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Conserved domains on  [gi|226443087|ref|NP_082551|]
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leucine-rich melanocyte differentiation-associated protein [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
23-159 1.56e-14

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.02  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087   23 EHLGRDFGHFaKRLDLSFNLLRSLEGLSAFRSLEELILDNNLL---GDDLVlPGLPHLHTLTLNKNQITDLEYLlDHLAE 99
Cdd:pfam14580  35 ENLGATLDQF-DTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLAS 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  100 VtPSLEYLSLLGNVAcpnelvnlekdeEDYKRYRCFVLHKLPKLKFLDAQKVTRQEREEA 159
Cdd:pfam14580 112 L-KKLTFLSLLRNPV------------TNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
23-159 1.56e-14

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.02  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087   23 EHLGRDFGHFaKRLDLSFNLLRSLEGLSAFRSLEELILDNNLL---GDDLVlPGLPHLHTLTLNKNQITDLEYLlDHLAE 99
Cdd:pfam14580  35 ENLGATLDQF-DTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLAS 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  100 VtPSLEYLSLLGNVAcpnelvnlekdeEDYKRYRCFVLHKLPKLKFLDAQKVTRQEREEA 159
Cdd:pfam14580 112 L-KKLTFLSLLRNPV------------TNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-147 2.78e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 2.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  34 KRLDLSFNLLRSL-EGLSAFRSLEELILDNNLLGD-DLVLPGLPHLHTLTLNKNQITDLEYLLDHLaevtPSLEYLSLLG 111
Cdd:COG4886  139 KELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlPEELGNLTNLKELDLSNNQITDLPEPLGNL----TNLEELDLSG 214

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 226443087 112 nvacpNELVNLEKDeedykryrcfvLHKLPKLKFLD 147
Cdd:COG4886  215 -----NQLTDLPEP-----------LANLTNLETLD 234
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-157 1.21e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  34 KRLDLSFNLLRSLEGLSAFRSLEEL----------------------------ILD--NNLLGDDLVLPGLPHLHTLTLN 83
Cdd:cd21340   71 KKLYLGGNRISVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrVLNisGNNIDSLEPLAPLRNLEQLDAS 150

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226443087  84 KNQITDLEYLLDHLAEVtPSLEYLSLLGNVACPNelvnlekdeedyKRYRCFVLHKLPKLKFLDAQKVTRQERE 157
Cdd:cd21340  151 NNQISDLEELLDLLSSW-PSLRELDLTGNPVCKK------------PKYRDKIILASKSLEVLDGKEITDTERQ 211
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
23-159 1.56e-14

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 69.02  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087   23 EHLGRDFGHFaKRLDLSFNLLRSLEGLSAFRSLEELILDNNLL---GDDLVlPGLPHLHTLTLNKNQITDLEYLlDHLAE 99
Cdd:pfam14580  35 ENLGATLDQF-DTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLAS 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  100 VtPSLEYLSLLGNVAcpnelvnlekdeEDYKRYRCFVLHKLPKLKFLDAQKVTRQEREEA 159
Cdd:pfam14580 112 L-KKLTFLSLLRNPV------------TNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-147 2.78e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 2.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  34 KRLDLSFNLLRSL-EGLSAFRSLEELILDNNLLGD-DLVLPGLPHLHTLTLNKNQITDLEYLLDHLaevtPSLEYLSLLG 111
Cdd:COG4886  139 KELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlPEELGNLTNLKELDLSNNQITDLPEPLGNL----TNLEELDLSG 214

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 226443087 112 nvacpNELVNLEKDeedykryrcfvLHKLPKLKFLD 147
Cdd:COG4886  215 -----NQLTDLPEP-----------LANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-129 1.04e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  34 KRLDLSFNLLRSLEGLSAFRSLEELILDNNLLGDDLVLPGLPHLHTLTLNKNQITD--LEYLLDHLAEVTPSLEYLSLLG 111
Cdd:COG4886  231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNL 310

                         90
                 ....*....|....*...
gi 226443087 112 NVACPNELVNLEKDEEDY 129
Cdd:COG4886  311 LELLILLLLLTTLLLLLL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-157 1.21e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  34 KRLDLSFNLLRSLEGLSAFRSLEEL----------------------------ILD--NNLLGDDLVLPGLPHLHTLTLN 83
Cdd:cd21340   71 KKLYLGGNRISVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrVLNisGNNIDSLEPLAPLRNLEQLDAS 150

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226443087  84 KNQITDLEYLLDHLAEVtPSLEYLSLLGNVACPNelvnlekdeedyKRYRCFVLHKLPKLKFLDAQKVTRQERE 157
Cdd:cd21340  151 NNQISDLEELLDLLSSW-PSLRELDLTGNPVCKK------------PKYRDKIILASKSLEVLDGKEITDTERQ 211
LRR_8 pfam13855
Leucine rich repeat;
53-112 1.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226443087   53 RSLEELILDNNLLG--DDLVLPGLPHLHTLTLNKNQITDLEY-LLDHLaevtPSLEYLSLLGN 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGL----PSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-111 9.48e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 9.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226443087  27 RDFGHFAKRLDLSFNLLRS------LEGLSAFRSLEELILDNNLLGDDLV------LPGLPHLHTLTLNKNQITDLEYLL 94
Cdd:cd00116  133 KDLPPALEKLVLGRNRLEGascealAKALRANRDLKELNLANNGIGDAGIralaegLKANCNLEVLDLNNNGLTDEGASA 212

                         90
                 ....*....|....*..
gi 226443087  95 dhLAEVTPSLEYLSLLG 111
Cdd:cd00116  213 --LAETLASLKSLEVLN 227
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 54-93 1.80e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 1.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 226443087   54 SLEELILDNNLLGDDLVLPGLPHLHTLTL-NKNQITDLEYL 93
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDL 42
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 34-69 3.81e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 3.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 226443087   34 KRLDLSFNLLRSLEGLSAFRSLEELILDNNLLGDDL 69
Cdd:pfam12799   4 EVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDL 39
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 75-112 8.58e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.37  E-value: 8.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 226443087   75 PHLHTLTLNKNQITDLEyLLDHLaevtPSLEYLSLLGN 112
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKL----PNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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