NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1822620898|ref|NP_114130|]
View 

radial spoke head protein 3 homolog isoform 1 [Homo sapiens]

Protein Classification

radial spoke RSP3 family protein( domain architecture ID 12068743)

radial spoke RSP3 family protein is found in the flagella and cilia of eukaryotic cells, and is a member of the A-kinase anchoring protein (AKAP) family, which anchor protein kinases to specific cellular locations.

Gene Ontology:  GO:2000145|GO:0005929

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 46-326 7.21e-133

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


:

Pssm-ID: 461827  Cd Length: 286  Bit Score: 383.14  E-value: 7.21e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898  46 YGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLR---PQTPEPVEGRKHVDVQTELYLEEI 122
Cdd:pfam06098   1 YGNIMYDRRVVRGNTYASHILPTSAQPDPLEAQREAEARRRALARKRAKEQRRrglLGTPPPVEGRKHIDVQTELYLEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898 123 ADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRA 202
Cdd:pfam06098  81 TDRPPEVDVDTQTDAFLDRPPTPLFVPAKTGIDVETQIEEGDLFDFDTEVQPILEVLVGKTLEQALLEVLEEEELANLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898 203 SQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYD 282
Cdd:pfam06098 161 QQRAFEELRNAELAEVQRLEEQERRLREEKERRIAQQREALKKEKETAEKIAARAFAQGYLSDLLPSVFDSLEDSGYFYD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1822620898 283 PIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRL 326
Cdd:pfam06098 241 PVERDVETEFLPWLMEEVAKELEKRVAARELLDSIIREVVETRL 284
 
Name Accession Description Interval E-value
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 46-326 7.21e-133

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 383.14  E-value: 7.21e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898  46 YGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLR---PQTPEPVEGRKHVDVQTELYLEEI 122
Cdd:pfam06098   1 YGNIMYDRRVVRGNTYASHILPTSAQPDPLEAQREAEARRRALARKRAKEQRRrglLGTPPPVEGRKHIDVQTELYLEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898 123 ADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRA 202
Cdd:pfam06098  81 TDRPPEVDVDTQTDAFLDRPPTPLFVPAKTGIDVETQIEEGDLFDFDTEVQPILEVLVGKTLEQALLEVLEEEELANLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898 203 SQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYD 282
Cdd:pfam06098 161 QQRAFEELRNAELAEVQRLEEQERRLREEKERRIAQQREALKKEKETAEKIAARAFAQGYLSDLLPSVFDSLEDSGYFYD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1822620898 283 PIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRL 326
Cdd:pfam06098 241 PVERDVETEFLPWLMEEVAKELEKRVAARELLDSIIREVVETRL 284
 
Name Accession Description Interval E-value
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 46-326 7.21e-133

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 383.14  E-value: 7.21e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898  46 YGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLR---PQTPEPVEGRKHVDVQTELYLEEI 122
Cdd:pfam06098   1 YGNIMYDRRVVRGNTYASHILPTSAQPDPLEAQREAEARRRALARKRAKEQRRrglLGTPPPVEGRKHIDVQTELYLEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898 123 ADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRA 202
Cdd:pfam06098  81 TDRPPEVDVDTQTDAFLDRPPTPLFVPAKTGIDVETQIEEGDLFDFDTEVQPILEVLVGKTLEQALLEVLEEEELANLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822620898 203 SQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYD 282
Cdd:pfam06098 161 QQRAFEELRNAELAEVQRLEEQERRLREEKERRIAQQREALKKEKETAEKIAARAFAQGYLSDLLPSVFDSLEDSGYFYD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1822620898 283 PIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRL 326
Cdd:pfam06098 241 PVERDVETEFLPWLMEEVAKELEKRVAARELLDSIIREVVETRL 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH