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Conserved domains on  [gi|58037529|ref|NP_084411|]
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cystatin-14 precursor [Mus musculus]

Protein Classification

cystatin family protein( domain architecture ID 430)

cystatin family protein may function as a cysteine protease inhibitor, such as Glycine max cystatin that inhibits papain and cathepsin B

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
PubMed:  1855589|9007972|3555466|14587292
SCOP:  4001013

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 35-128 1.12e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 54.36  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037529     35 FVASVEFAVAQFNDNNpeENTYKLLEVGRAQKKTW---TMIFLMDLEMGRTICKKHDENIHNCPLLQgsrEKKVHCVFQV 111
Cdd:smart00043  16 VQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQvvaGTNYYLKVEVGETNCKKLSVDLENCPFLD---QGEKFCTAKV 90

                           90
                   ....*....|....*..
gi 58037529    112 DARPWFSHFTILTSTCV 128
Cdd:smart00043  91 WEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 35-128 1.12e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 54.36  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037529     35 FVASVEFAVAQFNDNNpeENTYKLLEVGRAQKKTW---TMIFLMDLEMGRTICKKHDENIHNCPLLQgsrEKKVHCVFQV 111
Cdd:smart00043  16 VQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQvvaGTNYYLKVEVGETNCKKLSVDLENCPFLD---QGEKFCTAKV 90

                           90
                   ....*....|....*..
gi 58037529    112 DARPWFSHFTILTSTCV 128
Cdd:smart00043  91 WEKPWENKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 39-116 1.60e-10

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.88  E-value: 1.60e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58037529    39 VEFAVAQFNDNNpEENTYKLLEVGRAQKKTWT-MIFLMDLEMGRTICKKHDENIHNCPLLqgSREKKVHCVFQVDARPW 116
Cdd:pfam00031  17 LDFALAEYNAKT-DNYYFELVEVKRAKSQVVAgTNYFIKVEVGETDCSKSKKLLEDCPLL--DEKWLGLCSAQVYKVPW 92
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-127 9.21e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 49.39  E-value: 9.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037529  39 VEFAVAQFNDNNpEENTYKLLEVGRAQKKTW-TMIFLMDLEMGRTICKKHDENIHNCPLLQGSREKKVHCVFQVDARPWF 117
Cdd:cd00042  17 ADFAVAEYNKKS-NDKYLEFFKVLSAKSQVVaGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTAKVWEKPWE 95

                        90
                ....*....|
gi 58037529 118 SHFTILTSTC 127
Cdd:cd00042  96 NFKELLSFKC 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 35-128 1.12e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 54.36  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037529     35 FVASVEFAVAQFNDNNpeENTYKLLEVGRAQKKTW---TMIFLMDLEMGRTICKKHDENIHNCPLLQgsrEKKVHCVFQV 111
Cdd:smart00043  16 VQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQvvaGTNYYLKVEVGETNCKKLSVDLENCPFLD---QGEKFCTAKV 90

                           90
                   ....*....|....*..
gi 58037529    112 DARPWFSHFTILTSTCV 128
Cdd:smart00043  91 WEKPWENKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 39-116 1.60e-10

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.88  E-value: 1.60e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58037529    39 VEFAVAQFNDNNpEENTYKLLEVGRAQKKTWT-MIFLMDLEMGRTICKKHDENIHNCPLLqgSREKKVHCVFQVDARPW 116
Cdd:pfam00031  17 LDFALAEYNAKT-DNYYFELVEVKRAKSQVVAgTNYFIKVEVGETDCSKSKKLLEDCPLL--DEKWLGLCSAQVYKVPW 92
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-127 9.21e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 49.39  E-value: 9.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037529  39 VEFAVAQFNDNNpEENTYKLLEVGRAQKKTW-TMIFLMDLEMGRTICKKHDENIHNCPLLQGSREKKVHCVFQVDARPWF 117
Cdd:cd00042  17 ADFAVAEYNKKS-NDKYLEFFKVLSAKSQVVaGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTAKVWEKPWE 95

                        90
                ....*....|
gi 58037529 118 SHFTILTSTC 127
Cdd:cd00042  96 NFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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