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Conserved domains on  [gi|14196477|ref|NP_114476|]
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protocadherin gamma-A7 isoform 2 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 1.18e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.82  E-value: 1.18e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    31 ILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILM 110
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81


                  ..
gi 14196477   111 ED 112
Cdd:pfam08266  82 EN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 1.25e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.25e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 246 QYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDG- 324
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                        90       100
                ....*....|....*....|
gi 14196477 325 -PGSLTKAKVLITVLDVNDN 343
Cdd:cd11304  79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 1.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 1.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 456 SYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSlaedtIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAH 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14196477 536 DSGDPPLSSNMSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 4.35e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 137 EINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLS---PNRHFSLAVQSGddetkypELVLERVLDREEERVHHLVLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 14196477 214 ASDGGDPPRSSTAHIQVTVVDVNDH 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 355-448 7.01e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 7.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 355 SIPEDTPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKsidNYYRLVTTKNLDRETLSLYNITLKATDGGTPP 431
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 14196477 432 LSRETHIFMQVADTNDN 448
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 2.22e-23

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 94.51  E-value: 2.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   688 DLTLYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASeGGLANVPTSHFVGMDGVQAFLQTYSHEVSLTADSRKSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSS-GNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 14196477   768 LIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 2.82e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 2.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 14196477 658 VTLTVAVAD 666
Cdd:cd11304  86 ATVTITVLD 94
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 1.18e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.82  E-value: 1.18e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    31 ILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILM 110
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81


                  ..
gi 14196477   111 ED 112
Cdd:pfam08266  82 EN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 1.25e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.25e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 246 QYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDG- 324
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                        90       100
                ....*....|....*....|
gi 14196477 325 -PGSLTKAKVLITVLDVNDN 343
Cdd:cd11304  79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 1.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 1.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 456 SYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSlaedtIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAH 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14196477 536 DSGDPPLSSNMSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 4.35e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 137 EINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLS---PNRHFSLAVQSGddetkypELVLERVLDREEERVHHLVLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 14196477 214 ASDGGDPPRSSTAHIQVTVVDVNDH 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 355-448 7.01e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 7.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 355 SIPEDTPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKsidNYYRLVTTKNLDRETLSLYNITLKATDGGTPP 431
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 14196477 432 LSRETHIFMQVADTNDN 448
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 2.22e-23

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 94.51  E-value: 2.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   688 DLTLYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASeGGLANVPTSHFVGMDGVQAFLQTYSHEVSLTADSRKSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSS-GNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 14196477   768 LIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 2.82e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 2.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 14196477 658 VTLTVAVAD 666
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 3.37e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 3.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    475 TAQDHDSEDNAQITYSlaedtIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYS-----ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 14196477    555 QNDNPP 560
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
247-338 2.78e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 2.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   247 YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD--G 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsgG 78

                          90
                  ....*....|....
gi 14196477   325 PGSLTKAKVLITVL 338
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 4.40e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 4.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    265 HAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTATVTITVLDVND 78


                   ...
gi 14196477    343 NAP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 2.55e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    157 AGDPDVGTNSLQSYQLSPN---RHFSLavqsgDDETKypELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVV 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSI-----DPETG--EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 14196477    234 DVNDHTP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
457-553 9.82e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 9.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   457 YSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDtiqgaPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 14196477   537 SGDPPLSSNMSLSLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-450 3.98e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 3.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    373 DRDSGKNGEVTCTI---PENLPFKLEKSIDnyyRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNP 449
Cdd:smart00112   4 DADSGENGKVTYSIlsgNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 14196477    450 P 450
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-666 8.48e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 8.48e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14196477    592 VAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
579-664 1.53e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 14196477   658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
138-232 3.86e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 3.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   138 INVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLS---PNRHFSLAVQSGDdetkypeLVLERVLDREEERVHHLVLTA 214
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEA 73

                          90
                  ....*....|....*...
gi 14196477   215 SDGGDPPRSSTAHIQVTV 232
Cdd:pfam00028  74 TDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
355-438 7.25e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   355 SIPEDTPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKSIDnyyRLVTTKNLDRETLSLYNITLKATDGGTPP 431
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPP 80


                  ....*..
gi 14196477   432 LSRETHI 438
Cdd:pfam00028  81 LSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 3.32e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.93  E-value: 3.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477  33 YSVSEETDKGSFVGDI-AKDLGLEPreLAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEicaqsaRCLVNFNILME 111
Cdd:cd11304   4 VSVPENAPPGTVVLTVsATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE------QSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14196477 112 DKMNLY-----PIDVEIIDINDN 129
Cdd:cd11304  76 DGGGPPlsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 6.49e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 6.49e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14196477     65 RIISRGRTQLFALNQRSGSLVTAGRIDREEicaqsaRCLVNFNILMEDKMNLY-----PIDVEIIDINDNVP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEATDGGGPPlsstaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 1.18e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.82  E-value: 1.18e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    31 ILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILM 110
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81


                  ..
gi 14196477   111 ED 112
Cdd:pfam08266  82 EN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 1.25e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.25e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 246 QYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDG- 324
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                        90       100
                ....*....|....*....|
gi 14196477 325 -PGSLTKAKVLITVLDVNDN 343
Cdd:cd11304  79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 1.07e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 1.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 456 SYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSlaedtIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAH 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14196477 536 DSGDPPLSSNMSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 4.35e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 4.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 137 EINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLS---PNRHFSLAVQSGddetkypELVLERVLDREEERVHHLVLT 213
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                        90       100
                ....*....|....*....|....*
gi 14196477 214 ASDGGDPPRSSTAHIQVTVVDVNDH 238
Cdd:cd11304  74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 355-448 7.01e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 7.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 355 SIPEDTPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKsidNYYRLVTTKNLDRETLSLYNITLKATDGGTPP 431
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 14196477 432 LSRETHIFMQVADTNDN 448
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 2.22e-23

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 94.51  E-value: 2.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   688 DLTLYLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASeGGLANVPTSHFVGMDGVQAFLQTYSHEVSLTADSRKSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSS-GNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 14196477   768 LIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 2.82e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 2.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 14196477 658 VTLTVAVAD 666
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 3.37e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 3.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    475 TAQDHDSEDNAQITYSlaedtIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYS-----ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 14196477    555 QNDNPP 560
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
247-338 2.78e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 2.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   247 YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD--G 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsgG 78

                          90
                  ....*....|....
gi 14196477   325 PGSLTKAKVLITVL 338
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 4.40e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 4.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    265 HAIDLDEGVNGEVTYSFrkITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTATVTITVLDVND 78


                   ...
gi 14196477    343 NAP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 2.55e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    157 AGDPDVGTNSLQSYQLSPN---RHFSLavqsgDDETKypELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVV 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSI-----DPETG--EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 14196477    234 DVNDHTP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
457-553 9.82e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 9.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   457 YSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDtiqgaPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 14196477   537 SGDPPLSSNMSLSLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-450 3.98e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 3.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477    373 DRDSGKNGEVTCTI---PENLPFKLEKSIDnyyRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNP 449
Cdd:smart00112   4 DADSGENGKVTYSIlsgNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 14196477    450 P 450
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-666 8.48e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 8.48e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14196477    592 VAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
579-664 1.53e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 14196477   658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
138-232 3.86e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 3.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   138 INVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLS---PNRHFSLAVQSGDdetkypeLVLERVLDREEERVHHLVLTA 214
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEA 73

                          90
                  ....*....|....*...
gi 14196477   215 SDGGDPPRSSTAHIQVTV 232
Cdd:pfam00028  74 TDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
355-438 7.25e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477   355 SIPEDTPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKSIDnyyRLVTTKNLDRETLSLYNITLKATDGGTPP 431
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPP 80


                  ....*..
gi 14196477   432 LSRETHI 438
Cdd:pfam00028  81 LSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 3.32e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.93  E-value: 3.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477  33 YSVSEETDKGSFVGDI-AKDLGLEPreLAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEicaqsaRCLVNFNILME 111
Cdd:cd11304   4 VSVPENAPPGTVVLTVsATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE------QSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 14196477 112 DKMNLY-----PIDVEIIDINDN 129
Cdd:cd11304  76 DGGGPPlsstaTVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 5.06e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.49  E-value: 5.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14196477  33 YSVSEETDKGSFVGDIAKDLGleprELAERGVRIISRGR---TQLFALNQRSGSLVTAGRIDREEICA---QSARCLVNF 106
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVhyiSVSAASLGA 79

                        90       100
                ....*....|....*....|...
gi 14196477 107 NIlMEDKMNlypIDVEIIDINDN 129
Cdd:cd00031  80 NV-PQTSSV---FSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 6.49e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 6.49e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14196477     65 RIISRGRTQLFALNQRSGSLVTAGRIDREEicaqsaRCLVNFNILMEDKMNLY-----PIDVEIIDINDNVP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEATDGGGPPlsstaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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