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Conserved domains on  [gi|166851848|ref|NP_082167|]
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leucine-rich repeat and WD repeat-containing protein 1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein; WD40 repeat domain-containing protein( domain architecture ID 1904871)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions| WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-123 9.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 9.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  19 KLGKIQSLNLSGLQLlsEHLdPNLLGRLKKLRELDLSNNLLETLPANLG-LSHLRILRCTNNQLGDVTA-LHQFPELEEL 96
Cdd:COG4886  111 NLTNLESLDLSGNQL--TDL-PEELANLTNLKELDLSNNQLTDLPEPLGnLTNLKSLDLSNNQLTDLPEeLGNLTNLKEL 187

                         90       100
                 ....*....|....*....|....*..
gi 166851848  97 NLEGNPFLTVSDNLKVsflLPKLRKVN 123
Cdd:COG4886  188 DLSNNQITDLPEPLGN---LTNLEELD 211
WD40 COG2319
WD40 repeat [General function prediction only];
189-585 1.08e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 189 QWRVRMIAEELVASGGAQVQDAKVPVEHPQAAGASKFRAREVASKRPGKDPVTLPPSKRVRALPPAQ-AEGSPMGADGGQ 267
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPdGRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 268 AAL----HLEPLHFLQCHSRnnspkdletQLWACAFEPareeghsraTSQTVATCGG-EAVCVIDCQTGLVLHKYKVPGE 342
Cdd:COG2319  102 VRLwdlaTGLLLRTLTGHTG---------AVRSVAFSP---------DGKTLASGSAdGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 343 EFFSVAWTAltvvtqAGHkkrwnMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHEThLFTASYDKRIILW 422
Cdd:COG2319  164 AVTSVAFSP------DGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLW 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 423 DIGvpnqdykfQASQLLTLNCGSVPLRlcPVATCPDDFLLA--GCEGGCYCWDV---RLDQPQKQRVCEVNFI-FSEDSK 496
Cdd:COG2319  232 DLA--------TGKLLRTLTGHSGSVR--SVAFSPDGRLLAsgSADGTVRLWDLatgELLRTLTGHSGGVNSVaFSPDGK 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 497 vsgqrvdglafvnedVVASkGSGQGTIYLWSWSQTWagrgrqsvlPVVILVRLQWSPTNLAyFSlstcPGKNLVLCGDEE 576
Cdd:COG2319  302 ---------------LLAS-GSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVA-FS----PDGKTLASGSDD 351


                 ....*....
gi 166851848 577 GSVWIYDVE 585
Cdd:COG2319  352 GTVRLWDLA 360
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-123 9.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 9.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  19 KLGKIQSLNLSGLQLlsEHLdPNLLGRLKKLRELDLSNNLLETLPANLG-LSHLRILRCTNNQLGDVTA-LHQFPELEEL 96
Cdd:COG4886  111 NLTNLESLDLSGNQL--TDL-PEELANLTNLKELDLSNNQLTDLPEPLGnLTNLKSLDLSNNQLTDLPEeLGNLTNLKEL 187

                         90       100
                 ....*....|....*....|....*..
gi 166851848  97 NLEGNPFLTVSDNLKVsflLPKLRKVN 123
Cdd:COG4886  188 DLSNNQITDLPEPLGN---LTNLEELD 211
WD40 COG2319
WD40 repeat [General function prediction only];
189-585 1.08e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 189 QWRVRMIAEELVASGGAQVQDAKVPVEHPQAAGASKFRAREVASKRPGKDPVTLPPSKRVRALPPAQ-AEGSPMGADGGQ 267
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPdGRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 268 AAL----HLEPLHFLQCHSRnnspkdletQLWACAFEPareeghsraTSQTVATCGG-EAVCVIDCQTGLVLHKYKVPGE 342
Cdd:COG2319  102 VRLwdlaTGLLLRTLTGHTG---------AVRSVAFSP---------DGKTLASGSAdGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 343 EFFSVAWTAltvvtqAGHkkrwnMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHEThLFTASYDKRIILW 422
Cdd:COG2319  164 AVTSVAFSP------DGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLW 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 423 DIGvpnqdykfQASQLLTLNCGSVPLRlcPVATCPDDFLLA--GCEGGCYCWDV---RLDQPQKQRVCEVNFI-FSEDSK 496
Cdd:COG2319  232 DLA--------TGKLLRTLTGHSGSVR--SVAFSPDGRLLAsgSADGTVRLWDLatgELLRTLTGHSGGVNSVaFSPDGK 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 497 vsgqrvdglafvnedVVASkGSGQGTIYLWSWSQTWagrgrqsvlPVVILVRLQWSPTNLAyFSlstcPGKNLVLCGDEE 576
Cdd:COG2319  302 ---------------LLAS-GSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVA-FS----PDGKTLASGSDD 351


                 ....*....
gi 166851848 577 GSVWIYDVE 585
Cdd:COG2319  352 GTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 295-585 1.45e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 295 WACAFEPareeghsraTSQTVATCGGEAVC-VIDCQTGLVLHKYKVPGEEFFSVAWTALTvvtqaghkkrwNMLAAAGLR 373
Cdd:cd00200   13 TCVAFSP---------DGKLLATGSGDGTIkVWDLETGELLRTLKGHTGPVRDVAASADG-----------TYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 374 GMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHEThLFTASYDKRIILWDIgvpnQDYKFQAsqllTLNC--GSVplrLC 451
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDV----ETGKCLT----TLRGhtDWV---NS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 452 pVATCPDDFLLAGCEGGCYC--WDVRLDQPQKQRV---CEVNFI-FSEDskvsgqrvdglafvNEDVVASkgSGQGTIYL 525
Cdd:cd00200  141 -VAFSPDGTFVASSSQDGTIklWDLRTGKCVATLTghtGEVNSVaFSPD--------------GEKLLSS--SSDGTIKL 203

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 526 WSwsqtwagrgrqsvLPVVILVRLQWSPTNLAYfSLSTCPGKNLVLCGDEEGSVWIYDVE 585
Cdd:cd00200  204 WD-------------LSTGKCLGTLRGHENGVN-SVAFSPDGYLLASGSEDGTIRVWDLR 249
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-140 9.04e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 9.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  27 NLSGLQLLSE-HL-------------DPNLLGRLKK-LRELDLSNNLLETLpANL-GLSHLRILRCTNNQLGDVTA---- 86
Cdd:cd21340   85 GLENLTNLEElHIenqrlppgekltfDPRSLAALSNsLRVLNISGNNIDSL-EPLaPLRNLEQLDASNNQISDLEElldl 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 166851848  87 LHQFPELEELNLEGNPFLTVS---DNLKVSflLPKLRKVNGKD-TASTCSQVENLDRE 140
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKKPkyrDKIILA--SKSLEVLDGKEiTDTERQFLKRLKAR 219
LRR_8 pfam13855
Leucine rich repeat;
22-81 1.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166851848   22 KIQSLNLSGLQLLseHLDPNLLGRLKKLRELDLSNNLLETLPANL--GLSHLRILRCTNNQL 81
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 386-423 3.52e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 166851848   386 CCSVIRAHKKAIATLCFSPSHeTHLFTASYDKRIILWD 423
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
384-423 1.56e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 166851848  384 GFCCSVIRAHKKAIATLCFSPSHeTHLFTASYDKRIILWD 423
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
LRR smart00370
Leucine-rich repeats, outliers;
46-66 1.81e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.81e-03
                           10        20
                   ....*....|....*....|.
gi 166851848    46 LKKLRELDLSNNLLETLPANL 66
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
PLN03150 PLN03150
hypothetical protein; Provisional
 19-86 3.04e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166851848  19 KLGKIQSLNLSGLQLLSEhlDPNLLGRLKKLRELDLSNNLLE-TLPANLG-LSHLRILRCTNNQL-GDVTA 86
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGN--IPPSLGSITSLEVLDLSYNSFNgSIPESLGqLTSLRILNLNGNSLsGRVPA 508
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-123 9.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 9.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  19 KLGKIQSLNLSGLQLlsEHLdPNLLGRLKKLRELDLSNNLLETLPANLG-LSHLRILRCTNNQLGDVTA-LHQFPELEEL 96
Cdd:COG4886  111 NLTNLESLDLSGNQL--TDL-PEELANLTNLKELDLSNNQLTDLPEPLGnLTNLKSLDLSNNQLTDLPEeLGNLTNLKEL 187

                         90       100
                 ....*....|....*....|....*..
gi 166851848  97 NLEGNPFLTVSDNLKVsflLPKLRKVN 123
Cdd:COG4886  188 DLSNNQITDLPEPLGN---LTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-141 6.34e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 6.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  19 KLGKIQSLNLSGLQLlsEHLdPNLLGRLKKLRELDLSNNLLETLPANLG------------------------LSHLRIL 74
Cdd:COG4886  157 NLTNLKSLDLSNNQL--TDL-PEELGNLTNLKELDLSNNQITDLPEPLGnltnleeldlsgnqltdlpeplanLTNLETL 233

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 166851848  75 RCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKvsflLPKLRKVNGKDTASTCSQVENLDREL 141
Cdd:COG4886  234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN----LTNLKTLDLSNNQLTDLKLKELELLL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-163 7.19e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 7.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  19 KLGKIQSLNLSGLQLlsEHLdPNLLGRLKKLRELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTALHQFPELEELNL 98
Cdd:COG4886  203 NLTNLEELDLSGNQL--TDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDL 279

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 166851848  99 EGNPFltvsDNLKVSFLLPKLRKVNGKDTASTCSQVENLDRELMDRVTAHWQKFIATVSPEEETD 163
Cdd:COG4886  280 SNNQL----TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-123 8.59e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 8.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  19 KLGKIQSLNLSGLQLLSEhldpnllgrLKKLRELDLSNNLLETLPANLG-LSHLRILRCTNNQLGDV-TALHQFPELEEL 96
Cdd:COG4886   94 DLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELAnLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                         90       100
                 ....*....|....*....|....*..
gi 166851848  97 NLEGNPFLTVSDNLKvsfLLPKLRKVN 123
Cdd:COG4886  165 DLSNNQLTDLPEELG---NLTNLKELD 188
WD40 COG2319
WD40 repeat [General function prediction only];
189-585 1.08e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 189 QWRVRMIAEELVASGGAQVQDAKVPVEHPQAAGASKFRAREVASKRPGKDPVTLPPSKRVRALPPAQ-AEGSPMGADGGQ 267
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPdGRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 268 AAL----HLEPLHFLQCHSRnnspkdletQLWACAFEPareeghsraTSQTVATCGG-EAVCVIDCQTGLVLHKYKVPGE 342
Cdd:COG2319  102 VRLwdlaTGLLLRTLTGHTG---------AVRSVAFSP---------DGKTLASGSAdGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 343 EFFSVAWTAltvvtqAGHkkrwnMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHEThLFTASYDKRIILW 422
Cdd:COG2319  164 AVTSVAFSP------DGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLW 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 423 DIGvpnqdykfQASQLLTLNCGSVPLRlcPVATCPDDFLLA--GCEGGCYCWDV---RLDQPQKQRVCEVNFI-FSEDSK 496
Cdd:COG2319  232 DLA--------TGKLLRTLTGHSGSVR--SVAFSPDGRLLAsgSADGTVRLWDLatgELLRTLTGHSGGVNSVaFSPDGK 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 497 vsgqrvdglafvnedVVASkGSGQGTIYLWSWSQTWagrgrqsvlPVVILVRLQWSPTNLAyFSlstcPGKNLVLCGDEE 576
Cdd:COG2319  302 ---------------LLAS-GSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVA-FS----PDGKTLASGSDD 351


                 ....*....
gi 166851848 577 GSVWIYDVE 585
Cdd:COG2319  352 GTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 295-585 1.45e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 295 WACAFEPareeghsraTSQTVATCGGEAVC-VIDCQTGLVLHKYKVPGEEFFSVAWTALTvvtqaghkkrwNMLAAAGLR 373
Cdd:cd00200   13 TCVAFSP---------DGKLLATGSGDGTIkVWDLETGELLRTLKGHTGPVRDVAASADG-----------TYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 374 GMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHEThLFTASYDKRIILWDIgvpnQDYKFQAsqllTLNC--GSVplrLC 451
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDV----ETGKCLT----TLRGhtDWV---NS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 452 pVATCPDDFLLAGCEGGCYC--WDVRLDQPQKQRV---CEVNFI-FSEDskvsgqrvdglafvNEDVVASkgSGQGTIYL 525
Cdd:cd00200  141 -VAFSPDGTFVASSSQDGTIklWDLRTGKCVATLTghtGEVNSVaFSPD--------------GEKLLSS--SSDGTIKL 203

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 526 WSwsqtwagrgrqsvLPVVILVRLQWSPTNLAYfSLSTCPGKNLVLCGDEEGSVWIYDVE 585
Cdd:cd00200  204 WD-------------LSTGKCLGTLRGHENGVN-SVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 303-583 3.83e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 303 REEGHSR--------ATSQTVATCGGEAVCVI-DCQTGLVLHKYKVPGEEFFSVAWTaltvvtQAGHkkrwnMLAAAGLR 373
Cdd:cd00200   46 TLKGHTGpvrdvaasADGTYLASGSSDKTIRLwDLETGECVRTLTGHTSYVSSVAFS------PDGR-----ILSSSSRD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 374 GMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHeTHLFTASYDKRIILWDIGvpnqdyKFQASQLLTLNCGSVplrLCpV 453
Cdd:cd00200  115 KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLR------TGKCVATLTGHTGEV---NS-V 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 454 ATCPD--DFLLAGCEGGCYCWDVRLDQPQKQRVCEVNFIFSedskvsgqrvdgLAF-VNEDVVASkGSGQGTIYLWSWsq 530
Cdd:cd00200  184 AFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS------------VAFsPDGYLLAS-GSEDGTIRVWDL-- 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 166851848 531 tWAGRGRQSVlpvvilvrlqWSPTNLAYfSLSTCPGKNLVLCGDEEGSVWIYD 583
Cdd:cd00200  249 -RTGECVQTL----------SGHTNSVT-SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
312-424 6.27e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 6.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 312 SQTVATCGGE-AVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTvvtqaghkkrwNMLAAAGLRGMVRLLHVRAGFCCSVI 390
Cdd:COG2319  300 GKLLASGSDDgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-----------KTLASGSDDGTVRLWDLATGELLRTL 368

                         90       100       110
                 ....*....|....*....|....*....|....
gi 166851848 391 RAHKKAIATLCFSPSHEThLFTASYDKRIILWDI 424
Cdd:COG2319  369 TGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDL 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-140 9.04e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 9.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848  27 NLSGLQLLSE-HL-------------DPNLLGRLKK-LRELDLSNNLLETLpANL-GLSHLRILRCTNNQLGDVTA---- 86
Cdd:cd21340   85 GLENLTNLEElHIenqrlppgekltfDPRSLAALSNsLRVLNISGNNIDSL-EPLaPLRNLEQLDASNNQISDLEElldl 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 166851848  87 LHQFPELEELNLEGNPFLTVS---DNLKVSflLPKLRKVNGKD-TASTCSQVENLDRE 140
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKKPkyrDKIILA--SKSLEVLDGKEiTDTERQFLKRLKAR 219
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 386-585 1.42e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 386 CCSVIRAHKKAIATLCFSPSHEtHLFTASYDKRIILWDigvpnqdykFQASQLLTLNCG-SVPLRLCpvATCPDDFLLA- 463
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWD---------LETGELLRTLKGhTGPVRDV--AASADGTYLAs 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848 464 -GCEGGCYCWDVRLDQpqkqrvcEVNFIFSEDSKVSgqrvdGLAFVNEDVVASKGSGQGTIYLWSWSQtwagrGRQsvlp 542
Cdd:cd00200   69 gSSDKTIRLWDLETGE-------CVRTLTGHTSYVS-----SVAFSPDGRILSSSSRDKTIKVWDVET-----GKC---- 127

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 166851848 543 vVILVRLQWSPTNlayfSLSTCPGKNLVLCGDEEGSVWIYDVE 585
Cdd:cd00200  128 -LTTLRGHTDWVN----SVAFSPDGTFVASSSQDGTIKLWDLR 165
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-123 1.20e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851848   4 LTpQLLLQRgrpktDKLGKIQslNLSGLQLLSE-HLDPNL------LGRLKKLRELDLSNNLL---ETL---PANL-GLS 69
Cdd:cd21340   48 LT-HLYLQN-----NQIEKIE--NLENLVNLKKlYLGGNRisvvegLENLTNLEELHIENQRLppgEKLtfdPRSLaALS 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 166851848  70 H-LRILRCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKVSFLLPKLRKVN 123
Cdd:cd21340  120 NsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELD 174
LRR_8 pfam13855
Leucine rich repeat;
22-81 1.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166851848   22 KIQSLNLSGLQLLseHLDPNLLGRLKKLRELDLSNNLLETLPANL--GLSHLRILRCTNNQL 81
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 386-423 3.52e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 166851848   386 CCSVIRAHKKAIATLCFSPSHeTHLFTASYDKRIILWD 423
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 47-87 3.55e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.16  E-value: 3.55e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 166851848   47 KKLRELDLSNNLLETLPANLGLSHLRILRCT-NNQLGDVTAL 87
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDL 42
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 70-105 8.33e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.00  E-value: 8.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 166851848   70 HLRILRCTNNQLGDVTALHQFPELEELNLEGNPFLT 105
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKIT 37
WD40 pfam00400
WD domain, G-beta repeat;
384-423 1.56e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 166851848  384 GFCCSVIRAHKKAIATLCFSPSHeTHLFTASYDKRIILWD 423
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
LRR smart00370
Leucine-rich repeats, outliers;
46-66 1.81e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.81e-03
                           10        20
                   ....*....|....*....|.
gi 166851848    46 LKKLRELDLSNNLLETLPANL 66
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
46-66 1.81e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.81e-03
                           10        20
                   ....*....|....*....|.
gi 166851848    46 LKKLRELDLSNNLLETLPANL 66
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGA 21
PLN03150 PLN03150
hypothetical protein; Provisional
 19-86 3.04e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166851848  19 KLGKIQSLNLSGLQLLSEhlDPNLLGRLKKLRELDLSNNLLE-TLPANLG-LSHLRILRCTNNQL-GDVTA 86
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGN--IPPSLGSITSLEVLDLSYNSFNgSIPESLGqLTSLRILNLNGNSLsGRVPA 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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