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Conserved domains on  [gi|229608967|ref|NP_115956|]
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spermatogenic leucine zipper protein 1 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
63-340 4.92e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967    63 QQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELF-----EETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKED 137
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLarleaEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA 780
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967   138 NEKKQEmiLETNITEDVSAHKENIRGLDKINEMLStnlpvslapekEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEK 217
Cdd:TIGR02168  781 EAEIEE--LEAQIEQLKEELKALREALDELRAELT-----------LLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967   218 KVLNETQQSQEKAKNRLNVQEETMKIrnnmeqllqEAEHWSKQHTELSKLIKSYQKSQKDISETLgnngvgfqtqpnnev 297
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELES---------ELEALLNERASLEEALALLRSELEELSEEL--------------- 903
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 229608967   298 sakHELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKE 340
Cdd:TIGR02168  904 ---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
63-340 4.92e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967    63 QQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELF-----EETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKED 137
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLarleaEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA 780
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967   138 NEKKQEmiLETNITEDVSAHKENIRGLDKINEMLStnlpvslapekEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEK 217
Cdd:TIGR02168  781 EAEIEE--LEAQIEQLKEELKALREALDELRAELT-----------LLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967   218 KVLNETQQSQEKAKNRLNVQEETMKIrnnmeqllqEAEHWSKQHTELSKLIKSYQKSQKDISETLgnngvgfqtqpnnev 297
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELES---------ELEALLNERASLEEALALLRSELEELSEEL--------------- 903
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 229608967   298 sakHELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKE 340
Cdd:TIGR02168  904 ---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
63-340 4.92e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967    63 QQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELF-----EETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKED 137
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLarleaEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA 780
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967   138 NEKKQEmiLETNITEDVSAHKENIRGLDKINEMLStnlpvslapekEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEK 217
Cdd:TIGR02168  781 EAEIEE--LEAQIEQLKEELKALREALDELRAELT-----------LLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608967   218 KVLNETQQSQEKAKNRLNVQEETMKIrnnmeqllqEAEHWSKQHTELSKLIKSYQKSQKDISETLgnngvgfqtqpnnev 297
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELES---------ELEALLNERASLEEALALLRSELEELSEEL--------------- 903
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 229608967   298 sakHELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKE 340
Cdd:TIGR02168  904 ---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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