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Conserved domains on  [gi|145309322|ref|NP_115983|]
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insulinoma-associated protein 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10442881)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 426-448 3.02e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 43.83  E-value: 3.02e-06
                          10        20
                  ....*....|....*....|...
gi 145309322  426 FVCPYCHKKFRRQAYLRKHLSTH 448
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 291-313 1.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|...
gi 145309322  291 YRCPECDKVFSCPANLASHRRWH 313
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
22-223 1.23e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322  22 AERVFPLLGPQGAPPFLEEAPSASLPGA--ERATPPTREEPGKglTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGR 99
Cdd:PRK07003 392 GASAVPAVTAVTGAAGAALAPKAAAAAAatRAEAPPAAPAPPA--TADRGDDAADGDAPVPAKANARASADSRCDERDAQ 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322 100 EGPGPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPgeqfllplRAPFPEPALQP 179
Cdd:PRK07003 470 PPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAP--------EARPPTPAAAA 541

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145309322 180 DPAPL---SAALQSLKRA-----AGGERRGKAPTDCASGPAAAgiKKPKAMR 223
Cdd:PRK07003 542 PAARAggaAAALDVLRNAgmrvsSDRGARAAAAAKPAAAPAAA--PKPAAPR 591
 
Name Accession Description Interval E-value
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 426-448 3.02e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 43.83  E-value: 3.02e-06
                          10        20
                  ....*....|....*....|...
gi 145309322  426 FVCPYCHKKFRRQAYLRKHLSTH 448
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
426-448 2.82e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 38.22  E-value: 2.82e-04
                           10        20
                   ....*....|....*....|...
gi 145309322   426 FVCPYCHKKFRRQAYLRKHLSTH 448
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 291-313 1.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|...
gi 145309322  291 YRCPECDKVFSCPANLASHRRWH 313
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
22-223 1.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322  22 AERVFPLLGPQGAPPFLEEAPSASLPGA--ERATPPTREEPGKglTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGR 99
Cdd:PRK07003 392 GASAVPAVTAVTGAAGAALAPKAAAAAAatRAEAPPAAPAPPA--TADRGDDAADGDAPVPAKANARASADSRCDERDAQ 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322 100 EGPGPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPgeqfllplRAPFPEPALQP 179
Cdd:PRK07003 470 PPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAP--------EARPPTPAAAA 541

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145309322 180 DPAPL---SAALQSLKRA-----AGGERRGKAPTDCASGPAAAgiKKPKAMR 223
Cdd:PRK07003 542 PAARAggaAAALDVLRNAgmrvsSDRGARAAAAAKPAAAPAAA--PKPAAPR 591
 
Name Accession Description Interval E-value
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 426-448 3.02e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 43.83  E-value: 3.02e-06
                          10        20
                  ....*....|....*....|...
gi 145309322  426 FVCPYCHKKFRRQAYLRKHLSTH 448
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
426-448 2.82e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 38.22  E-value: 2.82e-04
                           10        20
                   ....*....|....*....|...
gi 145309322   426 FVCPYCHKKFRRQAYLRKHLSTH 448
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 291-313 1.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|...
gi 145309322  291 YRCPECDKVFSCPANLASHRRWH 313
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
22-223 1.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322  22 AERVFPLLGPQGAPPFLEEAPSASLPGA--ERATPPTREEPGKglTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGR 99
Cdd:PRK07003 392 GASAVPAVTAVTGAAGAALAPKAAAAAAatRAEAPPAAPAPPA--TADRGDDAADGDAPVPAKANARASADSRCDERDAQ 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322 100 EGPGPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPgeqfllplRAPFPEPALQP 179
Cdd:PRK07003 470 PPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAP--------EARPPTPAAAA 541

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145309322 180 DPAPL---SAALQSLKRA-----AGGERRGKAPTDCASGPAAAgiKKPKAMR 223
Cdd:PRK07003 542 PAARAggaAAALDVLRNAgmrvsSDRGARAAAAAKPAAAPAAA--PKPAAPR 591
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
31-225 1.85e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322  31 PQGAPPFLEEAPSASLPGA--ERATPPTREEPGKGLTAEAAREQSGSPCRAagvSPGTGGREGAEWRAGGREGPGPSPSP 108
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAaaPAPAAPPAAPAAAPAAAAAARAVAAAPARR---SPAPEALAAARQASARGPGGAPAPAP 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309322 109 SPSPAkPAGAElrraflerclssPVSAESFPGGAAAVAAFSCSVAPAAAPTPGEQFLLP---LRAPFPEPAL-QPDPAPL 184
Cdd:PRK12323 453 APAAA-PAAAA------------RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPaQPDAAPA 519

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 145309322 185 SAALQSLKRAAGGERRGKAPTDCASGPAAAGIKKPKAMRKL 225
Cdd:PRK12323 520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPV 560
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 291-313 4.69e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 4.69e-03
                          10        20
                  ....*....|....*....|...
gi 145309322  291 YRCPECDKVFSCPANLASHRRWH 313
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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