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Conserved domains on  [gi|288541355|ref|NP_082496|]
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WD repeat-containing protein 17 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
340-665 5.31e-62

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.86  E-value: 5.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  340 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 419
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  420 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 497
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  498 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 575
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  576 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 653
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 288541355  654 CSRDSTVRLWSL 665
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
74-486 1.45e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   74 KLHAIMSEHKKTITAISWcphNPD--LFASSSTDNLVIIWNVAEQKviakldniketpaclgwcwnthdavafvsqkgpl 151
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGK---------------------------------- 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  152 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSisifqpdeedpvtalewdplstdyllvanlhf 229
Cdd:COG2319   196 LLRTLTGHTGAVrSV-----AFSPD-----------GKlLASGSADGT-------------------------------- 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  230 gIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppk 309
Cdd:COG2319   228 -VRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLT----------------- 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  310 kkfsvqspnknhyisstseavpppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDp 389
Cdd:COG2319   286 ----------------------------------------------------------------GHSGGVNSVAFSPDG- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  390 NVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYI 469
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHT-GAVTSV 378

                         410
                  ....*....|....*..
gi 288541355  470 AWSHkDSKRIATCSGDG 486
Cdd:COG2319   379 AFSP-DGRTLASGSADG 394
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
340-665 5.31e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.86  E-value: 5.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  340 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 419
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  420 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 497
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  498 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 575
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  576 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 653
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 288541355  654 CSRDSTVRLWSL 665
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 374-664 5.33e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.18  E-value: 5.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  374 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 453
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  454 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 531
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  532 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 611
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288541355  612 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 664
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
74-486 1.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   74 KLHAIMSEHKKTITAISWcphNPD--LFASSSTDNLVIIWNVAEQKviakldniketpaclgwcwnthdavafvsqkgpl 151
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGK---------------------------------- 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  152 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSisifqpdeedpvtalewdplstdyllvanlhf 229
Cdd:COG2319   196 LLRTLTGHTGAVrSV-----AFSPD-----------GKlLASGSADGT-------------------------------- 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  230 gIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppk 309
Cdd:COG2319   228 -VRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLT----------------- 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  310 kkfsvqspnknhyisstseavpppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDp 389
Cdd:COG2319   286 ----------------------------------------------------------------GHSGGVNSVAFSPDG- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  390 NVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYI 469
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHT-GAVTSV 378

                         410
                  ....*....|....*..
gi 288541355  470 AWSHkDSKRIATCSGDG 486
Cdd:COG2319   379 AFSP-DGRTLASGSADG 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-281 3.42e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   74 KLHAIMSEHKKTITAISWCPHNPdLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWnTHDAVAFVSQKGPLLI 153
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  154 W---------TISGPDSGV---SVHKEAHSF---ASDICIFRW--HTQKKGKVAFGHidgsisifqpdeEDPVTALEWDP 216
Cdd:cd00200   162 WdlrtgkcvaTLTGHTGEVnsvAFSPDGEKLlssSSDGTIKLWdlSTGKCLGTLRGH------------ENGVNSVAFSP 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288541355  217 lSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAavSVQCLAWVPSAPgMFITGdSQVGVLRIWN 281
Cdd:cd00200   230 -DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 538-578 2.10e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 2.10e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 288541355    538 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 578
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 512-665 1.18e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  512 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 591
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288541355  592 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 665
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
539-578 7.11e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 7.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541355   539 NQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWD 578
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 288541355     73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 59-117 2.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288541355   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 117
Cdd:PTZ00420   97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
73-112 3.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541355    73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
340-665 5.31e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.86  E-value: 5.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  340 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 419
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  420 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 497
Cdd:COG2319   163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  498 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 575
Cdd:COG2319   239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  576 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 653
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                         330
                  ....*....|..
gi 288541355  654 CSRDSTVRLWSL 665
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 374-664 5.33e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.18  E-value: 5.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  374 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 453
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  454 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 531
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  532 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 611
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288541355  612 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 664
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
340-624 8.45e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.20  E-value: 8.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  340 AFSlPPGH-VVCCFLDGGVGLYDMGAKKwdFLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPG 417
Cdd:COG2319   127 AFS-PDGKtLASGSADGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  418 NEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGK 496
Cdd:COG2319   203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  497 LLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVR 575
Cdd:COG2319   280 LLRTLTgHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVR 355

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 288541355  576 IWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWDTRG 624
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 340-621 8.89e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 8.89e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  340 AFSLPPGHVVCCFLDGGVGLYDMgAKKWDFLRELGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 419
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  420 GVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLL 498
Cdd:cd00200    94 SYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  499 HKYK-HPAAVFGCDWSQNNKDMIATGCeDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIW 577
Cdd:cd00200   171 ATLTgHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVW 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 288541355  578 DYTQDACVSTLNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 621
Cdd:cd00200   247 DLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 414-665 8.72e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.96  E-value: 8.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  414 TSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RT 492
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASA-DGTYLASGSSDKTIRLwDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  493 VDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlREGILCSGSDD 571
Cdd:cd00200    81 ETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  572 GSVRIWDYTQDACVSTLNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtM 651
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-L 234

                         250
                  ....*....|....
gi 288541355  652 ASCSRDSTVRLWSL 665
Cdd:cd00200   235 ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-665 6.03e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.10  E-value: 6.03e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  455 IQRFNEHGKnGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 532
Cdd:cd00200     2 RRTLKGHTG-GVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  533 yvATSSNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGS 612
Cdd:cd00200    79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288541355  613 WDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 665
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 541-666 3.46e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 3.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  541 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 618
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 288541355  619 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 666
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
428-665 3.76e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 3.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  428 APGDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAA 506
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLA-AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  507 VFGCDWSQNNKdMIATGCEDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVS 586
Cdd:COG2319    81 VLSVAFSPDGR-LLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  587 TLNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLW 663
Cdd:COG2319   157 TLTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLW 231


                  ..
gi 288541355  664 SL 665
Cdd:COG2319   232 DL 233
WD40 COG2319
WD40 repeat [General function prediction only];
74-486 1.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   74 KLHAIMSEHKKTITAISWcphNPD--LFASSSTDNLVIIWNVAEQKviakldniketpaclgwcwnthdavafvsqkgpl 151
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGK---------------------------------- 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  152 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSisifqpdeedpvtalewdplstdyllvanlhf 229
Cdd:COG2319   196 LLRTLTGHTGAVrSV-----AFSPD-----------GKlLASGSADGT-------------------------------- 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  230 gIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppk 309
Cdd:COG2319   228 -VRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLT----------------- 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  310 kkfsvqspnknhyisstseavpppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDp 389
Cdd:COG2319   286 ----------------------------------------------------------------GHSGGVNSVAFSPDG- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  390 NVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYI 469
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHT-GAVTSV 378

                         410
                  ....*....|....*..
gi 288541355  470 AWSHkDSKRIATCSGDG 486
Cdd:COG2319   379 AFSP-DGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
74-408 4.26e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   74 KLHAIMSEHKKTITAISWcphNPD--LFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKG 149
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDG 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  150 PLLIW---------TISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPD----------EEDP 208
Cdd:COG2319   185 TVRLWdlatgkllrTLTGHTGAVrSV-----AFSPD-----------GKlLASGSADGTVRLWDLAtgkllrtltgHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  209 VTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapG-MFITGdSQVGVLRIWNVSrttp 287
Cdd:COG2319   249 VRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD--GkLLASG-SDDGTVRLWDLA---- 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  288 idnfklkkTGfHCFHVVNSPPKKKFSVQ-SPNKNHYISSTSeavpppnltqnqafslppghvvccflDGGVGLYDMGAKK 366
Cdd:COG2319   319 --------TG-KLLRTLTGHTGAVRSVAfSPDGKTLASGSD--------------------------DGTVRLWDLATGE 363

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 288541355  367 WdfLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 408
Cdd:COG2319   364 L--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-281 3.42e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   74 KLHAIMSEHKKTITAISWCPHNPdLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWnTHDAVAFVSQKGPLLI 153
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  154 W---------TISGPDSGV---SVHKEAHSF---ASDICIFRW--HTQKKGKVAFGHidgsisifqpdeEDPVTALEWDP 216
Cdd:cd00200   162 WdlrtgkcvaTLTGHTGEVnsvAFSPDGEKLlssSSDGTIKLWdlSTGKCLGTLRGH------------ENGVNSVAFSP 229

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288541355  217 lSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAavSVQCLAWVPSAPgMFITGdSQVGVLRIWN 281
Cdd:cd00200   230 -DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 538-578 2.10e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 2.10e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 288541355    538 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 578
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 512-665 1.18e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  512 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 591
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288541355  592 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 665
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 539-621 2.12e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  539 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 608
Cdd:PTZ00420   64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                          90
                  ....*....|...
gi 288541355  609 ISGSWDYTIKVWD 621
Cdd:PTZ00420  142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
539-578 7.11e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 7.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541355   539 NQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWD 578
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 584-621 1.46e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.46e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 288541355    584 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 621
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
584-621 9.47e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 9.47e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 288541355   584 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 621
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 373-461 1.14e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  373 LGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIFALSWAPGDLNCIAGATSRNGAF 445
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                          90
                  ....*....|....*.
gi 288541355  446 IWDIQKGKIIQRFNEH 461
Cdd:PTZ00421  152 VWDVERGKAVEVIKCH 167
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 446-592 4.21e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  446 IWDIQKGKIIQRFNEHGKNgIFYIAWSHKDSKRIATCSGDGFCIIRTVD-GKLLHKYKHPAAVFGCDWSQNNKDMIATGC 524
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKR-VWSIDYSSADPTLLASGSDDGSVKLWSINqGVSIGTIKTKANICCVQFPSESGRSLAFGS 637

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288541355  525 EDKNIrVFYVATSSNQPLKVFSGHTARVFHVKWspLREGILCSGSDDGSVRIWDYTQDAC------VSTLNGHT 592
Cdd:PLN00181  638 ADHKV-YYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 518-578 5.72e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.72e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288541355  518 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 578
Cdd:PTZ00420   88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 572-688 6.13e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 6.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  572 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 643
Cdd:PTZ00420   54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 288541355  644 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 688
Cdd:PTZ00420  134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-405 1.23e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.23e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 288541355    374 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 405
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 288541355     73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 537-634 1.97e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  537 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 616
Cdd:PTZ00421  113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                          90
                  ....*....|....*...
gi 288541355  617 IKVWDTRGGVCLDTVYDH 634
Cdd:PTZ00421  192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
374-405 3.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.22e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 288541355   374 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 405
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
625-664 3.49e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.49e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541355   625 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 664
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 537-662 4.44e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  537 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 609
Cdd:PTZ00421   65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288541355  610 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 662
Cdd:PTZ00421  143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 625-664 4.71e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 288541355    625 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 664
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 374-461 1.49e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  374 GHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSW-APGDLNCiagATSRNGAF-IWDIQK 451
Cdd:PTZ00421  123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWnLDGSLLC---TTSKDKKLnIIDPRD 199

                          90
                  ....*....|
gi 288541355  452 GKIIQRFNEH 461
Cdd:PTZ00421  200 GTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 494-532 1.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.82e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 288541355    494 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 532
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 597-665 2.61e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 288541355  597 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 665
Cdd:PLN00181  537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
PTZ00420 PTZ00420
coronin; Provisional
 59-117 2.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288541355   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 117
Cdd:PTZ00420   97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
73-112 3.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541355    73 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-216 6.81e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 6.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355   51 DRFAYCATL--AIYIYQLdhryNEFKLHAIMSEHKKTITAISWCPhNPDLFASSSTDNLVIIWNVAEQKVIAKLdniket 128
Cdd:cd00200   147 GTFVASSSQdgTIKLWDL----RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTL------ 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541355  129 PACLGWCWnthdAVAFvSQKGPLLiwtISGPDSGVsvhkeahsfasdICIFRWHTQKKGKVAFGHidgsisifqpdeEDP 208
Cdd:cd00200   216 RGHENGVN----SVAF-SPDGYLL---ASGSEDGT------------IRVWDLRTGECVQTLSGH------------TNS 263


                  ....*...
gi 288541355  209 VTALEWDP 216
Cdd:cd00200   264 VTSLAWSP 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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