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Conserved domains on  [gi|34328501|ref|NP_081211|]
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sulfotransferase 1C2 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-288 2.66e-116

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 334.70  E-value: 2.66e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501    39 PDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTII---QHRHPFIEW----ARPPQPSGVDKANEMPAPRILRTHLP 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   112 TQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEPGTWDEYFETFINGKVSWGSWFDHVKGWWEIRDKYQILF 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   192 LFYEDMKRNPKHEIQKVMQFMGKNLDEDVVDKIVLETSFEKMKENPMTNRSTAPKsildqSISPFMRKGTVGDWKNHFTV 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 34328501   272 AQNERFDEIYKQKMGRT 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-288 2.66e-116

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 334.70  E-value: 2.66e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501    39 PDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTII---QHRHPFIEW----ARPPQPSGVDKANEMPAPRILRTHLP 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   112 TQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEPGTWDEYFETFINGKVSWGSWFDHVKGWWEIRDKYQILF 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   192 LFYEDMKRNPKHEIQKVMQFMGKNLDEDVVDKIVLETSFEKMKENPMTNRSTAPKsildqSISPFMRKGTVGDWKNHFTV 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 34328501   272 AQNERFDEIYKQKMGRT 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-290 1.52e-34

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 128.11  E-value: 1.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   35 FEAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTIIQHR-H---PFIEWARPPQPSgVDKANEMPAPrILRTHL 110
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPS-VDVLKDKGNT-LFSTHI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501  111 PTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEP-GTWDEYFETFINGKVSWGSWFDHVKGWWEI--RDKY 187
Cdd:PLN02164 153 PYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAyqENPD 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501  188 QILFLFYEDMKRNPKHEIQKVMQFMGKNLDED-----VVDKIVLETSFEKMKeNPMTNRSTAPKSILDQ--SISPFMRKG 260
Cdd:PLN02164 233 RILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPAvyANSAYFRKG 311

                        250       260       270
                 ....*....|....*....|....*....|
gi 34328501  261 TVGDWKNHFTVAQNERFDEIYKQKMGRTSL 290
Cdd:PLN02164 312 KVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-288 2.66e-116

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 334.70  E-value: 2.66e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501    39 PDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTII---QHRHPFIEW----ARPPQPSGVDKANEMPAPRILRTHLP 111
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   112 TQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEPGTWDEYFETFINGKVSWGSWFDHVKGWWEIRDKYQILF 191
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   192 LFYEDMKRNPKHEIQKVMQFMGKNLDEDVVDKIVLETSFEKMKENPMTNRSTAPKsildqSISPFMRKGTVGDWKNHFTV 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPK-----EVSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 34328501   272 AQNERFDEIYKQKMGRT 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-290 1.52e-34

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 128.11  E-value: 1.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   35 FEAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTIIQHR-H---PFIEWARPPQPSgVDKANEMPAPrILRTHL 110
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPS-VDVLKDKGNT-LFSTHI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501  111 PTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEP-GTWDEYFETFINGKVSWGSWFDHVKGWWEI--RDKY 187
Cdd:PLN02164 153 PYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAyqENPD 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501  188 QILFLFYEDMKRNPKHEIQKVMQFMGKNLDED-----VVDKIVLETSFEKMKeNPMTNRSTAPKSILDQ--SISPFMRKG 260
Cdd:PLN02164 233 RILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPAvyANSAYFRKG 311

                        250       260       270
                 ....*....|....*....|....*....|
gi 34328501  261 TVGDWKNHFTVAQNERFDEIYKQKMGRTSL 290
Cdd:PLN02164 312 KVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
48-213 9.64e-06

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 44.97  E-value: 9.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501    48 PKSGTTWIQEIVD-------MIEQNGDVEKCRRTIIQHRHPFIEWARPPQPS--GVDKaneMP-----APRILRthlptq 113
Cdd:pfam13469   7 PRSGTTLLHRLLAahpdvrpPEETWFVIPRILALLQAWGKSLEALARVPSYArwLCDK---SPshlfhLDLLLK------ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328501   114 LLPpsfwtnNCKFLYVARNAKDCMVSyyHFYRMSQVLPEPgtWDEYFETFINGKVSWgsWFDHVKGWWEIRDKY---QIL 190
Cdd:pfam13469  78 AFP------DAKFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVppgRFL 145

                         170       180
                  ....*....|....*....|...
gi 34328501   191 FLFYEDMKRNPKHEIQKVMQFMG 213
Cdd:pfam13469 146 DVRYEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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