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Conserved domains on  [gi|70608157|ref|NP_081809|]
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tetraspanin-2 isoform 1 [Mus musculus]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509|32974937
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
11-212 1.88e-30

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 110.87  E-value: 1.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157    11 IKYLLLGFNLLFWLAGSAVIAFGLWFRfggtMKDLSSEDKSPEYFYVGLYVLVGAGALMMTVGFFGCCGAMRESQCVLGS 90
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLL----SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157    91 FFTCLLVIFAAEVTTGVFAFIGKDVAIRHVQSMY----EEAYSDYLKDRARGNGTLITFHSAFQCCGkesseqvqptcpk 166
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLkkslEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 70608157   167 elpghkNCIDKIETVISAKLQLIGIVGIGIAGLTIFGMIFSMVLCC 212
Cdd:pfam00335 144 ------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
11-212 1.88e-30

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 110.87  E-value: 1.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157    11 IKYLLLGFNLLFWLAGSAVIAFGLWFRfggtMKDLSSEDKSPEYFYVGLYVLVGAGALMMTVGFFGCCGAMRESQCVLGS 90
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLL----SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157    91 FFTCLLVIFAAEVTTGVFAFIGKDVAIRHVQSMY----EEAYSDYLKDRARGNGTLITFHSAFQCCGkesseqvqptcpk 166
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLkkslEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 70608157   167 elpghkNCIDKIETVISAKLQLIGIVGIGIAGLTIFGMIFSMVLCC 212
Cdd:pfam00335 144 ------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 110-186 1.43e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 100.19  E-value: 1.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157 110 FIGKDVAIRHVQSMYEEAYSDYLKD-RARGNGTLITFHSAFQCCGKESSEQ-----VQPTCPKELP-GHKNCIDKIETVI 182
Cdd:cd03151   1 FINKDQIIKEVQNFYDSAYQDAVTDtRSKGTAVLKTFHSTLDCCGKGNLTAllsllSTDLCPKKLLlDTKDCHQEIDDLF 80


                ....
gi 70608157 183 SAKL 186
Cdd:cd03151  81 SEKL 84
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
11-212 1.88e-30

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 110.87  E-value: 1.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157    11 IKYLLLGFNLLFWLAGSAVIAFGLWFRfggtMKDLSSEDKSPEYFYVGLYVLVGAGALMMTVGFFGCCGAMRESQCVLGS 90
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLL----SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157    91 FFTCLLVIFAAEVTTGVFAFIGKDVAIRHVQSMY----EEAYSDYLKDRARGNGTLITFHSAFQCCGkesseqvqptcpk 166
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLkkslEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 70608157   167 elpghkNCIDKIETVISAKLQLIGIVGIGIAGLTIFGMIFSMVLCC 212
Cdd:pfam00335 144 ------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 110-186 1.43e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 100.19  E-value: 1.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157 110 FIGKDVAIRHVQSMYEEAYSDYLKD-RARGNGTLITFHSAFQCCGKESSEQ-----VQPTCPKELP-GHKNCIDKIETVI 182
Cdd:cd03151   1 FINKDQIIKEVQNFYDSAYQDAVTDtRSKGTAVLKTFHSTLDCCGKGNLTAllsllSTDLCPKKLLlDTKDCHQEIDDLF 80


                ....
gi 70608157 183 SAKL 186
Cdd:cd03151  81 SEKL 84
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 110-186 8.16e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 45.46  E-value: 8.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608157 110 FIGKDVAIRHVQSMYEEAYSDYLKDR-ARGNGTLITFHSAFQCCGKES--SEQVQPTCPK-ELPGH---KNCIDKIETVI 182
Cdd:cd03152   1 FSNKDKVVKEVQTFYRQTYAKYKQSRdPPLKETLKAIHFALDCCGPTGglEQFVTDTCPKkEGLENlitKSCPDAIDDVF 80


                ....
gi 70608157 183 SAKL 186
Cdd:cd03152  81 NSKL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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