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Conserved domains on  [gi|148747238|ref|NP_083689|]
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MORC family CW-type zinc finger protein 4 isoform B [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 266-400 1.20e-61

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 204.70  E-value: 1.20e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238  266 YSLRAFCSILYMK--PRMKIFLRQKKVTTQMIAKSLANVEYDIYKPTS---TNKQVRITFGF--SCKYHNQFGVMMYHNN 338
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVgggKEVVVITTIGFlkEAPHINVHGFNVYHKN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747238  339 RLIKAFEKAGCQLKptcGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALARKLNAYW 400
Cdd:pfam17942  81 RLIKPFWRVGNQAG---SKGRGVIGVLEANFIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 39-156 2.00e-53

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16931:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 118  Bit Score: 181.45  E-value: 2.00e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238  39 YLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKK-KPCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQrP 117
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRgGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHD-H 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148747238 118 IGVFGNGFKSGSMRLGKDALVFTKNGNTLAVGLLSQTYL 156
Cdd:cd16931   80 IGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 422-467 2.43e-21

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 87.75  E-value: 2.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148747238  422 TWVQCDECLKWRRLPGMVDPSTLPARWFCYYNPHPKFKRCSVPEEQ 467
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYELPEPWYCSMNPDPKYNSCDAPEEI 46
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 266-400 1.20e-61

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 204.70  E-value: 1.20e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238  266 YSLRAFCSILYMK--PRMKIFLRQKKVTTQMIAKSLANVEYDIYKPTS---TNKQVRITFGF--SCKYHNQFGVMMYHNN 338
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVgggKEVVVITTIGFlkEAPHINVHGFNVYHKN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747238  339 RLIKAFEKAGCQLKptcGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALARKLNAYW 400
Cdd:pfam17942  81 RLIKPFWRVGNQAG---SKGRGVIGVLEANFIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 39-156 2.00e-53

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 181.45  E-value: 2.00e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238  39 YLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKK-KPCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQrP 117
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRgGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHD-H 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148747238 118 IGVFGNGFKSGSMRLGKDALVFTKNGNTLAVGLLSQTYL 156
Cdd:cd16931   80 IGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 422-467 2.43e-21

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 87.75  E-value: 2.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148747238  422 TWVQCDECLKWRRLPGMVDPSTLPARWFCYYNPHPKFKRCSVPEEQ 467
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYELPEPWYCSMNPDPKYNSCDAPEEI 46
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 50-184 2.56e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 76.22  E-value: 2.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238   50 PFSAIAELLDNAVDPDVSARTVFIDVEEVKKKPClTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQRPIGVFGNGFKSGS 129
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNRGGGTEI-VIEDDGHGMSPEELINALRLATSAKEAKRGSTDLGRYGIGLKLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148747238  130 MRLGKDALVFTKNGNTLAVGLLSQTYLECIQAqAVIVPIVPFSQQNKKMIVTEDS 184
Cdd:pfam13589  80 LSLGAKLTVTSKKEGKSSTLTLDRDKISNEND-WLLPLLTPAPIENFDELDKDAH 133
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 53-125 6.08e-06

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 46.10  E-value: 6.08e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148747238    53 AIAELLDNAVDPDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHRMLSFGFTdkvIKKSQRPIGVFGNGF 125
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFR---TDKRSRKIGGTGLGL 78
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 57-101 3.10e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 44.02  E-value: 3.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 148747238  57 LLDNAVD--PDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHRM 101
Cdd:COG4191  264 LLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
mutL PRK00095
DNA mismatch repair endonuclease MutL;
49-106 7.70e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 7.70e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148747238  49 RPFSAIAELLDNAVDPDvsARTVFIDVEE--VKKkpcLTFTDDGCGMTP---------H---KLH------RMLSFGF 106
Cdd:PRK00095  22 RPASVVKELVENALDAG--ATRIDIEIEEggLKL---IRVRDNGCGISKedlalalarHatsKIAslddleAIRTLGF 94
 
Name Accession Description Interval E-value
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 266-400 1.20e-61

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 204.70  E-value: 1.20e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238  266 YSLRAFCSILYMK--PRMKIFLRQKKVTTQMIAKSLANVEYDIYKPTS---TNKQVRITFGF--SCKYHNQFGVMMYHNN 338
Cdd:pfam17942   1 YSLRAYASILYLRlpPNFQIILRGKKVEHHNIADDLKYPEKITYKPQVgggKEVVVITTIGFlkEAPHINVHGFNVYHKN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747238  339 RLIKAFEKAGCQLKptcGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALARKLNAYW 400
Cdd:pfam17942  81 RLIKPFWRVGNQAG---SKGRGVIGVLEANFIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 39-156 2.00e-53

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 181.45  E-value: 2.00e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238  39 YLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKK-KPCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQrP 117
Cdd:cd16931    1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRgGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHD-H 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148747238 118 IGVFGNGFKSGSMRLGKDALVFTKNGNTLAVGLLSQTYL 156
Cdd:cd16931   80 IGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 422-467 2.43e-21

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 87.75  E-value: 2.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148747238  422 TWVQCDECLKWRRLPGMVDPSTLPARWFCYYNPHPKFKRCSVPEEQ 467
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYELPEPWYCSMNPDPKYNSCDAPEEI 46
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 50-184 2.56e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 76.22  E-value: 2.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747238   50 PFSAIAELLDNAVDPDVSARTVFIDVEEVKKKPClTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQRPIGVFGNGFKSGS 129
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNRGGGTEI-VIEDDGHGMSPEELINALRLATSAKEAKRGSTDLGRYGIGLKLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148747238  130 MRLGKDALVFTKNGNTLAVGLLSQTYLECIQAqAVIVPIVPFSQQNKKMIVTEDS 184
Cdd:pfam13589  80 LSLGAKLTVTSKKEGKSSTLTLDRDKISNEND-WLLPLLTPAPIENFDELDKDAH 133
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 51-100 1.46e-06

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 47.60  E-value: 1.46e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 148747238  51 FSAIAELLDNAVDPDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHR 100
Cdd:cd00075    2 EQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLER 51
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 53-125 6.08e-06

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 46.10  E-value: 6.08e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148747238    53 AIAELLDNAVDPDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHRMLSFGFTdkvIKKSQRPIGVFGNGF 125
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFR---TDKRSRKIGGTGLGL 78
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 48-119 1.32e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 45.05  E-value: 1.32e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747238   48 TRPFSAIAELLDNAVDPDVSARTVFIDVEEVKKKpCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQRPIG 119
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAKAGEITVTLSEGGEL-TLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLG 74
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 48-106 9.33e-05

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 44.35  E-value: 9.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747238  48 TRPFSAIAELLDNAVDPDvsARTVFIDVEEVKKKpCLTFTDDGCGMTP------------------HKLHRMLSFGF 106
Cdd:cd16926   12 ERPASVVKELVENSIDAG--ATRIDVEIEEGGLK-LIRVTDNGSGISRedlelaferhatskissfEDLFSITTLGF 85
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 57-101 3.10e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 44.02  E-value: 3.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 148747238  57 LLDNAVD--PDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHRM 101
Cdd:COG4191  264 LLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
49-95 7.42e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.11  E-value: 7.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 148747238  49 RPFSAIAELLDNAVDPDvsARTVFIDVEEVKKKpCLTFTDDGCGMTP 95
Cdd:COG0323   23 RPASVVKELVENAIDAG--ATRIEVEIEEGGKS-LIRVTDNGCGMSP 66
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 52-109 5.27e-03

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 40.22  E-value: 5.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747238  52 SAIAELLDNAVD----PDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHRMLSFGFTDK 109
Cdd:COG3290  284 TILGNLLDNAIEavekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTK 345
mutL PRK00095
DNA mismatch repair endonuclease MutL;
49-106 7.70e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 7.70e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148747238  49 RPFSAIAELLDNAVDPDvsARTVFIDVEE--VKKkpcLTFTDDGCGMTP---------H---KLH------RMLSFGF 106
Cdd:PRK00095  22 RPASVVKELVENALDAG--ATRIDIEIEEggLKL---IRVRDNGCGISKedlalalarHatsKIAslddleAIRTLGF 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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