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Conserved domains on  [gi|58037121|ref|NP_081006|]
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glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 1 precursor [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 59-141 1.05e-33

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467105  Cd Length: 83  Bit Score: 116.28  E-value: 1.05e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  59 APLQCYFCQVLHSGESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWCTDTCQPIIKTVGGTQMTQTCCQSTLCNIP 138
Cdd:cd23575   1 HSLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVS 80


                ...
gi 58037121 139 PWQ 141
Cdd:cd23575  81 GAQ 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 59-141 1.05e-33

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 116.28  E-value: 1.05e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  59 APLQCYFCQVLHSGESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWCTDTCQPIIKTVGGTQMTQTCCQSTLCNIP 138
Cdd:cd23575   1 HSLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVS 80


                ...
gi 58037121 139 PWQ 141
Cdd:cd23575  81 GAQ 83
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 61-139 1.09e-05

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 42.52  E-value: 1.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121     61 LQCYFCQVLhSGESCNQTQSCSSSKPFCITLVSHSGTD-KGYLTTYSMWCTDTCQP---IIKTVGGTQMTQTCCQSTLCN 136
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDsRGSVVYKGCATSPICPGshgYEINLTIAFLKVSCCQTDLCN 79


                   ...
gi 58037121    137 IPP 139
Cdd:smart00134  80 AAG 82
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 63-136 3.49e-05

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 40.99  E-value: 3.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037121    63 CYFCQVLHSgESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWC-TDTCQPIIK---TVGGTQMTQTCCQSTLCN 136
Cdd:pfam00021   1 CYSCLGVSN-EDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCaRSSCPRLLSdfiNGGIISVSESCCQSDLCN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 59-141 1.05e-33

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 116.28  E-value: 1.05e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  59 APLQCYFCQVLHSGESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWCTDTCQPIIKTVGGTQMTQTCCQSTLCNIP 138
Cdd:cd23575   1 HSLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVS 80


                ...
gi 58037121 139 PWQ 141
Cdd:cd23575  81 GAQ 83
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 60-136 1.70e-08

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 50.05  E-value: 1.70e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58037121  60 PLQCYFCQVLHSGESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWCTDTCQPIIKTVGGTQMTQTCCQSTLCN 136
Cdd:cd23543   2 SLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGSSSGVRITKKCSPKCPETNVNIGIASVSTSCCQSSLCN 78
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 61-136 7.84e-07

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 45.48  E-value: 7.84e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037121  61 LQCYFCQvlhSGESCNQTQSCSSSKPFCITLVSHSGtdKGYLTTYSmwCTDTCQP--IIKTVGGTQMTQTCCQSTLCN 136
Cdd:cd23542   6 LQCHVCN---SSSNCTNPVNCEGSERYCKTTTVVQP--SGNLVKKG--CAETCPPstSRQQVGSGISSVTCCQGDLCN 76
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 61-139 1.09e-05

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 42.52  E-value: 1.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121     61 LQCYFCQVLhSGESCNQTQSCSSSKPFCITLVSHSGTD-KGYLTTYSMWCTDTCQP---IIKTVGGTQMTQTCCQSTLCN 136
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDsRGSVVYKGCATSPICPGshgYEINLTIAFLKVSCCQTDLCN 79


                   ...
gi 58037121    137 IPP 139
Cdd:smart00134  80 AAG 82
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 61-136 1.34e-05

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 42.09  E-value: 1.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  61 LQCYFCQVLHSGESCN---QTQSCSSSKPFCITLVSHSGTDKGYLT---TYSMWCTDTCQPIIKTVGGTQMTqTCCQSTL 134
Cdd:cd00117   1 LKCYQCNSSNDPNCCNsspTLVTCSSPETFCRKIVGKVGGGETLVIrgcATECECGCTECCSGTGTSGTTCT-SCCDTDL 79


                ..
gi 58037121 135 CN 136
Cdd:cd00117  80 CN 81
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 63-136 3.49e-05

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 40.99  E-value: 3.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037121    63 CYFCQVLHSgESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWC-TDTCQPIIK---TVGGTQMTQTCCQSTLCN 136
Cdd:pfam00021   1 CYSCLGVSN-EDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCaRSSCPRLLSdfiNGGIISVSESCCQSDLCN 77
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 61-136 1.33e-04

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 39.62  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  61 LQCYFCQVLHSGESCNQTqSCSSSKPFCITLVSHSGTDKGYLTTYSMWCTDTCQP---IIKTVGGTQ--MTQTCCQSTLC 135
Cdd:cd23541   3 LRCYQCLGVPLETSCPSV-TCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKnlyFLEEILGTTvnVKTSCCKEDLC 81


                .
gi 58037121 136 N 136
Cdd:cd23541  82 N 82
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 61-136 2.80e-04

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 38.07  E-value: 2.80e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037121  61 LQCYFCqVLHSGeSCNQTQSCSSSKPFCITLVShsgtdkGYLTTYSMWCTDTC--QPIIKTVGGTQMTQTCCQSTLCN 136
Cdd:cd23554   1 LKCYNC-PNPTS-NCNTNVTCSSNLDACLIVKA------GNRIYRQCWKYSDCnfDFISERFGESNFKYRCCQKDLCN 70
TFP_LU_ECD_Ly6PGE cd23553
extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) ...
 61-136 5.69e-04

extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) and similar proteins; Ly6PGE is an uncharacterized Ly-6/uPAR family protein. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467083  Cd Length: 77  Bit Score: 37.44  E-value: 5.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  61 LQCYFCQvlHSGESCNQT--QSCSSSKPFCITLVSHSGTDKGYLT--TYSMWCTDTCQpIIKTVGGTQMTQTCCQSTLCN 136
Cdd:cd23553   1 LKCYQCV--GSEDDCNKQksVVCPSSHDRCITVTGRNEGKTTVTKscSYKSFCDQASE-SCSLVKREGCNVSCCDSDGCN 77
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 61-136 1.13e-03

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 36.65  E-value: 1.13e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58037121  61 LQCYFCQVLHSGESCNQTQSCSSSKPFCITLVShsgTDKGYLTTYSMWCTDTCQPIIKTVGGTQMTQTCCQSTLCN 136
Cdd:cd23573   3 LQCYTCKAQLSNSNCQTETPCRENAKACKTDVI---RAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCN 75
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 61-137 4.59e-03

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 35.13  E-value: 4.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  61 LQCYFCQvlhSGESCNQTQSCSSSKPFCITLVSHSGTDKGYLTTYSMWCTDTCQP---IIKTVG--GTQMTQTCCQSTLC 135
Cdd:cd23556   1 LRCYSCK---SNGDCRVEEVCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTnasSSYRTGlnINSLQETVCSSDLC 77


                ..
gi 58037121 136 NI 137
Cdd:cd23556  78 NQ 79
TFP_LU_ECD_SLURP1_like cd23560
extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like ...
 61-136 9.51e-03

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467090  Cd Length: 78  Bit Score: 33.96  E-value: 9.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037121  61 LQCYFCQVLHSGESCNQTQSCSSSKPFCITLVShsGTDKGYL----TTYSMWCTDTCQPI-IKTVGGTQMTqTCCQSTLC 135
Cdd:cd23560   1 LRCYTCPEPTDSSLCTTIVNCSPNETACKTTLY--SVDSGYPffgnITVTRGCASECIPSdPDGIGETHPI-SCCNTDLC 77


                .
gi 58037121 136 N 136
Cdd:cd23560  78 N 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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