BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTL 85
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNL 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 41056113  86 NLDSWNVKEIHQAADYLKVEEVVTKCKIKME 116
Cdd:cd18217  81 NLDSWNVAEIHQAASYLGMEEVVAKCKIKME 111

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 41056113   345 LKTHVRTHTGERPYKCELCDKGFAQ 369
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 41056113   430 LTYHVRRHTGEKPYVCDTCGKAFA 453
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113 439 GEKPYVCDT--CGKAFAVSSSLITHsRKHtgekpyicGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKK 516
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                ....*.
gi 41056113 517 HKTKVH 522
Cdd:COG5189 417 HRKHSH 422

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTL 85
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNL 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 41056113  86 NLDSWNVKEIHQAADYLKVEEVVTKCKIKME 116
Cdd:cd18217  81 NLDSWNVAEIHQAASYLGMEEVVAKCKIKME 111

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113     25 DCTVVIGEFQFKAHRNVLASFSEYFGAIY----RSTSENNVFLDQsqVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAAD 100
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFssdfKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 41056113    101 YLKVEEVVTKCKIKMEDF 118
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 41056113   316 SLRRHMRIHKGVKPYVCHLCGKAFTQ 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113 354 GERPYKCEL--CDKGFAQKCQLVFHsrMHHGEekpykcdvCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLT 431
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH--MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415

                ....*..
gi 41056113 432 YHvRRHT 438
Cdd:COG5189 416 YH-RKHS 421

FOG: Zn-finger [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113 291 EELDARFSKAKPMCNTCGKVFSEASSLRRHMR--IH--KGVKPYVC--HLCGKAFTQCNQLKTHVRTHTGERPYKCELCd 364
Cdd:COG5048 279 DSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLL- 357

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113 365 kgfaqkcqlvfHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYvcdrcgqrFAQASTLTYHVRRHTGEKPYV 444
Cdd:COG5048 358 -----------NSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN--------FKRDSNLSLHIITHLSFRPYN 418

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 41056113 445 CD--TCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHF 490
Cdd:COG5048 419 CKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 41056113 356 RPYkCELCDKGFAQKCQLVFHSRMHHgeekpYKCDVCNLQFATSSNLKIHA 406
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH-----FKCHICHKKLYTAGGLAVHC 45

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113 439 GEKPYVCDT--CGKAFAVSSSLITHsRKHtgekpyicGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKK 516
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                ....*.
gi 41056113 517 HKTKVH 522
Cdd:COG5189 417 HRKHSH 422

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTL 85
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNL 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 41056113  86 NLDSWNVKEIHQAADYLKVEEVVTKCKIKME 116
Cdd:cd18217  81 NLDSWNVAEIHQAASYLGMEEVVAKCKIKME 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   1 MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENN--VFLDQSQVKADGFQKLLE 78
Cdd:cd18325   1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRdiVHLNSDIVTAPAFSLLLE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 41056113  79 FIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMED 117
Cdd:cd18325  81 FMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKD 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   1 MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENN--VFLDQSQVKADGFQKLLE 78
Cdd:cd18324   1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRdiVHLNSDIVTAPAFALLLE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 41056113  79 FIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIASPSSTE 128
Cdd:cd18324  81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKK 130

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113    14 LNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSE--NNVFLDQSQVKADGFQKLLEFIYTGTLNLDSwN 91
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLDDVSPEDFEALLEFMYTGKLISEE-N 79

                          90       100
                  ....*....|....*....|....
gi 41056113    92 VKEIHQAADYLKVEEVVTKCKIKM 115
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113  23 LCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRS----TSENNVFLDqsQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQA 98
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSgmkeSSSSEIELD--DVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                ....
gi 41056113  99 ADYL 102
Cdd:cd18186  79 ADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIY---RSTSENNVFLDQSQVKADGFQKLLEFIYT 82
Cdd:cd18230   4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqvQKTSDQATVTHLDIVTAQGFKAIIDFMYS 83

                        90       100
                ....*....|....*....|....*....
gi 41056113  83 GTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18230  84 AHLALTSKNVIEVMSAASYLQMTDIVQAC 112

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113     25 DCTVVIGEFQFKAHRNVLASFSEYFGAIY----RSTSENNVFLDQsqVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAAD 100
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFssdfKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 41056113    101 YLKVEEVVTKCKIKMEDF 118
Cdd:smart00225  79 YLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRS-TSENNVFLDQSQ-VKADGFQKLLEFIYTG 83
Cdd:cd18256   3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGgMSESSKDVVQIHgVEPDIFHILLDFIYTG 82

                        90       100
                ....*....|....*....|....*...
gi 41056113  84 TLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18256  83 VVEVTVSNVQELLVAADMLQLTEVVEIC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVfldQSQV------KADGFQKLL 77
Cdd:cd18329   2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETG---QPTVatfdvfSPDTFTIIL 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 41056113  78 EFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCK 112
Cdd:cd18329  79 DFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYrsTSENNVFLDQSQVKADGFQKLLEFIYTG 83
Cdd:cd18216   1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV--LHDNLIHLDQDMVSPTVFQQILDFIYTG 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 41056113  84 TLnLDSW----NVKEIHQAADYLKVEEVVTKCKIKM 115
Cdd:cd18216  79 KL-LDSLfeepNLSEVLAAANYLQLPDLAALCRSKL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTS--ENNVF-LDQSQVkaDGFQKLLEFIYT 82
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSsqKNDVFhLDIKNV--GGIGQILDFMYT 78

                        90       100
                ....*....|....*....|....*....
gi 41056113  83 GTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18233  79 SHLDLNQDNVQVMLDIAQCLQVQNVLNMC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLD-QSQVKADGFQKLLEFIYTGT 84
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSlPEEVTARGFGPLLQFAYTAK 93

                        90       100
                ....*....|....*....|....*..
gi 41056113  85 LNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18278  94 LLLSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYrsTSENNVFLDQSQVKADGFQKLLEFIYTGTL 85
Cdd:cd18333   4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLV--VHDNLINLDHEMVSPGIFRLILDYIYTGRL 81

                        90       100       110
                ....*....|....*....|....*....|....*
gi 41056113  86 N----LDSWNVKEIHQAADYLKVEEVVTKCKIKME 116
Cdd:cd18333  82 SegdpGSEQNLGAVLAAASYLQIPDLVALCKKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113  10 LLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIY----RSTSENNVFLDQSQVKADGFQKLLEFIYTGTL 85
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnynpPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90
                ....*....|....*..
gi 41056113  86 NLDSWNVKEIHQAADYL 102
Cdd:cd18245  81 KLSEDNIQDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTG 83
Cdd:cd18193   2 ANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVRLKPTDIQPDIFSYLLHLMYTG 81

                ..
gi 41056113  84 TL 85
Cdd:cd18193  82 KM 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   3 YSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRS---TSENNVFlDQSQVKADGFQKLLEF 79
Cdd:cd18198   5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSgavVDQQNVY-EIDFVSPEALTALLEF 83

                        90       100       110
                ....*....|....*....|....*....|..
gi 41056113  80 IYTGTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18198  84 AYTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNV-FLD-QSQVKADGFQKLLEFIYTG 83
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVsVINlDPEIEPEGFRILLDFMYTS 81

                        90       100
                ....*....|....*....|....*...
gi 41056113  84 TLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18215  82 RLNLREGNIMAVMATAMYLQMEHVVDTC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIY----RSTSENNVFLDqsQVKADGFQKLLEFIY 81
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFtggmRESSQDEIELK--GVSAKGLKHILDFAY 78

                        90       100       110
                ....*....|....*....|....*....|
gi 41056113  82 TGTLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18255  79 TSELTLDLDCIQDVLGAAVHLQMLPVVELC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRS--TSENNVFLDQSQVKADGFQKLLEFIYTG 83
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSemSEKGKSEVELQGLTASTMEILLDFVYTE 83

                        90       100
                ....*....|....*....|....*...
gi 41056113  84 TLNLDSWNVKEIHQAADYLKVEEVVTKC 111
Cdd:cd18242  84 TVHVTVENVQELLPAACLLQLKGVKQAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41056113   3 YSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLASFSEYFGAIYRSTSennvFLDQSQ------VKADGFQKL 76
Cdd:cd18328   5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGT----LADQPYvyeidfVTPEALSAI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 41056113  77 LEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKME 116
Cdd:cd18328  81 LEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120