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Conserved domains on  [gi|239787080|ref|NP_112234|]
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zinc finger protein 611 isoform a [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 4.24e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.24e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 239787080   24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-698 2.77e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 256 DKQYKCDVCGKLFNHEQYLACHDRCHTVEKPYKC--KECGKTFSQESSLTCHRRLHT-GVKRYNCNECGKIFGQNSALLI 332
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 333 DKAI---DTGENPYKCNECDKAFNQQSQLSHHRIHTGEKPYKceecDKVFSRKSTIETHKRIHTGEKPYRCKvcdTAFTW 409
Cdd:COG5048  111 SSSSsnsNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSK---DPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 410 HSQLARHRRIHTAKKTYKCNECGKTfSHKSSLVCHHRLHGGEKSYKCkvcdkafvwssqlakHTRIDCGEKPYkcNECGK 489
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPL---------------TTNSQLSPKSL--LSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 490 TFGQNSDLLIHKSIHtgeqpYKCDECEKVFSRKSSLETHKIGHTG-EKPYKCKVCDKAFACHSYLAKHTR--IHSGE--K 564
Cdd:COG5048  246 SSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 565 PYKCNE--CSKTFSHRSYLVCHHRVHSGEKPYKC--NECSKTFSRRS--SLHCHRRLHSGEKPYKCNEC--GNTFRHCSS 636
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKR 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 239787080 637 ---LIYHRRLHTGEKS--YKCTICDKAFVRNSLLSRHTRIHTAEKPYkCNECGKAFNQQSHLSRHHR 698
Cdd:COG5048  401 dsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 4.24e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.24e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 239787080   24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-60 5.42e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.40  E-value: 5.42e-18
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 239787080    24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 2.44e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 2.44e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 239787080  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-698 2.77e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 256 DKQYKCDVCGKLFNHEQYLACHDRCHTVEKPYKC--KECGKTFSQESSLTCHRRLHT-GVKRYNCNECGKIFGQNSALLI 332
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 333 DKAI---DTGENPYKCNECDKAFNQQSQLSHHRIHTGEKPYKceecDKVFSRKSTIETHKRIHTGEKPYRCKvcdTAFTW 409
Cdd:COG5048  111 SSSSsnsNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSK---DPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 410 HSQLARHRRIHTAKKTYKCNECGKTfSHKSSLVCHHRLHGGEKSYKCkvcdkafvwssqlakHTRIDCGEKPYkcNECGK 489
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPL---------------TTNSQLSPKSL--LSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 490 TFGQNSDLLIHKSIHtgeqpYKCDECEKVFSRKSSLETHKIGHTG-EKPYKCKVCDKAFACHSYLAKHTR--IHSGE--K 564
Cdd:COG5048  246 SSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 565 PYKCNE--CSKTFSHRSYLVCHHRVHSGEKPYKC--NECSKTFSRRS--SLHCHRRLHSGEKPYKCNEC--GNTFRHCSS 636
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKR 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 239787080 637 ---LIYHRRLHTGEKS--YKCTICDKAFVRNSLLSRHTRIHTAEKPYkCNECGKAFNQQSHLSRHHR 698
Cdd:COG5048  401 dsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
665-689 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 239787080  665 LSRHTRIHTAEKPYKCNECGKAFNQ 689
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 4.24e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.24e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 239787080   24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-60 5.42e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.40  E-value: 5.42e-18
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 239787080    24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 2.44e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 2.44e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 239787080  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-698 2.77e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 256 DKQYKCDVCGKLFNHEQYLACHDRCHTVEKPYKC--KECGKTFSQESSLTCHRRLHT-GVKRYNCNECGKIFGQNSALLI 332
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 333 DKAI---DTGENPYKCNECDKAFNQQSQLSHHRIHTGEKPYKceecDKVFSRKSTIETHKRIHTGEKPYRCKvcdTAFTW 409
Cdd:COG5048  111 SSSSsnsNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSK---DPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 410 HSQLARHRRIHTAKKTYKCNECGKTfSHKSSLVCHHRLHGGEKSYKCkvcdkafvwssqlakHTRIDCGEKPYkcNECGK 489
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPL---------------TTNSQLSPKSL--LSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 490 TFGQNSDLLIHKSIHtgeqpYKCDECEKVFSRKSSLETHKIGHTG-EKPYKCKVCDKAFACHSYLAKHTR--IHSGE--K 564
Cdd:COG5048  246 SSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 565 PYKCNE--CSKTFSHRSYLVCHHRVHSGEKPYKC--NECSKTFSRRS--SLHCHRRLHSGEKPYKCNEC--GNTFRHCSS 636
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKR 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 239787080 637 ---LIYHRRLHTGEKS--YKCTICDKAFVRNSLLSRHTRIHTAEKPYkCNECGKAFNQQSHLSRHHR 698
Cdd:COG5048  401 dsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 339-417 2.17e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 339 GENPYKCN--ECDKAFNQQSQLSHHRIHTGEKPYKCEECDKvfsrkstiETHKRIHTGEKPYRCKVCDTAFTWHSQLARH 416
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 .
gi 239787080 417 R 417
Cdd:COG5189  418 R 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-587 4.09e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 206 NNYGNNPLNSSLLPQKQEvhmreKSFQCNKSGKAFNCSSL--LRKHQIPHLGDKQYKCDvcgKLFNHEQYLACHDR---- 279
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNS---KSLPLSNSKASSSSlsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 280 CHTVEKPYKCKECGKTFSQESSLTCHRRLHT-------------GVKRYNCNE----------CGKIFGQNSALLIDKAI 336
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrnnplpgnnssSVNTPQSNSlhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 337 DTGENPYKCNECDKAFNQQSQLSHHRIHTGEKPYKCEECDKVF-------SRKSTIETHKRIHTGEKPYRCKvCDTAFTW 409
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSL-PTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 410 HSQLARHRRIHTAKKT-YKCNECGKTFSHKSSLVCH--HRLHGGE--KSYKCKV--CDKAFVWSSQLAKHTRIDCGEKPY 482
Cdd:COG5048  273 SSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 483 KC--NECGKTFGQNSD-----LLIHKSIHTGEQPYKCD--ECEKVFSRKSSLETHKIGHTGEKP--YKCKVCDKAFACHS 551
Cdd:COG5048  353 KEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 239787080 552 YLAKHTRIHSgEKPYKCNECSKTFSHRSYLVCHHRV 587
Cdd:COG5048  433 NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
665-689 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 239787080  665 LSRHTRIHTAEKPYKCNECGKAFNQ 689
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 465-589 1.07e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 465 WSSQLAKHTRIDCGEKPYKCNECGKTFGQNSDLLIHKS----IHTGEQPYKCD--ECEKVFSRKSSLETHKI-GHTGEKP 537
Cdd:COG5189  301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPsrmlKVKDGKPYKCPveGCNKKYKNQNGLKYHMLhGHQNQKL 380

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 239787080 538 YKCKVCDKafachsylakHTRIHSGEKPYKCNECSKTFSHRSYLVcHHRVHS 589
Cdd:COG5189  381 HENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK-YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
552-577 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 239787080  552 YLAKHTRIHSGEKPYKCNECSKTFSH 577
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
396-702 2.80e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 396 KPYRCKVCDTAFTWHSQLARHRRIHTAKKTYKCN--ECGKTFSHKSSLVCHHRLHGGEKSYKCkvCDKAFVWSSQLAKHT 473
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 474 RIDCGEKPYKCN-ECGKTFGQNSDLLIHKSIHTGEQPYKCDECEKVFSRKSSLETHKIGHTGEKPYKCKVCDKAFACHSy 552
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 553 lakHTRIHSGEKPYKCNECSKTFSHRSYLVCHHRVHSGEKPYKCNECSKTFSRRSSLHCHRRLHSGEKPYKCNECGNTFR 632
Cdd:COG5048  189 ---SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 633 HCSSLIYHRRLHTGE-------KSYKCTICDKAFVRNSLLSRHTR--IHTAE--KPYKCNE--CGKAFNQQSHLSRHHRI 699
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 ...
gi 239787080 700 HTG 702
Cdd:COG5048  346 HTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
524-549 3.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 239787080  524 SLETHKIGHTGEKPYKCKVCDKAFAC 549
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 562-641 4.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 562 GEKPYKCN--ECSKTFSHRSYLVcHHRVHSgekpykcnECSKTFSRRSSLHCHRRLHSGEKPYKCNECGNTFRHCSSLIY 639
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLK-YHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 239787080 640 HR 641
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-381 6.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.86e-03
                          10        20
                  ....*....|....*....|...
gi 239787080  359 SHHRIHTGEKPYKCEECDKVFSR 381
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 678-700 7.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.02e-03
                          10        20
                  ....*....|....*....|...
gi 239787080  678 YKCNECGKAFNQQSHLSRHHRIH 700
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-365 7.17e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239787080 284 EKPYKCK--ECGKTFSQESSLTCHRrLHtgvkryncNECGKIFGQNSALLIDKAIDTGENPYKCNECDKAFNQQSQLSHH 361
Cdd:COG5189  347 GKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ....
gi 239787080 362 RIHT 365
Cdd:COG5189  418 RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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