|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
181-425 |
2.76e-116 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 346.54 E-value: 2.76e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLESADHGfligrGGYQPSDLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIRALVVL 260
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSSKST-----PPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPRLRALIVV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 261 PTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKTADGFRCLADIVVATPGRLVDHIDQTPGFSLQQLRFL 340
Cdd:cd17956 76 PTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTSGRYLSRVDILVATPGRLVDHLNSTPGFTLKHLRFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 341 IIDEADRMIDSMHQSWLPRVVAAAFYSEGPtgscallqrTQPQALTAASTCVPQMPLQKLLFSATLTQDPEKLQRLGLYQ 420
Cdd:cd17956 156 VIDEADRLLNQSFQDWLETVMKALGRPTAP---------DLGSFGDANLLERSVRPLQKLLFSATLTRDPEKLSSLKLHR 226
|
....*
gi 40538825 421 PRLFS 425
Cdd:cd17956 227 PRLFT 231
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
177-639 |
6.08e-91 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 287.81 E-value: 6.08e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 177 VHPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIRA 256
Cdd:COG0513 9 LSPPLLKALAELGYTTPTPIQAQAIPLILA--------GR------DVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAPQA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 257 LVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQtpG-FSLQ 335
Cdd:COG0513 75 LILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRG--------VDIVVATPGRLLDLIER--GaLDLS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 336 QLRFLIIDEADRM-----IDSMHQswlprvvaaafysegptgscaLLQRTQPQAltaastcvpqmplQKLLFSATLtqdP 410
Cdd:COG0513 145 GVETLVLDEADRMldmgfIEDIER---------------------ILKLLPKER-------------QTLLFSATM---P 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 411 EKLQRLglyqprlfSTRLgQQSPKdTAEVDENSGKytfPVGLTHHYVPCRLSSKPLIVLHLVLRMSCSRALCFTNSRENS 490
Cdd:COG0513 188 PEIRKL--------AKRY-LKNPV-RIEVAPENAT---AETIEQRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRGA 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 491 HRL--YLLAQafgGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGR 568
Cdd:COG0513 255 DRLaeKLQKR---GISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGR 331
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40538825 569 TARAGKTGQAFTLLLKvQERKFLQMvseagVPELTHHEIPRKLLQPLVARYETALSQLEKTVKEEQKLKAA 639
Cdd:COG0513 332 TGRAGAEGTAISLVTP-DERRLLRA-----IEKLIGQKIEEEELPGFEPVEEKRLERLKPKIKEKLKGKKA 396
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
181-421 |
2.89e-50 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 173.01 E-value: 2.89e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVC---HIRAL 257
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILS--------GR------DVIGQAQTGSGKTLAFLLPILEKLLPEPKKkgrGPQAL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 258 VVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQTPgFSLQQL 337
Cdd:cd00268 67 VLAPTRELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKG--------PDIVVGTPGRLLDLIERGK-LDLSNV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 338 RFLIIDEADRMIDsmhQSWLPRVVaaafysegptgscALLQRTQPQaltaastcvpqmpLQKLLFSATLTQDPEKLQRLG 417
Cdd:cd00268 138 KYLVLDEADRMLD---MGFEEDVE-------------KILSALPKD-------------RQTLLFSATLPEEVKELAKKF 188
|
....
gi 40538825 418 LYQP 421
Cdd:cd00268 189 LKNP 192
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
176-639 |
1.28e-46 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 170.51 E-value: 1.28e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 176 EVHPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALL---HRVVC 252
Cdd:PRK11192 7 ELDESLLEALQDKGYTRPTAIQAEAIPPALD--------GR------DVLGSAPTGTGKTAAFLLPALQHLLdfpRRKSG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 253 HIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAkEQESLVQKTadgfrclADIVVATPGRLVDHIDQTpGF 332
Cdd:PRK11192 73 PPRILILTPTRELAMQVADQARELAKHTHLDIATITGGVAYM-NHAEVFSEN-------QDIVVATPGRLLQYIKEE-NF 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 333 SLQQLRFLIIDEADRMIDsMhqswlprvvaaafysegptGSCALLQRtqpqalTAASTcvpQMPLQKLLFSATLtqDPEK 412
Cdd:PRK11192 144 DCRAVETLILDEADRMLD-M-------------------GFAQDIET------IAAET---RWRKQTLLFSATL--EGDA 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 413 LQRlglyqprlFSTRLgqqsPKDTAEVDENSGKYTFPVGLTHHYVPCRLSSKPLIVLHLVLRMSCSRALCFTNSRENSHR 492
Cdd:PRK11192 193 VQD--------FAERL----LNDPVEVEAEPSRRERKKIHQWYYRADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHE 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 493 LY-LLAQAfgGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTAR 571
Cdd:PRK11192 261 LAgWLRKA--GINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGR 338
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40538825 572 AGKTGQAFTL-------LLKVQERKFLQMVSEAGVPEL--THHEIPRKLLQPLVARyeTALSQLEKTVKEEQKLKAA 639
Cdd:PRK11192 339 AGRKGTAISLveahdhlLLGKIERYIEEPLKARVIDELrpKTKAPSEKKTGKPSKK--VLAKRAEKKEKEKEKPKVK 413
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
78-616 |
1.07e-45 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 168.94 E-value: 1.07e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 78 GSATPNSEAPRAKRRKADKDVDAGRGEEAPEELSAGAEDPGAnpqedvqRPPAPGRvlgdfaRRKTPKVQPfLPAWlaKP 157
Cdd:PRK01297 12 GEAEQPAPAPPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRA-------EKPKKDK------PRRERKPKP-ASLW--KL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 158 SCVKKSVTEDLTPIEDIpEVHPDLQKQLRANGITSYFPVQAAVIPALLESADhgfLIGRggyqpsdlcvsAPTGSGKTLA 237
Cdd:PRK01297 76 EDFVVEPQEGKTRFHDF-NLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHD---AIGR-----------AQTGTGKTAA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 238 FVIPVVQALLH------RVVCHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrcL 311
Cdd:PRK01297 141 FLISIINQLLQtpppkeRYMGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEAR-------F 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 312 ADIVVATPGRLVDhIDQTPGFSLQQLRFLIIDEADRMIDsmhQSWLPRVvaaafysegptgscALLQRTQPqaltaastc 391
Cdd:PRK01297 214 CDILVATPGRLLD-FNQRGEVHLDMVEVMVLDEADRMLD---MGFIPQV--------------RQIIRQTP--------- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 392 vPQMPLQKLLFSATLTQDPEKLQRLGLYQPRLFSTRlGQQSPKDTAEvdensgkytfpvglTHHYVPCRlSSKPLIVLHL 471
Cdd:PRK01297 267 -RKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIE-PENVASDTVE--------------QHVYAVAG-SDKYKLLYNL 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 472 VLRMSCSRALCFTNSRENSHRLYLLAQAfGGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVI 551
Cdd:PRK01297 330 VTQNPWERVMVFANRKDEVRRIEERLVK-DGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVI 408
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40538825 552 NYDAPQYLRTYVHRVGRTARAGKTGQAFTLLLKvQERKFLQMVSEAGVPELTHHEIPRKLLQPLV 616
Cdd:PRK01297 409 NFTLPEDPDDYVHRIGRTGRAGASGVSISFAGE-DDAFQLPEIEELLGRKISCEMPPAELLKPVP 472
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
452-582 |
2.00e-41 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 146.50 E-value: 2.00e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 452 LTHHYVPCRLSSKPLIVL-HLVLRMSCSRALCFTNSRENSHRLY-LLAQAfgGVSVAEFSSRYGPGQRKKILKQFEQGKI 529
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAeLLEEL--GIKVAALHGDLSQEERERALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 40538825 530 QLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGKTGQAFTLL 582
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
181-424 |
1.42e-40 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 146.63 E-value: 1.42e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHR--VVCHIRALV 258
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALL--------GK------DICASAVTGSGKTAAFLLPILERLLYRpkKKAATRVLV 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 259 VLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLaKEQESLVqktadgfRCLADIVVATPGRLVDHIDQTPGFSLQQLR 338
Cdd:cd17947 67 LVPTRELAMQCFSVLQQLAQFTDITFALAVGGLSL-KAQEAAL-------RARPDIVIATPGRLIDHLRNSPSFDLDSIE 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 339 FLIIDEADRMIDsmhqswlprvvaaafysEGPTGSCALLQRTQPQAltaastcvpqmpLQKLLFSATLTQDPEKLQRLGL 418
Cdd:cd17947 139 ILVLDEADRMLE-----------------EGFADELKEILRLCPRT------------RQTMLFSATMTDEVKDLAKLSL 189
|
....*..
gi 40538825 419 YQP-RLF 424
Cdd:cd17947 190 NKPvRVF 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
195-413 |
1.68e-40 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 145.08 E-value: 1.68e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVcHIRALVVLPTKELAQQVSKVFN 274
Cdd:pfam00270 2 PIQAEAIPAILE--------GR------DVLVQAPTGSGKTLAFLLPALEALDKLDN-GPQALVLAPTRELAEQIYEELK 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 275 IYTDTTPLRVALVTGQKSLAKEQESLVQktadgfrclADIVVATPGRLVDHIDQTPgfSLQQLRFLIIDEADRMIDSMHQ 354
Cdd:pfam00270 67 KLGKGLGLKVASLLGGDSRKEQLEKLKG---------PDILVGTPGRLLDLLQERK--LLKNLKLLVLDEAHRLLDMGFG 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 40538825 355 SWLPRVVaaafysegptgscallqrtqpqaltaasTCVPQmPLQKLLFSATLTQDPEKL 413
Cdd:pfam00270 136 PDLEEIL----------------------------RRLPK-KRQILLLSATLPRNLEDL 165
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
176-581 |
7.80e-40 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 153.95 E-value: 7.80e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 176 EVHPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVC--- 252
Cdd:PRK04537 15 DLHPALLAGLESAGFTRCTPIQALTLPVALP--------GG------DVAGQAQTGTGKTLAFLVAVMNRLLSRPALadr 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 253 ---HIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQT 329
Cdd:PRK04537 81 kpeDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQG--------VDVIIATPGRLIDYVKQH 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 330 PGFSLQQLRFLIIDEADRMIDSmhqswlprvvaaafyseGPTGSCALLQRTQPQALTAastcvpqmplQKLLFSATLTQ- 408
Cdd:PRK04537 153 KVVSLHACEICVLDEADRMFDL-----------------GFIKDIRFLLRRMPERGTR----------QTLLFSATLSHr 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 409 ----------DPEKLQrlgLYQPRLFSTRLGQQSpkdtaevdensgkytfpvglthhYVPCRLSSKPLIvLHLVLRMSCS 478
Cdd:PRK04537 206 vlelayehmnEPEKLV---VETETITAARVRQRI-----------------------YFPADEEKQTLL-LGLLSRSEGA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 479 RALCFTNSRENSHRlylLAQAF--GGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAP 556
Cdd:PRK04537 259 RTMVFVNTKAFVER---VARTLerHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLP 335
|
410 420
....*....|....*....|....*
gi 40538825 557 QYLRTYVHRVGRTARAGKTGQAFTL 581
Cdd:PRK04537 336 FDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
178-581 |
5.56e-39 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 149.57 E-value: 5.56e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 178 HPDLQKQLRANGITSYFPVQAAVIPALLESADhgfLIGRggyqpsdlcvsAPTGSGKTLAFVIpvvqALLHRV-VCHIR- 255
Cdd:PRK11776 12 PPALLANLNELGYTEMTPIQAQSLPAILAGKD---VIAQ-----------AKTGSGKTAAFGL----GLLQKLdVKRFRv 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 -ALVVLPTKELAQQVSKVF--------NIytdttplRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHI 326
Cdd:PRK11776 74 qALVLCPTRELADQVAKEIrrlarfipNI-------KVLTLCGGVPMGPQIDSLEHG--------AHIIVGTPGRILDHL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 327 DQTpGFSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAAfysegPTgscallQRtqpqaltaastcvpqmplQKLLFSATL 406
Cdd:PRK11776 139 RKG-TLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQA-----PA------RR------------------QTLLFSATY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 407 TQDPEKLQRLGLYQPRLFSTrlgqQSPKDTAEVD------ENSGKYTFPVGLTHHYVPcrlsskplivlhlvlrMSCsra 480
Cdd:PRK11776 189 PEGIAAISQRFQRDPVEVKV----ESTHDLPAIEqrfyevSPDERLPALQRLLLHHQP----------------ESC--- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 481 LCFTNSRENSHRLYLLAQAFGGVSVA---EFSSRygpgQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQ 557
Cdd:PRK11776 246 VVFCNTKKECQEVADALNAQGFSALAlhgDLEQR----DRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELAR 321
|
410 420
....*....|....*....|....
gi 40538825 558 YLRTYVHRVGRTARAGKTGQAFTL 581
Cdd:PRK11776 322 DPEVHVHRIGRTGRAGSKGLALSL 345
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
181-415 |
1.18e-38 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 141.19 E-value: 1.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALL-HRVVCHIRALVV 259
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLH--------GR------DLLACAPTGSGKTLAFLIPILQKLGkPRKKKGLRALIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 260 LPTKELAQQVSKVFNIYTDTTPLRVALVtgQKSLAKEQESLVQKTADgfrclADIVVATPGRLVDHIDQTPgFSLQQLRF 339
Cdd:cd17957 67 APTRELASQIYRELLKLSKGTGLRIVLL--SKSLEAKAKDGPKSITK-----YDILVSTPLRLVFLLKQGP-IDLSSVEY 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40538825 340 LIIDEADRMIDSMHQSWLPRVVAAafysegptgsCallqrTQPQaltaastcvpqmpLQKLLFSATLTQDPEKLQR 415
Cdd:cd17957 139 LVLDEADKLFEPGFREQTDEILAA----------C-----TNPN-------------LQRSLFSATIPSEVEELAR 186
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
195-421 |
4.17e-38 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 140.14 E-value: 4.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLESADhgfLIGRggyqpsdlcvsAPTGSGKTLAFVIPVVQALLHRVVcHIRALVVLPTKELAQQVSKVFN 274
Cdd:cd17954 25 KIQEEAIPVALQGRD---IIGL-----------AETGSGKTAAFALPILQALLENPQ-RFFALVLAPTRELAQQISEQFE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 275 IYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQ 354
Cdd:cd17954 90 ALGSSIGLKSAVLVGGMDMMAQAIALAKK--------PHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLNMDFE 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40538825 355 SWLPRVVAaafysegptgscallqrtqpqaltaastcvpQMPLQK--LLFSATLTQDPEKLQRLGLYQP 421
Cdd:cd17954 162 PEIDKILK-------------------------------VIPRERttYLFSATMTTKVAKLQRASLKNP 199
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
182-422 |
1.04e-36 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 135.88 E-value: 1.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 182 QKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQaLLHRV----VCHIRAL 257
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQ--------GR------DILGAAKTGSGKTLAFLVPLLE-KLYRErwtpEDGLGAL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 258 VVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQktadgfrclADIVVATPGRLVDHIDQTPGFSLQQL 337
Cdd:cd17941 67 IISPTRELAMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINR---------MNILVCTPGRLLQHMDETPGFDTSNL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 338 RFLIIDEADRMIDSMHQSWLPRVVaaafySEGPTgscallQRtqpqaltaastcvpqmplQKLLFSATLTQDPEKLQRLG 417
Cdd:cd17941 138 QMLVLDEADRILDMGFKETLDAIV-----ENLPK------SR------------------QTLLFSATQTKSVKDLARLS 188
|
....*
gi 40538825 418 LYQPR 422
Cdd:cd17941 189 LKNPE 193
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
179-609 |
1.44e-36 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 142.64 E-value: 1.44e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 179 PDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVcH----- 253
Cdd:PRK10590 10 PDILRAVAEQGYREPTPIQQQAIPAVLE--------GR------DLMASAQTGTGKTAGFTLPLLQHLITRQP-Hakgrr 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 254 -IRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLvqktadgfRCLADIVVATPGRLVDhIDQTPGF 332
Cdd:PRK10590 75 pVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKL--------RGGVDVLVATPGRLLD-LEHQNAV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 333 SLQQLRFLIIDEADRMIDSMHQSWLPRVVAaafysegptgscallqrtqpqaltaastcvpQMPL--QKLLFSATLTQDP 410
Cdd:PRK10590 146 KLDQVEILVLDEADRMLDMGFIHDIRRVLA-------------------------------KLPAkrQNLLFSATFSDDI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 411 EKLQRLGLYQPRLFS-TRLGQQSPKDTAEVdensgkytfpvglthHYVPCRlsSKPLIVLHLVLRMSCSRALCFTNSREN 489
Cdd:PRK10590 195 KALAEKLLHNPLEIEvARRNTASEQVTQHV---------------HFVDKK--RKRELLSQMIGKGNWQQVLVFTRTKHG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 490 SHRlylLAQAFG--GVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVG 567
Cdd:PRK10590 258 ANH---LAEQLNkdGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIG 334
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 40538825 568 RTARAGKTGQAFTLLLkVQERKFLQmvseaGVPELTHHEIPR 609
Cdd:PRK10590 335 RTGRAAATGEALSLVC-VDEHKLLR-----DIEKLLKKEIPR 370
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
177-425 |
1.92e-36 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 135.43 E-value: 1.92e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 177 VHPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVcHIRA 256
Cdd:cd17955 6 LSSWLVKQCASLGIKEPTPIQKLCIPEILA--------GR------DVIGGAKTGSGKTAAFALPILQRLSEDPY-GIFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 257 LVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQTPG--FSL 334
Cdd:cd17955 71 LVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKR--------PHIVVATPGRLADHLRSSDDttKVL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 335 QQLRFLIIDEADRMIDSMHQSWLPRVVAaafysegptgscallqrtqpqaltaastCVPQMPlQKLLFSATLTQDPEKLQ 414
Cdd:cd17955 143 SRVKFLVLDEADRLLTGSFEDDLATILS----------------------------ALPPKR-QTLLFSATLTDALKALK 193
|
250
....*....|.
gi 40538825 415 RLGLYQPRLFS 425
Cdd:cd17955 194 ELFGNKPFFWE 204
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
185-427 |
2.82e-33 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 126.45 E-value: 2.82e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 185 LRANGITSYFPVQAAVIPALLESadhgfligrggyqPSDLCVSAPTGSGKTLAFVIPVVQALLHRVvcHIRALVVLPTKE 264
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSG-------------LRDVILAAPTGSGKTLAALLPALEALKRGK--GGRVLVLVPTRE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 265 LAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLvqktadgFRCLADIVVATPGRLVDHIDQTPgFSLQQLRFLIIDE 344
Cdd:smart00487 66 LAEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKL-------ESGKTDILVTTPGRLLDLLENDK-LSLSNVDLVILDE 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 345 ADRMIDSMHQSWLPRvvaaafysegptgscaLLQRTQPQaltaastcvpqmpLQKLLFSATLTQDPEKLQRLGLYQPRLF 424
Cdd:smart00487 138 AHRLLDGGFGDQLEK----------------LLKLLPKN-------------VQLLLLSATPPEEIENLLELFLNDPVFI 188
|
...
gi 40538825 425 STR 427
Cdd:smart00487 189 DVG 191
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
181-421 |
1.17e-32 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 124.61 E-value: 1.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLESadhgfligrggyqpSDLCVSAPTGSGKTLAFVIPVVQALLHRVVC----HIRA 256
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSN--------------KDVVVEAVTGSGKTLAFLIPVLEILLKRKANlkkgQVGA 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 257 LVVLPTKELAQQVSKVFNIYTD--TTPLRVALVTGQKSLAKEQESLVQKTadgfrclADIVVATPGRLVDHID-QTPGFS 333
Cdd:cd17960 67 LIISPTRELATQIYEVLQSFLEhhLPKLKCQLLIGGTNVEEDVKKFKRNG-------PNILVGTPGRLEELLSrKADKVK 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 334 LQQLRFLIIDEADRMID-----SMHQ--SWLPRvvaaafysegptgscallQRTqpqalTAastcvpqmplqklLFSATL 406
Cdd:cd17960 140 VKSLEVLVLDEADRLLDlgfeaDLNRilSKLPK------------------QRR-----TG-------------LFSATQ 183
|
250
....*....|....*
gi 40538825 407 TQDPEKLQRLGLYQP 421
Cdd:cd17960 184 TDAVEELIKAGLRNP 198
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
177-418 |
2.45e-31 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 121.15 E-value: 2.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 177 VHPDLQKQLRANGITSYFPVQAAVIPALLESADhgfligrggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHR----VVC 252
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGD-------------DVLARAKTGTGKTLAFLLPAIQSLLNTkpagRRS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 253 HIRALVVLPTKELAQQVSKVFN-IYTDTTPLRVALVTGQKSLAKEQESLVQktadgFRClaDIVVATPGRLVDHI-DQTP 330
Cdd:cd17964 68 GVSALIISPTRELALQIAAEAKkLLQGLRKLRVQSAVGGTSRRAELNRLRR-----GRP--DILVATPGRLIDHLeNPGV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 331 GFSLQQLRFLIIDEADRMIDSMHQSWLPRVVaaafysegptgscallqrtqpQALTAAStcvpQMPLQKLLFSATLTQDP 410
Cdd:cd17964 141 AKAFTDLDYLVLDEADRLLDMGFRPDLEQIL---------------------RHLPEKN----ADPRQTLLFSATVPDEV 195
|
....*...
gi 40538825 411 EKLQRLGL 418
Cdd:cd17964 196 QQIARLTL 203
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
178-581 |
2.48e-31 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 126.62 E-value: 2.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 178 HPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALL------HRVV 251
Cdd:PRK04837 16 HPQVVEALEKKGFHNCTPIQALALPLTLA--------GR------DVAGQAQTGTGKTMAFLTATFHYLLshpapeDRKV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 252 CHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQTPg 331
Cdd:PRK04837 82 NQPRALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESG--------VDILIGTTGRLIDYAKQNH- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 332 FSLQQLRFLIIDEADRMIDsmhqswLPRVVAAAFysegptgscaLLQRtqpqaltaastcvpqMPLQK----LLFSATLT 407
Cdd:PRK04837 153 INLGAIQVVVLDEADRMFD------LGFIKDIRW----------LFRR---------------MPPANqrlnMLFSATLS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 408 -----------QDPEK-----LQRLG------LYQP------RLFSTRLGQQSPkDTAEVDENsgkytfpvglTHHyvpc 459
Cdd:PRK04837 202 yrvrelafehmNNPEYvevepEQKTGhrikeeLFYPsneekmRLLQTLIEEEWP-DRAIIFAN----------TKH---- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 460 rlsSKPLIVLHLVlrmscsralcftnsrENSHRLYLLAqafGGVSvaefssrygpgQRK--KILKQFEQGKIQLLISTDA 537
Cdd:PRK04837 267 ---RCEEIWGHLA---------------ADGHRVGLLT---GDVA-----------QKKrlRILEEFTRGDLDILVATDV 314
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 40538825 538 TARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGKTGQAFTL 581
Cdd:PRK04837 315 AARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
183-415 |
6.04e-30 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 118.11 E-value: 6.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 183 KQLRANGITSYFPVQAAVIPALLesadhgfligRGGYqpsDLCVSAPTGSGKTLAFVIPVVQALL--------HRVVCHI 254
Cdd:cd17946 3 RALADLGFSEPTPIQALALPAAI----------RDGK---DVIGAAETGSGKTLAFGIPILERLLsqkssngvGGKQKPL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 255 RALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQTPGF-- 332
Cdd:cd17946 70 RALILTPTRELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKR--------PEIVVATPGRLWELIQEGNEHla 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 333 SLQQLRFLIIDEADRMIDSMHQSWLPRVVaaafysegptgscALLQRTQPQAltaastcVPQMplQKLLFSATLT---QD 409
Cdd:cd17946 142 NLKSLRFLVLDEADRMLEKGHFAELEKIL-------------ELLNKDRAGK-------KRKR--QTFVFSATLTldhQL 199
|
....*.
gi 40538825 410 PEKLQR 415
Cdd:cd17946 200 PLKLNS 205
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
195-594 |
6.52e-30 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 124.96 E-value: 6.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPvvqaLLHRVVCHIRA---LVVLPTKELAQQVSK 271
Cdd:PRK11634 31 PIQAECIPHLLN--------GR------DVLGMAQTGSGKTAAFSLP----LLHNLDPELKApqiLVLAPTRELAVQVAE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 272 VFNIYTDTTPLR--VALVTGQKSLakeqeslVQKTAdgFRCLADIVVATPGRLVDHIDQTPgFSLQQLRFLIIDEADRMI 349
Cdd:PRK11634 93 AMTDFSKHMRGVnvVALYGGQRYD-------VQLRA--LRQGPQIVVGTPGRLLDHLKRGT-LDLSKLSGLVLDEADEML 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 350 dsmhqswlprvvAAAFYSEgptgscallqrtqpqaltaASTCVPQMPL--QKLLFSATLtqdPEKLQRLglyqPRLFStr 427
Cdd:PRK11634 163 ------------RMGFIED-------------------VETIMAQIPEghQTALFSATM---PEAIRRI----TRRFM-- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 428 lgqqspKDTAEVDENSGKYTFPvGLTHHYVPCRLSSKPLIVLHLVLRMSCSRALCFTNSRENSHRLyllAQAF--GGVSV 505
Cdd:PRK11634 203 ------KEPQEVRIQSSVTTRP-DISQSYWTVWGMRKNEALVRFLEAEDFDAAIIFVRTKNATLEV---AEALerNGYNS 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 506 AEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGKTGQAFtLLLKV 585
Cdd:PRK11634 273 AALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRAL-LFVEN 351
|
....*....
gi 40538825 586 QERKFLQMV 594
Cdd:PRK11634 352 RERRLLRNI 360
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
181-421 |
2.14e-29 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 115.76 E-value: 2.14e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRAN-GITSYFPVQAAVIPALLesadhgfligrggyQPSDLCVSAPTGSGKTLAFVIPVVQaLLHRVVCHIR---- 255
Cdd:cd17949 1 LVSHLKSKmGIEKPTAIQKLAIPVLL--------------QGRDVLVRSQTGSGKTLAYLLPIIQ-RLLSLEPRVDrsdg 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 --ALVVLPTKELAQQVSKVFNIYTDTTP-LRVALVTGQKSLAKEQESLvqktadgfRCLADIVVATPGRLVDHIDQTPGF 332
Cdd:cd17949 66 tlALVLVPTRELALQIYEVLEKLLKPFHwIVPGYLIGGEKRKSEKARL--------RKGVNILIATPGRLLDHLKNTQSF 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 333 SLQQLRFLIIDEADRMIDSMHQSWLPRVVAAAfysegptgscallqRTQPQALTAASTCVPQmpLQKLLFSATLTQDPEK 412
Cdd:cd17949 138 DVSNLRWLVLDEADRLLDMGFEKDITKILELL--------------DDKRSKAGGEKSKPSR--RQTVLVSATLTDGVKR 201
|
....*....
gi 40538825 413 LQRLGLYQP 421
Cdd:cd17949 202 LAGLSLKDP 210
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
179-582 |
2.23e-29 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 122.96 E-value: 2.23e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 179 PD-LQKQLRANGITSYFPVQAAVIPALLESADhgfLIGRggyqpsdlcvsAPTGSGKTLAFVIPVVqallhrvvCHIRA- 256
Cdd:PTZ00110 138 PDyILKSLKNAGFTEPTPIQVQGWPIALSGRD---MIGI-----------AETGSGKTLAFLLPAI--------VHINAq 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 257 -----------LVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDH 325
Cdd:PTZ00110 196 pllrygdgpivLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRG--------VEILIACPGRLIDF 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 326 IDQTPGfSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAAfyseGPTGSCALLQRTQP---QALtAASTCvPQMPLQKLLF 402
Cdd:PTZ00110 268 LESNVT-NLRRVTYLVLDEADRMLDMGFEPQIRKIVSQI----RPDRQTLMWSATWPkevQSL-ARDLC-KEEPVHVNVG 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 403 SATLT------------QDPEKLQRLglyqpRLFSTRLGQQSPKDTAEVDENSGKYTFPVGLthhyvpcRLSSKPlivlh 470
Cdd:PTZ00110 341 SLDLTachnikqevfvvEEHEKRGKL-----KMLLQRIMRDGDKILIFVETKKGADFLTKEL-------RLDGWP----- 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 471 lvlrmscsrALCFTNSRENSHRLYllaqafggvsvaefssrygpgqrkkILKQFEQGKIQLLISTDATARGIDVQGVELV 550
Cdd:PTZ00110 404 ---------ALCIHGDKKQEERTW-------------------------VLNEFKTGKSPIMIATDVASRGLDVKDVKYV 449
|
410 420 430
....*....|....*....|....*....|..
gi 40538825 551 INYDAPQYLRTYVHRVGRTARAGKTGQAFTLL 582
Cdd:PTZ00110 450 INFDFPNQIEDYVHRIGRTGRAGAKGASYTFL 481
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
179-421 |
2.35e-29 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 115.37 E-value: 2.35e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 179 PDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHR--VVCH--- 253
Cdd:cd17961 3 PRLLKAIAKLGWEKPTLIQSKAIPLALE--------GK------DILARARTGSGKTAAYALPIIQKILKAkaESGEeqg 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 254 IRALVVLPTKELAQQVSKVFNIYTD--TTPLRVALVTGQKSlAKEQESLVqktadgfRCLADIVVATPGRLVDHIDQTPG 331
Cdd:cd17961 69 TRALILVPTRELAQQVSKVLEQLTAycRKDVRVVNLSASSS-DSVQRALL-------AEKPDIVVSTPARLLSHLESGSL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 332 FSLQQLRFLIIDEADRMIDSMHQSWLPRVVaaafySEGPTGscallqrtqpqaltaastcvpqmpLQKLLFSATLTQDPE 411
Cdd:cd17961 141 LLLSTLKYLVIDEADLVLSYGYEEDLKSLL-----SYLPKN------------------------YQTFLMSATLSEDVE 191
|
250
....*....|
gi 40538825 412 KLQRLGLYQP 421
Cdd:cd17961 192 ALKKLVLHNP 201
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
179-416 |
3.36e-29 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 115.66 E-value: 3.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 179 PDLQKQLRAN----GITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALL------- 247
Cdd:cd17967 5 AGLRELLLENikraGYTKPTPVQKYAIPIILA--------GR------DLMACAQTGSGKTAAFLLPIISKLLedgppsv 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 248 --HRVVCHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQktadGfrclADIVVATPGRLVDH 325
Cdd:cd17967 71 grGRRKAYPSALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLR----G----CDILVATPGRLVDF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 326 IDQtpGF-SLQQLRFLIIDEADRMIDsmhQSWLP---RVVAAafysegptgscallqrtqpqaltaastcvPQMPL---- 397
Cdd:cd17967 143 IER--GRiSLSSIKFLVLDEADRMLD---MGFEPqirKIVEH-----------------------------PDMPPkger 188
|
250
....*....|....*....
gi 40538825 398 QKLLFSATLtqdPEKLQRL 416
Cdd:cd17967 189 QTLMFSATF---PREIQRL 204
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
182-424 |
1.38e-28 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 113.22 E-value: 1.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 182 QKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQaLLHRVVCHIR----AL 257
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLE--------GR------DVLGAAKTGSGKTLAFLIPAIE-LLYKLKFKPRngtgVI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 258 VVLPTKELAQQ---VSKVFNIYTDTTplrVALVTGQKSLAKEQESLVQKTadgfrclaDIVVATPGRLVDHIDQTPGFSL 334
Cdd:cd17942 67 IISPTRELALQiygVAKELLKYHSQT---FGIVIGGANRKAEAEKLGKGV--------NILVATPGRLLDHLQNTKGFLY 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 335 QQLRFLIIDEADRMI-----DSMHQ--SWLPRvvaaafysegptgscallQRtqpqaltaastcvpqmplQKLLFSATLT 407
Cdd:cd17942 136 KNLQCLIIDEADRILeigfeEEMRQiiKLLPK------------------RR------------------QTMLFSATQT 179
|
250
....*....|....*..
gi 40538825 408 QDPEKLQRLGLYQPRLF 424
Cdd:cd17942 180 RKVEDLARISLKKKPLY 196
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
228-582 |
1.46e-27 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 115.31 E-value: 1.46e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 228 APTGSGKTLAFVIPVVQALLHRVVChIRALVVLPTKELAQQVSKVFNIYTDTTPLRV-ALVTGqkslakeqeSLVQKTAD 306
Cdd:PTZ00424 72 AQSGTGKTATFVIAALQLIDYDLNA-CQALILAPTRELAQQIQKVVLALGDYLKVRChACVGG---------TVVRDDIN 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 307 GFRCLADIVVATPGRLVDHIDQTpGFSLQQLRFLIIDEADRMIdsmhqswlprvvaaafySEGPTGSCALLQRTQPQALT 386
Cdd:PTZ00424 142 KLKAGVHMVVGTPGRVYDMIDKR-HLRVDDLKLFILDEADEML-----------------SRGFKGQIYDVFKKLPPDVQ 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 387 AAstcvpqmplqklLFSATLTQDPEKLQRLGLYQPRlfstRLGQQSPKDTAEvdensgkytfpvGLTHHYVPCRLSSKPL 466
Cdd:PTZ00424 204 VA------------LFSATMPNEILELTTKFMRDPK----RILVKKDELTLE------------GIRQFYVAVEKEEWKF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 467 IVL-HLVLRMSCSRALCFTNSRENSHRLYLLAQAfGGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQ 545
Cdd:PTZ00424 256 DTLcDLYETLTITQAIIYCNTRRKVDYLTKKMHE-RDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQ 334
|
330 340 350
....*....|....*....|....*....|....*..
gi 40538825 546 GVELVINYDAPQYLRTYVHRVGRTARAGKTGQAFTLL 582
Cdd:PTZ00424 335 QVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFV 371
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
195-421 |
1.42e-26 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 108.18 E-value: 1.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLESADhgfLIGrggyqpsdlcvSAPTGSGKTLAFVIPVVQALLHRVVCHIR-------ALVVLPTKELAQ 267
Cdd:cd17945 15 PIQRQAIPIGLQNRD---IIG-----------IAETGSGKTAAFLIPLLVYISRLPPLDEEtkddgpyALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 268 QVSKVFNIYTDTTPLRVALVTGQKSLaKEQESLVQKTadgfrclADIVVATPGRLVDHIDQTPgFSLQQLRFLIIDEADR 347
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSI-EEQAFSLRNG-------CEILIATPGRLLDCLERRL-LVLNQCTYVVLDEADR 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40538825 348 MIDSMHQSWLPRVVAAafysegpTGSCALLQRTQPQALTAASTcvPQMPLQKLLFSATLTQDPEKLQRLGLYQP 421
Cdd:cd17945 152 MIDMGFEPQVTKILDA-------MPVSNKKPDTEEAEKLAASG--KHRYRQTMMFTATMPPAVEKIAKGYLRRP 216
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
463-573 |
7.43e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 102.29 E-value: 7.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 463 SKPLIVLHLVLRMSCSRALCFTNSRENSHRLYLLAQAfgGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGI 542
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEAELLLEKE--GIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 40538825 543 DVQGVELVINYDAPQYLRTYVHRVGRTARAG 573
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
179-612 |
9.69e-26 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 111.42 E-value: 9.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 179 PDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQAllhrvVCHIR--- 255
Cdd:PLN00206 130 PKLLLNLETAGYEFPTPIQMQAIPAALS--------GR------SLLVSADTGSGKTASFLVPIISR-----CCTIRsgh 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 --------ALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEqeslVQKTADGfrclADIVVATPGRLVDHID 327
Cdd:PLN00206 191 pseqrnplAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQ----LYRIQQG----VELIVGTPGRLIDLLS 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 328 QTpGFSLQQLRFLIIDEADRMIDSMHQSWLPRVVaaafysegptgscallqrtqpQALTAastcvPQMplqkLLFSATLT 407
Cdd:PLN00206 263 KH-DIELDNVSVLVLDEVDCMLERGFRDQVMQIF---------------------QALSQ-----PQV----LLFSATVS 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 408 QDPEKlqrlglyqprlFSTRLGqqspKDTAEVD-ENSGKYTFPVGLTHHYVPCRLSSKPLivlhLVLRMSCSR----ALC 482
Cdd:PLN00206 312 PEVEK-----------FASSLA----KDIILISiGNPNRPNKAVKQLAIWVETKQKKQKL----FDILKSKQHfkppAVV 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 483 FTNSRENSHrlyLLAQAFGGVSVAEFSSRYGP---GQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYL 559
Cdd:PLN00206 373 FVSSRLGAD---LLANAITVVTGLKALSIHGEksmKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTI 449
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 40538825 560 RTYVHRVGRTARAGKTGQAFTLLLKVQERKFLQMVS---EAGVPelthheIPRKLL 612
Cdd:PLN00206 450 KEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVAllkSSGAA------IPRELA 499
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
178-423 |
1.14e-25 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 105.08 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 178 HPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQAL-LHRVVCHIRA 256
Cdd:cd17959 9 SPPLLRAIKKKGYKVPTPIQRKTIPLILD--------GR------DVVAMARTGSGKTAAFLIPMIEKLkAHSPTVGARA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 257 LVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQTpGFSLQQ 336
Cdd:cd17959 75 LILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASN--------PDIIIATPGRLLHLLVEM-NLKLSS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 337 LRFLIIDEADRMIDSMHQSWLPrvvaaafysegptgscALLQRTQPQAltaastcvpqmplQKLLFSATLtqdPEKL--- 413
Cdd:cd17959 146 VEYVVFDEADRLFEMGFAEQLH----------------EILSRLPENR-------------QTLLFSATL---PKLLvef 193
|
250
....*....|
gi 40538825 414 QRLGLYQPRL 423
Cdd:cd17959 194 AKAGLNEPVL 203
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
195-406 |
2.16e-25 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 103.94 E-value: 2.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLesadhgfligrGGyqpSDLCVSAPTGSGKTLAFVIPVVQAllhrvvchIRALVVLPTKELAQQVS---K 271
Cdd:cd17938 24 DIQAEAIPLIL-----------GG---GDVLMAAETGSGKTGAFCLPVLQI--------VVALILEPSRELAEQTYnciE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 272 VFNIYTDTTPLRVALVTGQKSlAKEQESLVQKTadgfrclADIVVATPGRLVDHIdQTPGFSLQQLRFLIIDEADRMIDS 351
Cdd:cd17938 82 NFKKYLDNPKLRVALLIGGVK-AREQLKRLESG-------VDIVVGTPGRLEDLI-KTGKLDLSSVRFFVLDEADRLLSQ 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 40538825 352 MHQSWLPRVvaaafYSEGPTGSCAlLQRtqpqaltaastcvpqmpLQKLLFSATL 406
Cdd:cd17938 153 GNLETINRI-----YNRIPKITSD-GKR-----------------LQVIVCSATL 184
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
176-416 |
2.39e-24 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 102.74 E-value: 2.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 176 EVHPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIR 255
Cdd:cd18052 49 NLCETLLKNIRKAGYEKPTPVQKYAIPIILA--------GR------DLMACAQTGSGKTAAFLLPVLTGMMKEGLTASS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 --------ALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAkEQESLVQKTADgfrcladIVVATPGRLVDHID 327
Cdd:cd18052 115 fsevqepqALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVG-HQIRQIEKGCH-------ILVATPGRLLDFIG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 328 QTPgFSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAafysegptgscallqrtqpqaltaastcvPQMPL----QKLLFS 403
Cdd:cd18052 187 RGK-ISLSKLKYLILDEADRMLDMGFGPEIRKLVSE-----------------------------PGMPSkedrQTLMFS 236
|
250
....*....|...
gi 40538825 404 ATLtqdPEKLQRL 416
Cdd:cd18052 237 ATF---PEEIQRL 246
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
185-350 |
6.75e-23 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 97.82 E-value: 6.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 185 LRANGITSYFPVQAAVIPALLesadhgfligRGGYQpsdLCvSAPTGSGKTLAFVIPVVQALLHR-VVC-----HIRALV 258
Cdd:cd17948 5 LQRQGITKPTTVQKQGIPSIL----------RGRNT---LC-AAETGSGKTLTYLLPIIQRLLRYkLLAegpfnAPRGLV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 259 VLPTKELAQQVSKVFNIYTDTTPLRVALVTG----QKSLAKEQESlvqktadgfrclADIVVATPGRLV----DHIdqtp 330
Cdd:cd17948 71 ITPSRELAEQIGSVAQSLTEGLGLKVKVITGgrtkRQIRNPHFEE------------VDILVATPGALSklltSRI---- 134
|
170 180
....*....|....*....|
gi 40538825 331 gFSLQQLRFLIIDEADRMID 350
Cdd:cd17948 135 -YSLEQLRHLVLDEADTLLD 153
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
172-582 |
5.54e-22 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 100.68 E-value: 5.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 172 EDIPE-VHPDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRV 250
Cdd:COG1205 35 APWPDwLPPELRAALKKRGIERLYSHQAEAIEAARA--------GK------NVVIATPTASGKSLAYLLPVLEALLEDP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 251 VChiRALVVLPTKELAQ-QVSKvFNIYTDTTPL--RVALVTG-----QKSLAKEQeslvqktadgfrclADIVVATP--- 319
Cdd:COG1205 101 GA--TALYLYPTKALARdQLRR-LRELAEALGLgvRVATYDGdtppeERRWIREH--------------PDIVLTNPdml 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 320 --GRLVDHidqtPGFS--LQQLRFLIIDEAD--RMIDSMHQSW----LPRVvaAAFYSEGPTGSCAllqrtqpqaltaas 389
Cdd:COG1205 164 hyGLLPHH----TRWArfFRNLRYVVIDEAHtyRGVFGSHVANvlrrLRRI--CRHYGSDPQFILA-------------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 390 tcvpqmplqkllfSATLtQDPEKL-QRLglyqprlfstrLGQqspkDTAEVDENSGkytfPVGLTHHYV--------PCR 460
Cdd:COG1205 224 -------------SATI-GNPAEHaERL-----------TGR----PVTVVDEDGS----PRGERTFVLwnpplvddGIR 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 461 LSSKPL---IVLHLVLRMscSRALCFTNSRENSHRLYLLAQAF-----GGVSVAEFSSRYGPGQRKKILKQFEQGKIQLL 532
Cdd:COG1205 271 RSALAEaarLLADLVREG--LRTLVFTRSRRGAELLARYARRAlrepdLADRVAAYRAGYLPEERREIERGLRSGELLGV 348
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 40538825 533 ISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGKTGQAFTLL 582
Cdd:COG1205 349 VSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLVA 398
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
194-350 |
7.20e-22 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 94.37 E-value: 7.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 194 FPVQAAVIPALLESADhgfLIGrggyqpsdlcvSAPTGSGKTLAFVIPVVQALLH-RVVCHIR---ALVVLPTKELAQQV 269
Cdd:cd17953 36 TPIQAQALPAIMSGRD---VIG-----------IAKTGSGKTLAFLLPMFRHIKDqRPVKPGEgpiGLIMAPTRELALQI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 270 SKVFNIYTDTTPLRVALVTGQKSLaKEQESLVQKTadgfrclADIVVATPGRLVDHIDQTPG--FSLQQLRFLIIDEADR 347
Cdd:cd17953 102 YVECKKFSKALGLRVVCVYGGSGI-SEQIAELKRG-------AEIVVCTPGRMIDILTANNGrvTNLRRVTYVVLDEADR 173
|
...
gi 40538825 348 MID 350
Cdd:cd17953 174 MFD 176
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
183-350 |
2.14e-21 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 92.79 E-value: 2.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 183 KQLRANGITSYFPVQAAVIPALLESADhgfLIGrggyqpsdlcvSAPTGSGKTLAFVIPVV-QALLHRVVCHIR------ 255
Cdd:cd17951 3 KGLKKKGIKKPTPIQMQGLPTILSGRD---MIG-----------IAFTGSGKTLVFTLPLImFALEQEKKLPFIkgegpy 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 ALVVLPTKELAQQVSKVFNIYTDT------TPLRVALVTGQKSLaKEQESLVQKtadGFRcladIVVATPGRLVDHIdQT 329
Cdd:cd17951 69 GLIVCPSRELARQTHEVIEYYCKAlqeggyPQLRCLLCIGGMSV-KEQLEVIRK---GVH----IVVATPGRLMDML-NK 139
|
170 180
....*....|....*....|.
gi 40538825 330 PGFSLQQLRFLIIDEADRMID 350
Cdd:cd17951 140 KKINLDICRYLCLDEADRMID 160
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
502-573 |
2.32e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 85.73 E-value: 2.32e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40538825 502 GVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAG 573
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
181-421 |
3.72e-20 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 89.01 E-value: 3.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLESADhgfLIGrggyqpsdlcvSAPTGSGKTLAFVIPVV-----QALLHRVVCHIr 255
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRD---MIG-----------IAKTGSGKTAAFIWPMLvhimdQRELEKGEGPI- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 ALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLvqktadgfRCLADIVVATPGRLVDHIdQTPGFSLQ 335
Cdd:cd17952 66 AVIVAPTRELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKAL--------QEGAEIVVATPGRLIDMV-KKKATNLQ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 336 QLRFLIIDEADRMIDsmhqswlprvvaAAFysegptgscallqrtQPQALTAASTCVPQMplQKLLFSATLTQDPEKLQR 415
Cdd:cd17952 137 RVTYLVLDEADRMFD------------MGF---------------EYQVRSIVGHVRPDR--QTLLFSATFKKKIEQLAR 187
|
....*.
gi 40538825 416 LGLYQP 421
Cdd:cd17952 188 DILSDP 193
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
181-350 |
7.38e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 87.81 E-value: 7.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVV-----QALLHRVVCHIr 255
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALS--------GR------DMVGIAQTGSGKTLAFLLPAIvhinaQPPLERGDGPI- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 ALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDHIDQ--TPgfs 333
Cdd:cd17966 66 VLVLAPTRELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRG--------VEICIATPGRLIDFLDQgkTN--- 134
|
170
....*....|....*..
gi 40538825 334 LQQLRFLIIDEADRMID 350
Cdd:cd17966 135 LRRVTYLVLDEADRMLD 151
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
183-391 |
3.88e-18 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 82.97 E-value: 3.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 183 KQLRANGITSYFPVQAAVIPALlesadhgfligrggYQPSDLCVSAPTGSGKTLAFVIPVVQAlLHRVVCHIR------A 256
Cdd:cd17944 3 KLLQARGVTYLFPIQVKTFHPV--------------YSGKDLIAQARTGTGKTFSFAIPLIEK-LQEDQQPRKrgrapkV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 257 LVVLPTKELAQQVSKVFNiyTDTTPLRVALVTGQKSLakeqeslvQKTADGFRCLADIVVATPGRLVDHIdQTPGFSLQQ 336
Cdd:cd17944 68 LVLAPTRELANQVTKDFK--DITRKLSVACFYGGTPY--------QQQIFAIRNGIDILVGTPGRIKDHL-QNGRLDLTK 136
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 40538825 337 LRFLIIDEADRMIDSMHQSWLPRVVAAAFYSEgptgscallQRTQPQALTAASTC 391
Cdd:cd17944 137 LKHVVLDEVDQMLDMGFAEQVEEILSVSYKKD---------SEDNPQTLLFSATC 182
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
178-405 |
5.45e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 82.62 E-value: 5.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 178 HPDLQKQLRANGITSYFPVQAAVIPALLESAdhgfligrggyqPSDLCVSAPTGSGKTLAFVIpvvqALLHRVVCHIR-- 255
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETALPLILSDP------------PENLIAQSQSGTGKTAAFVL----AMLSRVDPTLKsp 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 -ALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQktadgfrcladIVVATPGRLVDHIdQTPGFSL 334
Cdd:cd17963 66 qALCLAPTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPRGKKITAQ-----------IVIGTPGTVLDWL-KKRQLDL 133
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40538825 335 QQLRFLIIDEADRMIDSMHQSwlprvvaaafysegptGSCALLQRTQPQaltaastcvpqmPLQKLLFSAT 405
Cdd:cd17963 134 KKIKILVLDEADVMLDTQGHG----------------DQSIRIKRMLPR------------NCQILLFSAT 176
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
183-354 |
1.20e-17 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 81.54 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 183 KQLRANGITSYFPVQAAVIPallesadhgflIGRGGYqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVcHIRALVVLPT 262
Cdd:cd17943 3 EGLKAAGFQRPSPIQLAAIP-----------LGLAGH---DLIVQAKSGTGKTLVFVVIALESLDLERR-HPQVLILAPT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 263 KELAQQVSKVF-NIYTDTTPLRVALVTGQKSLAKEQESLVQktadgfrclADIVVATPGRLVdHIDQTPGFSLQQLRFLI 341
Cdd:cd17943 68 REIAVQIHDVFkKIGKKLEGLKCEVFIGGTPVKEDKKKLKG---------CHIAVGTPGRIK-QLIELGALNVSHVRLFV 137
|
170
....*....|...
gi 40538825 342 IDEADRMIDSMHQ 354
Cdd:cd17943 138 LDEADKLMEGSFQ 150
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
223-351 |
2.60e-17 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 80.83 E-value: 2.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 223 DLCVSAPTGSGKTLAFVIPVVQALlHRVVCHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQ 302
Cdd:cd17939 36 DVIAQAQSGTGKTATFSIGALQRI-DTTVRETQALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQY 114
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 40538825 303 KTadgfrclaDIVVATPGRLVDHIdQTPGFSLQQLRFLIIDEADRMIDS 351
Cdd:cd17939 115 GP--------HIVVGTPGRVFDML-QRRSLRTDKIKMFVLDEADEMLSR 154
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
195-358 |
5.86e-17 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 80.88 E-value: 5.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLESadhgfLIGRGGYQPSD-------LCVSAPTGSGKTLAFVIPVVQAL----------------LHRVV 251
Cdd:cd17965 33 PIQTLAIKKLLKT-----LMRKVTKQTSNeepklevFLLAAETGSGKTLAYLAPLLDYLkrqeqepfeeaeeeyeSAKDT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 252 CHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSlakeqeSLVQKTADGFRCLADIVVATPGRLVDhIDQTPG 331
Cdd:cd17965 108 GRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFG------PSYQRLQLAFKGRIDILVTTPGKLAS-LAKSRP 180
|
170 180
....*....|....*....|....*..
gi 40538825 332 FSLQQLRFLIIDEADRMIDsmhQSWLP 358
Cdd:cd17965 181 KILSRVTHLVVDEADTLFD---RSFLQ 204
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
226-357 |
7.85e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 77.83 E-value: 7.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 226 VSAPTGSGKTLAFVIPVVQALLHRvvcHIRALVVLPTKELAQQVSKVFNIYTDTtPLRVALVTGQKSlAKEQESLvqkta 305
Cdd:cd00046 6 ITAPTGSGKTLAALLAALLLLLKK---GKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSS-AEEREKN----- 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 40538825 306 dgFRCLADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQSWL 357
Cdd:cd00046 76 --KLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALI 125
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
179-350 |
3.17e-16 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 77.72 E-value: 3.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 179 PDLQKQLRANGITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALlHRVVCHIRALV 258
Cdd:cd17940 8 RELLMGIFEKGFEKPSPIQEESIPIALS--------GR------DILARAKNGTGKTGAYLIPILEKI-DPKKDVIQALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 259 VLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKTadgfrclaDIVVATPGRLVDHIDQTPGfSLQQLR 338
Cdd:cd17940 73 LVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTV--------HVLVGTPGRILDLAKKGVA-DLSHCK 143
|
170
....*....|..
gi 40538825 339 FLIIDEADRMID 350
Cdd:cd17940 144 TLVLDEADKLLS 155
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
172-582 |
5.11e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 78.14 E-value: 5.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 172 EDIPEVHPDLQKQLRANGITSYF-----PVQAAVIPALLESADHGfligrggyqPSDLCVSAPTGSGKTLAFVipvvqAL 246
Cdd:COG1061 55 EEDTERELAEAEALEAGDEASGTsfelrPYQQEALEALLAALERG---------GGRGLVVAPTGTGKTVLAL-----AL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 247 LHRVVCHIRALVVLPTKELAQQVSKVFniytdttpLRVALVTGQKSLAKEQEslvqktadgfrclADIVVATPGRLV--D 324
Cdd:COG1061 121 AAELLRGKRVLVLVPRRELLEQWAEEL--------RRFLGDPLAGGGKKDSD-------------APITVATYQSLArrA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 325 HIDQTPG-FSLqqlrfLIIDEAdrmidsmHQswlprvVAAAFYSEgptgscaLLQRTQPQ---ALTAasTcvP-----QM 395
Cdd:COG1061 180 HLDELGDrFGL-----VIIDEA-------HH------AGAPSYRR-------ILEAFPAAyrlGLTA--T--PfrsdgRE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 396 PLQKLLFSATLTQDPEKLQRLGLYQPRLFSTRLGQQSPKdTAEVDENSGKytfpvgLTHHYVPCRlSSKPLIVLHLVLRM 475
Cdd:COG1061 231 ILLFLFDGIVYEYSLKEAIEDGYLAPPEYYGIRVDLTDE-RAEYDALSER------LREALAADA-ERKDKILRELLREH 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 476 -SCSRALCFTNSRENSHRlylLAQAFG--GVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVIN 552
Cdd:COG1061 303 pDDRKTLVFCSSVDHAEA---LAELLNeaGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAIL 379
|
410 420 430
....*....|....*....|....*....|
gi 40538825 553 YDAPQYLRTYVHRVGRTARAGKTGQAFTLL 582
Cdd:COG1061 380 LRPTGSPREFIQRLGRGLRPAPGKEDALVY 409
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
226-345 |
8.65e-15 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 73.00 E-value: 8.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 226 VSAPTGSGKTLAFVIPVVQALLHRVvcHIRALVVLPTKELAQ-QVSKVFNIYTDT-TPLRVALVTGQKSLAKEQESLvqk 303
Cdd:cd17923 20 VTTGTASGKSLCYQLPILEALLRDP--GSRALYLYPTKALAQdQLRSLRELLEQLgLGIRVATYDGDTPREERRAII--- 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 40538825 304 tadgfRCLADIVVATPGRL---VDHIDQTPGFSLQQLRFLIIDEA 345
Cdd:cd17923 95 -----RNPPRILLTNPDMLhyaLLPHHDRWARFLRNLRYVVLDEA 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
194-351 |
1.81e-14 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 71.91 E-value: 1.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 194 FPVQAAVIPALLESaDHGFLigrggyqpsdlcVSAPTGSGKTLAFVIPVVQALLHrvvCHIRALVVLPTKELAQQVSKVF 273
Cdd:cd17921 3 NPIQREALRALYLS-GDSVL------------VSAPTSSGKTLIAELAILRALAT---SGGKAVYIAPTRALVNQKEADL 66
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40538825 274 NIYTDTTPLRVALVTGQKSLAKEQESlvqktadgfrcLADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDS 351
Cdd:cd17921 67 RERFGPLGKNVGLLTGDPSVNKLLLA-----------EADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLIGDG 133
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
223-352 |
2.05e-14 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 72.38 E-value: 2.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 223 DLCVSAPTGSGKTLAFVIPVVQALLHrVVCHIRALVVLPTKELAQQVSKVFNIYTDTTP-LRVALVTGQKSLAKEQESLV 301
Cdd:cd17950 41 DVLCQAKSGMGKTAVFVLSTLQQLEP-VDGQVSVLVICHTRELAFQISNEYERFSKYMPnVKTAVFFGGVPIKKDIEVLK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 40538825 302 QKTADgfrcladIVVATPGRLVDHIDQTpGFSLQQLRFLIIDEADRMIDSM 352
Cdd:cd17950 120 NKCPH-------IVVGTPGRILALVREK-KLKLSHVKHFVLDECDKMLEQL 162
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
195-416 |
2.49e-14 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 73.15 E-value: 2.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 195 PVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLH---------------RVVCHIRALVV 259
Cdd:cd18051 46 PVQKHAIPIIKS--------KR------DLMACAQTGSGKTAAFLLPILSQIYEqgpgeslpsesgyygRRKQYPLALVL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 260 LPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQKtadgfrClaDIVVATPGRLVDHIDQTPgFSLQQLRF 339
Cdd:cd18051 112 APTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERG------C--HLLVATPGRLVDMLERGK-IGLDYCKY 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40538825 340 LIIDEADRMIDSMHQSWLPRVVaaafysegptgscalLQRTQPqaltaastcvPQMPLQKLLFSATLtqdPEKLQRL 416
Cdd:cd18051 183 LVLDEADRMLDMGFEPQIRRIV---------------EQDTMP----------PTGERQTLMFSATF---PKEIQML 231
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
223-400 |
3.13e-14 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 71.71 E-value: 3.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 223 DLCVSAPTGSGKTLAFVIPVVQALLHRVVcHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLvq 302
Cdd:cd18046 38 DVIAQAQSGTGKTATFSISILQQIDTSLK-ATQALVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKL-- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 303 ktadgfRCLADIVVATPGRLVDHIDQTpGFSLQQLRFLIIDEADRMIDSMHQSWLPRVvaaaFYSEGPTGSCALLQRTQP 382
Cdd:cd18046 115 ------QAGPHIVVGTPGRVFDMINRR-YLRTDYIKMFVLDEADEMLSRGFKDQIYDI----FQKLPPDTQVVLLSATMP 183
|
170
....*....|....*...
gi 40538825 383 QALTAASTCVPQMPLQKL 400
Cdd:cd18046 184 NDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
181-350 |
3.39e-14 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 71.73 E-value: 3.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLesadhgfligrggyQPSDLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIR----- 255
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIIL--------------QGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQrngpg 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 256 ALVVLPTKELAQQVSKVFNIYTDTTpLRVALVTGQKSLAKEQESLVQKtadgfrclADIVVATPGRLVDhIDQTPGFSLQ 335
Cdd:cd17958 67 VLVLTPTRELALQIEAECSKYSYKG-LKSVCVYGGGNRNEQIEDLSKG--------VDIIIATPGRLND-LQMNNVINLK 136
|
170
....*....|....*
gi 40538825 336 QLRFLIIDEADRMID 350
Cdd:cd17958 137 SITYLVLDEADRMLD 151
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
223-361 |
1.39e-13 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 70.81 E-value: 1.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 223 DLCVSAPTGSGKTLAFVIPVV-----QALLHR---VVChiraLVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLA 294
Cdd:cd18049 63 DMVGVAQTGSGKTLSYLLPAIvhinhQPFLERgdgPIC----LVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKG 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40538825 295 KEQESLVQKTadgfrclaDIVVATPGRLVDHIDQTPGfSLQQLRFLIIDEADRMIDSMHQSWLPRVV 361
Cdd:cd18049 139 PQIRDLERGV--------EICIATPGRLIDFLEAGKT-NLRRCTYLVLDEADRMLDMGFEPQIRKIV 196
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
223-361 |
2.97e-13 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 70.42 E-value: 2.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 223 DLCVSAPTGSGKTLAFVIPVV-----QALLHR---VVChiraLVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLA 294
Cdd:cd18050 101 DMVGIAQTGSGKTLAYLLPAIvhinhQPYLERgdgPIC----LVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKG 176
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40538825 295 KEQESLVQKTadgfrclaDIVVATPGRLVDHIdQTPGFSLQQLRFLIIDEADRMIDSMHQSWLPRVV 361
Cdd:cd18050 177 PQIRDLERGV--------EICIATPGRLIDFL-EAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIV 234
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
181-349 |
4.92e-13 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 67.96 E-value: 4.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAAVIPALLesadhgflIGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIrALVVL 260
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGL--------LGR------DILASADTGSGKTAAFLLPVIIRCLTEHRNPS-ALILT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 261 PTKELAQQVSK-VFNIYTDTTPLRVALVTGQKSLAKEQESLVQKTadgfrclaDIVVATPGRLVDHIDQTpGFSLQQLRF 339
Cdd:cd17962 66 PTRELAVQIEDqAKELMKGLPPMKTALLVGGLPLPPQLYRLQQGV--------KVIIATPGRLLDILKQS-SVELDNIKI 136
|
170
....*....|
gi 40538825 340 LIIDEADRMI 349
Cdd:cd17962 137 VVVDEADTML 146
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
171-351 |
9.20e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 71.08 E-value: 9.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 171 IEDIPEVHpdLQKQLRANGITSYFPVQAAVIPALLESADHgfligrggyqpsdLCVSAPTGSGKTLAFVIPVVQALLHrv 250
Cdd:COG1204 3 VAELPLEK--VIEFLKERGIEELYPPQAEALEAGLLEGKN-------------LVVSAPTASGKTLIAELAILKALLN-- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 251 vcHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGqkslakEQESLVQKTADgfrclADIVVATPGRLVDHIDQTP 330
Cdd:COG1204 66 --GGKALYIVPLRALASEKYREFKRDFEELGIKVGVSTG------DYDSDDEWLGR-----YDILVATPEKLDSLLRNGP 132
|
170 180
....*....|....*....|.
gi 40538825 331 GFsLQQLRFLIIDEAdRMIDS 351
Cdd:COG1204 133 SW-LRDVDLVVVDEA-HLIDD 151
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
478-584 |
6.51e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 65.52 E-value: 6.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 478 SRALCFTNSRENSHRLY-LLAQAfgGVSVAEF---SSRYGPG-----QRKKILKQFEQGKIQLLISTDATARGIDVQGVE 548
Cdd:COG1111 354 SRIIVFTQYRDTAEMIVeFLSEP--GIKAGRFvgqASKEGDKgltqkEQIEILERFRAGEFNVLVATSVAEEGLDIPEVD 431
|
90 100 110
....*....|....*....|....*....|....*..
gi 40538825 549 LVINYDA-PQYLRtYVHRVGRTARAGKtGQAFTLLLK 584
Cdd:COG1111 432 LVIFYEPvPSEIR-SIQRKGRTGRKRE-GRVVVLIAK 466
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
220-349 |
3.39e-10 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 60.17 E-value: 3.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 220 QPSDLCVSAPTGSGKTLAFVIPVVQALlHRVVCHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEqes 299
Cdd:cd18045 35 KGRDVIAQSQSGTGKTATFSISVLQCL-DIQVRETQALILSPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDD--- 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 40538825 300 lVQKTADGFRcladIVVATPGRLVDHIdQTPGFSLQQLRFLIIDEADRMI 349
Cdd:cd18045 111 -IRKLDYGQH----IVSGTPGRVFDMI-RRRSLRTRHIKMLVLDEADEML 154
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
478-582 |
2.64e-09 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 55.82 E-value: 2.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 478 SRALCFTNSRENSHRLY-LLAQAFGGVSVAEF----SSRYGPG----QRKKILKQFEQGKIQLLISTDATARGIDVQGVE 548
Cdd:cd18801 31 TRVIIFSEFRDSAEEIVnFLSKIRPGIRATRFigqaSGKSSKGmsqkEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVD 110
|
90 100 110
....*....|....*....|....*....|....*
gi 40538825 549 LVINYDA-PQYLRTyVHRVGRTARaGKTGQAFTLL 582
Cdd:cd18801 111 LIICYDAsPSPIRM-IQRMGRTGR-KRQGRVVVLL 143
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
478-572 |
1.86e-08 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 53.36 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 478 SRALCFTNSR------------ENSHRLYLLAQAF--GGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGID 543
Cdd:cd18802 26 FRGIIFVERRatavvlsrllkeHPSTLAFIRCGFLigRGNSSQRKRSLMTQRKQKETLDKFRDGELNLLIATSVLEEGID 105
|
90 100
....*....|....*....|....*....
gi 40538825 544 VQGVELVINYDAPQYLRTYVHRVGRtARA 572
Cdd:cd18802 106 VPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
194-354 |
5.68e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 52.67 E-value: 5.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 194 FPVQAAVIPALLESADHGFLIGrggyqpsdlCVSAPTGSGKTL--AFVIpvvqALLHRVVCHIRALVVLPTKELAQQVSK 271
Cdd:pfam04851 5 RPYQIEAIENLLESIKNGQKRG---------LIVMATGSGKTLtaAKLI----ARLFKKGPIKKVLFLVPRKDLLEQALE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 272 VFNIYTDTTPLRVALVTGQKSLAKEQESlvqktadgfrclaDIVVATPGRL-VDHIDQTPGFSLQQLRFLIIDEADRMID 350
Cdd:pfam04851 72 EFKKFLPNYVEIGEIISGDKKDESVDDN-------------KIVVTTIQSLyKALELASLELLPDFFDVIIIDEAHRSGA 138
|
....
gi 40538825 351 SMHQ 354
Cdd:pfam04851 139 SSYR 142
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
528-581 |
7.91e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.01 E-value: 7.91e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 40538825 528 KIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGKT-GQAFTL 581
Cdd:cd18785 22 SLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDeGEVILF 76
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
478-584 |
6.27e-07 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 52.57 E-value: 6.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 478 SRALCFTNSRENSHRLY-LLAQAfgGVSVAEF---SSRYGP-G----QRKKILKQFEQGKIQLLISTDATARGIDVQGVE 548
Cdd:PRK13766 366 SRIIVFTQYRDTAEKIVdLLEKE--GIKAVRFvgqASKDGDkGmsqkEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVD 443
|
90 100 110
....*....|....*....|....*....|....*..
gi 40538825 549 LVINYDA-PQYLRTyVHRVGRTARaGKTGQAFTLLLK 584
Cdd:PRK13766 444 LVIFYEPvPSEIRS-IQRKGRTGR-QEEGRVVVLIAK 478
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
226-347 |
6.59e-07 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 50.51 E-value: 6.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 226 VSAPTGSGKTLAFVIpVVQALLHRVVCHIRALVVL--PTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQK 303
Cdd:cd17927 22 ICLPTGSGKTFVAVL-ICEHHLKKFPAGRKGKVVFlaNKVPLVEQQKEVFRKHFERPGYKVTGLSGDTSENVSVEQIVES 100
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 40538825 304 tadgfrclADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADR 347
Cdd:cd17927 101 --------SDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
226-351 |
8.02e-07 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 50.02 E-value: 8.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 226 VSAPTGSGKT-LAFVIPVVQALLHRvvchiRALVVLPTKELAQQVSKVFNIYTDTTPLRV-ALVTGQKSLAKEQESLVQK 303
Cdd:cd17924 37 IIAPTGVGKTtFGLATSLYLASKGK-----RSYLIFPTKSLVKQAYERLSKYAEKAGVEVkILVYHSRLKKKEKEELLEK 111
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 40538825 304 TADG-FrclaDIVVATPGRLVDHIDQTPGFSLQqlrFLIIDEADRMIDS 351
Cdd:cd17924 112 IEKGdF----DILVTTNQFLSKNFDLLSNKKFD---FVFVDDVDAVLKS 153
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
194-353 |
1.39e-06 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 48.87 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 194 FPVQAAVIPALLESADhgfligrggyqpsDLCVSAPTGSGKTLAFVIpvvqALLHRVVCHIRALVVLPTKELAQQVSKVF 273
Cdd:cd18028 3 YPPQAEAVRAGLLKGE-------------NLLISIPTASGKTLIAEM----AMVNTLLEGGKALYLVPLRALASEKYEEF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 274 NIYTDTTpLRVALVTGqkslakEQESLVQKTADgfrclADIVVATPGRLVDHIDQTPGFsLQQLRFLIIDEAdRMIDSMH 353
Cdd:cd18028 66 KKLEEIG-LKVGISTG------DYDEDDEWLGD-----YDIIVATYEKFDSLLRHSPSW-LRDVGVVVVDEI-HLISDEE 131
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
513-574 |
1.61e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 47.59 E-value: 1.61e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40538825 513 GPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGK 574
Cdd:cd18794 65 EPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGL 126
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
226-345 |
1.86e-06 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 48.80 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 226 VSAPTGSGKTLAFVIpVVQALLHRVVC----HIRALVVLPTKELAQQVSKVFNIYtdtTPLRVALVTGQKSLAKEQESLV 301
Cdd:cd18034 21 VVLPTGSGKTLIAVM-LIKEMGELNRKeknpKKRAVFLVPTVPLVAQQAEAIRSH---TDLKVGEYSGEMGVDKWTKERW 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 40538825 302 QKTADGFrclaDIVVATPGRLVDHIDQtpGF-SLQQLRFLIIDEA 345
Cdd:cd18034 97 KEELEKY----DVLVMTAQILLDALRH--GFlSLSDINLLIFDEC 135
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
479-574 |
4.81e-06 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 46.48 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 479 RALCFTNSRENSHRLYLLAQAfGGVSVAEFSSR-------YGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVI 551
Cdd:cd18797 37 KTIVFCRSRKLAELLLRYLKA-RLVEEGPLASKvasyragYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVV 115
|
90 100
....*....|....*....|...
gi 40538825 552 NYDAPQYLRTYVHRVGRTARAGK 574
Cdd:cd18797 116 LAGYPGSLASLWQQAGRAGRRGK 138
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
225-345 |
7.36e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 46.14 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 225 CVSAPTGSGKTL-AFVIPvvqALLHRVvchiRALVVLPTKELAQQVSKVFNIYTDTTPLrvalvtgqkslaKEQESLVQK 303
Cdd:cd17926 22 ILVLPTGSGKTLtALALI---AYLKEL----RTLIVVPTDALLDQWKERFEDFLGDSSI------------GLIGGGKKK 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 40538825 304 TADGfrclADIVVATPgRLVDHIDQTPGFSLQQLRFLIIDEA 345
Cdd:cd17926 83 DFDD----ANVVVATY-QSLSNLAEEEKDLFDQFGLLIVDEA 119
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
171-344 |
1.01e-05 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 46.98 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 171 IEDIPEvhpdlQKQLRANGITSYFPVQAAVIPALLESADHgfligrggyqpsdLCVSAPTGSGKTLAFVIPVVQAL-LHR 249
Cdd:cd18019 1 IEELPD-----WAQPAFEGFKSLNRIQSKLFPAAFETDEN-------------LLLCAPTGAGKTNVALLTILREIgKHR 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 250 V------VCHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQESLVQktadgfrcladIVVATPGRLv 323
Cdd:cd18019 63 NpdgtinLDAFKIVYIAPMKALVQEMVGNFSKRLAPYGITVAELTGDQQLTKEQISETQ-----------IIVTTPEKW- 130
|
170 180
....*....|....*....|...
gi 40538825 324 DHIDQTPGF-SLQQL-RFLIIDE 344
Cdd:cd18019 131 DIITRKSGDrTYTQLvRLIIIDE 153
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
223-344 |
1.40e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 45.65 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 223 DLCVSAPTGSGKTLAFVIPVVQALLHRVVCHIRALVVLPTKELAQQVSKVFNIYTD--TTPLRVALVTGQKSLAKEQESL 300
Cdd:cd17922 3 NVLIAAPTGSGKTEAAFLPALSSLADEPEKGVQVLYISPLKALINDQERRLEEPLDeiDLEIPVAVRHGDTSQSEKAKQL 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 40538825 301 VQktadgfrcLADIVVATPGRLVDHIDQTPGFS-LQQLRFLIIDE 344
Cdd:cd17922 83 KN--------PPGILITTPESLELLLVNKKLRElFAGLRYVVVDE 119
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
196-344 |
1.77e-05 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 46.20 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 196 VQAAVIPALLESADhgfligrggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRVVC---HIRALVVLPTKELAQQVskv 272
Cdd:cd18023 5 IQSEVFPDLLYSDK-------------NFVVSAPTGSGKTVLFELAILRLLKERNPLpwgNRKVVYIAPIKALCSEK--- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 273 fniYTDTTP------LRVALVTGQKSLAKEQEslVQKtadgfrclADIVVATPGR--LVDHIDQTPGFSLQQLRFLIIDE 344
Cdd:cd18023 69 ---YDDWKEkfgplgLSCAELTGDTEMDDTFE--IQD--------ADIILTTPEKwdSMTRRWRDNGNLVQLVALVLIDE 135
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
177-360 |
2.97e-05 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 45.48 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 177 VHPDLQKQLRANGITSYFPVQAAVIPALLESAdhgfligrggyqPSDLCVSAPTGSGKTLAFVIpvvqALLHRV--VCH- 253
Cdd:cd18047 8 LKPQLLQGVYAMGFNRPSKIQENALPLMLAEP------------PQNLIAQSQSGTGKTAAFVL----AMLSQVepANKy 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 254 IRALVVLPTKELAQQVSKVFNIYTDTTPlRVALVTGQKSLAKEQeslvqktadGFRCLADIVVATPGRLVDHIDQTPGFS 333
Cdd:cd18047 72 PQCLCLSPTYELALQTGKVIEQMGKFYP-ELKLAYAVRGNKLER---------GQKISEQIVIGTPGTVLDWCSKLKFID 141
|
170 180
....*....|....*....|....*...
gi 40538825 334 LQQLRFLIIDEADRMIDSM-HQSWLPRV 360
Cdd:cd18047 142 PKKIKVFVLDEADVMIATQgHQDQSIRI 169
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
468-574 |
3.75e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 44.18 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 468 VLHLVLRMSCSraLCFTNSRENSHRLY-LLAQAFGGVSVAEFS----SRYGPGQRKKILKQFEQGKIQLLISTDATARGI 542
Cdd:cd18796 31 VIFLLERHKST--LVFTNTRSQAERLAqRLRELCPDRVPPDFIalhhGSLSRELREEVEAALKRGDLKVVVATSSLELGI 108
|
90 100 110
....*....|....*....|....*....|..
gi 40538825 543 DVQGVELVINYDAPQYLRTYVHRVGRTARAGK 574
Cdd:cd18796 109 DIGDVDLVIQIGSPKSVARLLQRLGRSGHRPG 140
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
221-304 |
1.14e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 43.17 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 221 PSDLCVSAPTGSGKTLAFVIPVVQALLHrvvcHIRALVVLPTKELAQQVSKVFNIYtdTTPLRVALVT-GQKSLAKEQES 299
Cdd:cd17918 36 PMDRLLSGDVGSGKTLVALGAALLAYKN----GKQVAILVPTEILAHQHYEEARKF--LPFINVELVTgGTKAQILSGIS 109
|
....*
gi 40538825 300 LVQKT 304
Cdd:cd17918 110 LLVGT 114
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
502-571 |
1.38e-04 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 43.06 E-value: 1.38e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40538825 502 GVSVAEFSSRygpgqRKKILKQFEQGKIQLLISTdATARGIDVQGVEL------VINYDAPqyLRTYVHRVGRTAR 571
Cdd:cd18798 51 GIKAELALSS-----TEKNLEKFEEGEIDVLIGV-ASYYGVLVRGIDLperikyAIFYGVP--VTTYIQASGRTSR 118
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
189-345 |
2.55e-04 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 42.52 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 189 GITSYFPVQAAVIPALLEsadhgfliGRggyqpsDLCVSAPTGSGKTLAFVIPvvqALLHRVVChiraLVVLPTKELAQ- 267
Cdd:cd17920 9 GYDEFRPGQLEAINAVLA--------GR------DVLVVMPTGGGKSLCYQLP---ALLLDGVT----LVVSPLISLMQd 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 268 QVSKVfniytDTTPLRVALVTGQKSlAKEQESLVQKTADGfrcLADIVVATPGRLvdhidQTPGF--SLQQLR------F 339
Cdd:cd17920 68 QVDRL-----QQLGIRAAALNSTLS-PEEKREVLLRIKNG---QYKLLYVTPERL-----LSPDFleLLQRLPerkrlaL 133
|
....*.
gi 40538825 340 LIIDEA 345
Cdd:cd17920 134 IVVDEA 139
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
181-289 |
2.62e-04 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 44.04 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 181 LQKQLRANGITSYFPVQAavipallESADHGFLIGRggyqpsDLCVSAPTGSGKTLAFVIPVVQALLHRvvcHIRALVVL 260
Cdd:PRK00254 12 IKRVLKERGIEELYPPQA-------EALKSGVLEGK------NLVLAIPTASGKTLVAEIVMVNKLLRE---GGKAVYLV 75
|
90 100
....*....|....*....|....*....
gi 40538825 261 PTKELAQQVSKVFNIYtDTTPLRVALVTG 289
Cdd:PRK00254 76 PLKALAEEKYREFKDW-EKLGLRVAMTTG 103
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
461-567 |
9.73e-04 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 39.77 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 461 LSSKPLIVLHLV--LRMSCSRALCFTNSRENshrLYLLAQAFG--GVSVAEFSSRYGPGQRKKILKQF--EQGKIQLLIS 534
Cdd:cd18793 9 VSGKLEALLELLeeLREPGEKVLIFSQFTDT---LDILEEALRerGIKYLRLDGSTSSKERQKLVDRFneDPDIRVFLLS 85
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 40538825 535 TDATARGIDVQGVELVINYDA---PQYL-----RtyVHRVG 567
Cdd:cd18793 86 TKAGGVGLNLTAANRVILYDPwwnPAVEeqaidR--AHRIG 124
|
|
| DEXHc_TRCF |
cd17991 |
DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
221-347 |
1.30e-03 |
|
DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350749 [Multi-domain] Cd Length: 193 Bit Score: 40.25 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 221 PSDLCVSAPTGSGKT-LAfvipvVQALLHRVVCHIRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSlAKEQES 299
Cdd:cd17991 36 PMDRLICGDVGFGKTeVA-----MRAAFKAVLSGKQVAVLVPTTLLAQQHYETFKERFANFPVNVELLSRFTT-AAEQRE 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 40538825 300 LVQKTADGfrcLADIVVATpGRLVdhidqTPGFSLQQLRFLIIDEADR 347
Cdd:cd17991 110 ILEGLKEG---KVDIVIGT-HRLL-----SKDVEFKNLGLLIIDEEQR 148
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
171-318 |
1.42e-03 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 41.87 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 171 IEDIPeVHPDLQKQLRANGITSYFPVQAAVIPAllesadhGFLIGRggyqpsDLCVSAPTGSGKTLafvipVVQ-ALLHR 249
Cdd:PRK02362 3 IAELP-LPEGVIEFYEAEGIEELYPPQAEAVEA-------GLLDGK------NLLAAIPTASGKTL-----IAElAMLKA 63
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40538825 250 VVCHIRALVVLPTKELAQQVSKVFNIYTDTTpLRVALVTGqkSLAKEQESLVQKtadgfrclaDIVVAT 318
Cdd:PRK02362 64 IARGGKALYIVPLRALASEKFEEFERFEELG-VRVGISTG--DYDSRDEWLGDN---------DIIVAT 120
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
224-347 |
1.92e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 41.40 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 224 LCVsAPTGSGKTlAFVIPVVQALLHRVVChiRALVVLPTKELAQQVSKVFNIYTDTTPLRVALVTGQKSLAKEQEsLVQK 303
Cdd:PRK13766 33 LVV-LPTGLGKT-AIALLVIAERLHKKGG--KVLILAPTKPLVEQHAEFFRKFLNIPEEKIVVFTGEVSPEKRAE-LWEK 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 40538825 304 tadgfrclADIVVATP---------GRLvdhidqtpgfSLQQLRFLIIDEADR 347
Cdd:PRK13766 108 --------AKVIVATPqviendliaGRI----------SLEDVSLLIFDEAHR 142
|
|
| SF2_C_priA |
cd18804 |
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication ... |
496-579 |
2.03e-03 |
|
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350191 [Multi-domain] Cd Length: 238 Bit Score: 40.31 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 496 LAQAFGGVSVAEFSSR--YGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELV--INYDAPQYL-------RTY-- 562
Cdd:cd18804 110 LKTLFPEARIARIDRDttRKKGALEKLLDQFERGEIDILIGTQMIAKGLDFPNVTLVgiLNADSGLNSpdfraseRAFql 189
|
90
....*....|....*...
gi 40538825 563 VHRV-GRTARAGKTGQAF 579
Cdd:cd18804 190 LTQVsGRAGRGDKPGKVI 207
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
502-581 |
5.15e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 40.08 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 502 GVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTYVHRVGRTARAGKTGQAFTL 581
Cdd:PRK11057 260 GISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLF 339
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
484-617 |
6.09e-03 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 39.35 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 484 TNSRENSHRLY-LLAQAfgGVSVAEFSSRYGPGQRKKILKQFEQGKIQLLISTDATARGIDVQGVELVINYDAPQYLRTY 562
Cdd:COG0514 237 CLSRKKVEELAeWLREA--GIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAY 314
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 40538825 563 VHRVGRTARAGKtgQAFTLLL-----KVQERKFLqmvsEAGVPELTHHEIPRKLLQPLVA 617
Cdd:COG0514 315 YQEIGRAGRDGL--PAEALLLygpedVAIQRFFI----EQSPPDEERKRVERAKLDAMLA 368
|
|
| |
