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Conserved domains on  [gi|320461717|ref|NP_112453|]
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tenascin-X isoform 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
2908-3117 1.70e-112

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 356.83  E-value: 1.70e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2908 FPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNIS-GEFWLGN 2986
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2987 EALHSLTQAGDYSLRVDLRAGK-EAVFAQYDFFRVDSAKENYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3058
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320461717  3059 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2641-2720 3.42e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.60  E-value: 3.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2641 PRDLQFSDIGETSAKVKWVPPT---SRVDSFKISYQLADGGEPQSVQVDGRTQTQ-ILQGLIPDTRYEVTVVSVRGFEES 2716
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 320461717 2717 EPLT 2720
Cdd:cd00063    84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
1945-2025 1.08e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1945 PQLGELTVTDATPDSLSLSWTVPE---GQFDQFVIQYKNGDGQ--PKVVRVPGHEDQVTISGLEPDHKYKLNLYGIhSGQ 2019
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NGG 79


                   ....*.
gi 320461717  2020 RFGPVS 2025
Cdd:pfam00041   80 GEGPPS 85
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
2582-2886 1.16e-12

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.88  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2582 NPRTLQQRELMVPGVRRSAMLRDLRPGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSDIGETSAKVKWVPP 2661
Cdd:COG3401    66 GLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2662 TSRVDSFKISYQLADGGEPQSVQ------------------VDGRTQTQILQGLIPDTRYEVTVVSVRGFEESEPLTGFL 2723
Cdd:COG3401   146 GLYGVDGANASGTTASSVAGAGVvvspdtsataavattsltVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVS 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2724 ----TTVPDGPTQLRALNLTDGSALLHWKP-PHKPVDKYDVEVESPGAPPLQASAPGSAVDYPLTDLALDTNYTATVRGL 2798
Cdd:COG3401   226 vttpTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2799 RGPNFTSPAS--ITFTTGL---KPPQDLEAKEVTPRTALLTWTE-PEVPPTGYLLSFDT-PGGQIQEILLPAGTTSHRLL 2871
Cdd:COG3401   306 DAAGNESAPSnvVSVTTDLtppAAPSGLTATAVGSSSITLSWTAsSDADVTGYNVYRSTsGGGTYTKIAETVTTTSYTDT 385

                         330
                  ....*....|....*
gi 320461717 2872 RLFPSTFYSAQLRAI 2886
Cdd:COG3401   386 GLTPGTTYYYKVTAV 400
fn3 pfam00041
Fibronectin type III domain;
2334-2409 1.87e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2334 PQPRlgELSVTEETSDSMHLSWS---VAQGPFDSFLVQYKDRDGQ--LQTVSLAADQREVTIEGLQPGRKYKFLLYGLTG 2408
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   .
gi 320461717  2409 G 2409
Cdd:pfam00041   79 G 79
fn3 pfam00041
Fibronectin type III domain;
927-1004 3.35e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   927 PRLGELTVTGLTSDSLLLHWTVPE---GEFDSFLIQYKDKDGPQA---ISVEGPQRSTPISGLEPGRKYKFILYGLIGKK 1000
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 320461717  1001 RHGP 1004
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
830-906 3.52e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   830 PQDLRVVAVTPTTLDLSWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADRTQLTDLMPGVEYVVTVTAERGHAVS 904
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 320461717   905 YP 906
Cdd:pfam00041   83 PP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
2191-2552 1.65e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2191 MVPVSGDLGEVTVSGLEPARKYKFLLFGLKDGKRHGPVST-EAKTVSDAKLLPrlGELTVTDTTQNSVGLSWT-VPEGEF 2268
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvSVTTPTTPPSAP--TGLTATADTPGSVTLSWDpVTESDA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2269 DSFLVQYKNRGGQVQVVPAAADQREVTISSLEPNRKYRFLLFGLIGLKRLGPVSVEGTTAPVEKTPQPRLGeLSVTEETS 2348
Cdd:COG3401   262 TGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPSG-LTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2349 DSMHLSWS-VAQGPFDSFLVQYKDR-DGQLQTVSLAADQREVTIEGLQPGRKYKFllygltggkRLGPISALGVTASEVD 2426
Cdd:COG3401   341 SSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYY---------KVTAVDAAGNESAPSE 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2427 ISAPDHTEPPHAPGLGTLAVTEATPDSLRLSWA-VARGPFDSFVVQYQDTENETQALLVDGDQDKVLISGLEPKTSYKFF 2505
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAaSAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSV 491

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 320461717 2506 LYGLrEGTRHGPVSVEGTTDPVPAGQGPGDPGPRLSQLSVSDVTTSS 2552
Cdd:COG3401   492 TTGS-LVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
1234-1311 2.16e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1234 RELIVTDTTPNSLSLSWTVSE---GQFDQFVIQYKNGDGQ--PKVVRVPGHEDQVTISGLEPDHKYKMNLYGIhSGQRVG 1308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NGGGEG 82


                   ...
gi 320461717  1309 PVS 1311
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
2056-2126 4.71e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 4.71e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  2056 GELTVTGSSPDSLSLSWTVP---QGDFDSFTVQYKDSDG--RPQVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEG 2126
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
737-818 4.90e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 4.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   737 PAIQNMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPMTEGvSPPFTARVPSSASAYDQRGLAPGQDYQVTVRALRGT 813
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 320461717   814 SWGPP 818
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1534-1601 1.94e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 1.94e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320461717  1534 PEPRlgELTVTDVTPDSVGLLWTVPE---GEFDSFTVQYKDRDGQ--PHVVSVAADLREVTIPGLEPSRKYKF 1601
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1342-1412 2.14e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 2.14e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  1342 GELTVTGSSPDSLSLSWTVP---QGDFDSFTVQYKSSDG--RPQVMRVGGQEREVIVRDLDPGHKYKMNLYGLHEG 1412
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1119-1192 2.86e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.86e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  1119 PPRlgELTVTGVTPDSLRLSWT---VARGPFDSFVILYKDAQGQ--PQSVPIEGDENEVTVPGLESNRKYKMNLYGLRG 1192
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2149-2214 9.90e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 9.90e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320461717  2149 PRLGELAAVEVTSSTVHLSWT---VAQGPFDSFLVQYK--DTQGQPQMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1021-1101 1.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1021 SPPRlgELWVTDPTPHSLHLSWTVL---GGQFDSFVVQYRDKEGQP--RVVPVEGPDRSVVISPLDPNRKYRFTLFGIaN 1095
Cdd:cd00063     2 SPPT--NLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-N 78


                  ....*.
gi 320461717 1096 KKRYGP 1101
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1436-1516 1.89e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1436 PRLEELTVTGVTPNSVSLSWIVPE---GQFDSFVVQYQDRDGQ--PREVPLTAEQREVTVLDLDPARIYKMNFYGLHGrR 1510
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-G 79


                   ....*.
gi 320461717  1511 RVGPLS 1516
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1732-1794 2.90e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.90e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717  1732 EELRVTGVTQNSVDLSWTVSE---GQFDSFVVQYKDRDGQS--QVVPVDGSHREVRVSGLDPGRRYKL 1794
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1630-1697 4.92e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 4.92e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717  1630 GAPPRLGelwVTDPTTDSLRLSWTVPE---GHFDSFVVQFKDKSGPRV---VPVKGQERTATITALDAGRKYRF 1697
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 298-325 3.99e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 48.45  E-value: 3.99e-07
                           10        20
                   ....*....|....*....|....*...
gi 320461717   298 CPRGCSQRGRCEDGRCVCDPGYSGEDCS 325
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 360-386 3.55e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 45.75  E-value: 3.55e-06
                           10        20
                   ....*....|....*....|....*..
gi 320461717   360 CPRDCRGRGRCEDGECICDAGYSGDDC 386
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1841-1909 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 4.09e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717 1841 LRVEEATPHSLHLSWVV---TEGEFNSFEVQYTDRDGQ--LRVASTEGDQTDITLTGLESNHRYLITLYGFHDG 1909
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
C_rich_MXAN6577 super family cl49352
MXAN_6577-like cysteine-rich domain;
308-432 2.25e-05

MXAN_6577-like cysteine-rich domain;


The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 46.67  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  308 CEDGRCVCDPGYS--GEDC-SMRT-------CPWDCGDGGRCVDGRCVCWPGYS--GEDC-STRTCPRDCRGRGR----- 369
Cdd:NF041328   14 CPEPGAVCPEGLSvcGGACvDLRSdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAacapg 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  370 --CEDGEC--ICDAGYSgdDCGvRSCPGDCNQRGHCedGRC--VCWPGytgadcstracpRDCRGrGRC 432
Cdd:NF041328   94 qvCEGGACreACSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG------------ESCRG-GAC 144
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 267-293 5.47e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 42.29  E-value: 5.47e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   267 CPRGCSQRGRCENGLCVCNPGYSGEDC 293
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 236-262 8.50e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 41.90  E-value: 8.50e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   236 CPRNCNQRGRCEEGRCVCDPGYSGEDC 262
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 super family cl49352
MXAN_6577-like cysteine-rich domain;
581-690 8.67e-05

MXAN_6577-like cysteine-rich domain;


The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 45.13  E-value: 8.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  581 CSQHG-VCQDGLCMChagyAGEDCSIRTCPADCRRRG-------RCEDGRCVCNPGYT--GPAC-ATRTCPADCRGRGR- 648
Cdd:NF041328   14 CPEPGaVCPEGLSVC----GGACVDLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320461717  649 ------CVQGVCMCYVGYSGEDCGQ-------EEPPASACPGGCGPRELCRAGQC 690
Cdd:NF041328   90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 706-732 9.75e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 41.52  E-value: 9.75e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   706 CPGDCRSRGECIQGRCVCQEGYAGDDC 732
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 484-510 3.02e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 40.36  E-value: 3.02e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   484 CPGDCRGRGRCVDGRCVCNPGFTGEDC 510
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 422-448 6.00e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.59  E-value: 6.00e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   422 CPRDCRGRGRCEDGVCVCHAGYSGEDC 448
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 546-572 8.88e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.82  E-value: 8.88e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   546 CPSDCRGRGQCLNGLCECDEGYSGEDC 572
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 456-479 9.06e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 9.06e-04
                           10        20
                   ....*....|....*....|....*.
gi 320461717   456 DCRGRGNCES--GRCVCWPGYTGRDC 479
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 208-231 1.19e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.19e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   208 DCQGRGRCVK--GVCVCRAGFSGPDC 231
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 177-200 2.72e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 2.72e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   177 DCNDQGRCVR--GRCVCFPGYSGPSC 200
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 515-542 6.16e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.51  E-value: 6.16e-03
                           10        20
                   ....*....|....*....|....*...
gi 320461717   515 CPGDCRGHGHCENGVCVCAVGYSGDDCS 542
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
2908-3117 1.70e-112

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 356.83  E-value: 1.70e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2908 FPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNIS-GEFWLGN 2986
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2987 EALHSLTQAGDYSLRVDLRAGK-EAVFAQYDFFRVDSAKENYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3058
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320461717  3059 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 2908-3117 4.41e-110

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 349.65  E-value: 4.41e-110
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   2908 FPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNISGEFWLGNE 2987
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   2988 ALHSLTQAGDYSLRVDLR-AGKEAVFAQYDFFRVDSAKENYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 3065
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 320461717   3066 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 2907-3117 7.27e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 349.23  E-value: 7.27e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2907 PFPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNISGEFWLGN 2986
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2987 EALHSLTQAGDYSLRVDLRAGK-EAVFAQYDFFRVDSAKENYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 3065
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEDWEgNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717 3066 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2641-2720 3.42e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.60  E-value: 3.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2641 PRDLQFSDIGETSAKVKWVPPT---SRVDSFKISYQLADGGEPQSVQVDGRTQTQ-ILQGLIPDTRYEVTVVSVRGFEES 2716
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 320461717 2717 EPLT 2720
Cdd:cd00063    84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
2640-2718 6.21e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 6.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2640 SPRDLQFSDIGETSAKVKWVPPTSR---VDSFKISYQLADGGEP-QSVQVDGRTQTQILQGLIPDTRYEVTVVSVRGFEE 2715
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 320461717  2716 SEP 2718
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
1945-2025 1.08e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1945 PQLGELTVTDATPDSLSLSWTVPE---GQFDQFVIQYKNGDGQ--PKVVRVPGHEDQVTISGLEPDHKYKLNLYGIhSGQ 2019
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NGG 79


                   ....*.
gi 320461717  2020 RFGPVS 2025
Cdd:pfam00041   80 GEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2582-2886 1.16e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.88  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2582 NPRTLQQRELMVPGVRRSAMLRDLRPGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSDIGETSAKVKWVPP 2661
Cdd:COG3401    66 GLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2662 TSRVDSFKISYQLADGGEPQSVQ------------------VDGRTQTQILQGLIPDTRYEVTVVSVRGFEESEPLTGFL 2723
Cdd:COG3401   146 GLYGVDGANASGTTASSVAGAGVvvspdtsataavattsltVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVS 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2724 ----TTVPDGPTQLRALNLTDGSALLHWKP-PHKPVDKYDVEVESPGAPPLQASAPGSAVDYPLTDLALDTNYTATVRGL 2798
Cdd:COG3401   226 vttpTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2799 RGPNFTSPAS--ITFTTGL---KPPQDLEAKEVTPRTALLTWTE-PEVPPTGYLLSFDT-PGGQIQEILLPAGTTSHRLL 2871
Cdd:COG3401   306 DAAGNESAPSnvVSVTTDLtppAAPSGLTATAVGSSSITLSWTAsSDADVTGYNVYRSTsGGGTYTKIAETVTTTSYTDT 385

                         330
                  ....*....|....*
gi 320461717 2872 RLFPSTFYSAQLRAI 2886
Cdd:COG3401   386 GLTPGTTYYYKVTAV 400
fn3 pfam00041
Fibronectin type III domain;
2334-2409 1.87e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2334 PQPRlgELSVTEETSDSMHLSWS---VAQGPFDSFLVQYKDRDGQ--LQTVSLAADQREVTIEGLQPGRKYKFLLYGLTG 2408
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   .
gi 320461717  2409 G 2409
Cdd:pfam00041   79 G 79
fn3 pfam00041
Fibronectin type III domain;
927-1004 3.35e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   927 PRLGELTVTGLTSDSLLLHWTVPE---GEFDSFLIQYKDKDGPQA---ISVEGPQRSTPISGLEPGRKYKFILYGLIGKK 1000
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 320461717  1001 RHGP 1004
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
830-906 3.52e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   830 PQDLRVVAVTPTTLDLSWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADRTQLTDLMPGVEYVVTVTAERGHAVS 904
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 320461717   905 YP 906
Cdd:pfam00041   83 PP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2191-2552 1.65e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2191 MVPVSGDLGEVTVSGLEPARKYKFLLFGLKDGKRHGPVST-EAKTVSDAKLLPrlGELTVTDTTQNSVGLSWT-VPEGEF 2268
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvSVTTPTTPPSAP--TGLTATADTPGSVTLSWDpVTESDA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2269 DSFLVQYKNRGGQVQVVPAAADQREVTISSLEPNRKYRFLLFGLIGLKRLGPVSVEGTTAPVEKTPQPRLGeLSVTEETS 2348
Cdd:COG3401   262 TGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPSG-LTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2349 DSMHLSWS-VAQGPFDSFLVQYKDR-DGQLQTVSLAADQREVTIEGLQPGRKYKFllygltggkRLGPISALGVTASEVD 2426
Cdd:COG3401   341 SSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYY---------KVTAVDAAGNESAPSE 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2427 ISAPDHTEPPHAPGLGTLAVTEATPDSLRLSWA-VARGPFDSFVVQYQDTENETQALLVDGDQDKVLISGLEPKTSYKFF 2505
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAaSAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSV 491

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 320461717 2506 LYGLrEGTRHGPVSVEGTTDPVPAGQGPGDPGPRLSQLSVSDVTTSS 2552
Cdd:COG3401   492 TTGS-LVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
1234-1311 2.16e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1234 RELIVTDTTPNSLSLSWTVSE---GQFDQFVIQYKNGDGQ--PKVVRVPGHEDQVTISGLEPDHKYKMNLYGIhSGQRVG 1308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NGGGEG 82


                   ...
gi 320461717  1309 PVS 1311
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
2056-2126 4.71e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 4.71e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  2056 GELTVTGSSPDSLSLSWTVP---QGDFDSFTVQYKDSDG--RPQVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEG 2126
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
737-818 4.90e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 4.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   737 PAIQNMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPMTEGvSPPFTARVPSSASAYDQRGLAPGQDYQVTVRALRGT 813
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 320461717   814 SWGPP 818
Cdd:pfam00041   80 GEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1936-2202 9.06e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.72  E-value: 9.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1936 PPTMTPEPrPQlgELTVTDATPDSLSLSWT-VPEGQFDQFVIQYKNGDGQP--KVVRVPGHEdqVTISGLEPDHKYK--- 2009
Cdd:COG3401   228 TPTTPPSA-PT--GLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPftKVATVTTTS--YTDTGLTNGTTYYyrv 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2010 --LNLYGIHSgqrfGPVSTVGVTAAVEEPPSPTepsieapepteepllgELTVTGSSPDSLSLSWT-VPQGDFDSFTVQY 2086
Cdd:COG3401   303 taVDAAGNES----APSNVVSVTTDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYR 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2087 KDS-DGRPQVMRVGGQEREVIVRDLDPGRKYK-----MNLYGLhEGRRVGPVSTVGVTAS---LTTEPPIEPRLGELAAV 2157
Cdd:COG3401   363 STSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAAsgeSLTASVDAVPLTDVAGA 441

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 320461717 2158 EVTSSTVHLSWTVAQGPFDSFLVQYKDTQGQPQMVPVSGDLGEVT 2202
Cdd:COG3401   442 TAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTT 486
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 828-908 1.71e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  828 DGPQDLRVVAVTPTTLDLSWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADRTQ--LTDLMPGVEYVVTVTAERGHA 902
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSytLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 320461717  903 VSYPAS 908
Cdd:cd00063    82 ESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
1534-1601 1.94e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 1.94e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320461717  1534 PEPRlgELTVTDVTPDSVGLLWTVPE---GEFDSFTVQYKDRDGQ--PHVVSVAADLREVTIPGLEPSRKYKF 1601
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1342-1412 2.14e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 2.14e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  1342 GELTVTGSSPDSLSLSWTVP---QGDFDSFTVQYKSSDG--RPQVMRVGGQEREVIVRDLDPGHKYKMNLYGLHEG 1412
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1119-1192 2.86e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.86e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  1119 PPRlgELTVTGVTPDSLRLSWT---VARGPFDSFVILYKDAQGQ--PQSVPIEGDENEVTVPGLESNRKYKMNLYGLRG 1192
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 828-901 5.85e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 5.85e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717    828 DGPQDLRVVAVTPTTLDLSWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADRTQLTDLMPGVEYVVTVTAERGH 901
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn3 pfam00041
Fibronectin type III domain;
2149-2214 9.90e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 9.90e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320461717  2149 PRLGELAAVEVTSSTVHLSWT---VAQGPFDSFLVQYK--DTQGQPQMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2640-2716 1.85e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.85e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   2640 SPRDLQFSDIGETSAKVKWVPPTS-RVDSFKISYQLADGGEP---QSVQVDGRTQTQILQGLIPDTRYEVTVVSVRGFEE 2715
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 320461717   2716 S 2716
Cdd:smart00060   83 G 83
fn3 pfam00041
Fibronectin type III domain;
2444-2517 4.67e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 4.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  2444 LAVTEATPDSLRLSW---AVARGPFDSFVVQYQ--DTENETQALLVDGDQDKVLISGLEPKTSYKFFLYGLREGTRHGP 2517
Cdd:pfam00041    6 LTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1225-1316 6.23e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 6.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1225 PEPPEKpllreLIVTDTTPNSLSLSWTVSE---GQFDQFVIQYKNGDGQP--KVVRVPGHEDQVTISGLEPDHKYKMNLY 1299
Cdd:cd00063     1 PSPPTN-----LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*..
gi 320461717 1300 GIHSGQRVGPVSVVGVT 1316
Cdd:cd00063    76 AVNGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1950-2026 7.72e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 7.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1950 LTVTDATPDSLSLSWTVPE---GQFDQFVIQYKNGDGQP--KVVRVPGHEDQVTISGLEPDHKYKLNLYGIhSGQRFGPV 2024
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NGGGESPP 85


                  ..
gi 320461717 2025 ST 2026
Cdd:cd00063    86 SE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1021-1101 1.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1021 SPPRlgELWVTDPTPHSLHLSWTVL---GGQFDSFVVQYRDKEGQP--RVVPVEGPDRSVVISPLDPNRKYRFTLFGIaN 1095
Cdd:cd00063     2 SPPT--NLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-N 78


                  ....*.
gi 320461717 1096 KKRYGP 1101
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1021-1103 1.49e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 1.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1021 SPPRlgELWVTDPTPHSLHLSWT---VLGGQFDSFVVQYR--DKEGQPRVVPVEGPDRSVVISPLDPNRKYRFTLFGIaN 1095
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-N 77


                   ....*...
gi 320461717  1096 KKRYGPLT 1103
Cdd:pfam00041   78 GGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1436-1516 1.89e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1436 PRLEELTVTGVTPNSVSLSWIVPE---GQFDSFVVQYQDRDGQ--PREVPLTAEQREVTVLDLDPARIYKMNFYGLHGrR 1510
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-G 79


                   ....*.
gi 320461717  1511 RVGPLS 1516
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1019-1100 1.99e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 1.99e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   1019 PGSPPRLgelWVTDPTPHSLHLSWT-----VLGGQFDSFVVQYRDKEGQPRVVPVEGPDRSVVISPLDPNRKYRFTLFGI 1093
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*..
gi 320461717   1094 aNKKRYG 1100
Cdd:smart00060   78 -NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2247-2307 2.28e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 2.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717 2247 LTVTDTTQNSVGLSWTVPE---GEFDSFLVQYKNRGGQ--VQVVPAAADQREVTISSLEPNRKYRF 2307
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
1732-1794 2.90e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.90e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717  1732 EELRVTGVTQNSVDLSWTVSE---GQFDSFVVQYKDRDGQS--QVVPVDGSHREVRVSGLDPGRRYKL 1794
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 920-994 3.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  920 PGKPSvqprlgELTVTGLTSDSLLLHWTVPE---GEFDSFLIQYKDKDGPQAISVE---GPQRSTPISGLEPGRKYKFIL 993
Cdd:cd00063     1 PSPPT------NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRV 74


                  .
gi 320461717  994 Y 994
Cdd:cd00063    75 R 75
fn3 pfam00041
Fibronectin type III domain;
2817-2894 4.50e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 4.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2817 PPQDLEAKEVTPRTALLTWTEPEV---PPTGYLLSFDTPGGQ--IQEILLPAGTTSHRLLRLFPSTFYSAQLRAIWGESL 2891
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 320461717  2892 TPP 2894
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
1630-1697 4.92e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 4.92e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717  1630 GAPPRLGelwVTDPTTDSLRLSWTVPE---GHFDSFVVQFKDKSGPRV---VPVKGQERTATITALDAGRKYRF 1697
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2341-2409 4.93e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 4.93e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717   2341 LSVTEETSDSMHLSWS-----VAQGPFDSFLVQYKDRDGQLQTVSLAADQREVTIEGLQPGRKYKFLLYGLTGG 2409
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1950-2015 5.33e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 5.33e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320461717   1950 LTVTDATPDSLSLSWTVPE-----GQFDQFVIQYKNGDGQPKVVRVPGHEDQVTISGLEPDHKYKLNLYGI 2015
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2341-2409 6.05e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 6.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717 2341 LSVTEETSDSMHLSWSVAQ---GPFDSFLVQYKDRD-GQLQTVSL-AADQREVTIEGLQPGRKYKFLLYGLTGG 2409
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1732-1829 6.35e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1732 EELRVTGVTQNSVDLSWTVSE---GQFDSFVVQYKDRDGQ--SQVVPVDGSHREVRVSGLDPGRRYKlllyglrdskrvg 1806
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE------------- 71

                          90       100
                  ....*....|....*....|...
gi 320461717 1807 pLSVIAVTDPRETTEAWTEVPTT 1829
Cdd:cd00063    72 -FRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2817-2901 8.93e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 8.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2817 PPQDLEAKEVTPRTALLTWTEPE---VPPTGYLLSF-DTPGGQIQEILLPAGT-TSHRLLRLFPSTFYSAQLRAI--WGE 2889
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVEVTPGSeTSYTLTGLKPGTEYEFRVRAVngGGE 82

                          90
                  ....*....|..
gi 320461717 2890 SlTPPVLTSFTT 2901
Cdd:cd00063    83 S-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1623 1.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1541 LTVTDVTPDSVGLLWTVPE---GEFDSFTVQYKDRDGQP--HVVSVAADLREVTIPGLEPSRKYKFLLFGVqDGKRRSQV 1615
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NGGGESPP 85


                  ....*...
gi 320461717 1616 SVEAKTAT 1623
Cdd:cd00063    86 SESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2058-2138 1.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2058 LTVTGSSPDSLSLSWTVPQGD---FDSFTVQYKDSDGRP--QVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEGRRVGPV 2132
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 320461717 2133 STVGVT 2138
Cdd:cd00063    87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2817-2886 1.98e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 1.98e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   2817 PPQDLEAKEVTPRTALLTWTEPEVPP-----TGYLLSFDTPGGQIQEILLPAGTTSHRLLRLFPSTFYSAQLRAI 2886
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2247-2307 2.09e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 2.09e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   2247 LTVTDTTQNSVGLSWTVPE-----GEFDSFLVQYKNRGGQVQVVPAAADQREVTISSLEPNRKYRF 2307
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1344-1423 2.17e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1344 LTVTGSSPDSLSLSWTVPQGD---FDSFTVQYKSSDGRP--QVMRVGGQEREVIVRDLDPGHKYKMNLYGLHEGHRvGPV 1418
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPP 85


                  ....*
gi 320461717 1419 STVGT 1423
Cdd:cd00063    86 SESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1225-1301 2.24e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 2.24e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   1225 PEPPekpllRELIVTDTTPNSLSLSWT-----VSEGQFDQFVIQYKNGDGQPKVVRVPGHEDQVTISGLEPDHKYKMNLY 1299
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ..
gi 320461717   1300 GI 1301
Cdd:smart00060   76 AV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1629-1697 3.71e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 3.71e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717 1629 PGAPprlGELWVTDPTTDSLRLSWTVPE---GHFDSFVVQFKDKSGPRVVPVK---GQERTATITALDAGRKYRF 1697
Cdd:cd00063     1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1119-1202 3.86e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 3.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1119 PPRLGELTVTGVTPDSLRLSWTVAR---GPFDSFVILYKDA-QGQPQSVPIE-GDENEVTVPGLESNRKYKMNLYGLRGR 1193
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ....*....
gi 320461717 1194 QRVGPVSVV 1202
Cdd:cd00063    81 GESPPSESV 89
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 298-325 3.99e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 3.99e-07
                           10        20
                   ....*....|....*....|....*...
gi 320461717   298 CPRGCSQRGRCEDGRCVCDPGYSGEDCS 325
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1601 4.76e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 4.76e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   1541 LTVTDVTPDSVGLLWTVPE-----GEFDSFTVQYKDRDGQPHVVSVAADLREVTIPGLEPSRKYKF 1601
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1732-1794 6.14e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 6.14e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717   1732 EELRVTGVTQNSVDLSWT-----VSEGQFDSFVVQYKDRDGQSQVVPVDGSHREVRVSGLDPGRRYKL 1794
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 737-825 8.67e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  737 PAIQNMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPMTEGVSPPFTARVPSSASaYDQRGLAPGQDYQVTVRALRGT 813
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 320461717  814 SWGPPA-SKTITT 825
Cdd:cd00063    81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1119-1188 1.28e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.28e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   1119 PPRLGELTVTGVTPDSLRLSWT-----VARGPFDSFVILYKDAQGQPQSVPIEGDENEVTVPGLESNRKYKMNLY 1188
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 920-991 1.37e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.37e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717    920 PGKPSvqprlgELTVTGLTSDSLLLHWTVPEGE-FDSFLIQYKDKDGP-----QAISVEGPQRSTPISGLEPGRKYKF 991
Cdd:smart00060    1 PSPPS------NLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2058-2121 1.42e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.42e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717   2058 LTVTGSSPDSLSLSWTVPQGD-----FDSFTVQYKDSDGRPQVMRVGGQEREVIVRDLDPGRKYKMNLY 2121
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1344-1407 1.70e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.70e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717   1344 LTVTGSSPDSLSLSWTVPQGD-----FDSFTVQYKSSDGRPQVMRVGGQEREVIVRDLDPGHKYKMNLY 1407
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1629-1697 1.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 1.96e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   1629 PGAPPRLgelWVTDPTTDSLRLSWTVPE-GHFDSFVVQFKDKSGP-----RVVPVKGQERTATITALDAGRKYRF 1697
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 360-386 3.55e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.75  E-value: 3.55e-06
                           10        20
                   ....*....|....*....|....*..
gi 320461717   360 CPRDCRGRGRCEDGECICDAGYSGDDC 386
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1841-1909 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 4.09e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717 1841 LRVEEATPHSLHLSWVV---TEGEFNSFEVQYTDRDGQ--LRVASTEGDQTDITLTGLESNHRYLITLYGFHDG 1909
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2154-2214 5.17e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 5.17e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   2154 LAAVEVTSSTVHLSWT-----VAQGPFDSFLVQYKDTQGQPQMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2154-2214 1.65e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.65e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717 2154 LAAVEVTSSTVHLSWTVAQ---GPFDSFLVQYKDTQGQP--QMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
1836-1909 1.87e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 1.87e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  1836 PRLGELRVEEATPHSLHLSW---VVTEGEFNSFEVQYTDRDGQLRVA--STEGDQTDITLTGLESNHRYLITLYGFHDG 1909
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNeiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
308-432 2.25e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 46.67  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  308 CEDGRCVCDPGYS--GEDC-SMRT-------CPWDCGDGGRCVDGRCVCWPGYS--GEDC-STRTCPRDCRGRGR----- 369
Cdd:NF041328   14 CPEPGAVCPEGLSvcGGACvDLRSdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAacapg 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  370 --CEDGEC--ICDAGYSgdDCGvRSCPGDCNQRGHCedGRC--VCWPGytgadcstracpRDCRGrGRC 432
Cdd:NF041328   94 qvCEGGACreACSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG------------ESCRG-GAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1433-1500 2.52e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 2.52e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320461717   1433 PLEPRleELTVTGVTPNSVSLSWIVPE-----GQFDSFVVQYQDRDGQPREVPLTAEQREVTVLDLDPARIYK 1500
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 267-293 5.47e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.29  E-value: 5.47e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   267 CPRGCSQRGRCENGLCVCNPGYSGEDC 293
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1439-1501 6.17e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 6.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717 1439 EELTVTGVTPNSVSLSWIVPE---GQFDSFVVQYQDRD-GQPREVPLT-AEQREVTVLDLDPARIYKM 1501
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTpGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1832-1904 7.19e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 7.19e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717   1832 PAAVPRLgelRVEEATPHSLHLSWVVTEGEFN-----SFEVQYTDRDGQLRVASTEGDQTDITLTGLESNHRYLITLY 1904
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDGItgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 236-262 8.50e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.90  E-value: 8.50e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   236 CPRNCNQRGRCEEGRCVCDPGYSGEDC 262
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
581-690 8.67e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 45.13  E-value: 8.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  581 CSQHG-VCQDGLCMChagyAGEDCSIRTCPADCRRRG-------RCEDGRCVCNPGYT--GPAC-ATRTCPADCRGRGR- 648
Cdd:NF041328   14 CPEPGaVCPEGLSVC----GGACVDLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320461717  649 ------CVQGVCMCYVGYSGEDCGQ-------EEPPASACPGGCGPRELCRAGQC 690
Cdd:NF041328   90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 706-732 9.75e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 9.75e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   706 CPGDCRSRGECIQGRCVCQEGYAGDDC 732
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 577-604 1.14e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 1.14e-04
                           10        20
                   ....*....|....*....|....*...
gi 320461717   577 CPRDCSQHGVCQDGLCMCHAGYAGEDCS 604
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 2912-2951 1.16e-04

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 41.78  E-value: 1.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 320461717 2912 CGEELKNGPSA-SKTTTIFLNGNRER-PLDVFCDMETDGGGW 2951
Cdd:NF040941    2 CWEILQAGPSApSGVYWIDPDGMGGLaPFQVYCDMTTDGGGW 43
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 484-510 3.02e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 3.02e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   484 CPGDCRGRGRCVDGRCVCNPGFTGEDC 510
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 329-356 3.71e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 3.71e-04
                           10        20
                   ....*....|....*....|....*...
gi 320461717   329 CPWDCGDGGRCVDGRCVCWPGYSGEDCS 356
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-816 4.76e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 4.76e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717    737 PAIQNMRMHLLEETTVRTEWTRAPGP-VDAYEIQFIPMTEGVSPPF-TARVPSSASAYDQRGLAPGQDYQVTVRALRGTS 814
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 320461717    815 WG 816
Cdd:smart00060   82 EG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 422-448 6.00e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 6.00e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   422 CPRDCRGRGRCEDGVCVCHAGYSGEDC 448
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 546-572 8.88e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 8.88e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   546 CPSDCRGRGQCLNGLCECDEGYSGEDC 572
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 456-479 9.06e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 9.06e-04
                           10        20
                   ....*....|....*....|....*.
gi 320461717   456 DCRGRGNCES--GRCVCWPGYTGRDC 479
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 208-231 1.19e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.19e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   208 DCQGRGRCVK--GVCVCRAGFSGPDC 231
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 177-200 2.72e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 2.72e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   177 DCNDQGRCVR--GRCVCFPGYSGPSC 200
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
249-343 5.49e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 39.74  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  249 GRCVcDPGYSGEDCGvrSCPRGCSQRGRCENGLCVCNPGysGEDCG-----VRNCPRGCSQRG-RCEDGRcVCDPGYSGE 322
Cdd:NF041328   30 GACV-DLRSDPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGACGaACAPGQ-VCEGGACRE 103

                          90       100       110
                  ....*....|....*....|....*....|....
gi 320461717  323 DCS------------MRTCPWDCGD-GGRCVDGR 343
Cdd:NF041328  104 ACSegltrcggacvdLATDPLHCGAcGVACDPGE 137
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 515-542 6.16e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 6.16e-03
                           10        20
                   ....*....|....*....|....*...
gi 320461717   515 CPGDCRGHGHCENGVCVCAVGYSGDDCS 542
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 284-656 7.33e-03

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 42.21  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  284 CNPGYSGEDCgvRNCPRGCSQrgrceDGRCVCDPGYSGEDCSMRTCpwdcgdggrcvdgRCVCWPGYSGEDCSTRTCPRD 363
Cdd:PTZ00214  379 CSAGYLGVDG--KSCSESCSG-----DTRGVCTKVAEGSESTEVSC-------------RCVCKPTFYNSSGTCTPCTDS 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  364 CrgrGRCEDGE---C-ICDAGYSGDDCGVRSCPGDCNQRghcedgrcvCWPGYTGADCS-TRACPRDCRgrgRCED---- 434
Cdd:PTZ00214  439 C---AVCKDGTptgCqQCSPGKILEFSIVSSESADCVDQ---------CSVGSECAECGiTIDGSRYCT---RCKDasty 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  435 ---GVCV--------CHAGYSGedcgvrSCPGdCRGRGNCESGRCVCWPGYTGRDCGTRACPGDC----RGRGRCVDGRC 499
Cdd:PTZ00214  504 pfnGVCIpntqrdayCTSTANG------ACTT-CSGAAFLMNGGCYTTEHYPGSTICDKQSNGKCtttkKGYGISPDGKL 576

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  500 V-CNP---GFTGEDCGS-RRCPGDC---RGHGhCENGVCV----CAVGYSGDD-----CSTRSCP--------SDCRGR- 553
Cdd:PTZ00214  577 LeCDPtclACTAPGPGRcTRCPSDKllkRASG-AATGSCVdpgaCVDGYYADGdaclpCATPGCKtcghasfcTECAGEl 655

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  554 -----GQCLNGLCECDEGYSGEDCGIRRCprdcsqhgVCQDGLCmchAGYAGEDCSIRT-CPADCRRRGRC-EDGRCV-C 625
Cdd:PTZ00214  656 fvsldGQSCLEECTGDKVVGEVSGGVRRC--------WCERGFL---PALDRSGCVLPTeCPPDMPSCAACdESGRCLlC 724

                         410       420       430
                  ....*....|....*....|....*....|.
gi 320461717  626 NPGYTGPACATRTCPADCRGRGRCVQGVCMC 656
Cdd:PTZ00214  725 VTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
2908-3117 1.70e-112

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 356.83  E-value: 1.70e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2908 FPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNIS-GEFWLGN 2986
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2987 EALHSLTQAGDYSLRVDLRAGK-EAVFAQYDFFRVDSAKENYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3058
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320461717  3059 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 2908-3117 4.41e-110

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 349.65  E-value: 4.41e-110
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   2908 FPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNISGEFWLGNE 2987
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   2988 ALHSLTQAGDYSLRVDLR-AGKEAVFAQYDFFRVDSAKENYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 3065
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 320461717   3066 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 2907-3117 7.27e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 349.23  E-value: 7.27e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2907 PFPRDCGEELKNGPSASKTTTIFLNGNReRPLDVFCDMETDGGGWLVFQRRMDGQTDFWRDWEEYAHGFGNISGEFWLGN 2986
Cdd:cd00087     1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2987 EALHSLTQAGDYSLRVDLRAGK-EAVFAQYDFFRVDSAKENYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 3065
Cdd:cd00087    80 EKIHLLTSQGPYELRIDLEDWEgNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717 3066 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYHWKGFEFSVPFTEMKLRPR 3117
Cdd:cd00087   160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2641-2720 3.42e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.60  E-value: 3.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2641 PRDLQFSDIGETSAKVKWVPPT---SRVDSFKISYQLADGGEPQSVQVDGRTQTQ-ILQGLIPDTRYEVTVVSVRGFEES 2716
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....
gi 320461717 2717 EPLT 2720
Cdd:cd00063    84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
2640-2718 6.21e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 6.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2640 SPRDLQFSDIGETSAKVKWVPPTSR---VDSFKISYQLADGGEP-QSVQVDGRTQTQILQGLIPDTRYEVTVVSVRGFEE 2715
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 320461717  2716 SEP 2718
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
1945-2025 1.08e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1945 PQLGELTVTDATPDSLSLSWTVPE---GQFDQFVIQYKNGDGQ--PKVVRVPGHEDQVTISGLEPDHKYKLNLYGIhSGQ 2019
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NGG 79


                   ....*.
gi 320461717  2020 RFGPVS 2025
Cdd:pfam00041   80 GEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2582-2886 1.16e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.88  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2582 NPRTLQQRELMVPGVRRSAMLRDLRPGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSDIGETSAKVKWVPP 2661
Cdd:COG3401    66 GLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2662 TSRVDSFKISYQLADGGEPQSVQ------------------VDGRTQTQILQGLIPDTRYEVTVVSVRGFEESEPLTGFL 2723
Cdd:COG3401   146 GLYGVDGANASGTTASSVAGAGVvvspdtsataavattsltVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVS 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2724 ----TTVPDGPTQLRALNLTDGSALLHWKP-PHKPVDKYDVEVESPGAPPLQASAPGSAVDYPLTDLALDTNYTATVRGL 2798
Cdd:COG3401   226 vttpTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2799 RGPNFTSPAS--ITFTTGL---KPPQDLEAKEVTPRTALLTWTE-PEVPPTGYLLSFDT-PGGQIQEILLPAGTTSHRLL 2871
Cdd:COG3401   306 DAAGNESAPSnvVSVTTDLtppAAPSGLTATAVGSSSITLSWTAsSDADVTGYNVYRSTsGGGTYTKIAETVTTTSYTDT 385

                         330
                  ....*....|....*
gi 320461717 2872 RLFPSTFYSAQLRAI 2886
Cdd:COG3401   386 GLTPGTTYYYKVTAV 400
fn3 pfam00041
Fibronectin type III domain;
2334-2409 1.87e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2334 PQPRlgELSVTEETSDSMHLSWS---VAQGPFDSFLVQYKDRDGQ--LQTVSLAADQREVTIEGLQPGRKYKFLLYGLTG 2408
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   .
gi 320461717  2409 G 2409
Cdd:pfam00041   79 G 79
fn3 pfam00041
Fibronectin type III domain;
927-1004 3.35e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   927 PRLGELTVTGLTSDSLLLHWTVPE---GEFDSFLIQYKDKDGPQA---ISVEGPQRSTPISGLEPGRKYKFILYGLIGKK 1000
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 320461717  1001 RHGP 1004
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
830-906 3.52e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.52e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   830 PQDLRVVAVTPTTLDLSWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADRTQLTDLMPGVEYVVTVTAERGHAVS 904
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 320461717   905 YP 906
Cdd:pfam00041   83 PP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2191-2552 1.65e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2191 MVPVSGDLGEVTVSGLEPARKYKFLLFGLKDGKRHGPVST-EAKTVSDAKLLPrlGELTVTDTTQNSVGLSWT-VPEGEF 2268
Cdd:COG3401   184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvSVTTPTTPPSAP--TGLTATADTPGSVTLSWDpVTESDA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2269 DSFLVQYKNRGGQVQVVPAAADQREVTISSLEPNRKYRFLLFGLIGLKRLGPVSVEGTTAPVEKTPQPRLGeLSVTEETS 2348
Cdd:COG3401   262 TGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPSG-LTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2349 DSMHLSWS-VAQGPFDSFLVQYKDR-DGQLQTVSLAADQREVTIEGLQPGRKYKFllygltggkRLGPISALGVTASEVD 2426
Cdd:COG3401   341 SSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYY---------KVTAVDAAGNESAPSE 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2427 ISAPDHTEPPHAPGLGTLAVTEATPDSLRLSWA-VARGPFDSFVVQYQDTENETQALLVDGDQDKVLISGLEPKTSYKFF 2505
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAaSAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSV 491

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 320461717 2506 LYGLrEGTRHGPVSVEGTTDPVPAGQGPGDPGPRLSQLSVSDVTTSS 2552
Cdd:COG3401   492 TTGS-LVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
1234-1311 2.16e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1234 RELIVTDTTPNSLSLSWTVSE---GQFDQFVIQYKNGDGQ--PKVVRVPGHEDQVTISGLEPDHKYKMNLYGIhSGQRVG 1308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NGGGEG 82


                   ...
gi 320461717  1309 PVS 1311
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
2056-2126 4.71e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 4.71e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  2056 GELTVTGSSPDSLSLSWTVP---QGDFDSFTVQYKDSDG--RPQVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEG 2126
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
737-818 4.90e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 4.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   737 PAIQNMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPMTEGvSPPFTARVPSSASAYDQRGLAPGQDYQVTVRALRGT 813
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 320461717   814 SWGPP 818
Cdd:pfam00041   80 GEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1936-2202 9.06e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.72  E-value: 9.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1936 PPTMTPEPrPQlgELTVTDATPDSLSLSWT-VPEGQFDQFVIQYKNGDGQP--KVVRVPGHEdqVTISGLEPDHKYK--- 2009
Cdd:COG3401   228 TPTTPPSA-PT--GLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPftKVATVTTTS--YTDTGLTNGTTYYyrv 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2010 --LNLYGIHSgqrfGPVSTVGVTAAVEEPPSPTepsieapepteepllgELTVTGSSPDSLSLSWT-VPQGDFDSFTVQY 2086
Cdd:COG3401   303 taVDAAGNES----APSNVVSVTTDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYR 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2087 KDS-DGRPQVMRVGGQEREVIVRDLDPGRKYK-----MNLYGLhEGRRVGPVSTVGVTAS---LTTEPPIEPRLGELAAV 2157
Cdd:COG3401   363 STSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAAsgeSLTASVDAVPLTDVAGA 441

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 320461717 2158 EVTSSTVHLSWTVAQGPFDSFLVQYKDTQGQPQMVPVSGDLGEVT 2202
Cdd:COG3401   442 TAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTT 486
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 828-908 1.71e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  828 DGPQDLRVVAVTPTTLDLSWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADRTQ--LTDLMPGVEYVVTVTAERGHA 902
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSytLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 320461717  903 VSYPAS 908
Cdd:cd00063    82 ESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
1534-1601 1.94e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 1.94e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320461717  1534 PEPRlgELTVTDVTPDSVGLLWTVPE---GEFDSFTVQYKDRDGQ--PHVVSVAADLREVTIPGLEPSRKYKF 1601
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1342-1412 2.14e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 2.14e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  1342 GELTVTGSSPDSLSLSWTVP---QGDFDSFTVQYKSSDG--RPQVMRVGGQEREVIVRDLDPGHKYKMNLYGLHEG 1412
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1119-1192 2.86e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.86e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  1119 PPRlgELTVTGVTPDSLRLSWT---VARGPFDSFVILYKDAQGQ--PQSVPIEGDENEVTVPGLESNRKYKMNLYGLRG 1192
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 828-901 5.85e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 5.85e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717    828 DGPQDLRVVAVTPTTLDLSWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADRTQLTDLMPGVEYVVTVTAERGH 901
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn3 pfam00041
Fibronectin type III domain;
2149-2214 9.90e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 9.90e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320461717  2149 PRLGELAAVEVTSSTVHLSWT---VAQGPFDSFLVQYK--DTQGQPQMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2607-2851 1.28e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.87  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2607 PGTLYSLTL--YGLRGPHK-ADSIQGTARTLSPvlESPRDLQFSDIGETSAKVKWVPPT-SRVDSFKISYQLADGGEPqs 2682
Cdd:COG3401   201 PGTTYYYRVaaTDTGGESApSNEVSVTTPTTPP--SAPTGLTATADTPGSVTLSWDPVTeSDATGYRVYRSNSGDGPF-- 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2683 VQVDGRTQTQIL-QGLIPDTRYEVTVVSVRGFEE----SEPLTGFL-TTVPDGPTQLRALNLTDGSALLHWKPPH-KPVD 2755
Cdd:COG3401   277 TKVATVTTTSYTdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTdLTPPAAPSGLTATAVGSSSITLSWTASSdADVT 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2756 KYDVE-VESPGAPPLQASAPGSAVDYPLTDLALDTNYTATVR-----GLRGPnFTSPASITFTTGLKPPQDLEAKEVTPR 2829
Cdd:COG3401   357 GYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTavdaaGNESA-PSEEVSATTASAASGESLTASVDAVPL 435

                         250       260
                  ....*....|....*....|..
gi 320461717 2830 TALLTWTEPEVPPTGYLLSFDT 2851
Cdd:COG3401   436 TDVAGATAAASAASNPGVSAAV 457
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2640-2716 1.85e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.85e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   2640 SPRDLQFSDIGETSAKVKWVPPTS-RVDSFKISYQLADGGEP---QSVQVDGRTQTQILQGLIPDTRYEVTVVSVRGFEE 2715
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 320461717   2716 S 2716
Cdd:smart00060   83 G 83
fn3 pfam00041
Fibronectin type III domain;
2444-2517 4.67e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 4.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  2444 LAVTEATPDSLRLSW---AVARGPFDSFVVQYQ--DTENETQALLVDGDQDKVLISGLEPKTSYKFFLYGLREGTRHGP 2517
Cdd:pfam00041    6 LTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2538-2620 5.62e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 5.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2538 PRLSQLSVSDVTTSSLRLNWEAPL---GAFDSFLLRFgvpllstleQNPRTLQQ-RELMVPGVRRSAMLRDLRPGTLYSL 2613
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---------RPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEV 71


                   ....*..
gi 320461717  2614 TLYGLRG 2620
Cdd:pfam00041   72 RVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1225-1316 6.23e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 6.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1225 PEPPEKpllreLIVTDTTPNSLSLSWTVSE---GQFDQFVIQYKNGDGQP--KVVRVPGHEDQVTISGLEPDHKYKMNLY 1299
Cdd:cd00063     1 PSPPTN-----LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*..
gi 320461717 1300 GIHSGQRVGPVSVVGVT 1316
Cdd:cd00063    76 AVNGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
2242-2307 6.90e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 6.90e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320461717  2242 PRLGELTVTDTTQNSVGLSWTVPE---GEFDSFLVQYK--NRGGQVQVVPAAADQREVTISSLEPNRKYRF 2307
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1950-2026 7.72e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 7.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1950 LTVTDATPDSLSLSWTVPE---GQFDQFVIQYKNGDGQP--KVVRVPGHEDQVTISGLEPDHKYKLNLYGIhSGQRFGPV 2024
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NGGGESPP 85


                  ..
gi 320461717 2025 ST 2026
Cdd:cd00063    86 SE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1212-1571 1.24e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1212 DQPLSPPEPSTEAPEPPEKPLlrELIVTDTTPNSLSLSWT-VSEGQFDQFVIQYKNGDGQP--KVVRVPGHEdqVTISGL 1288
Cdd:COG3401   217 ESAPSNEVSVTTPTTPPSAPT--GLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPftKVATVTTTS--YTDTGL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1289 EPDHKYK-----MNLYGIHSGqrvgPVSVVGVTAAeeeppsptepsteaPEPTEEPLlgELTVTGSSPDSLSLSWT-VPQ 1362
Cdd:COG3401   293 TNGTTYYyrvtaVDAAGNESA----PSNVVSVTTD--------------LTPPAAPS--GLTATAVGSSSITLSWTaSSD 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1363 GDFDSFTVQYK-SSDGRPQVMRVGGQEREVIVRDLDPGHKYK-----MNLYGLhEGHRVGPVSTVGTTDKQPEekPPLEP 1436
Cdd:COG3401   353 ADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGE--SLTAS 429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1437 RLEELTVTGVTPNSVSLSWIVPEGQFDSFVVQYQDRDGQPREVPLTAEQREVTVLDLDPARIYKmNFYGLHGRRRVGPLS 1516
Cdd:COG3401   430 VDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTT-GSLVGGSGASSVTNS 508

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320461717 1517 VSAMTAPAPATEASKLLPEPRLGELTVTDVTPDSVGLLWTVPEGEFDSFTVQYKD 1571
Cdd:COG3401   509 VSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSG 563
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1021-1101 1.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1021 SPPRlgELWVTDPTPHSLHLSWTVL---GGQFDSFVVQYRDKEGQP--RVVPVEGPDRSVVISPLDPNRKYRFTLFGIaN 1095
Cdd:cd00063     2 SPPT--NLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-N 78


                  ....*.
gi 320461717 1096 KKRYGP 1101
Cdd:cd00063    79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1021-1103 1.49e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 1.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1021 SPPRlgELWVTDPTPHSLHLSWT---VLGGQFDSFVVQYR--DKEGQPRVVPVEGPDRSVVISPLDPNRKYRFTLFGIaN 1095
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-N 77


                   ....*...
gi 320461717  1096 KKRYGPLT 1103
Cdd:pfam00041   78 GGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1436-1516 1.89e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 1.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  1436 PRLEELTVTGVTPNSVSLSWIVPE---GQFDSFVVQYQDRDGQ--PREVPLTAEQREVTVLDLDPARIYKMNFYGLHGrR 1510
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-G 79


                   ....*.
gi 320461717  1511 RVGPLS 1516
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1019-1100 1.99e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 1.99e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   1019 PGSPPRLgelWVTDPTPHSLHLSWT-----VLGGQFDSFVVQYRDKEGQPRVVPVEGPDRSVVISPLDPNRKYRFTLFGI 1093
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*..
gi 320461717   1094 aNKKRYG 1100
Cdd:smart00060   78 -NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2247-2307 2.28e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 2.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717 2247 LTVTDTTQNSVGLSWTVPE---GEFDSFLVQYKNRGGQ--VQVVPAAADQREVTISSLEPNRKYRF 2307
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
1732-1794 2.90e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.90e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717  1732 EELRVTGVTQNSVDLSWTVSE---GQFDSFVVQYKDRDGQS--QVVPVDGSHREVRVSGLDPGRRYKL 1794
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 920-994 3.12e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  920 PGKPSvqprlgELTVTGLTSDSLLLHWTVPE---GEFDSFLIQYKDKDGPQAISVE---GPQRSTPISGLEPGRKYKFIL 993
Cdd:cd00063     1 PSPPT------NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRV 74


                  .
gi 320461717  994 Y 994
Cdd:cd00063    75 R 75
fn3 pfam00041
Fibronectin type III domain;
2817-2894 4.50e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 4.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  2817 PPQDLEAKEVTPRTALLTWTEPEV---PPTGYLLSFDTPGGQ--IQEILLPAGTTSHRLLRLFPSTFYSAQLRAIWGESL 2891
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 320461717  2892 TPP 2894
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
1630-1697 4.92e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 4.92e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717  1630 GAPPRLGelwVTDPTTDSLRLSWTVPE---GHFDSFVVQFKDKSGPRV---VPVKGQERTATITALDAGRKYRF 1697
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2341-2409 4.93e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 4.93e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717   2341 LSVTEETSDSMHLSWS-----VAQGPFDSFLVQYKDRDGQLQTVSLAADQREVTIEGLQPGRKYKFLLYGLTGG 2409
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1950-2015 5.33e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 5.33e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320461717   1950 LTVTDATPDSLSLSWTVPE-----GQFDQFVIQYKNGDGQPKVVRVPGHEDQVTISGLEPDHKYKLNLYGI 2015
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2341-2409 6.05e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 6.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717 2341 LSVTEETSDSMHLSWSVAQ---GPFDSFLVQYKDRD-GQLQTVSL-AADQREVTIEGLQPGRKYKFLLYGLTGG 2409
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1732-1829 6.35e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 6.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1732 EELRVTGVTQNSVDLSWTVSE---GQFDSFVVQYKDRDGQ--SQVVPVDGSHREVRVSGLDPGRRYKlllyglrdskrvg 1806
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE------------- 71

                          90       100
                  ....*....|....*....|...
gi 320461717 1807 pLSVIAVTDPRETTEAWTEVPTT 1829
Cdd:cd00063    72 -FRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2817-2901 8.93e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 8.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2817 PPQDLEAKEVTPRTALLTWTEPE---VPPTGYLLSF-DTPGGQIQEILLPAGT-TSHRLLRLFPSTFYSAQLRAI--WGE 2889
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVEVTPGSeTSYTLTGLKPGTEYEFRVRAVngGGE 82

                          90
                  ....*....|..
gi 320461717 2890 SlTPPVLTSFTT 2901
Cdd:cd00063    83 S-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1623 1.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1541 LTVTDVTPDSVGLLWTVPE---GEFDSFTVQYKDRDGQP--HVVSVAADLREVTIPGLEPSRKYKFLLFGVqDGKRRSQV 1615
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NGGGESPP 85


                  ....*...
gi 320461717 1616 SVEAKTAT 1623
Cdd:cd00063    86 SESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2058-2138 1.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2058 LTVTGSSPDSLSLSWTVPQGD---FDSFTVQYKDSDGRP--QVMRVGGQEREVIVRDLDPGRKYKMNLYGLHEGRRVGPV 2132
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                  ....*.
gi 320461717 2133 STVGVT 2138
Cdd:cd00063    87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2727-2813 1.87e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2727 PDGPTQLRALNLTDGSALLHWKPP---HKPVDKYDVEVESPGAPPLQ--ASAPGSAVDYPLTDLALDTNYTATVRGLRGP 2801
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 320461717 2802 NFTSPA-SITFTT 2813
Cdd:cd00063    81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2817-2886 1.98e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 1.98e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   2817 PPQDLEAKEVTPRTALLTWTEPEVPP-----TGYLLSFDTPGGQIQEILLPAGTTSHRLLRLFPSTFYSAQLRAI 2886
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2247-2307 2.09e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 2.09e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   2247 LTVTDTTQNSVGLSWTVPE-----GEFDSFLVQYKNRGGQVQVVPAAADQREVTISSLEPNRKYRF 2307
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1344-1423 2.17e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1344 LTVTGSSPDSLSLSWTVPQGD---FDSFTVQYKSSDGRP--QVMRVGGQEREVIVRDLDPGHKYKMNLYGLHEGHRvGPV 1418
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPP 85


                  ....*
gi 320461717 1419 STVGT 1423
Cdd:cd00063    86 SESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1225-1301 2.24e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 2.24e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717   1225 PEPPekpllRELIVTDTTPNSLSLSWT-----VSEGQFDQFVIQYKNGDGQPKVVRVPGHEDQVTISGLEPDHKYKMNLY 1299
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ..
gi 320461717   1300 GI 1301
Cdd:smart00060   76 AV 77
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
777-1169 2.83e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  777 VSPPFTARVPSSASAYDQRGLAPGQDYQVTVRALRGTSWGPPASKTITTMIDGPQD----LRVVAVTPTTLDLSWLRPQA 852
Cdd:COG3401    87 APPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYAlgagLYGVDGANASGTTASSVAGA 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  853 EVDRFVVSYVSAGNQRVRLEVPPEADRTQLTDLMPGVEYVVTVTAERGHAVSYPASIRANTDrAQEQPGKPSvqprlgEL 932
Cdd:COG3401   167 GVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTT-PTTPPSAPT------GL 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  933 TVTGLTSDSLLLHWT-VPEGEFDSFLIQYKDKDGPQAISVEGPQRSTPI-SGLEPGRKYKFILYGLIGKKRHGPLMAEAK 1010
Cdd:COG3401   240 TATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTdTGLTNGTTYYYRVTAVDAAGNESAPSNVVS 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1011 ilIQSDPDPGSPPRlgELWVTDPTPHSLHLSWT-VLGGQFDSFVVqYRDK--EGQPRVVPVEGPDRSVVISPLDPNRKYR 1087
Cdd:COG3401   320 --VTTDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYY 394

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1088 FTLFgiankkrygPLTADGTTAAETKEESsepprlGELTVTGVTPDSLRLSWTVARGPFDSFVILYKDAQGQPQSVPIEG 1167
Cdd:COG3401   395 YKVT---------AVDAAGNESAPSEEVS------ATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLA 459


                  ..
gi 320461717 1168 DE 1169
Cdd:COG3401   460 DG 461
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1629-1697 3.71e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 3.71e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717 1629 PGAPprlGELWVTDPTTDSLRLSWTVPE---GHFDSFVVQFKDKSGPRVVPVK---GQERTATITALDAGRKYRF 1697
Cdd:cd00063     1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1119-1202 3.86e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 3.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1119 PPRLGELTVTGVTPDSLRLSWTVAR---GPFDSFVILYKDA-QGQPQSVPIE-GDENEVTVPGLESNRKYKMNLYGLRGR 1193
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                  ....*....
gi 320461717 1194 QRVGPVSVV 1202
Cdd:cd00063    81 GESPPSESV 89
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 298-325 3.99e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 3.99e-07
                           10        20
                   ....*....|....*....|....*...
gi 320461717   298 CPRGCSQRGRCEDGRCVCDPGYSGEDCS 325
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1952-2270 4.54e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.11  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1952 VTDATPDSLSLSWTVPEGQFDQFVIQYKNGDgqpkVVRVPGHEDQV----TISGLEPDHKYKLnLYGIHSGQRFGPvSTV 2027
Cdd:COG4733   431 PVTMEAGDRYLRVRLPDGTSVARTVQSVAGR----TLTVSTAYSETpeagAVWAFGPDELETQ-LFRVVSIEENED-GTY 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2028 GVTAAVEEP---PSPTEPSIE----APEPTEEPLLGELTVT--GSSPDSLSLSWTVPQGDFdSFTVQYKDSDGRPQ-VMR 2097
Cdd:COG4733   505 TITAVQHAPekyAAIDAGAFDdvppQWPPVNVTTSESLSVVaqGTAVTTLTVSWDAPAGAV-AYEVEWRRDDGNWVsVPR 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2098 VGGQEREviVRDLDPGRkYKMNLYGLHE-GRRVGPVSTVGVTASLTTEPPIEPrlgelAAVEVTSST--VHLSWTVAQGP 2174
Cdd:COG4733   584 TSGTSFE--VPGIYAGD-YEVRVRAINAlGVSSAWAASSETTVTGKTAPPPAP-----TGLTATGGLggITLSWSFPVDA 655

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2175 -FDSFLVQYKDTQ--GQPQMVPVSGDLGEVTVSGLEPARKYKFLLFGLKDGKRHGPVSTEAKTVSDAKLLPR--LGELTV 2249
Cdd:COG4733   656 dTLRTEIRYSTTGdwASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGILDaiTGQILE 735

                         330       340
                  ....*....|....*....|.
gi 320461717 2250 TDTTQNSVGLSWTVPEGEFDS 2270
Cdd:COG4733   736 TELGQELDAIIQNATVAEVVA 756
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1601 4.76e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 4.76e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   1541 LTVTDVTPDSVGLLWTVPE-----GEFDSFTVQYKDRDGQPHVVSVAADLREVTIPGLEPSRKYKF 1601
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1395-1652 5.64e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 55.39  E-value: 5.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1395 DLDPGHKYKMNLYGLHEGHRVGPVSTVGTTdkqPEEKPPLEPrlEELTVTGVTPNSVSLSW-IVPEGQFDSFVVQYQDRD 1473
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVT---TPTTPPSAP--TGLTATADTPGSVTLSWdPVTESDATGYRVYRSNSG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1474 GQPREVPLTAEQREVTVLDLDPARIYK-----MNFYGlhgrrrvgplSVSAMTAPAPATEASKLLPEPRlgELTVTDVTP 1548
Cdd:COG3401   273 DGPFTKVATVTTTSYTDTGLTNGTTYYyrvtaVDAAG----------NESAPSNVVSVTTDLTPPAAPS--GLTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1549 DSVGLLWT-VPEGEFDSFTVQYKDR-DGQPHVVSVAADLREVTIPGLEPSRKYKFLLFGVQDGKRRSQVSVEAKTAThdd 1626
Cdd:COG3401   341 SSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATT--- 417

                         250       260
                  ....*....|....*....|....*.
gi 320461717 1627 TSPGAPPRLGELWVTDPTTDSLRLSW 1652
Cdd:COG3401   418 ASAASGESLTASVDAVPLTDVAGATA 443
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1732-1794 6.14e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 6.14e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717   1732 EELRVTGVTQNSVDLSWT-----VSEGQFDSFVVQYKDRDGQSQVVPVDGSHREVRVSGLDPGRRYKL 1794
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2436-2524 6.41e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 6.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2436 PHAPGlgTLAVTEATPDSLRLSWAVAR---GPFDSFVVQYQDTENET--QALLVDGDQDKVLISGLEPKTSYKFFLYGLR 2510
Cdd:cd00063     1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 320461717 2511 EGTRHGPV-SVEGTT 2524
Cdd:cd00063    79 GGGESPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2730-2800 7.22e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 7.22e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717  2730 PTQLRALNLTDGSALLHWKPPHK---PVDKYDVEVESPGA--PPLQASAPGSAVDYPLTDLALDTNYTATVRGLRG 2800
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
750-947 8.64e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.62  E-value: 8.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  750 TTVRTEWTRAPGP-VDAYEIQFIPMTEGvspPFTARVPSSASAYDQRGLAPGQDYQVTVRAL--RGTSWGPPASKTITTM 826
Cdd:COG3401   247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  827 I---DGPQDLRVVAVTPTTLDLSW-LRPQAEVDRFVVsYVSAGNQRVRLEVPPEADRTQLTD--LMPGVEYVVTVTA--E 898
Cdd:COG3401   324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 320461717  899 RGHAVSYPASIRANTDRAQeQPGKPSVQPRLGELTVTGLTSDSLLLHWT 947
Cdd:COG3401   403 AGNESAPSEEVSATTASAA-SGESLTASVDAVPLTDVAGATAAASAASN 450
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 737-825 8.67e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  737 PAIQNMRMHLLEETTVRTEWTRAP---GPVDAYEIQFIPMTEGVSPPFTARVPSSASaYDQRGLAPGQDYQVTVRALRGT 813
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 320461717  814 SWGPPA-SKTITT 825
Cdd:cd00063    81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1119-1188 1.28e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.28e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   1119 PPRLGELTVTGVTPDSLRLSWT-----VARGPFDSFVILYKDAQGQPQSVPIEGDENEVTVPGLESNRKYKMNLY 1188
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 920-991 1.37e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.37e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717    920 PGKPSvqprlgELTVTGLTSDSLLLHWTVPEGE-FDSFLIQYKDKDGP-----QAISVEGPQRSTPISGLEPGRKYKF 991
Cdd:smart00060    1 PSPPS------NLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2058-2121 1.42e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.42e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717   2058 LTVTGSSPDSLSLSWTVPQGD-----FDSFTVQYKDSDGRPQVMRVGGQEREVIVRDLDPGRKYKMNLY 2121
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1344-1407 1.70e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.70e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717   1344 LTVTGSSPDSLSLSWTVPQGD-----FDSFTVQYKSSDGRPQVMRVGGQEREVIVRDLDPGHKYKMNLY 1407
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2391-2563 1.78e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.85  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2391 EGLQPGRKYKFLLYGLTGGKRLGPISALGVTASevdisapdhTEPPHAPGlgTLAVTEATPDSLRLSW-AVARGPFDSFV 2469
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP---------TTPPSAPT--GLTATADTPGSVTLSWdPVTESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 2470 VQYQDTENETQALLVDGDQDKVLISGLEPKTSYKFFLYGLREGTRHGPVS--VEGTTDPVPagqgPGDPgprlSQLSVSD 2547
Cdd:COG3401   266 VYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTP----PAAP----SGLTATA 337

                         170
                  ....*....|....*.
gi 320461717 2548 VTTSSLRLNWEAPLGA 2563
Cdd:COG3401   338 VGSSSITLSWTASSDA 353
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1629-1697 1.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 1.96e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   1629 PGAPPRLgelWVTDPTTDSLRLSWTVPE-GHFDSFVVQFKDKSGP-----RVVPVKGQERTATITALDAGRKYRF 1697
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 360-386 3.55e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.75  E-value: 3.55e-06
                           10        20
                   ....*....|....*....|....*..
gi 320461717   360 CPRDCRGRGRCEDGECICDAGYSGDDC 386
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1841-1909 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 4.09e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320461717 1841 LRVEEATPHSLHLSWVV---TEGEFNSFEVQYTDRDGQ--LRVASTEGDQTDITLTGLESNHRYLITLYGFHDG 1909
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2444-2504 4.78e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 4.78e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   2444 LAVTEATPDSLRLSW-----AVARGPFDSFVVQYQDTENETQALLVDGDQDKVLISGLEPKTSYKF 2504
Cdd:smart00060    7 LRVTDVTSTSVTLSWepppdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2154-2214 5.17e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 5.17e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717   2154 LAAVEVTSSTVHLSWT-----VAQGPFDSFLVQYKDTQGQPQMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2727-2796 7.65e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 7.65e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717   2727 PDGPTQLRALNLTDGSALLHWKPP-----HKPVDKYDVEVESPGAPPLQASAPGSAVDYPLTDLALDTNYTATVR 2796
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2154-2214 1.65e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.65e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320461717 2154 LAAVEVTSSTVHLSWTVAQ---GPFDSFLVQYKDTQGQP--QMVPVSGDLGEVTVSGLEPARKYKF 2214
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2541-2616 1.66e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.66e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320461717   2541 SQLSVSDVTTSSLRLNWEAPLGA-FDSFLLRFgvpllsTLEQNPRTLQQRELMVPGVRRSAMLRDLRPGTLYSLTLY 2616
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1836-1909 1.87e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 1.87e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  1836 PRLGELRVEEATPHSLHLSW---VVTEGEFNSFEVQYTDRDGQLRVA--STEGDQTDITLTGLESNHRYLITLYGFHDG 1909
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNeiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
308-432 2.25e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 46.67  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  308 CEDGRCVCDPGYS--GEDC-SMRT-------CPWDCGDGGRCVDGRCVCWPGYS--GEDC-STRTCPRDCRGRGR----- 369
Cdd:NF041328   14 CPEPGAVCPEGLSvcGGACvDLRSdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAacapg 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717  370 --CEDGEC--ICDAGYSgdDCGvRSCPGDCNQRGHCedGRC--VCWPGytgadcstracpRDCRGrGRC 432
Cdd:NF041328   94 qvCEGGACreACSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG------------ESCRG-GAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1433-1500 2.52e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 2.52e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320461717   1433 PLEPRleELTVTGVTPNSVSLSWIVPE-----GQFDSFVVQYQDRDGQPREVPLTAEQREVTVLDLDPARIYK 1500
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
982-1183 3.33e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  982 GLEPGRKYKFILYGlIGKKRHGPLMAEAKILIQSDPdPGSPprlGELWVTDPTPHSLHLSWT-VLGGQFDSFVVqYRDKE 1060
Cdd:COG3401   198 DIEPGTTYYYRVAA-TDTGGESAPSNEVSVTTPTTP-PSAP---TGLTATADTPGSVTLSWDpVTESDATGYRV-YRSNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1061 GQPRVVPV-EGPDRSVVISPLDPNRKYRFTLFGIANKKRYGPLTAdgTTAAETKEESSEPPRlgELTVTGVTPDSLRLSW 1139
Cdd:COG3401   272 GDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSN--VVSVTTDLTPPAAPS--GLTATAVGSSSITLSW 347

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 320461717 1140 T-VARGPFDSFVILYKDAQ-GQPQSVPIEGDENEVTVPGLESNRKY 1183
Cdd:COG3401   348 TaSSDADVTGYNVYRSTSGgGTYTKIAETVTTTSYTDTGLTPGTTY 393
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1516-1899 4.80e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.23  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1516 SVSAMTAPAPATEASKLLPEPRLGELTVTDVTPDSVGLLWTVPEGEFDSFTVQYKDRDGQPHVVSVAADLREVTIPglep 1595
Cdd:COG3401    37 LVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLT---- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1596 srkYKFLLFGVQDGKRRSQVSVEAKTATHDDTSPGAPPRLGELWVTDPTTDSLrlSWTVPEGHFDSFVVQFKDKSGPRVV 1675
Cdd:COG3401   113 ---SSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASS--VAGAGVVVSPDTSATAAVATTSLTV 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1676 PVKGQERTATITALDAGRKYRFLLYGLLGRKRFGP-LTAEGITE----PTNaadhtksrlgeeLRVTGVTQNSVDLSWT- 1749
Cdd:COG3401   188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNeVSVTTPTTppsaPTG------------LTATADTPGSVTLSWDp 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717 1750 VSEGQFDSFVVQYKDRDGQSQVVPVDGSHREVRVSGLDPGRRYKlllYglrdskrvgplSVIAVtDPRETTEAWTE---V 1826
Cdd:COG3401   256 VTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---Y-----------RVTAV-DAAGNESAPSNvvsV 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320461717 1827 PTTSTPAAVPRlgELRVEEATPHSLHLSW-VVTEGEFNSFEVQY-TDRDGQLRVASTEGDQTDITLTGLESNHRY 1899
Cdd:COG3401   321 TTDLTPPAAPS--GLTATAVGSSSITLSWtASSDADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTY 393
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 267-293 5.47e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.29  E-value: 5.47e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   267 CPRGCSQRGRCENGLCVCNPGYSGEDC 293
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1439-1501 6.17e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 6.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717 1439 EELTVTGVTPNSVSLSWIVPE---GQFDSFVVQYQDRD-GQPREVPLT-AEQREVTVLDLDPARIYKM 1501
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTpGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1832-1904 7.19e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 7.19e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320461717   1832 PAAVPRLgelRVEEATPHSLHLSWVVTEGEFN-----SFEVQYTDRDGQLRVASTEGDQTDITLTGLESNHRYLITLY 1904
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPDDGItgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 236-262 8.50e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.90  E-value: 8.50e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   236 CPRNCNQRGRCEEGRCVCDPGYSGEDC 262
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
581-690 8.67e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 45.13  E-value: 8.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  581 CSQHG-VCQDGLCMChagyAGEDCSIRTCPADCRRRG-------RCEDGRCVCNPGYT--GPAC-ATRTCPADCRGRGR- 648
Cdd:NF041328   14 CPEPGaVCPEGLSVC----GGACVDLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320461717  649 ------CVQGVCMCYVGYSGEDCGQ-------EEPPASACPGGCGPRELCRAGQC 690
Cdd:NF041328   90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 706-732 9.75e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 9.75e-05
                           10        20
                   ....*....|....*....|....*..
gi 320461717   706 CPGDCRSRGECIQGRCVCQEGYAGDDC 732
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 577-604 1.14e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 1.14e-04
                           10        20
                   ....*....|....*....|....*...
gi 320461717   577 CPRDCSQHGVCQDGLCMCHAGYAGEDCS 604
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 2912-2951 1.16e-04

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 41.78  E-value: 1.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 320461717 2912 CGEELKNGPSA-SKTTTIFLNGNRER-PLDVFCDMETDGGGW 2951
Cdd:NF040941    2 CWEILQAGPSApSGVYWIDPDGMGGLaPFQVYCDMTTDGGGW 43
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 484-510 3.02e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 3.02e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   484 CPGDCRGRGRCVDGRCVCNPGFTGEDC 510
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 329-356 3.71e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 3.71e-04
                           10        20
                   ....*....|....*....|....*...
gi 320461717   329 CPWDCGDGGRCVDGRCVCWPGYSGEDCS 356
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-816 4.76e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 4.76e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717    737 PAIQNMRMHLLEETTVRTEWTRAPGP-VDAYEIQFIPMTEGVSPPF-TARVPSSASAYDQRGLAPGQDYQVTVRALRGTS 814
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 320461717    815 WG 816
Cdd:smart00060   82 EG 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 394-417 4.88e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 4.88e-04
                           10        20
                   ....*....|....*....|....*.
gi 320461717   394 DCNQRGHCED--GRCVCWPGYTGADC 417
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 422-448 6.00e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 6.00e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   422 CPRDCRGRGRCEDGVCVCHAGYSGEDC 448
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 487-510 6.24e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 6.24e-04
                           10        20
                   ....*....|....*....|....*.
gi 320461717   487 DCRGRGRCVD--GRCVCNPGFTGEDC 510
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 546-572 8.88e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 8.88e-04
                           10        20
                   ....*....|....*....|....*..
gi 320461717   546 CPSDCRGRGQCLNGLCECDEGYSGEDC 572
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 456-479 9.06e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 9.06e-04
                           10        20
                   ....*....|....*....|....*.
gi 320461717   456 DCRGRGNCES--GRCVCWPGYTGRDC 479
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 208-231 1.19e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.19e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   208 DCQGRGRCVK--GVCVCRAGFSGPDC 231
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 240-262 1.38e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.38e-03
                           10        20
                   ....*....|....*....|....*
gi 320461717   240 CNQRGRCE--EGRCVCDPGYSGEDC 262
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 363-386 1.44e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.44e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   363 DCRGRGRCED--GECICDAGYSGDDC 386
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 302-324 1.67e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.67e-03
                           10        20
                   ....*....|....*....|....*
gi 320461717   302 CSQRGRCED--GRCVCDPGYSGEDC 324
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 391-418 2.19e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 2.19e-03
                           10        20
                   ....*....|....*....|....*...
gi 320461717   391 CPGDCNQRGHCEDGRCVCWPGYTGADCS 418
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 205-232 2.26e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|....*...
gi 320461717   205 CPGDCQGRGRCVKGVCVCRAGFSGPDCS 232
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 177-200 2.72e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 2.72e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   177 DCNDQGRCVR--GRCVCFPGYSGPSC 200
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 639-665 3.09e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 3.09e-03
                           10        20
                   ....*....|....*....|....*..
gi 320461717   639 CPADCRGRGRCVQGVCMCYVGYSGEDC 665
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2541-2616 3.25e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461717 2541 SQLSVSDVTTSSLRLNWEAPL---GAFDSFLLRFGvpllSTLEQNPRTLQQrelmVPGVRRSAMLRDLRPGTLYSLTLY 2616
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYR----EKGSGDWKEVEV----TPGSETSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 271-293 3.58e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 3.58e-03
                           10        20
                   ....*....|....*....|....*
gi 320461717   271 CSQRGRCEN--GLCVCNPGYSGEDC 293
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 549-572 4.53e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.94  E-value: 4.53e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   549 DCRGRGQC--LNGLCECDEGYSGEDC 572
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 425-448 5.15e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 5.15e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   425 DCRGRGRCED--GVCVCHAGYSGEDC 448
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
249-343 5.49e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 39.74  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  249 GRCVcDPGYSGEDCGvrSCPRGCSQRGRCENGLCVCNPGysGEDCG-----VRNCPRGCSQRG-RCEDGRcVCDPGYSGE 322
Cdd:NF041328   30 GACV-DLRSDPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGACGaACAPGQ-VCEGGACRE 103

                          90       100       110
                  ....*....|....*....|....*....|....
gi 320461717  323 DCS------------MRTCPWDCGD-GGRCVDGR 343
Cdd:NF041328  104 ACSegltrcggacvdLATDPLHCGAcGVACDPGE 137
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 515-542 6.16e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 6.16e-03
                           10        20
                   ....*....|....*....|....*...
gi 320461717   515 CPGDCRGHGHCENGVCVCAVGYSGDDCS 542
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 608-635 7.13e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 7.13e-03
                           10        20
                   ....*....|....*....|....*...
gi 320461717   608 CPADCRRRGRCEDGRCVCNPGYTGPACA 635
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 284-656 7.33e-03

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 42.21  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  284 CNPGYSGEDCgvRNCPRGCSQrgrceDGRCVCDPGYSGEDCSMRTCpwdcgdggrcvdgRCVCWPGYSGEDCSTRTCPRD 363
Cdd:PTZ00214  379 CSAGYLGVDG--KSCSESCSG-----DTRGVCTKVAEGSESTEVSC-------------RCVCKPTFYNSSGTCTPCTDS 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  364 CrgrGRCEDGE---C-ICDAGYSGDDCGVRSCPGDCNQRghcedgrcvCWPGYTGADCS-TRACPRDCRgrgRCED---- 434
Cdd:PTZ00214  439 C---AVCKDGTptgCqQCSPGKILEFSIVSSESADCVDQ---------CSVGSECAECGiTIDGSRYCT---RCKDasty 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  435 ---GVCV--------CHAGYSGedcgvrSCPGdCRGRGNCESGRCVCWPGYTGRDCGTRACPGDC----RGRGRCVDGRC 499
Cdd:PTZ00214  504 pfnGVCIpntqrdayCTSTANG------ACTT-CSGAAFLMNGGCYTTEHYPGSTICDKQSNGKCtttkKGYGISPDGKL 576

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  500 V-CNP---GFTGEDCGS-RRCPGDC---RGHGhCENGVCV----CAVGYSGDD-----CSTRSCP--------SDCRGR- 553
Cdd:PTZ00214  577 LeCDPtclACTAPGPGRcTRCPSDKllkRASG-AATGSCVdpgaCVDGYYADGdaclpCATPGCKtcghasfcTECAGEl 655

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461717  554 -----GQCLNGLCECDEGYSGEDCGIRRCprdcsqhgVCQDGLCmchAGYAGEDCSIRT-CPADCRRRGRC-EDGRCV-C 625
Cdd:PTZ00214  656 fvsldGQSCLEECTGDKVVGEVSGGVRRC--------WCERGFL---PALDRSGCVLPTeCPPDMPSCAACdESGRCLlC 724

                         410       420       430
                  ....*....|....*....|....*....|.
gi 320461717  626 NPGYTGPACATRTCPADCRGRGRCVQGVCMC 656
Cdd:PTZ00214  725 VTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 332-355 9.66e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 9.66e-03
                           10        20
                   ....*....|....*....|....*.
gi 320461717   332 DCGDGGRCVD--GRCVCWPGYSGEDC 355
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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