FHF complex subunit HOOK-interacting protein 1B isoform 1 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| RAI16-like | pfam10257 | Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ... |
97-426 | 5.59e-111 | ||||||
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans. : Pssm-ID: 370927 Cd Length: 357 Bit Score: 347.00 E-value: 5.59e-111
|
||||||||||
| DUF5917 | pfam19314 | Family of unknown function (DUF5917); This short presumed domain is found close to the ... |
752-845 | 2.72e-40 | ||||||
Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. : Pssm-ID: 466037 Cd Length: 94 Bit Score: 143.48 E-value: 2.72e-40
|
||||||||||
| KELAA | pfam19311 | KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ... |
933-964 | 1.65e-08 | ||||||
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named. : Pssm-ID: 466035 Cd Length: 32 Bit Score: 50.96 E-value: 1.65e-08
|
||||||||||
| KLF9_13_N-like super family | cl41730 | Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
449-559 | 7.56e-03 | ||||||
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins. The actual alignment was detected with superfamily member cd21576: Pssm-ID: 425361 [Multi-domain] Cd Length: 195 Bit Score: 38.65 E-value: 7.56e-03
|
||||||||||
| Name | Accession | Description | Interval | E-value | ||||||
| RAI16-like | pfam10257 | Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ... |
97-426 | 5.59e-111 | ||||||
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans. Pssm-ID: 370927 Cd Length: 357 Bit Score: 347.00 E-value: 5.59e-111
|
||||||||||
| DUF5917 | pfam19314 | Family of unknown function (DUF5917); This short presumed domain is found close to the ... |
752-845 | 2.72e-40 | ||||||
Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. Pssm-ID: 466037 Cd Length: 94 Bit Score: 143.48 E-value: 2.72e-40
|
||||||||||
| KELAA | pfam19311 | KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ... |
933-964 | 1.65e-08 | ||||||
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named. Pssm-ID: 466035 Cd Length: 32 Bit Score: 50.96 E-value: 1.65e-08
|
||||||||||
| KLF14_N | cd21576 | N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ... |
449-559 | 7.56e-03 | ||||||
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14. Pssm-ID: 409238 [Multi-domain] Cd Length: 195 Bit Score: 38.65 E-value: 7.56e-03
|
||||||||||
| Name | Accession | Description | Interval | E-value | ||||||
| RAI16-like | pfam10257 | Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ... |
97-426 | 5.59e-111 | ||||||
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans. Pssm-ID: 370927 Cd Length: 357 Bit Score: 347.00 E-value: 5.59e-111
|
||||||||||
| DUF5917 | pfam19314 | Family of unknown function (DUF5917); This short presumed domain is found close to the ... |
752-845 | 2.72e-40 | ||||||
Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. Pssm-ID: 466037 Cd Length: 94 Bit Score: 143.48 E-value: 2.72e-40
|
||||||||||
| KELAA | pfam19311 | KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ... |
933-964 | 1.65e-08 | ||||||
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named. Pssm-ID: 466035 Cd Length: 32 Bit Score: 50.96 E-value: 1.65e-08
|
||||||||||
| KLF14_N | cd21576 | N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ... |
449-559 | 7.56e-03 | ||||||
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14. Pssm-ID: 409238 [Multi-domain] Cd Length: 195 Bit Score: 38.65 E-value: 7.56e-03
|
||||||||||
| Blast search parameters | ||||
|
