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Conserved domains on  [gi|21312195|ref|NP_081205|]
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glutathione-specific gamma-glutamylcyclotransferase 1 [Mus musculus]

Protein Classification

glutathione-specific gamma-glutamylcyclotransferase( domain architecture ID 10520616)

glutathione-specific gamma-glutamylcyclotransferase (gamma-glu-GCG or gamma-GCG) catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide; acts specifically on glutathione, but not on other gamma-glutamyl peptides

CATH:  3.10.490.10
EC:  4.3.2.7
Gene Ontology:  GO:0016746
PubMed:  18515354|23070364
SCOP:  4002485

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 34-209 7.06e-102

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


:

Pssm-ID: 398428  Cd Length: 176  Bit Score: 292.37  E-value: 7.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195    34 LWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGEQVNEALKYLN 113
Cdd:pfam04752   1 LWVFGYGSLIWKPGFPYTDSRTGFIHGYARRFWQGSTDHRGTPERPGRVLTLIEDEEGRTWGVAYRIPAETAEEVLEYLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195   114 VREAVlGGYDTKEVTFYP-QDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGP 192
Cdd:pfam04752  81 VREQI-NGYTTHEVPFYPdQDTDGRPVNALVYVATPKNPQYLGDDPLEQIAKQIATARGPSGPNAEYLFELAQALRKLGP 159

                         170
                  ....*....|....*..
gi 21312195   193 QAQDEHLEAIVDAVGTL 209
Cdd:pfam04752 160 GVQDDHLFELEKLVKKL 176
 
Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 34-209 7.06e-102

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


Pssm-ID: 398428  Cd Length: 176  Bit Score: 292.37  E-value: 7.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195    34 LWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGEQVNEALKYLN 113
Cdd:pfam04752   1 LWVFGYGSLIWKPGFPYTDSRTGFIHGYARRFWQGSTDHRGTPERPGRVLTLIEDEEGRTWGVAYRIPAETAEEVLEYLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195   114 VREAVlGGYDTKEVTFYP-QDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGP 192
Cdd:pfam04752  81 VREQI-NGYTTHEVPFYPdQDTDGRPVNALVYVATPKNPQYLGDDPLEQIAKQIATARGPSGPNAEYLFELAQALRKLGP 159

                         170
                  ....*....|....*..
gi 21312195   193 QAQDEHLEAIVDAVGTL 209
Cdd:pfam04752 160 GVQDDHLFELEKLVKKL 176
ChaC2 COG3703
Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and ...
 25-210 5.31e-58

Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and metabolism];


Pssm-ID: 442917  Cd Length: 190  Bit Score: 181.56  E-value: 5.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195  25 SWGDGDPqaLWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLleDREGCTWGVAYQVRGEQ 104
Cdd:COG3703   9 GRPGGGD--LWVFGYGSLIWNPGFEFVERRPARLHGWHRSFCLRSTVHRGTPERPGLVLGL--DRGGSCRGVAFRVPPED 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195 105 VNEALKYLNVREAVLGGYDTKEVtfyPQDTPD-QPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRL 183
Cdd:COG3703  85 AEAVLAYLWRREMVTGVYLPRWL---PVRLADgRRVEALAFVADRDHPQYAGGLSLEEQARIIAQAVGPSGSNADYLLNT 161

                       170       180
                ....*....|....*....|....*..
gi 21312195 184 ADFMQLCGpqAQDEHLEAIVDAVGTLL 210
Cdd:COG3703 162 AEHLRELG--IRDPHLEALARLVRALL 186
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 36-146 7.49e-16

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 70.45  E-value: 7.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195  36 IFGYGSLVWKPDFA-----YSDSRVGFVRGYSRRFWQGdtfhrgsdkmpGRVVTLLEDREGCTWGVAYQVrgeqVNEALK 110
Cdd:cd06661   1 LFVYGTLMDGEVLHarlgrALFLGPATLKGYRLVFGGG-----------SGYPGLVPGPGARVWGELYEV----DPEDLA 65

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21312195 111 YLNVREAVLGGYDTKEVTFYPQDtpDQPLTALAYVA 146
Cdd:cd06661  66 RLDAFEGVPGGYRREEVEVELED--GEGVEAWVYVA 99
 
Name Accession Description Interval E-value
ChaC pfam04752
ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases ...
 34-209 7.06e-102

ChaC-like protein; The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


Pssm-ID: 398428  Cd Length: 176  Bit Score: 292.37  E-value: 7.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195    34 LWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGEQVNEALKYLN 113
Cdd:pfam04752   1 LWVFGYGSLIWKPGFPYTDSRTGFIHGYARRFWQGSTDHRGTPERPGRVLTLIEDEEGRTWGVAYRIPAETAEEVLEYLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195   114 VREAVlGGYDTKEVTFYP-QDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGP 192
Cdd:pfam04752  81 VREQI-NGYTTHEVPFYPdQDTDGRPVNALVYVATPKNPQYLGDDPLEQIAKQIATARGPSGPNAEYLFELAQALRKLGP 159

                         170
                  ....*....|....*..
gi 21312195   193 QAQDEHLEAIVDAVGTL 209
Cdd:pfam04752 160 GVQDDHLFELEKLVKKL 176
ChaC2 COG3703
Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and ...
 25-210 5.31e-58

Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation) [Inorganic ion transport and metabolism];


Pssm-ID: 442917  Cd Length: 190  Bit Score: 181.56  E-value: 5.31e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195  25 SWGDGDPqaLWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLleDREGCTWGVAYQVRGEQ 104
Cdd:COG3703   9 GRPGGGD--LWVFGYGSLIWNPGFEFVERRPARLHGWHRSFCLRSTVHRGTPERPGLVLGL--DRGGSCRGVAFRVPPED 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195 105 VNEALKYLNVREAVLGGYDTKEVtfyPQDTPD-QPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRL 183
Cdd:COG3703  85 AEAVLAYLWRREMVTGVYLPRWL---PVRLADgRRVEALAFVADRDHPQYAGGLSLEEQARIIAQAVGPSGSNADYLLNT 161

                       170       180
                ....*....|....*....|....*..
gi 21312195 184 ADFMQLCGpqAQDEHLEAIVDAVGTLL 210
Cdd:COG3703 162 AEHLRELG--IRDPHLEALARLVRALL 186
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 36-146 7.49e-16

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 70.45  E-value: 7.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312195  36 IFGYGSLVWKPDFA-----YSDSRVGFVRGYSRRFWQGdtfhrgsdkmpGRVVTLLEDREGCTWGVAYQVrgeqVNEALK 110
Cdd:cd06661   1 LFVYGTLMDGEVLHarlgrALFLGPATLKGYRLVFGGG-----------SGYPGLVPGPGARVWGELYEV----DPEDLA 65

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21312195 111 YLNVREAVLGGYDTKEVTFYPQDtpDQPLTALAYVA 146
Cdd:cd06661  66 RLDAFEGVPGGYRREEVEVELED--GEGVEAWVYVA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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