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Conserved domains on  [gi|1937369643|ref|NP_113727|]
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T-cell surface glycoprotein CD8 beta chain precursor [Rattus norvegicus]

Protein Classification

IgV_CD8_beta domain-containing protein( domain architecture ID 10166777)

IgV_CD8_beta domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-134 1.94e-62

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


:

Pssm-ID: 409497  Cd Length: 116  Bit Score: 189.58  E-value: 1.94e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERVK--KNMTLSFNS-TLP 98
Cdd:cd07700     1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKDSHFEFLASWDPSKGIVYGEGVDqeKLIILSDSDsSRY 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1937369643  99 FLKIMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVV 134
Cdd:cd07700    81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
 
Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-134 1.94e-62

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 189.58  E-value: 1.94e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERVK--KNMTLSFNS-TLP 98
Cdd:cd07700     1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKDSHFEFLASWDPSKGIVYGEGVDqeKLIILSDSDsSRY 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1937369643  99 FLKIMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVV 134
Cdd:cd07700    81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-134 1.81e-22

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 87.51  E-value: 1.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKTFP--KGTTIYWLRelQDSNKNKHFEFLASRTSTKGIKYGERVKKNMtlSFNSTLPFLK 101
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYR--QPPGKGPTFLIAYYSNGSEEGVKKGRFSGRG--DPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1937369643 102 IMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVV 134
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-133 6.47e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.36  E-value: 6.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643   26 PSSLLVQTNQTAKMSCEAKTFPKgTTIYWLRELQdsnknkhfeflasrtstKGIKYGERVkknmTLSFNSTLPFLKIMDV 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYKQGG-----------------KLLAESGRF----SVSRSGSTSTLTISNV 58

                           90       100
                   ....*....|....*....|....*...
gi 1937369643  106 KPEDSGFYFCAMVGSPMVVFGtGTKLTV 133
Cdd:smart00410  59 TPEDSGTYTCAATNSSGSASS-GTTLTV 85
 
Name Accession Description Interval E-value
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 22-134 1.94e-62

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 189.58  E-value: 1.94e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERVK--KNMTLSFNS-TLP 98
Cdd:cd07700     1 LLQTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKDSHFEFLASWDPSKGIVYGEGVDqeKLIILSDSDsSRY 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1937369643  99 FLKIMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVV 134
Cdd:cd07700    81 ILSLMSVKPEDSGTYFCMTVGSPELIFGTGTKLSVV 116
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 22-133 6.78e-30

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 106.65  E-value: 6.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQdsnkNKHFEFLASRTSTKGiKYGERVKKNMTLSFNS-TLPFL 100
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKP----GQGPEFLIYLSSSKG-KTKGGVPGRFSGSRDGtSSFSL 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1937369643 101 KIMDVKPEDSGFYFCAMVGSP---MVVFGTGTKLTV 133
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSESGgtdKLTFGSGTRLTV 111
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-134 1.81e-22

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 87.51  E-value: 1.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKTFP--KGTTIYWLRelQDSNKNKHFEFLASRTSTKGIKYGERVKKNMtlSFNSTLPFLK 101
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYR--QPPGKGPTFLIAYYSNGSEEGVKKGRFSGRG--DPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1937369643 102 IMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVV 134
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 24-133 3.89e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 63.06  E-value: 3.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKTFPkGTTIYWLRElqdsNKNKHFEFLASRTSTKGIKYGERVKKNMTLSFNSTLpfLKIM 103
Cdd:cd04983     3 QSPQSLSVQEGENVTLNCNYSTST-FYYLFWYRQ----YPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSS--LHIS 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1937369643 104 DVKPEDSGFYFCAMVGSPM---VVFGTGTKLTV 133
Cdd:cd04983    76 AAQLSDSAVYFCALSESGGtgkLTFGKGTRLTV 108
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 24-133 2.31e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 61.14  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKtfpKG-TTIYWLRelQDSNKNKHF------EFLASRTSTKGIKY-GERVKKnmtlsfns 95
Cdd:cd05899     3 QSPRYLIKRRGQSVTLRCSQK---SGhDNMYWYR--QDPGKGLQLlfysygGGLNEEGDLPGDRFsASRPSL-------- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1937369643  96 TLPFLKIMDVKPEDSGFYFCAmVGSPMVV----FGTGTKLTV 133
Cdd:cd05899    70 TRSSLTIKSAEPEDSAVYLCA-SSLGGGAdeayFGPGTRLTV 110
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-133 6.47e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.36  E-value: 6.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643   26 PSSLLVQTNQTAKMSCEAKTFPKgTTIYWLRELQdsnknkhfeflasrtstKGIKYGERVkknmTLSFNSTLPFLKIMDV 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYKQGG-----------------KLLAESGRF----SVSRSGSTSTLTISNV 58

                           90       100
                   ....*....|....*....|....*...
gi 1937369643  106 KPEDSGFYFCAMVGSPMVVFGtGTKLTV 133
Cdd:smart00410  59 TPEDSGTYTCAATNSSGSASS-GTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
36-116 7.55e-11

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 56.24  E-value: 7.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643   36 TAKMSCEAKTFPK-GTTIYWLRELQDsnknKHFEFLASRTSTKGIKYGERVKK--NMTLSFNSTLPFLKIMDVKPEDSGF 112
Cdd:smart00406   1 SVTLSCKFSGSTFsSYYVSWVRQPPG----KGLEWLGYIGSNGSSYYQESYKGrfTISKDTSKNDVSLTISNLRVEDTGT 76


                   ....
gi 1937369643  113 YFCA 116
Cdd:smart00406  77 YYCA 80
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 23-133 2.59e-10

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 55.78  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  23 LQTPSSLLVQTNQTAKMSCEAKTFP-KGTTIYWLRELQdsnkNKHFEFLASRTSTKG-IKYGERVKKNMTLSFN---STL 97
Cdd:cd04981     2 LQESGPGLVKPGQSLKLSCKASGFTfTSYGMGWVRQAP----GKGLEWIGLIYPGGGdTYYADSFKGRFTITRDtskSTA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1937369643  98 pFLKIMDVKPEDSGFYFCAMVG-----SPMVVFGTGTKLTV 133
Cdd:cd04981    78 -YLQLNSLTSEDTAVYYCARGLggygySYFDYWGQGTTVTV 117
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 23-133 1.72e-09

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 53.23  E-value: 1.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  23 LQTPSSLLVQTNQTAKMSCEAKTFPKGT-TIYWLRELQDSNKNKHFEFLASRTStkGIKygERvkknMTLSFNSTLPFLK 101
Cdd:cd04984     2 LTQPSSLSVSPGETVTITCTGSSGNISGnYVNWYQQKPGSAPRYLIYEDKHRPS--GIP--DR----FSGSKSGNTASLT 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1937369643 102 IMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTV 133
Cdd:cd04984    74 ISGAQTEDEADYYCQVWDSNSYVFGGGTKLTV 105
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 22-133 9.37e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 51.60  E-value: 9.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSC--EAKTFPKgTTIYWLRElqdsNKNKHFEFLASRTSTKGIKY--GERVKK----NMTLSF 93
Cdd:cd04982     1 LEQPQLSITREESKSVTISCkvSGIDFST-TYIHWYRQ----KPGQALERLLYVSSTSAVRKdsGKTKNKfearKDVGKS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1937369643  94 NSTLpflKIMDVKPEDSGFYFCA--MVGSPMV--VFGTGTKLTV 133
Cdd:cd04982    76 TSTL---TITNLEKEDSATYYCAywESGSGYYikVFGSGTKLIV 116
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 22-133 3.58e-07

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 47.00  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRElQDSNKNKHFEFLASRTSTKgikygerVKKNMTLSFNSTLPFLK 101
Cdd:cd04980     3 MTQSPASLSVSPGERVTISCKASQSISSNYLAWYQQ-KPGQAPKLLIYYASTLHSG-------VPSRFSGSGSGTDFTLT 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1937369643 102 IMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTV 133
Cdd:cd04980    75 ISSVEPEDAAVYYCQQGYTFPYTFGGGTKLEI 106
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 24-133 8.99e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 43.28  E-value: 8.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDsnknKHFEFLASRTSTKGIKYGERVKKNMTLSFNSTlpFLKIM 103
Cdd:cd07706     4 QAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQLPS----GEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSI--SLTIS 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1937369643 104 DVKPEDSGFYFCAMVGSP---MVVFGTGTKLTV 133
Cdd:cd07706    78 ALQLEDSAKYFCALSLPYdtdKLIFGKGTRLTV 110
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 24-115 3.47e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 41.03  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQdsnknkhfeflasrtstkGIKYGERVKKNMTLSFNSTLPFLKim 103
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGG------------------TLIESLKVKHDNGRTTQSSLLISN-- 60

                          90
                  ....*....|..
gi 1937369643 104 dVKPEDSGFYFC 115
Cdd:pfam00047  61 -VTKEDAGTYTC 71
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 25-115 1.25e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  25 TPSSLLVQTNQTAKMSCEAKTFPKgTTIYWLRElqdsnknkhfeflasrtstKGIKYGERVKKNMTLSFNSTLpflKIMD 104
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEATGSPP-PTITWYKN-------------------GEPISSGSTRSRSLSGSNSTL---TISN 63

                          90
                  ....*....|.
gi 1937369643 105 VKPEDSGFYFC 115
Cdd:pfam13927  64 VTRSDAGTYTC 74
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 22-133 1.50e-04

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 39.85  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  22 LLQTPSSLLVQTNQTAKMSCEAKT-FPKGTtIYWLR------ELQDSNKNKHFEFLASRT-STKgikygervKKNMTLSf 93
Cdd:cd16097     2 VIQPEKSVSVAAGESATLHCTVTSlIPVGP-IQWFRgagpgrELIYNQKEGHFPRVTTVSdLTK--------RNNMDFS- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1937369643  94 nstlpfLKIMDVKPEDSGFYFCAMV--GSPMVV---FGTGTKLTV 133
Cdd:cd16097    72 ------IRISNITPADAGTYYCVKFrkGSPDDVefkSGAGTELSV 110
IgI_LRIG1-like cd05763
Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like ...
 24-134 1.13e-03

Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains; The members here are composed of subgroup of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. The ectodomain of LRIG1 has two distinct regions: the proposed 15 LRRs and three Ig-like domains closer to the membrane. LRIG1 has been reported to interact with many receptor tyrosine kinases, GDNF/c-Ret, E-cadherin, JAK/STAT, c-Met, and the EGFR family signaling systems. Immunoglobulin Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The structure of the LRIG1 extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of IgSF domains.


Pssm-ID: 409420 [Multi-domain]  Cd Length: 91  Bit Score: 36.83  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  24 QTPSSLLVQTNQTAKMSCEAKTFPKgTTIYWlrelqdsNKNKHFEFLASRtstkgikygERVKKNMTlsfnsTLPFLKIM 103
Cdd:cd05763     4 KTPHDITIRAGSTARLECAATGHPT-PQIAW-------QKDGGTDFPAAR---------ERRMHVMP-----EDDVFFIV 61

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1937369643 104 DVKPEDSGFYFCAMVGSPMVVFGTGTkLTVV 134
Cdd:cd05763    62 DVKIEDTGVYSCTAQNSAGSISANAT-LTVL 91
I-set pfam07679
Immunoglobulin I-set domain;
23-115 2.06e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.08  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937369643  23 LQTPSSLLVQTNQTAKMSCEAKTFPKgTTIYWLRELQDSNKNKHFEFLASRTSTkgikygervkknmtlsfnstlpFLKI 102
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCTVTGTPD-PEVSWFKDGQPLRSSDRFKVTYEGGTY----------------------TLTI 60

                          90
                  ....*....|...
gi 1937369643 103 MDVKPEDSGFYFC 115
Cdd:pfam07679  61 SNVQPDDSGKYTC 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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