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Conserved domains on  [gi|171906601|ref|NP_081763|]
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WASH complex subunit 3 isoform 3 [Mus musculus]

Protein Classification

WASH complex subunit 3( domain architecture ID 12103671)

WASH complex subunit 3 (WASHC3) acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting

Gene Symbol:  WASHC3
Gene Ontology:  GO:0006887|GO:0030041|GO:0071203
PubMed:  19922875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC53 pfam10152
Subunit CCDC53 of WASH complex; CCDC53 is a component of the WASH complex, which plays a key ...
 30-145 2.65e-54

Subunit CCDC53 of WASH complex; CCDC53 is a component of the WASH complex, which plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.


:

Pssm-ID: 462967  Cd Length: 146  Bit Score: 169.01  E-value: 2.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171906601   30 LNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVEVSPlnVTAVTNGSHSETTS-EQTQ 108
Cdd:pfam10152   1 LNHFIVHTVQFLNRFSAVCEEKLVEVELRLQRLEATLAILEAKLSSIPGLEEVTAETAE--TNAASNPPPPPPPSaEAAA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 171906601  109 QNSTQDSGAQES---------EAPSENVLTVAKDPRYARYLKMVQV 145
Cdd:pfam10152  79 AAPPAPPPSTAPesappeppaEEESENVITVADDPRYAKYFKMLQV 124
 
Name Accession Description Interval E-value
CCDC53 pfam10152
Subunit CCDC53 of WASH complex; CCDC53 is a component of the WASH complex, which plays a key ...
 30-145 2.65e-54

Subunit CCDC53 of WASH complex; CCDC53 is a component of the WASH complex, which plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.


Pssm-ID: 462967  Cd Length: 146  Bit Score: 169.01  E-value: 2.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171906601   30 LNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVEVSPlnVTAVTNGSHSETTS-EQTQ 108
Cdd:pfam10152   1 LNHFIVHTVQFLNRFSAVCEEKLVEVELRLQRLEATLAILEAKLSSIPGLEEVTAETAE--TNAASNPPPPPPPSaEAAA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 171906601  109 QNSTQDSGAQES---------EAPSENVLTVAKDPRYARYLKMVQV 145
Cdd:pfam10152  79 AAPPAPPPSTAPesappeppaEEESENVITVADDPRYAKYFKMLQV 124
 
Name Accession Description Interval E-value
CCDC53 pfam10152
Subunit CCDC53 of WASH complex; CCDC53 is a component of the WASH complex, which plays a key ...
 30-145 2.65e-54

Subunit CCDC53 of WASH complex; CCDC53 is a component of the WASH complex, which plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.


Pssm-ID: 462967  Cd Length: 146  Bit Score: 169.01  E-value: 2.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171906601   30 LNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVEVSPlnVTAVTNGSHSETTS-EQTQ 108
Cdd:pfam10152   1 LNHFIVHTVQFLNRFSAVCEEKLVEVELRLQRLEATLAILEAKLSSIPGLEEVTAETAE--TNAASNPPPPPPPSaEAAA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 171906601  109 QNSTQDSGAQES---------EAPSENVLTVAKDPRYARYLKMVQV 145
Cdd:pfam10152  79 AAPPAPPPSTAPesappeppaEEESENVITVADDPRYAKYFKMLQV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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