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Conserved domains on  [gi|21312470|ref|NP_082359|]
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chromatin assembly factor 1 subunit B isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 388-555 2.74e-77

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


:

Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 241.63  E-value: 2.74e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   388 GIPLKEKPVLSIRTPDTA-KKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP 466
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   467 LPQPSEE-KTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSG-TAPSTEEVQPEAPGEPPEE 544
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVvSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 21312470   545 PPELKRPRLEE 555
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 COG2319
WD40 repeat [General function prediction only];
13-375 3.81e-38

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 3.81e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  13 KEPVYSLDFQHGATWkihrLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:COG2319 120 TGAVRSVAFSPDGKT----LASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  93 WKMNDSKEpeqiafqdeeeaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS 172
Cdd:COG2319 189 WDLATGKL---------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 173 YVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVAFNIskmlsgQGPEGEARSfrmfhddsmksffrrLSFTPDGSLLLTp 252
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL------TGHSGGVNS---------------VAFSPDGKLLAS- 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 253 agcmeSGENvtNTTYVFSRKhLKRPIAHLPCPGKATLAVRccpvyfeLRPVAETekaseepspelvnlpyrmvFAVASED 332
Cdd:COG2319 306 -----GSDD--GTVRLWDLA-TGKLLRTLTGHTGAVRSVA-------FSPDGKT-------------------LASGSDD 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 21312470 333 -SVLLYDTQQSFPFGYVSNiHYHTLSDISWSSDGAFLAISSTDG 375
Cdd:COG2319 352 gTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADG 394
 
Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 388-555 2.74e-77

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 241.63  E-value: 2.74e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   388 GIPLKEKPVLSIRTPDTA-KKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP 466
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   467 LPQPSEE-KTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSG-TAPSTEEVQPEAPGEPPEE 544
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVvSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 21312470   545 PPELKRPRLEE 555
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 COG2319
WD40 repeat [General function prediction only];
13-375 3.81e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 3.81e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  13 KEPVYSLDFQHGATWkihrLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:COG2319 120 TGAVRSVAFSPDGKT----LASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  93 WKMNDSKEpeqiafqdeeeaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS 172
Cdd:COG2319 189 WDLATGKL---------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 173 YVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVAFNIskmlsgQGPEGEARSfrmfhddsmksffrrLSFTPDGSLLLTp 252
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL------TGHSGGVNS---------------VAFSPDGKLLAS- 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 253 agcmeSGENvtNTTYVFSRKhLKRPIAHLPCPGKATLAVRccpvyfeLRPVAETekaseepspelvnlpyrmvFAVASED 332
Cdd:COG2319 306 -----GSDD--GTVRLWDLA-TGKLLRTLTGHTGAVRSVA-------FSPDGKT-------------------LASGSDD 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 21312470 333 -SVLLYDTQQSFPFGYVSNiHYHTLSDISWSSDGAFLAISSTDG 375
Cdd:COG2319 352 gTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADG 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-251 4.83e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 4.83e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  13 KEPVYSLDFQHGATWkihrLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:cd00200  93 TSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  93 WkmndskepeqiafqdeeeaqlNKENWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS 172
Cdd:cd00200 162 W---------------------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312470 173 YVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRvafnISKMLSGqgpegearsfrmfHDDSMKSffrrLSFTPDGSLLLT 251
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSG-------------HTNSVTS----LAWSPDGKRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-157 7.57e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 7.57e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312470    118 NWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 2.05e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.05e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312470   119 WTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 31-202 6.88e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 6.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   31 RLASAGVDTAVRIWKLERGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE-ILASGGDDAVILLWKMNDSKepeqiafqde 109
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGK---------- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  110 eeaqlnkenwtVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS-YVQGVTWDPLGQYIAT 188
Cdd:PTZ00421 160 -----------AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaKSQRCLWAKRKDLIIT 228

                        170
                 ....*....|....*...
gi 21312470  189 LSCD----RVLRIYNTQK 202
Cdd:PTZ00421 229 LGCSksqqRQIMLWDTRK 246
PHA03247 PHA03247
large tegument protein UL36; Provisional
 389-529 5.13e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   389 IPLKEKPVLSIRTPDTAKKAKNQTHQGSSPGSRSVEGT-----PSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAiPAG 463
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STE 2896

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21312470   464 KSPLPQPSEEKTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPnSGTAPS 529
Cdd:PHA03247 2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP-SGAVPQ 2961
 
Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 388-555 2.74e-77

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 241.63  E-value: 2.74e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   388 GIPLKEKPVLSIRTPDTA-KKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP 466
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   467 LPQPSEE-KTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSG-TAPSTEEVQPEAPGEPPEE 544
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVvSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 21312470   545 PPELKRPRLEE 555
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 COG2319
WD40 repeat [General function prediction only];
13-375 3.81e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 3.81e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  13 KEPVYSLDFQHGATWkihrLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:COG2319 120 TGAVRSVAFSPDGKT----LASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  93 WKMNDSKEpeqiafqdeeeaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS 172
Cdd:COG2319 189 WDLATGKL---------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 173 YVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVAFNIskmlsgQGPEGEARSfrmfhddsmksffrrLSFTPDGSLLLTp 252
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL------TGHSGGVNS---------------VAFSPDGKLLAS- 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 253 agcmeSGENvtNTTYVFSRKhLKRPIAHLPCPGKATLAVRccpvyfeLRPVAETekaseepspelvnlpyrmvFAVASED 332
Cdd:COG2319 306 -----GSDD--GTVRLWDLA-TGKLLRTLTGHTGAVRSVA-------FSPDGKT-------------------LASGSDD 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 21312470 333 -SVLLYDTQQSFPFGYVSNiHYHTLSDISWSSDGAFLAISSTDG 375
Cdd:COG2319 352 gTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
30-375 9.78e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 9.78e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  30 HRLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWkmndskepeqiafqde 109
Cdd:COG2319  91 RLLASASADGTVRLWDLATG-------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW---------------- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 110 eeaqlNKENWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYIATL 189
Cdd:COG2319 148 -----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 190 SCDRVLRIYNTQKKRVAFNIskmlsgQGPEGEARSfrmfhddsmksffrrLSFTPDGSLLLTpagcmeSGENvtNTTYVF 269
Cdd:COG2319 223 SADGTVRLWDLATGKLLRTL------TGHSGSVRS---------------VAFSPDGRLLAS------GSAD--GTVRLW 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 270 SRKHlKRPIAHLPCPGKATLAVRCcpvyfelrpvaetekaseepSPElvnlpyRMVFAVASED-SVLLYDTQQSFPFGYV 348
Cdd:COG2319 274 DLAT-GELLRTLTGHSGGVNSVAF--------------------SPD------GKLLASGSDDgTVRLWDLATGKLLRTL 326

                       330       340
                ....*....|....*....|....*..
gi 21312470 349 SNiHYHTLSDISWSSDGAFLAISSTDG 375
Cdd:COG2319 327 TG-HTGAVRSVAFSPDGKTLASGSDDG 352
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-251 4.83e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 4.83e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  13 KEPVYSLDFQHGATWkihrLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILL 92
Cdd:cd00200  93 TSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  93 WkmndskepeqiafqdeeeaqlNKENWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS 172
Cdd:cd00200 162 W---------------------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312470 173 YVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRvafnISKMLSGqgpegearsfrmfHDDSMKSffrrLSFTPDGSLLLT 251
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE----CVQTLSG-------------HTNSVTS----LAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
11-201 6.79e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 6.79e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  11 HNKEPVYSLDFQHGATWkihrLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
Cdd:COG2319 244 GHSGSVRSVAFSPDGRL----LASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  91 LLWKMNDSKEpeqiafqdeeeaqlnkenwtvVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEH 170
Cdd:COG2319 313 RLWDLATGKL---------------------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                       170       180       190
                ....*....|....*....|....*....|.
gi 21312470 171 KSYVQGVTWDPLGQYIATLSCDRVLRIYNTQ 201
Cdd:COG2319 372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-375 7.08e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 7.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  11 HNKePVYSLDF-QHGatwkiHRLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAV 89
Cdd:cd00200   8 HTG-GVTCVAFsPDG-----KLLATGSGDGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  90 ILLWKMNDSKepeqiafqdeeeaqlnkenwtVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNE 169
Cdd:cd00200  75 IRLWDLETGE---------------------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 170 HKSYVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVafniSKMLSGqgpegearsfrmfHDDSMKSffrrLSFTPDGSLL 249
Cdd:cd00200 134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC----VATLTG-------------HTGEVNS----VAFSPDGEKL 192

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 250 LTPAGcmesgenvTNTTYVF---SRKHLKRPIAHlpcpgkaTLAVRCCPVyfelrpvaetekaseepspelvnLPYRMVF 326
Cdd:cd00200 193 LSSSS--------DGTIKLWdlsTGKCLGTLRGH-------ENGVNSVAF-----------------------SPDGYLL 234

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 21312470 327 AVASEDSVL-LYDTQQsfpfGYVSNI---HYHTLSDISWSSDGAFLAISSTDG 375
Cdd:cd00200 235 ASGSEDGTIrVWDLRT----GECVQTlsgHTNSVTSLAWSPDGKRLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-375 6.18e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 6.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 122 VKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYIATLSCDRVLRIYNTQ 201
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 202 KKRVafniskmlsgqgpegeARSFRMfHDDSMKSffrrLSFTPDGSLLltpAGCMESGE----NVTNTTYVFSRKhlkrp 277
Cdd:cd00200  82 TGEC----------------VRTLTG-HTSYVSS----VAFSPDGRIL---SSSSRDKTikvwDVETGKCLTTLR----- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 278 iAHlpcpgkaTLAVRCCPVyfelrpvaetekaseepspelvnLPYRMVFAVASED-SVLLYDTqQSFPFGYVSNIHYHTL 356
Cdd:cd00200 133 -GH-------TDWVNSVAF-----------------------SPDGTFVASSSQDgTIKLWDL-RTGKCVATLTGHTGEV 180

                       250
                ....*....|....*....
gi 21312470 357 SDISWSSDGAFLAISSTDG 375
Cdd:cd00200 181 NSVAFSPDGEKLLSSSSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
31-375 1.35e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 1.35e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  31 RLASAGVDTAVRIWKLERGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKMNDskepeqiafqdee 110
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA------------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 111 eaqlnkenWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYIATLS 190
Cdd:COG2319  68 --------GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 191 CDRVLRIYNTQKKRVAFNISkmlsgqGPEGEARSfrmfhddsmksffrrLSFTPDGSLLLTpagcmeSGENvtNTTYVFS 270
Cdd:COG2319 140 ADGTVRLWDLATGKLLRTLT------GHSGAVTS---------------VAFSPDGKLLAS------GSDD--GTVRLWD 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 271 RKHLKrPIAHLPCPGKATLAVRCcpvyfelrpvaetekaseepSP--ELVnlpyrmvfAVASED-SVLLYDTQQSfPFGY 347
Cdd:COG2319 191 LATGK-LLRTLTGHTGAVRSVAF--------------------SPdgKLL--------ASGSADgTVRLWDLATG-KLLR 240

                       330       340
                ....*....|....*....|....*...
gi 21312470 348 VSNIHYHTLSDISWSSDGAFLAISSTDG 375
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
30-97 2.15e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 2.15e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21312470  30 HRLASAGVDTAVRIWKLERGpdgkaivEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKMND 97
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-157 7.57e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 7.57e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312470    118 NWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWD 157
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 2.05e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.05e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312470   119 WTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWD 157
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-94 1.74e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.74e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21312470     57 EFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWK 94
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 160-199 6.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.42e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21312470    160 KGQKISIFNEHKSYVQGVTWDPLGQYIATLSCDRVLRIYN 199
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
57-93 3.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 21312470    57 EFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 31-202 6.88e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 6.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   31 RLASAGVDTAVRIWKLERGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE-ILASGGDDAVILLWKMNDSKepeqiafqde 109
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGK---------- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  110 eeaqlnkenwtVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKS-YVQGVTWDPLGQYIAT 188
Cdd:PTZ00421 160 -----------AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaKSQRCLWAKRKDLIIT 228

                        170
                 ....*....|....*...
gi 21312470  189 LSCD----RVLRIYNTQK 202
Cdd:PTZ00421 229 LGCSksqqRQIMLWDTRK 246
PTZ00421 PTZ00421
coronin; Provisional
 142-216 7.31e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 7.31e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21312470  142 NLMTSASVDNTVIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVAFNISKMLSGQ 216
Cdd:PTZ00421 139 NVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAK 213
PTZ00420 PTZ00420
coronin; Provisional
 62-206 1.87e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   62 LARHTKAVNVVRFSPT-GEILASGGDDAVILLWKM-------NDSKEPEQIafqdeeeaqlnkenwtvvktLRGHLEDVY 133
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIphndesvKEIKDPQCI--------------------LKGHKKKIS 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21312470  134 DICW-ATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKSyVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVA 206
Cdd:PTZ00420 130 IIDWnPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIA 202
WD40 pfam00400
WD domain, G-beta repeat;
161-199 4.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21312470   161 GQKISIFNEHKSYVQGVTWDPLGQYIATLSCDRVLRIYN 199
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 389-529 5.13e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   389 IPLKEKPVLSIRTPDTAKKAKNQTHQGSSPGSRSVEGT-----PSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAiPAG 463
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STE 2896

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21312470   464 KSPLPQPSEEKTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPnSGTAPS 529
Cdd:PHA03247 2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP-SGAVPQ 2961
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 108-179 6.99e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 6.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21312470   108 DEEEAQLNKENWTVVKTLRGHLED--VYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKSYVQGVTW 179
Cdd:pfam12894  15 EDGELLLHRLNWQRVWTLSPDKEDleVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
PHA03378 PHA03378
EBNA-3B; Provisional
 402-530 1.52e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470  402 PDTAKKAKNQTHQGSSPGSRSVEGTPSnRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP---LPQPSEEKTLQP 478
Cdd:PHA03378 736 PPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPpqaGPTSMQLMPRAA 814

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 21312470  479 AGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSGTAPST 530
Cdd:PHA03378 815 PGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKI 866
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-400 2.68e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470 321 PYRMVFAVASED-SVLLYDTQQSFPFgYVSNIHYHTLSDISWSSDGAFLAISSTDGYCTFVTFEKGELGIPLK--EKPVL 397
Cdd:cd00200  19 PDGKLLATGSGDgTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTghTSYVS 97


                ...
gi 21312470 398 SIR 400
Cdd:cd00200  98 SVA 100
EP400_N pfam15790
E1A-binding protein p400, N-terminal; EP400_N is a family of eukaryote proteins. the exact ...
 413-534 6.09e-03

E1A-binding protein p400, N-terminal; EP400_N is a family of eukaryote proteins. the exact function of this domain is not known. This family is largely low-complexity residues.


Pssm-ID: 434938 [Multi-domain]  Cd Length: 489  Bit Score: 39.21  E-value: 6.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   413 HQGSSPG--------SRSVEGTP-SNRTQDPSSPCTTPSP-TTQSPA--PSAIKDSPSAIPAGKSPLPQPSEEKTLQPAG 480
Cdd:pfam15790   2 HHGSGSQnvqrqlqrSKSVSGSEeQQQEQQPATVNHPQSPvTTFAPAasPSAPQSPNYQIIMSRSPVTGQNVNITLQNVG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21312470   481 QNMKAPQprRVTLNTLQTWGKTAP--------RRINLTPLK----TDTVPNP-QPNSGTAPSTEEVQ 534
Cdd:pfam15790  82 QMVAGNQ--QITLTPLPLQSPASPgfqhsapqWRFEHGSPSyiqvTSPLPQQvQPQSPTQHSPVPLQ 146
PTZ00420 PTZ00420
coronin; Provisional
 32-170 6.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.16  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312470   32 LASAGVDTAVRIWKLERGPDG-KAIVEFLSNLARHTKAVNVVRFSPTGE-ILASGGDDAVILLWKMndskEPEQIAFQDE 109
Cdd:PTZ00420  90 LASGSEDLTIRVWEIPHNDESvKEIKDPQCILKGHKKKISIIDWNPMNYyIMCSSGFDSFVNIWDI----ENEKRAFQIN 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21312470  110 EEAQLNKENWTVvktlrghledvydicwatDGNLMTSASVDNTVIIWDVSKGQKISIFNEH 170
Cdd:PTZ00420 166 MPKKLSSLKWNI------------------KGNLLSGTCVGKHMHIIDPRKQEIASSFHIH 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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