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Conserved domains on  [gi|124430553|ref|NP_081167|]
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codanin-1 [Mus musculus]

Protein Classification

Codanin-1_C domain-containing protein( domain architecture ID 10633841)

Codanin-1_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Codanin-1_C pfam15296
Codanin-1 C-terminus; This domain is found near to the C-terminus of codanin-1.
 789-904 8.41e-43

Codanin-1 C-terminus; This domain is found near to the C-terminus of codanin-1.


:

Pssm-ID: 464622  Cd Length: 120  Bit Score: 151.75  E-value: 8.41e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   789 LDSVPVVDQQLLYTCCPYIGELRKLL-ASWVSGSS---GRSGGFVRKITPTTTSSLGALPLQTSQGLQAQLAEAFFHNQP 864
Cdd:pfam15296    1 LDSLELVDEQLLYVCCPFLGEFRVLLtPSFVSGSSsrsRYRYITTRKITPVSAELPQSVKSQSRQQLQLQLEEAFFHSQP 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 124430553   865 PSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQE 904
Cdd:pfam15296   81 ASLRRTVEFVSERVASNVVKDIQSTLLLPSKAAADAQLNE 120
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 63-305 3.79e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   63 VLPQGPSTPAkTPVASAALPARQGAPARGGRGARSQLFPAAEPLSAAAEAPLARRAGRRRGPGPGpsrerggrGSGAAEE 142
Cdd:PHA03247 2749 ATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL--------APAAALP 2819

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  143 GASGESPPWAggrkPKGSGSPGSPRLSLSDPPnlsnlEEFPPVGTVPPGS-AGRTKPSRRINPTPVSEERslskpktcft 221
Cdd:PHA03247 2820 PAASPAGPLP----PPTSAQPTAPPPPPGPPP-----PSLPLGGSVAPGGdVRRRPPSRSPAAKPAAPAR---------- 2880

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  222 sPPISCVPSSQPStldTSPWGLGLPPgcrsLQEEREMLRKARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPARV 301
Cdd:PHA03247 2881 -PPVRRLARPAVS---RSTESFALPP----DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952


                  ....
gi 124430553  302 SSRQ 305
Cdd:PHA03247 2953 GEPS 2956
 
Name Accession Description Interval E-value
Codanin-1_C pfam15296
Codanin-1 C-terminus; This domain is found near to the C-terminus of codanin-1.
 789-904 8.41e-43

Codanin-1 C-terminus; This domain is found near to the C-terminus of codanin-1.


Pssm-ID: 464622  Cd Length: 120  Bit Score: 151.75  E-value: 8.41e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   789 LDSVPVVDQQLLYTCCPYIGELRKLL-ASWVSGSS---GRSGGFVRKITPTTTSSLGALPLQTSQGLQAQLAEAFFHNQP 864
Cdd:pfam15296    1 LDSLELVDEQLLYVCCPFLGEFRVLLtPSFVSGSSsrsRYRYITTRKITPVSAELPQSVKSQSRQQLQLQLEEAFFHSQP 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 124430553   865 PSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQE 904
Cdd:pfam15296   81 ASLRRTVEFVSERVASNVVKDIQSTLLLPSKAAADAQLNE 120
PHA03247 PHA03247
large tegument protein UL36; Provisional
 63-305 3.79e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   63 VLPQGPSTPAkTPVASAALPARQGAPARGGRGARSQLFPAAEPLSAAAEAPLARRAGRRRGPGPGpsrerggrGSGAAEE 142
Cdd:PHA03247 2749 ATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL--------APAAALP 2819

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  143 GASGESPPWAggrkPKGSGSPGSPRLSLSDPPnlsnlEEFPPVGTVPPGS-AGRTKPSRRINPTPVSEERslskpktcft 221
Cdd:PHA03247 2820 PAASPAGPLP----PPTSAQPTAPPPPPGPPP-----PSLPLGGSVAPGGdVRRRPPSRSPAAKPAAPAR---------- 2880

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  222 sPPISCVPSSQPStldTSPWGLGLPPgcrsLQEEREMLRKARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPARV 301
Cdd:PHA03247 2881 -PPVRRLARPAVS---RSTESFALPP----DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952


                  ....
gi 124430553  302 SSRQ 305
Cdd:PHA03247 2953 GEPS 2956
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 148-306 2.28e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   148 SPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSagrtkPSRRINPTPVSEERSLSKPKTCFTSPPISC 227
Cdd:pfam03154  182 SPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-----PHTLIQQTPTLHPQRLPSPHPPLQPMTQPP 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   228 VPSSQPSTLDTSPWGLG-LPPGCRSLQEEREMLRK-------ARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPA 299
Cdd:pfam03154  257 PPSQVSPQPLPQPSLHGqMPPMPHSLQTGPSHMQHpvppqpfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336


                   ....*..
gi 124430553   300 RVSSRQR 306
Cdd:pfam03154  337 QQPPREQ 343
 
Name Accession Description Interval E-value
Codanin-1_C pfam15296
Codanin-1 C-terminus; This domain is found near to the C-terminus of codanin-1.
 789-904 8.41e-43

Codanin-1 C-terminus; This domain is found near to the C-terminus of codanin-1.


Pssm-ID: 464622  Cd Length: 120  Bit Score: 151.75  E-value: 8.41e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   789 LDSVPVVDQQLLYTCCPYIGELRKLL-ASWVSGSS---GRSGGFVRKITPTTTSSLGALPLQTSQGLQAQLAEAFFHNQP 864
Cdd:pfam15296    1 LDSLELVDEQLLYVCCPFLGEFRVLLtPSFVSGSSsrsRYRYITTRKITPVSAELPQSVKSQSRQQLQLQLEEAFFHSQP 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 124430553   865 PSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQE 904
Cdd:pfam15296   81 ASLRRTVEFVSERVASNVVKDIQSTLLLPSKAAADAQLNE 120
PHA03247 PHA03247
large tegument protein UL36; Provisional
 63-305 3.79e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   63 VLPQGPSTPAkTPVASAALPARQGAPARGGRGARSQLFPAAEPLSAAAEAPLARRAGRRRGPGPGpsrerggrGSGAAEE 142
Cdd:PHA03247 2749 ATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL--------APAAALP 2819

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  143 GASGESPPWAggrkPKGSGSPGSPRLSLSDPPnlsnlEEFPPVGTVPPGS-AGRTKPSRRINPTPVSEERslskpktcft 221
Cdd:PHA03247 2820 PAASPAGPLP----PPTSAQPTAPPPPPGPPP-----PSLPLGGSVAPGGdVRRRPPSRSPAAKPAAPAR---------- 2880

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  222 sPPISCVPSSQPStldTSPWGLGLPPgcrsLQEEREMLRKARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPARV 301
Cdd:PHA03247 2881 -PPVRRLARPAVS---RSTESFALPP----DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952


                  ....
gi 124430553  302 SSRQ 305
Cdd:PHA03247 2953 GEPS 2956
PHA03247 PHA03247
large tegument protein UL36; Provisional
 58-286 5.64e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 5.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   58 EQSSRVLPQGPSTPAKTPVASAALPARQGAPARGGRGARSQLFPAAEPLSAAAeaplarRAGRRRGPGPGPSRERGGRGS 137
Cdd:PHA03247 2594 QSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV------PPPERPRDDPAPGRVSRPRRA 2667

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  138 GAAEEGASGESPPwaGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVP-------PGSAGRTKPSRRINP------ 204
Cdd:PHA03247 2668 RRLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSatplppgPAAARQASPALPAAPappavp 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  205 ----TPVSEERSLSKPKTCF-TSPPISCVPSSQPSTLDTSPWGLGLPPGCRSLQEERE-----MLRKARTKQLQQSPTPA 274
Cdd:PHA03247 2746 agpaTPGGPARPARPPTTAGpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDpadppAAVLAPAAALPPAASPA 2825

                         250
                  ....*....|..
gi 124430553  275 SPIPESGSPVPS 286
Cdd:PHA03247 2826 GPLPPPTSAQPT 2837
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 25-306 1.02e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   25 STPSSEDSSEVAALSALRPLRKEFVPFLLNFLREQSSrvlPQGPSTPAKTPV--------ASAALPARQGAPARGGRGAR 96
Cdd:PHA03307   74 GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPG---PSSPDPPPPTPPpaspppspAPDLSEMLRPVGSPGPPPAA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   97 SQLFPAAEPLSAAAEAPLARRAGRRRGPGPGPSR-------ERGGR-GSGAAEEGASGESPPWAGGRKPKGSGSPGSPRL 168
Cdd:PHA03307  151 SPPAAGASPAAVASDAASSRQAALPLSSPEETARapssppaEPPPStPPAAASPRPPRRSSPISASASSPAPAPGRSAAD 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  169 SLSDPPNLSNLEEFPPVGTVPPGSAGRTKPSRRINPTPVSE-ERSLSKPKTCFTSPPISCVPSSQPSTLDTSPWGLGLPP 247
Cdd:PHA03307  231 DAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEaSGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPS 310

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124430553  248 GCRSLQEE-----------------REMLRKARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPARVSSRQR 306
Cdd:PHA03307  311 SPRASSSSsssressssstssssesSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPT 386
PHA03247 PHA03247
large tegument protein UL36; Provisional
 62-307 7.14e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   62 RVLPQGPSTPAKTPVASAALPARQGAPARGGRGARSQLFPAAEPLSAAAEAPLARRAGRRRGPGPGPSRERGGrGSGAAE 141
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPG 2859

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  142 EGASGESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSAGRTKPSRRINPTPVSEERSLSKPKTCFT 221
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  222 SPPIS----CVPSSQPSTLDTSPWGLGLPPGcrslqeeremlRKARTKQLQQSPTPASPIPESgsPVPSRTGNLTA---- 293
Cdd:PHA03247 2940 QPPLApttdPAGAGEPSGAVPQPWLGALVPG-----------RVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSrvss 3006

                         250       260
                  ....*....|....*....|..
gi 124430553  294 --------EPADPARVSSRQRL 307
Cdd:PHA03247 3007 wasslalhEETDPPPVSLKQTL 3028
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
40-190 1.41e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   40 ALRPlrKEFVPFLLNFLREQSSRVLPQG----PSTPAKTPVASAAlPARQGAPARGGRGARSQLFPAAEPLSAAAEAPLA 115
Cdd:PRK12323  344 ALAP--DEYAGFTMTLLRMLAFRPGQSGggagPATAAAAPVAQPA-PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA 420

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124430553  116 RRAGRRR--GPGPGPSRERGGRGSGAAEEGASGESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPP 190
Cdd:PRK12323  421 AAPARRSpaPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP 497
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 47-300 1.66e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.77  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   47 EFVPFLLNFLREQSSRVLpQGPSTPAKTPVASAALPARQG-APARGGRGARSQLFPAAE----PLSAAAEAPLARRagrr 121
Cdd:PRK08691  344 EYAGFMMTLLRMLAFAPL-AAASCDANAVIENTELQSPSAqTAEKETAAKKPQPRPEAEtaqtPVQTASAAAMPSE---- 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  122 rgpgpgpsrergGRGSGAAEEGASGESPPWAGGRKPKGSGSPGSPRLSLS---------DPPN------LSNLEEFPPVG 186
Cdd:PRK08691  419 ------------GKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQTSAKSiqtaseaetPPENqvsknkAADNETDAPLS 486

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  187 TVPPGSAGRTKPSRRINPTPVSEERSLSKPKTCFTSPPISCvPSSQPSTLDTSPWGLGLPPGCRSLQEEREmlrkARTKQ 266
Cdd:PRK08691  487 EVPSENPIQATPNDEAVETETFAHEAPAEPFYGYGFPDNDC-PPEDGAEIPPPDWEHAAPADTAGGGADEE----AEAGG 561

                         250       260       270
                  ....*....|....*....|....*....|....
gi 124430553  267 LQQSPTPASPIPESGspvpsrTGNLTAEPADPAR 300
Cdd:PRK08691  562 IGGNNTPSAPPPEFS------TENWAAIVRHFAR 589
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 148-306 2.28e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   148 SPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSagrtkPSRRINPTPVSEERSLSKPKTCFTSPPISC 227
Cdd:pfam03154  182 SPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-----PHTLIQQTPTLHPQRLPSPHPPLQPMTQPP 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   228 VPSSQPSTLDTSPWGLG-LPPGCRSLQEEREMLRK-------ARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPA 299
Cdd:pfam03154  257 PPSQVSPQPLPQPSLHGqMPPMPHSLQTGPSHMQHpvppqpfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336


                   ....*..
gi 124430553   300 RVSSRQR 306
Cdd:pfam03154  337 QQPPREQ 343
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 66-301 4.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   66 QGPSTPAKTPVASAALPARQGAPAR------------GGRGARSQLFPAAEPLSAAAEAPLA-----------------R 116
Cdd:PHA03307  184 RAPSSPPAEPPPSTPPAAASPRPPRrsspisasasspAPAPGRSAADDAGASSSDSSSSESSgcgwgpenecplprpapI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  117 RAGRRRGPGPGPSRERGGRGSGAAEEGASGESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSAGRT 196
Cdd:PHA03307  264 TLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553  197 KPSRRINPTPVSEERSLSKPktcftSPPISCVPSSQPSTLDTSPwGLGLPPGCRSLQEEREmLRKARTKQLQQSPTPASP 276
Cdd:PHA03307  344 GPSPSRSPSPSRPPPPADPS-----SPRKRPRPSRAPSSPAASA-GRPTRRRARAAVAGRA-RRRDATGRFPAGRPRPSP 416

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 124430553  277 IPESGSP--VPSRTGNLT--------AEPADPARV 301
Cdd:PHA03307  417 LDAGAASgaFYARYPLLTpsgepwpgSPPPPPGRV 451
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
14-226 9.11e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 9.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   14 PVAAAVRWIARSTPSSEDSSEVAALSALRPlrkefvpfllnflreQSSRVLPQGPSTPAKTPVASAALP-ARQGAPARGG 92
Cdd:PRK12323  381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAP---------------AAAAAARAVAAAPARRSPAPEALAaARQASARGPG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124430553   93 RGARSQLFPAAEPLSAAAEAPLARRAGRRRGPGPGPSRERggrgsGAAEEGASGESPPWAggrkpKGSGSPGSPRLSLSD 172
Cdd:PRK12323  446 GAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP-----AAAPAPADDDPPPWE-----ELPPEFASPAPAQPD 515

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124430553  173 P-PNLSNLEEFPPVGTVPPGSAGRTKPSRRInPTPVSEERSLSKPKTCFTSPPIS 226
Cdd:PRK12323  516 AaPAGWVAESIPDPATADPDDAFETLAPAPA-AAPAPRAAAATEPVVAPRPPRAS 569
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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