NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|31980873|ref|NP_080940|]
View 

vacuolar protein sorting-associated protein 53 homolog isoform 1 [Mus musculus]

Protein Classification

Vps53-like N-terminal domain-containing protein( domain architecture ID 10513706)

Vps53-like N-terminal domain-containing protein similar to Arabidopsis thaliana vacuolar protein sorting-associated protein 53 B that is involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 40-452 0e+00

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


:

Pssm-ID: 427710  Cd Length: 372  Bit Score: 561.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873    40 ADFNAVEYINTLFPTEQSLANIDDVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAE 119
Cdd:pfam04100   1 PDFSAVEYINELFPTEQSLTNIDELIQKLQEEIRKLDNNIKTVVRGQANVGEKGEEALDEAQKAIRSLFQKIKEIKSVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   120 KSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQ 199
Cdd:pfam04100  81 STEEMVKEITRDIKQLDIAKRNLTTSITTLHHLHMLVTGVESLNALLSKRSYGEAASPLQAILQLLNHFIKYKSVDEIAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   200 LSERVKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQD 277
Cdd:pfam04100 161 LSESISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   278 VAWLDKIDRRYAWVKRQLVDYEEKYGRMFPREWCMTERISVEFCHVTRAELSKIMRARAKEIEVKLLLFAIQRTTNFEGF 357
Cdd:pfam04100 241 AAWLDKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   358 LAKRFsgctltdgtlkklespppstnpfleDETTPEMEELAlekgeleqpkkpkapdnpFHGIVSKCFEPHLYVYIESQD 437
Cdd:pfam04100 321 LDKRF-------------------------SKKTPEPKELA------------------FHGAISSCFEPHLTLYINSQE 357

                         410
                  ....*....|....*
gi 31980873   438 KNLSELIDRFVADFK 452
Cdd:pfam04100 358 KTLSELFDKFVSEPK 372
 
Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 40-452 0e+00

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 427710  Cd Length: 372  Bit Score: 561.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873    40 ADFNAVEYINTLFPTEQSLANIDDVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAE 119
Cdd:pfam04100   1 PDFSAVEYINELFPTEQSLTNIDELIQKLQEEIRKLDNNIKTVVRGQANVGEKGEEALDEAQKAIRSLFQKIKEIKSVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   120 KSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQ 199
Cdd:pfam04100  81 STEEMVKEITRDIKQLDIAKRNLTTSITTLHHLHMLVTGVESLNALLSKRSYGEAASPLQAILQLLNHFIKYKSVDEIAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   200 LSERVKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQD 277
Cdd:pfam04100 161 LSESISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   278 VAWLDKIDRRYAWVKRQLVDYEEKYGRMFPREWCMTERISVEFCHVTRAELSKIMRARAKEIEVKLLLFAIQRTTNFEGF 357
Cdd:pfam04100 241 AAWLDKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   358 LAKRFsgctltdgtlkklespppstnpfleDETTPEMEELAlekgeleqpkkpkapdnpFHGIVSKCFEPHLYVYIESQD 437
Cdd:pfam04100 321 LDKRF-------------------------SKKTPEPKELA------------------FHGAISSCFEPHLTLYINSQE 357

                         410
                  ....*....|....*
gi 31980873   438 KNLSELIDRFVADFK 452
Cdd:pfam04100 358 KTLSELFDKFVSEPK 372
 
Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 40-452 0e+00

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 427710  Cd Length: 372  Bit Score: 561.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873    40 ADFNAVEYINTLFPTEQSLANIDDVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAE 119
Cdd:pfam04100   1 PDFSAVEYINELFPTEQSLTNIDELIQKLQEEIRKLDNNIKTVVRGQANVGEKGEEALDEAQKAIRSLFQKIKEIKSVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   120 KSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQ 199
Cdd:pfam04100  81 STEEMVKEITRDIKQLDIAKRNLTTSITTLHHLHMLVTGVESLNALLSKRSYGEAASPLQAILQLLNHFIKYKSVDEIAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   200 LSERVKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQD 277
Cdd:pfam04100 161 LSESISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   278 VAWLDKIDRRYAWVKRQLVDYEEKYGRMFPREWCMTERISVEFCHVTRAELSKIMRARAKEIEVKLLLFAIQRTTNFEGF 357
Cdd:pfam04100 241 AAWLDKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31980873   358 LAKRFsgctltdgtlkklespppstnpfleDETTPEMEELAlekgeleqpkkpkapdnpFHGIVSKCFEPHLYVYIESQD 437
Cdd:pfam04100 321 LDKRF-------------------------SKKTPEPKELA------------------FHGAISSCFEPHLTLYINSQE 357

                         410
                  ....*....|....*
gi 31980873   438 KNLSELIDRFVADFK 452
Cdd:pfam04100 358 KTLSELFDKFVSEPK 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH