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Conserved domains on  [gi|20270208|ref|NP_083567|]
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activating signal cointegrator 1 complex subunit 2 isoform 1 [Mus musculus]

Protein Classification

ASCC2 family CUE domain-containing protein( domain architecture ID 10198858)

ASCC2 family CUE domain-containing protein similar to human activating signal cointegrator 1 complex subunit 2 (ASCC2) that plays a role in DNA damage repair as component of the ASCC complex

CATH:  1.10.8.10
Gene Ontology:  GO:0043130
PubMed:  12628920|12787494
SCOP:  4003786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 467-506 1.11e-19

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


:

Pssm-ID: 270547  Cd Length: 40  Bit Score: 82.41  E-value: 1.11e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20270208 467 DSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILED 506
Cdd:cd14364   1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
 
Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 467-506 1.11e-19

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 82.41  E-value: 1.11e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20270208 467 DSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILED 506
Cdd:cd14364   1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 465-507 9.37e-09

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 51.72  E-value: 9.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 20270208    465 ELDSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDR 507
Cdd:smart00546   1 ENDEALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 467-507 3.30e-08

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 50.17  E-value: 3.30e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 20270208   467 DSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDR 507
Cdd:pfam02845   2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 467-506 1.11e-19

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 82.41  E-value: 1.11e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20270208 467 DSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILED 506
Cdd:cd14364   1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 465-507 9.37e-09

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 51.72  E-value: 9.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 20270208    465 ELDSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDR 507
Cdd:smart00546   1 ENDEALHDLKEMFPNLDEEVIEAVLEANTGNVEATINNLLEGS 43
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 467-507 3.30e-08

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 50.17  E-value: 3.30e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 20270208   467 DSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDR 507
Cdd:pfam02845   2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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