NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27229267|ref|NP_084485|]
View 

cysteine-rich secretory protein LCCL domain-containing 2 isoform 2 precursor [Mus musculus]

Protein Classification

CAP domain-containing protein( domain architecture ID 10211329)

CAP (CSP/antigen 5/PR1) domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CAP super family cl00133
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-201 5.24e-106

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


The actual alignment was detected with superfamily member cd18816:

Pssm-ID: 412178  Cd Length: 146  Bit Score: 312.30  E-value: 5.24e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEV 135
Cdd:cd18816   1 KEEILQLHNKLRGQVYPSASNMEYMTWDDELERSAEAWAQQCIWEHGPTSLLPSIGQNLAVHWGRYRSPAFHVQSWYDEV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229267 136 KDYTYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18816  81 KDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNKVGCAVNVCRRMNVWGEIWENAVYLVCNYS 146
LCCL smart00603
LCCL domain;
283-367 9.65e-39

LCCL domain;


:

Pssm-ID: 128866  Cd Length: 85  Bit Score: 135.60  E-value: 9.65e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    283 QVVHCDTKMKDSCKGSTCNRYQCPAGCLSNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQKN 362
Cdd:smart00603   1 QAVTCDTRGLDLCKPVTDNRVLCPAGCLLEKAKVFGTIVYASLSSICRAAVHAGVISNSGGAVDVVRVGGRENYISSDAN 80


                   ....*
gi 27229267    363 GMESL 367
Cdd:smart00603  81 GIQSE 85
LCCL pfam03815
LCCL domain;
386-485 2.86e-38

LCCL domain;


:

Pssm-ID: 427521  Cd Length: 96  Bit Score: 134.72  E-value: 2.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267   386 VDCHATVAQLCPFEKPATHCPRIQCPARCGEEPsywAPVYGTNIYADTSSICKAAVHAGVIvDEVGGYADVMPVDKKKSY 465
Cdd:pfam03815   1 LSCSTTLLDICNFCPFTGTCFLVRCPANCADEK---ASVYGTDVYSSDSSICKAAIHAGVI-DNSGGLVVVRIVGGQNEY 76

                          90       100
                  ....*....|....*....|
gi 27229267   466 VGSLRNGVQSESLNTPQNGN 485
Cdd:pfam03815  77 TGSTQNGIESLSLSSWSKSF 96
 
Name Accession Description Interval E-value
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-201 5.24e-106

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 312.30  E-value: 5.24e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEV 135
Cdd:cd18816   1 KEEILQLHNKLRGQVYPSASNMEYMTWDDELERSAEAWAQQCIWEHGPTSLLPSIGQNLAVHWGRYRSPAFHVQSWYDEV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229267 136 KDYTYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18816  81 KDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNKVGCAVNVCRRMNVWGEIWENAVYLVCNYS 146
LCCL smart00603
LCCL domain;
283-367 9.65e-39

LCCL domain;


Pssm-ID: 128866  Cd Length: 85  Bit Score: 135.60  E-value: 9.65e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    283 QVVHCDTKMKDSCKGSTCNRYQCPAGCLSNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQKN 362
Cdd:smart00603   1 QAVTCDTRGLDLCKPVTDNRVLCPAGCLLEKAKVFGTIVYASLSSICRAAVHAGVISNSGGAVDVVRVGGRENYISSDAN 80


                   ....*
gi 27229267    363 GMESL 367
Cdd:smart00603  81 GIQSE 85
LCCL pfam03815
LCCL domain;
386-485 2.86e-38

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 134.72  E-value: 2.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267   386 VDCHATVAQLCPFEKPATHCPRIQCPARCGEEPsywAPVYGTNIYADTSSICKAAVHAGVIvDEVGGYADVMPVDKKKSY 465
Cdd:pfam03815   1 LSCSTTLLDICNFCPFTGTCFLVRCPANCADEK---ASVYGTDVYSSDSSICKAAIHAGVI-DNSGGLVVVRIVGGQNEY 76

                          90       100
                  ....*....|....*....|
gi 27229267   466 VGSLRNGVQSESLNTPQNGN 485
Cdd:pfam03815  77 TGSTQNGIESLSLSSWSKSF 96
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 54-202 1.72e-37

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 134.44  E-value: 1.72e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267     54 SDRQEILMLHNKLRGQV------YPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGllRSIGQNLAVHWGRYRSPGFH 127
Cdd:smart00198   1 AQQQEILDAHNKLRSQVaggflaAPAASNMLKLTWDCELASSAQNWANQCPFGHSTPR--PGYGENLAWWSSSTALPDTY 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229267    128 ----VQSWYDEVKDYTYPYPHeCTPrcrercSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWgdtwenAVYLVCNYSP 202
Cdd:smart00198  79 asaaVQLWYDEFQDYGYSSNT-CKD------TNGKIGHYTQVVWAKTYKVGCGVANCPDGTKK------KTVVVCNYDP 144
LCCL pfam03815
LCCL domain;
285-376 5.74e-37

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 131.25  E-value: 5.74e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267   285 VHCDTKMKDSCKGS----TCNRYQCPAGCLSNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQ 360
Cdd:pfam03815   1 LSCSTTLLDICNFCpftgTCFLVRCPANCADEKASVYGTDVYSSDSSICKAAIHAGVIDNSGGLVVVRIVGGQNEYTGST 80

                          90
                  ....*....|....*.
gi 27229267   361 KNGMESLSKYKPSSSF 376
Cdd:pfam03815  81 QNGIESLSLSSWSKSF 96
LCCL smart00603
LCCL domain;
385-476 1.44e-30

LCCL domain;


Pssm-ID: 128866  Cd Length: 85  Bit Score: 113.64  E-value: 1.44e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    385 AVDCHATVAQLCpfeKPATHCpRIQCPARCGEEPsywAPVYGTNIYADTSSICKAAVHAGVIvDEVGGYADVMPVDKKKS 464
Cdd:smart00603   2 AVTCDTRGLDLC---KPVTDN-RVLCPAGCLLEK---AKVFGTIVYASLSSICRAAVHAGVI-SNSGGAVDVVRVGGREN 73

                           90
                   ....*....|..
gi 27229267    465 YVGSLRNGVQSE 476
Cdd:smart00603  74 YISSDANGIQSE 85
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 62-200 4.68e-17

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 77.24  E-value: 4.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    62 LHNKLRgqvypPASNMEHMTWDEELERSAAAWAHRClWEHGPAGLLRSIGQNlavHWGRYRSPGFH------------VQ 129
Cdd:pfam00188   3 LHNEYR-----AAAGLPPLSWDNELAAAAQDHAKYC-ADNGSHNHRSPYGGN---IYARVVAAGYAlgdagpdsaedaVD 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229267   130 SWYDEVKDYTypyphectprcrercsgpmCTHYTQMVWATTNKIGCAVHTCRNmnvwgdtwENAVYLVCNY 200
Cdd:pfam00188  74 GWYDSPGTYN-------------------CGHRTNLLWPKSTKVGCAVAKCGD--------GGTYYFVCNY 117
 
Name Accession Description Interval E-value
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-201 5.24e-106

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 312.30  E-value: 5.24e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEV 135
Cdd:cd18816   1 KEEILQLHNKLRGQVYPSASNMEYMTWDDELERSAEAWAQQCIWEHGPTSLLPSIGQNLAVHWGRYRSPAFHVQSWYDEV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229267 136 KDYTYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18816  81 KDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNKVGCAVNVCRRMNVWGEIWENAVYLVCNYS 146
CAP_PI15-like cd18812
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 57-201 1.12e-99

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349406  Cd Length: 146  Bit Score: 296.05  E-value: 1.12e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  57 QEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEVK 136
Cdd:cd18812   2 NAILDYHNKLRGQVYPPAANMEYMVWDKELARSAEAWATQCIWEHGPSSLLRSIGQNLSAHWGRYRSPVFLVKSWYDEVK 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229267 137 DYTYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18812  82 DYLFPYPRDCNPHCPWRCSGPMCTHYTQMVWATSNRIGCAIHTCSNMNVWGNVWHRAVYLVCNYA 146
CAP_CRISPLD1 cd18813
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-201 3.08e-93

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349407  Cd Length: 146  Bit Score: 279.58  E-value: 3.08e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEV 135
Cdd:cd18813   1 MQLILDLHNKLRGQVYPPASNMEYMTWDVELERSAEAWAETCLWEHGPAHLLPSIGQNLGAHWGRYRPPTFHVQAWYDEV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229267 136 KDYTYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18813  81 RDFSYPYPQECNPYCPFRCSGPVCTHYTQVVWATSNRIGCAINLCHNMNVWGQIWPKAIYLVCNYS 146
CAP_PI15 cd18814
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 59-201 7.65e-81

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15; Peptidase inhibitor 15 (PI15) is also called 25 kDa trypsin inhibitor (p25TI), cysteine-rich secretory protein 8 (CRISP-8), or SugarCrisp. It is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. PI15 may also participate in the regulation of drug resistance in ovarian cancer and serve as a potential target in targeted therapies. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349408  Cd Length: 146  Bit Score: 247.61  E-value: 7.65e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  59 ILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEVKDY 138
Cdd:cd18814   4 ILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKPWYDEVKDY 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27229267 139 TYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18814  84 AFPYPQDCNPRCPLRCYGPMCTHYTQMVWATSNRIGCAIHTCHNMNVWGSVWRRAVYLVCNYS 146
CAP_R3HDML cd18815
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 59-201 4.33e-74

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML; Peptidase inhibitor R3HDML, also called cysteine-rich secretory protein R3HDML, is a putative serine protease inhibitor. The R3HDML gene may be associated with clinical dimensions of schizophrenia. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349409  Cd Length: 146  Bit Score: 230.55  E-value: 4.33e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  59 ILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEVKDY 138
Cdd:cd18815   4 LLDYHNRVRSQVFPPAANMEYMVWDERLAKSAEAWAAQCVWEHGPPQLMRYIGQNLSIHSGRYRSIVDLVKSWYDERQHY 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27229267 139 TYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYS 201
Cdd:cd18815  84 SFPHPRECNPRCPSKCSGAVCSHYTQMVWASSNRIGCAVHTCSNINVWGSTWRRATYLVCNYA 146
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-201 2.07e-44

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 152.57  E-value: 2.07e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAglLRSIGQNLAVHWGRYRSPGFHVQSWYDEV 135
Cdd:cd05559   1 KKLLVDLHNQYRSQVSPSAANMLKMTWDTELEALAKAYARKCIWEHNPD--RGRVGENLFASTGKPLDVELAVEDWHNEK 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229267 136 KDYTYPyPHECTPrcrercsGPMCTHYTQMVWATTNKIGCAVHTCRNMNvwGDTWENAVYLVCNYS 201
Cdd:cd05559  79 EYYNFE-TKTCAP-------GKMCGHYTQVVWANTEKIGCGSYFCETLE--GVEWENATLLVCNYE 134
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 56-201 1.08e-41

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 145.68  E-value: 1.08e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQV-------YPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFH- 127
Cdd:cd05380   1 RQEILDAHNELRSKVakgklkgLPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGVGQNLASVSSSGKDLKELi 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27229267 128 ---VQSWYDEVKDYTYPYPHECtprcrerCSGPMCTHYTQMVWATTNKIGCAVHTCrnmnvwGDTWENAVYLVCNYS 201
Cdd:cd05380  81 edaVNAWFDELKDYGFGSNPNN-------NFNSGIGHFTQMVWAKTTKVGCAVARC------PKGGGNKTYVVCNYS 144
LCCL smart00603
LCCL domain;
283-367 9.65e-39

LCCL domain;


Pssm-ID: 128866  Cd Length: 85  Bit Score: 135.60  E-value: 9.65e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    283 QVVHCDTKMKDSCKGSTCNRYQCPAGCLSNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQKN 362
Cdd:smart00603   1 QAVTCDTRGLDLCKPVTDNRVLCPAGCLLEKAKVFGTIVYASLSSICRAAVHAGVISNSGGAVDVVRVGGRENYISSDAN 80


                   ....*
gi 27229267    363 GMESL 367
Cdd:smart00603  81 GIQSE 85
LCCL pfam03815
LCCL domain;
386-485 2.86e-38

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 134.72  E-value: 2.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267   386 VDCHATVAQLCPFEKPATHCPRIQCPARCGEEPsywAPVYGTNIYADTSSICKAAVHAGVIvDEVGGYADVMPVDKKKSY 465
Cdd:pfam03815   1 LSCSTTLLDICNFCPFTGTCFLVRCPANCADEK---ASVYGTDVYSSDSSICKAAIHAGVI-DNSGGLVVVRIVGGQNEY 76

                          90       100
                  ....*....|....*....|
gi 27229267   466 VGSLRNGVQSESLNTPQNGN 485
Cdd:pfam03815  77 TGSTQNGIESLSLSSWSKSF 96
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 54-202 1.72e-37

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 134.44  E-value: 1.72e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267     54 SDRQEILMLHNKLRGQV------YPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGllRSIGQNLAVHWGRYRSPGFH 127
Cdd:smart00198   1 AQQQEILDAHNKLRSQVaggflaAPAASNMLKLTWDCELASSAQNWANQCPFGHSTPR--PGYGENLAWWSSSTALPDTY 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229267    128 ----VQSWYDEVKDYTYPYPHeCTPrcrercSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWgdtwenAVYLVCNYSP 202
Cdd:smart00198  79 asaaVQLWYDEFQDYGYSSNT-CKD------TNGKIGHYTQVVWAKTYKVGCGVANCPDGTKK------KTVVVCNYDP 144
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 58-204 3.35e-37

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 133.69  E-value: 3.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  58 EILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPA--------GLLRSIGQNLAVHWGRYRSPGFHVQ 129
Cdd:cd05385   5 ECVRIHNELRSKVSPPAANMRYMSWDKALAKTARAWARKCKFSHNIClkepgkchPNFTTLGENIWLGSIFSFSVESAIT 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229267 130 SWYDEVKDYTYPYphectprcrERCSGpMCTHYTQMVWATTNKIGCAVHTCRNMnVWGDTWENAVYLVCNYSPKG 204
Cdd:cd05385  85 SWYNEVKDYNFKT---------NSCSR-VCGHYTQVVWADSYKVGCAVHVCPNG-GGFFSGSSSAIFVCNYGPAG 148
LCCL pfam03815
LCCL domain;
285-376 5.74e-37

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 131.25  E-value: 5.74e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267   285 VHCDTKMKDSCKGS----TCNRYQCPAGCLSNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQ 360
Cdd:pfam03815   1 LSCSTTLLDICNFCpftgTCFLVRCPANCADEKASVYGTDVYSSDSSICKAAIHAGVIDNSGGLVVVRIVGGQNEYTGST 80

                          90
                  ....*....|....*.
gi 27229267   361 KNGMESLSKYKPSSSF 376
Cdd:pfam03815  81 QNGIESLSLSSWSKSF 96
LCCL smart00603
LCCL domain;
385-476 1.44e-30

LCCL domain;


Pssm-ID: 128866  Cd Length: 85  Bit Score: 113.64  E-value: 1.44e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    385 AVDCHATVAQLCpfeKPATHCpRIQCPARCGEEPsywAPVYGTNIYADTSSICKAAVHAGVIvDEVGGYADVMPVDKKKS 464
Cdd:smart00603   2 AVTCDTRGLDLC---KPVTDN-RVLCPAGCLLEK---AKVFGTIVYASLSSICRAAVHAGVI-SNSGGAVDVVRVGGREN 73

                           90
                   ....*....|..
gi 27229267    465 YVGSLRNGVQSE 476
Cdd:smart00603  74 YISSDANGIQSE 85
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-202 5.26e-30

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 113.99  E-value: 5.26e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAgLLRSI-----GQNLAVHWGRyRSPGFHVQS 130
Cdd:cd05383   3 QQEIVDLHNALRRSVNPPASNMLKMSWNPEAAENAQRWANRCNFTHSPP-NGRTIpgircGENIFMSSYP-ASWSEVIQA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27229267 131 WYDEVKDYTYPYpHECTPrcrercsGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWgdtwenAVYLVCNYSP 202
Cdd:cd05383  81 WYDEYKDFKYGV-GAKPP-------GSVTGHYTQVVWYSSYLVGCAVAYCPSQGSL------KYFYVCQYCP 138
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 57-212 6.95e-29

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 110.80  E-value: 6.95e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  57 QEILMLHNKLRGQVyppasNMEHMTWDEELERSAAAWAHR----CLWEH--GPagllrsIGQNLAVHWGRYRSPGFHVQS 130
Cdd:cd05381   2 QDFLDAHNQARAAV-----GVPPLVWDDTLAAYAQKYANQrrgdCSLVHsnGP------YGENLFWGSGDNWSPADAVKS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267 131 WYDEVKDYTYPYPHeCTPrcrercsGPMCTHYTQMVWATTNKIGCAVHTCRNmnvwgdtwENAVYLVCNYSPKGNWIGEA 210
Cdd:cd05381  71 WVDEKPYYDYASNT-CVG-------GKMCGHYTQVVWRNSTRLGCARVVCDN--------NGGTFVICNYDPPGNYIGER 134


                ..
gi 27229267 211 PY 212
Cdd:cd05381 135 PY 136
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 57-200 2.62e-28

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 108.86  E-value: 2.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  57 QEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAvhWGRYRSPGFHV-QSWYDEV 135
Cdd:cd00168   2 QEILDLHNSYRSSVSPPASNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQLAGENIA--ASSYDMDGVAAlQAWHNEI 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27229267 136 KDYTYPYPhECTPrcrercsGPMCTHYTQMVWATTNKIGCAVHTCRNmnvwgdtweNAVYLVCNY 200
Cdd:cd00168  80 KNYNFGTA-QPGF-------NSGTGHYTQMVWEKTTKLGCGVADCSD---------NSKFVVCNY 127
CAP_PRY1-like cd05384
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 54-208 1.08e-27

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349403  Cd Length: 129  Bit Score: 107.42  E-value: 1.08e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  54 SDRQEILMLHNKLRgqvyppasnMEH----MTWDEELERSAAAWAHRCL----WEH--GPagllrsIGQNLAVhwGrYRS 123
Cdd:cd05384   1 SFASSILDAHNKKR---------ALHgtqpLTWNDTLAEYAQDYADSYDcsgnLVHsgGP------YGENLAL--G-YSS 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267 124 PGFHVQSWYDEVKDYTYPYPHectprcrercSGPMCTHYTQMVWATTNKIGCAVHTCRnmNVWGDtwenavYLVCNYSPK 203
Cdd:cd05384  63 GAAAVDAWYDEISDYDYSNPG----------FSESTGHFTQLVWKSTTQVGCAYKDCG--GAWGL------YIVCEYDPA 124


                ....*
gi 27229267 204 GNWIG 208
Cdd:cd05384 125 GNVIG 129
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 56-206 7.73e-23

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 93.82  E-value: 7.73e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267  56 RQEILMLHNKLRGQ--VYPpasnmehMTWDEELERSAAAWA-----HRCLwEHGPaglLRSIGQNLAVHWGRYRSPGFH- 127
Cdd:cd05382   3 QKECLKAHNEYRALhgAPP-------LKLDKELSKEAQKWAeklasSGTL-QHSS---PSSYGENLAYFSGSGYDLTGEe 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267 128 -VQSWYDEVKDYTYPYPHectprcrercSGPMCTHYTQMVWATTNKIGCAVhtcrnmnVWGDTweNAVYLVCNYSPKGNW 206
Cdd:cd05382  72 aVDSWYNEIKNYNFNKPG----------FQSGTGHFTQVVWKSSTELGVGV-------AKSKD--GCVYVVARYSPAGNV 132
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 62-200 4.68e-17

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 77.24  E-value: 4.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229267    62 LHNKLRgqvypPASNMEHMTWDEELERSAAAWAHRClWEHGPAGLLRSIGQNlavHWGRYRSPGFH------------VQ 129
Cdd:pfam00188   3 LHNEYR-----AAAGLPPLSWDNELAAAAQDHAKYC-ADNGSHNHRSPYGGN---IYARVVAAGYAlgdagpdsaedaVD 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229267   130 SWYDEVKDYTypyphectprcrercsgpmCTHYTQMVWATTNKIGCAVHTCRNmnvwgdtwENAVYLVCNY 200
Cdd:pfam00188  74 GWYDSPGTYN-------------------CGHRTNLLWPKSTKVGCAVAKCGD--------GGTYYFVCNY 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH