|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
99-670 |
0e+00 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 731.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 99 TPQP---PASQEDRsengtdHAQGDYPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927 423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLII 255
Cdd:TIGR00927 497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKV---------TVSEAQAKA-STAGDKEEPTLPN 325
Cdd:TIGR00927 577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGeRTGEEGERPTEAE 656
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 326 KPRLQRGGSSASL------------------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGS 364
Cdd:TIGR00927 657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGE 736
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 365 YGKLKYYDTMTE------------------------EGRFREKASILHKIAKKKCQVDENERQNGAANHVDYAAEKIELP 420
Cdd:TIGR00927 737 EGEEVEDEGEGEaegkhevetegdrketehegeteaEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHE 816
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 421 NSTSTEVEMTPSSEASEPvQNGNLSHSIEAAD-------------------------------APQATETAEEDDDQPLS 469
Cdd:TIGR00927 817 GQSETQADDTEVKDETGE-QELNAENQGEAKQdekgvdggggsdggdseeeeeeeeeeeeeeeEEEEEEEEEEENEEPLS 895
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 470 LSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL 549
Cdd:TIGR00927 896 LEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTIL 975
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 550 AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILS 629
Cdd:TIGR00927 976 AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISS 1055
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 13994179 630 IALCKWRMNKILGFIMFGLYFAFLVVSVLLEDKVLECPVSI 670
Cdd:TIGR00927 1056 IASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
156-655 |
7.83e-40 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 147.97 E-value: 7.83e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 236 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqminrnkvvkvtvseaqakasta 315
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 316 gdkeeptlpnkprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyydtmteegrfrekasilhkiakkkc 395
Cdd:COG0530 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 396 qvdenerqngaanhvdyaaekielpnststevemtpsseasepvqngnlshSIEAADAPQATETAEEDDDQPlslswPSN 475
Cdd:COG0530 126 ---------------------------------------------------IRRARKEPAWEEVEEELEEKP-----KMS 149
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 476 TRKQITFLIVlpivfplwitlpdvrkpaskkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSI 555
Cdd:COG0530 150 LWKALLLLVL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSL 200
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 556 PDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFKPVTVSSNGLFcaiVLLFIMLIFVILSIALC-- 633
Cdd:COG0530 201 PELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLS---FDLPVMLAATLLLLGLLrt 270
|
490 500
....*....|....*....|..
gi 13994179 634 KWRMNKILGFIMFGLYFAFLVV 655
Cdd:COG0530 271 GGRIGRWEGLLLLALYLAYLAL 292
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
139-283 |
1.06e-32 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 123.10 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13994179 219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
538-655 |
4.14e-14 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 73.91 E-value: 4.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 538 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfkpvtvsSNGLFCAIV 617
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------------SPGEINPLA 271
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 13994179 618 L---LFIMLIFVILSIALC---KWRMNKILGFIMFGLYFAFLVV 655
Cdd:PRK10734 272 FsrdYWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
|
|
| 7tm_classC_mGluR-like |
cd13953 |
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ... |
594-659 |
7.68e-03 |
|
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.
Pssm-ID: 320091 [Multi-domain] Cd Length: 251 Bit Score: 38.76 E-value: 7.68e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13994179 594 LLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVIL-------SIALCKWRmnkilgFIMFGLYFAFlVVSVLL 659
Cdd:cd13953 21 WVVFIRYRNTPVVKASNRELSYLLLFGILLCFLLAflfllppSDVLCGLR------RFLFGLSFTL-VFSTLL 86
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
99-670 |
0e+00 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 731.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 99 TPQP---PASQEDRsengtdHAQGDYPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 175
Cdd:TIGR00927 423 SPSPsalPPGQPDL------HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 176 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLII 255
Cdd:TIGR00927 497 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLIL 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 256 FFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKV---------TVSEAQAKA-STAGDKEEPTLPN 325
Cdd:TIGR00927 577 FFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVmalgdlskgDVAEAEHTGeRTGEEGERPTEAE 656
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 326 KPRLQRGGSSASL------------------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGS 364
Cdd:TIGR00927 657 GENGEESGGEAEQegetetkgenesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGE 736
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 365 YGKLKYYDTMTE------------------------EGRFREKASILHKIAKKKCQVDENERQNGAANHVDYAAEKIELP 420
Cdd:TIGR00927 737 EGEEVEDEGEGEaegkhevetegdrketehegeteaEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHE 816
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 421 NSTSTEVEMTPSSEASEPvQNGNLSHSIEAAD-------------------------------APQATETAEEDDDQPLS 469
Cdd:TIGR00927 817 GQSETQADDTEVKDETGE-QELNAENQGEAKQdekgvdggggsdggdseeeeeeeeeeeeeeeEEEEEEEEEEENEEPLS 895
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 470 LSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL 549
Cdd:TIGR00927 896 LEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTIL 975
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 550 AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILS 629
Cdd:TIGR00927 976 AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISS 1055
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 13994179 630 IALCKWRMNKILGFIMFGLYFAFLVVSVLLEDKVLECPVSI 670
Cdd:TIGR00927 1056 IASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
138-652 |
2.09e-96 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 299.24 E-value: 2.09e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 138 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 217
Cdd:TIGR00367 1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 218 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLIMLIIFFLDNVimwWESLLLLTAYFAYVVFMKFNVQVERWVKqminr 297
Cdd:TIGR00367 81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVK----- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 298 nkvvkvtvseaqakastagdkeeptlpnkprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyYDTMTEE 377
Cdd:TIGR00367 151 -------------------------------------------------------------------------YDTYTEE 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 378 grfrekasilhkiakkkcQVDENERqngaanhvdyaaekielpnststevemtpsseasepvqngnlshsieaadapqat 457
Cdd:TIGR00367 158 ------------------NLDENNR------------------------------------------------------- 164
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 458 etaeedddqplslswpsntRKQITFLIVLPIVFplwitlpdvrkpaskkffpitffgsITWIAVFSYLMVWWAHQVGETI 537
Cdd:TIGR00367 165 -------------------RPQIFFSLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEIL 200
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 538 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIihRFKPVTVSSNGLFCAIV 617
Cdd:TIGR00367 201 GISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPI--PVEPLAYNLDAPVMVIV 278
|
490 500 510
....*....|....*....|....*....|....*
gi 13994179 618 LLFIMLIFVIlSIALCKWrmnkiLGFIMFGLYFAF 652
Cdd:TIGR00367 279 TLLLMLFFKT-SMKLGRW-----EGILLLALYIAY 307
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
156-655 |
7.83e-40 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 147.97 E-value: 7.83e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 156 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 235
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 236 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMkfnvqverwvkqminrnkvvkvtvseaqakasta 315
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 316 gdkeeptlpnkprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyydtmteegrfrekasilhkiakkkc 395
Cdd:COG0530 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 396 qvdenerqngaanhvdyaaekielpnststevemtpsseasepvqngnlshSIEAADAPQATETAEEDDDQPlslswPSN 475
Cdd:COG0530 126 ---------------------------------------------------IRRARKEPAWEEVEEELEEKP-----KMS 149
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 476 TRKQITFLIVlpivfplwitlpdvrkpaskkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSI 555
Cdd:COG0530 150 LWKALLLLVL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSL 200
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 556 PDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFKPVTVSSNGLFcaiVLLFIMLIFVILSIALC-- 633
Cdd:COG0530 201 PELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLS---FDLPVMLAATLLLLGLLrt 270
|
490 500
....*....|....*....|..
gi 13994179 634 KWRMNKILGFIMFGLYFAFLVV 655
Cdd:COG0530 271 GGRIGRWEGLLLLALYLAYLAL 292
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
139-283 |
1.06e-32 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 123.10 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 139 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13994179 219 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKF 283
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
507-658 |
5.12e-31 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 118.47 E-value: 5.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 507 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 586
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13994179 587 VGLPLPWLLyTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILSIALckWRMNKILGFIMFGLYFAFLVVSVL 658
Cdd:pfam01699 81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
143-281 |
1.20e-22 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 98.67 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 143 MIYMFIALA--IVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFV 220
Cdd:COG0530 154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13994179 221 IGMCALFSReiLNLTWWPLFRDVSFYIVDLIMLIIFFL-DNVIMWWESLLLLTAYFAYVVFM 281
Cdd:COG0530 234 LGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
530-657 |
1.15e-17 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 84.03 E-value: 1.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 530 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtiihrfkPVTVSS 609
Cdd:COG0530 8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-------PLAVDR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 13994179 610 NGLFCAI-VLLFIMLIFVILSIALckwRMNKILGFIMFGLYFAFLVVSV 657
Cdd:COG0530 81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLI 126
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
130-277 |
1.71e-16 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 80.83 E-value: 1.71e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 130 ERRKG---AIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGI 206
Cdd:TIGR00367 163 NRRPQiffSLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13994179 207 GTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLIMLIIFFLDNVIMWWESLLLLTAYFAY 277
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
97-278 |
1.89e-14 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 77.14 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 97 DYTPQPPASQEDRSENGTDHAQGD----------YPKDVfSLEERRKGAIILHVIgMIYMFIALAIVCDEFfVPSLTVIT 166
Cdd:TIGR00845 28 DHARALTEASSSGSNTGECTGSYYckegvilpiwEPQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRF-MASIEVIT 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 167 EK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNVGIGTIVGSAVFNILFVIGMC 224
Cdd:TIGR00845 105 SQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDLGPSTIVGSAAFNMFIIIAIC 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 225 ALF-----SREILNL------TWWPLFRDVSFYIVdlimlIIFFLDNVIMWWESLLLL-----TAYFAYV 278
Cdd:TIGR00845 184 VYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFfffplCVVFAWV 248
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
538-655 |
4.14e-14 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 73.91 E-value: 4.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 538 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfkpvtvsSNGLFCAIV 617
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI-------------SPGEINPLA 271
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 13994179 618 L---LFIMLIFVILSIALC---KWRMNKILGFIMFGLYFAFLVV 655
Cdd:PRK10734 272 FsrdYWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
533-663 |
2.05e-13 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 71.59 E-value: 2.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 533 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytiihrFKPVTVSSNGL 612
Cdd:TIGR00367 28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 13994179 613 FCAIvlLFIMLIFVILSIALCKWRMNKILGFIMFGLYFAFLVVSVLLEDKV 663
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNERWV 149
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
140-228 |
4.56e-10 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 61.59 E-value: 4.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 140 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 219
Cdd:PRK10734 180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254
|
....*....
gi 13994179 220 VIGMCALFS 228
Cdd:PRK10734 255 VLGLPALIS 263
|
|
| PLN03151 |
PLN03151 |
cation/calcium exchanger; Provisional |
141-657 |
8.26e-10 |
|
cation/calcium exchanger; Provisional
Pssm-ID: 215604 [Multi-domain] Cd Length: 650 Bit Score: 62.09 E-value: 8.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 141 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 218
Cdd:PLN03151 145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 219 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKqminR 297
Cdd:PLN03151 224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHAR----R 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 298 NKVVKVTvseaqakastagdkeePTLPnkprlqrggssaslhnslMRNSIFQlmihtlDPLAEELGSYGKLkyYDTMTEE 377
Cdd:PLN03151 300 LKLDVVT----------------PLLP------------------VQGSIFS------PSVEEDESMYSPL--LESDTES 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 378 GRFREKASILHKIAKKKCQVDENERQNGAANHVD-----YAAEKIELPNSTST--------EVEMTPSSEASEP-VQNGN 443
Cdd:PLN03151 338 DVPRLQTSLPQWMWASNVAIYSNHFAKGSVHDEErppwgWTDEGAEVESSLFScsklfsllEMPLTIPRRLTIPiVEEDR 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 444 LSHSIEAADAPQAtetaeedddqPLSLSWPSNTR-------KQITFLIVLPIVFPLWI-----TLPDvrKPASKKFFPIT 511
Cdd:PLN03151 418 WSKTYAVASASLA----------PVLLAFLWSSQddvslqaRIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWV 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 512 ---FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDI 585
Cdd:PLN03151 486 lggFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNT 564
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13994179 586 TVGLPLPWLLYTIIHRFKPVTV-SSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFAFLVVSV 657
Cdd:PLN03151 565 LVGLGMSMLLGAWSKSPESYMLpEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
526-640 |
1.80e-08 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 56.58 E-value: 1.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 526 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytiihrfKPV 605
Cdd:PRK10734 22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALI-------RPF 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 13994179 606 TVSSN------------GLFCAIVLLFIML-----IFVILSIALCKWRMNKI 640
Cdd:PRK10734 95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
511-642 |
8.81e-06 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 49.02 E-value: 8.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 511 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 589
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13994179 590 PLPWLLYTIIH-------RFKPVTVS-SNGLFCaivllfimlIFVILSIALCKWRMNKILG 642
Cdd:TIGR00845 838 GVAWSIAAIYHaangtqfKVSPGTLAfSVTLFT---------IFAFICIGVLLYRRRPEIG 889
|
|
| caca2 |
TIGR00846 |
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ... |
139-277 |
3.92e-03 |
|
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273297 [Multi-domain] Cd Length: 363 Bit Score: 40.13 E-value: 3.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13994179 139 HVIGMIYMFIALaIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 218
Cdd:TIGR00846 220 AAAWLVGTTIAI-ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIIL 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13994179 219 FVIGMCALFSreilnltwWPLFRDVS--FYIVDLIMLI-------IFFLDNVIMWWESLLLLTAYFAY 277
Cdd:TIGR00846 299 FVVPLVVLVA--------WMLGIPMDlnFGTFETIVLAlslflttITLQDGRSNYLEGAVLLALYIII 358
|
|
| 7tm_classC_mGluR-like |
cd13953 |
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ... |
594-659 |
7.68e-03 |
|
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.
Pssm-ID: 320091 [Multi-domain] Cd Length: 251 Bit Score: 38.76 E-value: 7.68e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13994179 594 LLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVIL-------SIALCKWRmnkilgFIMFGLYFAFlVVSVLL 659
Cdd:cd13953 21 WVVFIRYRNTPVVKASNRELSYLLLFGILLCFLLAflfllppSDVLCGLR------RFLFGLSFTL-VFSTLL 86
|
|
| |
