|
Name |
Accession |
Description |
Interval |
E-value |
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
1-314 |
1.46e-171 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 478.01 E-value: 1.46e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 1 MPNIKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIA 80
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENis 160
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 161 DWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30794182 241 ATRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
4-313 |
1.05e-160 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 450.34 E-value: 1.05e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASAS 83
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDwr 163
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 164 NCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGATR 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 244 VYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKMKQCSKIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
4-314 |
7.12e-154 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 433.24 E-value: 7.12e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIV-QSGCGEINDSLMELLIMINACKIASA 82
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDw 162
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 163 rNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGA 241
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30794182 242 TRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEdkmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
4-120 |
9.55e-69 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 209.97 E-value: 9.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASAS 83
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 30794182 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAG 120
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
147-274 |
1.36e-23 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 93.61 E-value: 1.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 147 AEPAVLKWIKENIsdWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223 1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 30794182 221 DMADTCGTICYAADKLLSEGATRVYAILTHGIFSGpaIARINGACFEAVVVTNT 274
Cdd:cd06223 79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEG--GARELASPGDPVYSLFT 130
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
1-314 |
1.46e-171 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 478.01 E-value: 1.46e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 1 MPNIKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIA 80
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENis 160
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 161 DWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30794182 241 ATRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
4-313 |
1.05e-160 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 450.34 E-value: 1.05e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASAS 83
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDwr 163
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 164 NCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGATR 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 244 VYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKMKQCSKIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
4-314 |
7.12e-154 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 433.24 E-value: 7.12e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIV-QSGCGEINDSLMELLIMINACKIASA 82
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDw 162
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 163 rNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGA 241
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30794182 242 TRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEdkmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| PLN02369 |
PLN02369 |
ribose-phosphate pyrophosphokinase |
14-313 |
7.45e-114 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 215209 [Multi-domain] Cd Length: 302 Bit Score: 331.27 E-value: 7.45e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 14 DLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASASRVTAVIPCFP 93
Cdd:PLN02369 2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 94 YARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDWRNCTIVSPDAG 173
Cdd:PLN02369 82 YARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDVG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 174 GAKRVTSIADHL-NVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGATRVYAILTHGI 252
Cdd:PLN02369 162 GVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAV 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30794182 253 FSGPAIARINGACFEAVVVTNTIPQEDKmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PLN02369 242 FSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
|
|
| PRK02812 |
PRK02812 |
ribose-phosphate pyrophosphokinase; Provisional |
4-313 |
8.58e-112 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235072 [Multi-domain] Cd Length: 330 Bit Score: 327.08 E-value: 8.58e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASAS 83
Cdd:PRK02812 22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKE-NISDw 162
Cdd:PRK02812 102 QITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASkNLED- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 163 rnCTIVSPDAGGAKRVTSIADHLN-VDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGA 241
Cdd:PRK02812 181 --IVVVSPDVGGVARARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGA 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30794182 242 TRVYAILTHGIFSGPAIARINGACFEAVVVTNTIP--QEDKMKQcskIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02812 259 KQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPvpEERRFPQ---LKVLSVANMLGEAIWRIHEESSVSSMF 329
|
|
| PRK03092 |
PRK03092 |
ribose-phosphate diphosphokinase; |
15-313 |
1.59e-110 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179535 [Multi-domain] Cd Length: 304 Bit Score: 323.05 E-value: 1.59e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 15 LSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASASRVTAVIPCFPY 94
Cdd:PRK03092 1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 95 ARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDwRNCTIVSPDAGG 174
Cdd:PRK03092 81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 175 AKRVTSIADHL-NVDFALIHKER--KKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGATRVYAILTHG 251
Cdd:PRK03092 160 VRVAEQWADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30794182 252 IFSGPAIARINGACFEAVVVTNTIPQEDKmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
|
|
| PRK04923 |
PRK04923 |
ribose-phosphate diphosphokinase; |
2-313 |
2.82e-109 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179893 [Multi-domain] Cd Length: 319 Bit Score: 320.34 E-value: 2.82e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 2 PNIKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIAS 81
Cdd:PRK04923 5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 82 ASRVTAVIPCFPYARQDKKDKS-RAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIkenis 160
Cdd:PRK04923 85 AASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADI----- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 161 dWR-----NCTIVSPDAGGAKRVTSIADHL-NVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAAD 234
Cdd:PRK04923 160 -WRaygtdNLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30794182 235 KLLSEGATRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKMKQCSKIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
|
|
| PRK02269 |
PRK02269 |
ribose-phosphate diphosphokinase; |
3-313 |
3.01e-109 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 167353 [Multi-domain] Cd Length: 320 Bit Score: 320.59 E-value: 3.01e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 3 NIKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASA 82
Cdd:PRK02269 5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDW 162
Cdd:PRK02269 85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 163 RNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERK--KANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEG 240
Cdd:PRK02269 165 DDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30794182 241 ATRVYAILTHGIFSGPAIARINGACFEAVVVTNTI--PQEdkmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02269 245 ATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIylPEE---RLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
|
|
| PTZ00145 |
PTZ00145 |
phosphoribosylpyrophosphate synthetase; Provisional |
1-313 |
8.72e-108 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 240290 [Multi-domain] Cd Length: 439 Bit Score: 321.05 E-value: 8.72e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 1 MPNIKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIA 80
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRA 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFD--IPVDNLYAEPAVLKWIKEN 158
Cdd:PTZ00145 197 SAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKK 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 159 isDWRNCTIVSPDAGGAKRVTSIADHLN------VDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYA 232
Cdd:PTZ00145 277 --DLYKPVIVSPDAGGVYRARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEA 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 233 ADKLLSEGATRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKMKQCSKIQVIDIAMILAEAIRRTHNGESVSYL 312
Cdd:PTZ00145 355 AKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDL 434
|
.
gi 30794182 313 F 313
Cdd:PTZ00145 435 F 435
|
|
| PRK02458 |
PRK02458 |
ribose-phosphate pyrophosphokinase; Provisional |
2-317 |
1.47e-93 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235039 [Multi-domain] Cd Length: 323 Bit Score: 280.47 E-value: 1.47e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 2 PNIKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIAS 81
Cdd:PRK02458 8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 82 ASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISD 161
Cdd:PRK02458 88 ANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 162 WRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVlVGDVKDRVAILVDDMADTCGTICYAADKLLSEGA 241
Cdd:PRK02458 168 GSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYI-IGDVAGKKAILIDDILNTGKTFAEAAKIVEREGA 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30794182 242 TRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDkmKQCSKIQVIDIAMILAEAIRRTHNGESVSYLFSHVP 317
Cdd:PRK02458 247 TEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKE--RVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNK 320
|
|
| PRK00553 |
PRK00553 |
ribose-phosphate pyrophosphokinase; Provisional |
6-314 |
1.70e-83 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 179062 [Multi-domain] Cd Length: 332 Bit Score: 255.23 E-value: 1.70e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 6 LFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASASRV 85
Cdd:PRK00553 12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 86 TAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDwRNC 165
Cdd:PRK00553 92 TAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLELLGK-KDL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 166 TIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGATRVY 245
Cdd:PRK00553 171 VVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVC 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30794182 246 AILTHGIFSGPAIARINGACFEAVV----VTNTIPQEdKMKQCSKIQVIDIAMILAEAIRRTHNGESVSYLFS 314
Cdd:PRK00553 251 VMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQT-KFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
4-120 |
9.55e-69 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 209.97 E-value: 9.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 4 IKLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASAS 83
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 30794182 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAG 120
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
|
|
| PRK00934 |
PRK00934 |
ribose-phosphate pyrophosphokinase; Provisional |
5-302 |
8.65e-65 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 234868 [Multi-domain] Cd Length: 285 Bit Score: 205.53 E-value: 8.65e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 5 KLFSGSSHQDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEiNDSLMELLIMINACKIASASR 84
Cdd:PRK00934 1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 85 VTAVIPCFPYARQDKKDKSRAPISAKLVANMLSIAGaDHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIsdwRN 164
Cdd:PRK00934 80 ITLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKL---DD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 165 CTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGATRV 244
Cdd:PRK00934 156 PLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKV 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 30794182 245 YAILTHGIFSGPAIARINGACFEAVVVTNTIPqedkmkqcSKIQVIDIAMILAEAIRR 302
Cdd:PRK00934 236 YVACVHPVLVGDAILKLYNAGVDEIIVTDTLE--------SEVSKISVAPLIADLLKK 285
|
|
| Pribosyl_synth |
pfam14572 |
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ... |
161-313 |
3.27e-47 |
|
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.
Pssm-ID: 434046 Cd Length: 184 Bit Score: 157.29 E-value: 3.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 161 DWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKA--NEVDR----------------------------MVLVGD 210
Cdd:pfam14572 1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAesDEVDGrqspppyrsrtvsrslglpeiipkekppMTVVGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 211 VKDRVAILVDDMADTCGTICYAADKLLSEGATRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKMKQCSKIQVI 290
Cdd:pfam14572 81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160
|
170 180
....*....|....*....|...
gi 30794182 291 DIAMILAEAIRRTHNGESVSYLF 313
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLF 183
|
|
| PRK07199 |
PRK07199 |
ribose-phosphate diphosphokinase; |
13-302 |
1.51e-40 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 235960 [Multi-domain] Cd Length: 301 Bit Score: 143.54 E-value: 1.51e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 13 QDLSQKITERLGLELSKVVTKKFSNQETCVEIGESVRGEDVYIVQSgCGEINDSLMELLIMINACKIASASRVTAVIPCF 92
Cdd:PRK07199 12 EAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCS-LDRPDEKLLPLLFAAEAARELGARRVGLVAPYL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 93 PYARQDKKDKSRAPISAKLVANMLSiAGADHIITMD--LH-ASQIQGFFDIPVDNLYAEPAVLKWIKENISDWrncTIVS 169
Cdd:PRK07199 91 AYMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVPRP---LLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 170 PDAGGAKRVTSIADHLNVDFALIHKERKKANEVDrmVLVGDV---KDRVAILVDDMADTCGTICYAADKLLSEGATRVYA 246
Cdd:PRK07199 167 PDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVE--ISLPDAapwAGRTPVLVDDIVSTGRTLIEAARQLRAAGAASPDC 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 30794182 247 ILTHGIFSGPAIARINGACFEAVVVTNTIPQEDkmkqcskiQVIDIAMILAEAIRR 302
Cdd:PRK07199 245 VVVHALFAGDAYSALAAAGIARVVSTDTVPHPS--------NAISLAPLLAEALRR 292
|
|
| PRK06827 |
PRK06827 |
phosphoribosylpyrophosphate synthetase; Provisional |
29-312 |
3.62e-40 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 180714 [Multi-domain] Cd Length: 382 Bit Score: 144.32 E-value: 3.62e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 29 KVVTKKFSNQETCVEIGESVRGEDVYIVQ---------SGCGE-----INDSLMELLIMINACKiASASRVTAVIPCFPY 94
Cdd:PRK06827 56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 95 ARQDKKdKSRAPISAKLVANMLSIAGADHIITMDLHASQIQGFFDI-PVDNLYAEPAVLKWIKENISDWR----NCTIVS 169
Cdd:PRK06827 135 SRQHKR-KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLmGFENLYPSYQIIKALLKNEKDLEidkdHLMVIS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 170 PDAGGAKRVTSIADHLNVDFALIHKERK-------KANEVDRMVLVGDVKDRVAILVDDMADTCGTICYAADKLLSEGAT 242
Cdd:PRK06827 214 PDTGAMDRAKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAK 293
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30794182 243 RVYAILTHGIFSGpAIARINGA----CFEAVVVTNTIPQEDKMKQCSKIQVIDIAMILAEAIRRTHNGESVSYL 312
Cdd:PRK06827 294 KIIVAATFGFFTN-GLEKFDKAyeegYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKL 366
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
147-274 |
1.36e-23 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 93.61 E-value: 1.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 147 AEPAVLKWIKENIsdWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223 1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 30794182 221 DMADTCGTICYAADKLLSEGATRVYAILTHGIFSGpaIARINGACFEAVVVTNT 274
Cdd:cd06223 79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEG--GARELASPGDPVYSLFT 130
|
|
| PLN02297 |
PLN02297 |
ribose-phosphate pyrophosphokinase |
3-300 |
3.32e-12 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 177934 [Multi-domain] Cd Length: 326 Bit Score: 66.25 E-value: 3.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 3 NIKLFSGSSHQDLSQKITERLG-LELSKVVTKKFSNQETCVEIG--ESVRGEDVYIVQSGcgEINDSLMELLIMINACKI 79
Cdd:PLN02297 16 QVHLFYCEETEELARKIAAESDaIELGSINWRKFPDGFPNLFINnaHGIRGQHVAFLASF--SSPAVIFEQLSVIYALPK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 80 ASASRVTAVIPCFP---YAR-QDKKDKSRAPISAKLVANM-LSIAGADHIITMDLHASQIQGFFDIPVDNLYAE--PAVL 152
Cdd:PLN02297 94 LFVASFTLVLPFFPtgtSERvEREGDVATAFTLARILSNIpISRGGPTSLVIFDIHALQERFYFGDNVLPCFESgiPLLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 153 KWIKEnISDWRNCTIVSPDAGGAKRVTSIADHlnVDFALIHKERkkanEVD-RMVLV--GDVKDRVAILVDDMADTCGTI 229
Cdd:PLN02297 174 KRLQQ-LPDSDNIVIAFPDDGAWKRFHKQFEH--FPMVVCTKVR----EGDkRIVRIkeGNPAGRHVVIVDDLVQSGGTL 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30794182 230 cYAADKLLSE-GATRVYAILTHGIFSGPAIARIN------GACFEAVVVTNTIPQEDK-MKQCSKIQVIDIAMILAEAI 300
Cdd:PLN02297 247 -IECQKVLAAhGAAKVSAYVTHGVFPNESWERFThdnggpEAGFAYFWITDSCPQTVKaVRGKAPFEVLSLAGSIADAL 324
|
|
| Pribosyltran |
pfam00156 |
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ... |
141-244 |
2.11e-09 |
|
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.
Pssm-ID: 425489 [Multi-domain] Cd Length: 150 Bit Score: 55.45 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794182 141 PVDNLYAEPAVLKWIKENIS------DWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKAN---EVDRMVLVGDV 211
Cdd:pfam00156 1 SVDEILDNPAILKAVARLAAqinedyGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDtseVMKTSSALPDL 80
|
90 100 110
....*....|....*....|....*....|...
gi 30794182 212 KDRVAILVDDMADTCGTICYAADKLLSEGATRV 244
Cdd:pfam00156 81 KGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
|
|
| PRK09162 |
PRK09162 |
hypoxanthine-guanine phosphoribosyltransferase; Provisional |
210-250 |
9.11e-03 |
|
hypoxanthine-guanine phosphoribosyltransferase; Provisional
Pssm-ID: 181675 Cd Length: 181 Bit Score: 36.38 E-value: 9.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 30794182 210 DVKDRVAILVDDMADTCGTICYAADKLLSEGATRVY-AILTH 250
Cdd:PRK09162 94 SLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYsAVLVD 135
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