDMVSSAYSSTKESHPLLKSVCDAAEKGVKTLTSAAATGAQPILDKLEPQIATANEYAC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312    98 RGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAqemvsssvssaKETVATRVTGAVDVTLGAVQNSVDKTKSAMTSGV 177
Cdd:pfam03036  81 KGLDKLEEKLPILQQPAEKVVSDAKGAVSTTVSGA-----------KDSVSVSVTGVVDKTKGAVQGSVELTKSVVSGGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   178 QSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALIATPPEDSDMASLQQqRQEQNYFVRLGSLSERLRNHAYEH 257
Cdd:pfam03036 150 STVMGSRVGQLVSSGVDLALGKSEELVDHYLPMTEEELAALAAPVEGFEVASVQQ-KKKPSYFVRLGSLSAKLRQRAYQH 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   258 SLGKLQNARQKAQETLQQLTSVLGLMESVKQGVDQRLGEGQEKLHQMWLSWNQKTPQDAEKDPAKPEQVEARALSMFRDI 337
Cdd:pfam03036 229 SLGKLRQAKQRTQEALSQLHSTLDLIEYARKGVDQKLQEGQEKLRQSWLEWKKGQPEGDQKEDSEAEEVESRTLSMARSL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   338 TQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLAQTRERIARAREALDNTVEYVAQNTP 417
Cdd:pfam03036 309 TQQLQSTCLSLVSSVQGLPQAVQEQVSQVRRSAEELQASFSNALSLQDLPDTVLAQSRAQLAKAKESLDEVLDYVVNNTP 388
                         410
                  ....*....|..
gi 13385312   418 AMWLVGPFAPGI 429
Cdd:pfam03036 389 LNWLVGPFAPES 400
 
Name Accession Description Interval E-value
Perilipin pfam03036
Perilipin family; The perilipin family includes lipid droplet-associated protein (perilipin), ...
18-429 0e+00

Perilipin family; The perilipin family includes lipid droplet-associated protein (perilipin), adipose differentiation-related protein (adipophilin) and TIP47, also known as perilin-3, altogether form the PAT family of proteins. They predominantly localize to the surface of intracellular neutral lipid droplets. Perilipin is a modulator of adipocyte lipid metabolism and adipophilinis and are involved in the development and maintenance of adipose tissue. This family appears to share some similarity with pfam08618.


Pssm-ID: 460784  Cd Length: 400  Bit Score: 580.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312    18 EPVVQPSVVDRVAGLPLISSTYGMVSAAYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAH 97
Cdd:pfam03036   1 EEPEQQSVVSRVANLPLVSSTCDMVSSAYSSTKESHPLLKSVCDAAEKGVKTLTSAAATGAQPILDKLEPQIATANEYAC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312    98 RGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAqemvsssvssaKETVATRVTGAVDVTLGAVQNSVDKTKSAMTSGV 177
Cdd:pfam03036  81 KGLDKLEEKLPILQQPAEKVVSDAKGAVSTTVSGA-----------KDSVSVSVTGVVDKTKGAVQGSVELTKSVVSGGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   178 QSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALIATPPEDSDMASLQQqRQEQNYFVRLGSLSERLRNHAYEH 257
Cdd:pfam03036 150 STVMGSRVGQLVSSGVDLALGKSEELVDHYLPMTEEELAALAAPVEGFEVASVQQ-KKKPSYFVRLGSLSAKLRQRAYQH 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   258 SLGKLQNARQKAQETLQQLTSVLGLMESVKQGVDQRLGEGQEKLHQMWLSWNQKTPQDAEKDPAKPEQVEARALSMFRDI 337
Cdd:pfam03036 229 SLGKLRQAKQRTQEALSQLHSTLDLIEYARKGVDQKLQEGQEKLRQSWLEWKKGQPEGDQKEDSEAEEVESRTLSMARSL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   338 TQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLAQTRERIARAREALDNTVEYVAQNTP 417
Cdd:pfam03036 309 TQQLQSTCLSLVSSVQGLPQAVQEQVSQVRRSAEELQASFSNALSLQDLPDTVLAQSRAQLAKAKESLDEVLDYVVNNTP 388
                         410
                  ....*....|..
gi 13385312   418 AMWLVGPFAPGI 429
Cdd:pfam03036 389 LNWLVGPFAPES 400
 
Name Accession Description Interval E-value
Perilipin pfam03036
Perilipin family; The perilipin family includes lipid droplet-associated protein (perilipin), ...
18-429 0e+00

Perilipin family; The perilipin family includes lipid droplet-associated protein (perilipin), adipose differentiation-related protein (adipophilin) and TIP47, also known as perilin-3, altogether form the PAT family of proteins. They predominantly localize to the surface of intracellular neutral lipid droplets. Perilipin is a modulator of adipocyte lipid metabolism and adipophilinis and are involved in the development and maintenance of adipose tissue. This family appears to share some similarity with pfam08618.


Pssm-ID: 460784  Cd Length: 400  Bit Score: 580.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312    18 EPVVQPSVVDRVAGLPLISSTYGMVSAAYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAH 97
Cdd:pfam03036   1 EEPEQQSVVSRVANLPLVSSTCDMVSSAYSSTKESHPLLKSVCDAAEKGVKTLTSAAATGAQPILDKLEPQIATANEYAC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312    98 RGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAqemvsssvssaKETVATRVTGAVDVTLGAVQNSVDKTKSAMTSGV 177
Cdd:pfam03036  81 KGLDKLEEKLPILQQPAEKVVSDAKGAVSTTVSGA-----------KDSVSVSVTGVVDKTKGAVQGSVELTKSVVSGGV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   178 QSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALIATPPEDSDMASLQQqRQEQNYFVRLGSLSERLRNHAYEH 257
Cdd:pfam03036 150 STVMGSRVGQLVSSGVDLALGKSEELVDHYLPMTEEELAALAAPVEGFEVASVQQ-KKKPSYFVRLGSLSAKLRQRAYQH 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   258 SLGKLQNARQKAQETLQQLTSVLGLMESVKQGVDQRLGEGQEKLHQMWLSWNQKTPQDAEKDPAKPEQVEARALSMFRDI 337
Cdd:pfam03036 229 SLGKLRQAKQRTQEALSQLHSTLDLIEYARKGVDQKLQEGQEKLRQSWLEWKKGQPEGDQKEDSEAEEVESRTLSMARSL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385312   338 TQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLAQTRERIARAREALDNTVEYVAQNTP 417
Cdd:pfam03036 309 TQQLQSTCLSLVSSVQGLPQAVQEQVSQVRRSAEELQASFSNALSLQDLPDTVLAQSRAQLAKAKESLDEVLDYVVNNTP 388
                         410
                  ....*....|..
gi 13385312   418 AMWLVGPFAPGI 429
Cdd:pfam03036 389 LNWLVGPFAPES 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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