|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
50-451 |
4.62e-177 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 501.44 E-value: 4.62e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFM-WLLDKRGLRITVLLTSFLMV 128
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMaWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 129 LGTGLRCIPIsDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVpap 208
Cdd:cd17397 81 AGTGLRCIPV-PNHLATWLIHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 209 ngtspllaaessrahikdrieavLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSVCRLLSNFRFLMIALA 288
Cdd:cd17397 157 -----------------------MYLEFGWSALIFLAMLIYFPSKPPTPPSVSASTQRLSYKSGILSLLKNKRFWLIALA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 289 YAIPLGVFAGWSGVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTC 368
Cdd:cd17397 214 YGIPTGVYAGWSGVLDVNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMKLILLLLFSGATGSFLWFTLIC 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 369 LNSIthlPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFLTFYHTELSWFNWC 448
Cdd:cd17397 294 LKLL---PFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILIIPNIGTSWMNWC 370
|
...
gi 14249552 449 LPG 451
Cdd:cd17397 371 LLG 373
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
50-451 |
7.49e-132 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 387.53 E-value: 7.49e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYG-FSSWDIALLVLWGPIGFLPCFAFMWLLDKRGLRITVLLTSFLMV 128
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDlSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 129 LGTGLRCIPIsDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAP 208
Cdd:cd17334 81 LGSVLKCIPL-GQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 209 NGTspllaaessrahiKDRIEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQR------LSYRRSVCRLLSNFRF 282
Cdd:cd17334 160 KGT-------------KKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQnsehviLELQKSISELLRNEPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 283 LMIALAYAIPLGVFAGWSGVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRgMLKLILLLLFSGATLSST 362
Cdd:cd17334 227 VLLAVAFSIMMGVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTR-MFKLIGLIILALGTVVCT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 363 WFTLTCLNSIthLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFLT------ 436
Cdd:cd17334 306 FFMLLVDRYG--LPYVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSellgpt 383
|
410
....*....|....*.
gi 14249552 437 -FYHTELSWFNWCLPG 451
Cdd:cd17334 384 pTESKYLLWFILCTVG 399
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
50-427 |
3.86e-32 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 126.97 E-value: 3.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLP-CFAFMWLLDKRGLRITVLLTSFLMV 128
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPlIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 129 LGTGLRCIPIS-DLIlkrRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPa 207
Cdd:cd17398 81 LGAWLKLFSSSpDLF---WVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVP- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 208 pngtspllaAESSRAHIKDRIEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRL------SYRRSVCRLLSNFR 281
Cdd:cd17398 157 ---------NSENKDEIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQElrsedqSYLGSLKRLFKNKG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 282 FLMIALAYAIPLGVFAGWSGVL-DLILTPAHVSQVDAGWIGFWSIVGGCV----VGIAMARFADFiRGMLKLILLLLFSG 356
Cdd:cd17398 228 FLLLLITYGINTGVYYAISTLLnQMVLEYFPNEEVNAGWIGLTLVIAGLVgsvvAGIWLDKTKKY-KETTIIVYILSFIG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14249552 357 ATLsstwFTLTC-LNSIthlplttVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMF 427
Cdd:cd17398 307 MVA----FTFTLdLGSI-------WVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIF 367
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
50-446 |
4.75e-29 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 118.52 E-value: 4.75e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPC-FAFMWLLDKRGLRITVLLTSFLMV 128
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVgFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 129 LGTGLRCIPISDLI---LKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVV 205
Cdd:cd17399 81 IGAVIRVISSLPFVdpsFRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 206 PAPNGTSPLLAAESSRAHIkdrieAVLYAEFGVVCLIFSATlayfpprpplpPSVAAASQRLSYRRSVCRLLSNFRFLMI 285
Cdd:cd17399 161 KSSEDIFLLLSIYTIPALI-----AVVLATFGVRSSVPPTP-----------PSASAAHESEPFFVGLKQLFKNKQYLIL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 286 ALAYAIPLGVFAGWSGVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFAD----FIRGMlklilLLLFSGATLSS 361
Cdd:cd17399 225 MLCFGGGIGLFNALSTLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDktkkFIEVT-----KVCFCLAVIFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 362 TWFTLtclnsITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVtFLSNMFMGVLLFFLTFYHTE 441
Cdd:cd17399 300 VAFLV-----VSRFPNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLI-FMSGQIQGIILVFIMQALAT 373
|
....*
gi 14249552 442 LSWFN 446
Cdd:cd17399 374 PLSVY 378
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
50-427 |
1.42e-21 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 96.39 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLP-CFAFMWLLDKRGLRITVLLTSFLMV 128
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPlIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 129 LGTGLRCIPISDLILKRRLIhgGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAP 208
Cdd:cd17456 81 LGAWIKTGSARPDLFPVTVL--GQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 209 NGTSPLlaaessRAHIKdrieAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAA------SQRLSYRRSVCRLLSNFRF 282
Cdd:cd17456 159 DDLDEL------AYHIS----IMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAaiqsipSQDYSYLQSILRLLKNVNF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 283 LMIALAYAIPLGVFAGWSGVLDLILTPAHV-SQVDAGWIGFWSIVGGCVVGIAMARFADFIRGM-LKLILLLLFSGATLS 360
Cdd:cd17456 229 ILLVVSYGLNTGCFYALSTLLNRMVIFHYPgEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYkQTTLAVYIMSLVGMV 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14249552 361 STWFTLtclnSITHLPLTTVTlyASCilLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMF 427
Cdd:cd17456 309 VYTFTL----NLGHLWVVFIT--AGT--LGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVF 367
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
69-427 |
5.71e-21 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 94.90 E-value: 5.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 69 WNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLP-CFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILKRRL 147
Cdd:cd17455 20 WIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPlIFPATWLLDLKGLRVTALLGAGLNCLGAWVKCASVRPDLFGVTM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 148 IhgGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAEssrahikdr 227
Cdd:cd17455 100 L--AQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTVDDIDLMGHN--------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 228 IEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAA------SQRLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSG 301
Cdd:cd17455 169 ISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAvlqgipSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVST 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 302 VLD-LILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGM-LKLILLLLFSGATLSSTWFTLTCLNSIthlpltt 379
Cdd:cd17455 249 LLNqMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYkQTTLIVYILSFIGMVVFTFTLDLGYLI------- 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 14249552 380 vTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMF 427
Cdd:cd17455 322 -VVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIF 368
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
49-401 |
9.97e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.20 E-value: 9.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 49 GRRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGF-LPCFAFMWLLDKRGLRITVLLTSFLM 127
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGaLLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 128 VLGTGLRCIPISDLILkrrLIHGgqMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPA 207
Cdd:COG2223 81 GIGLLLLALAVSYWLL---LLLG--LLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 208 PNGTSPLLAaessrahikdrieavlyaeFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRrsvcRLLSNFRFLMIAL 287
Cdd:COG2223 156 FGWRNAFLI-------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQL----EALRDPRFWLLSL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 288 AYAIPLGVFAGWSGVLDLILTPA-HVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGmlKLILLLLFSGATLSSTWFTL 366
Cdd:COG2223 213 LYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG--RRVLLIVFALMALGLLLLAL 290
|
330 340 350
....*....|....*....|....*....|....*
gi 14249552 367 TclnsithlPLTTVTLYASCILLGVFLNSSVPIFF 401
Cdd:COG2223 291 A--------LGSLWLFLVLFLLLGLALGGGNGAVF 317
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-207 |
1.50e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPC-FAFMWLLDKRGLRITVLLTSFLMV 128
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGqIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14249552 129 LGTGLRCIPISDLILKrrlihGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPA 207
Cdd:COG2271 87 LATLLFGFATSFWQLL-----LLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
66-340 |
3.84e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.02 E-value: 3.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 66 GLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFM-WLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILk 144
Cdd:COG2807 31 RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLApRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALL- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 145 rrliHGGQMLNGLAGPTVMNAAPFLSTTWFsADERATATAIASMLSYLGGAcaflVGPLVVPapngtsPLLAAESSRAHi 224
Cdd:COG2807 110 ----LAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAA----LAAGLTV------PLAAALGWRGA- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 225 kdrieavlYAEFGVVCLIfsATLAYFPPRPPLPPSVAAASQRLSYRRsvcrLLSNFRFLMIALAYAIPLGVFAGWSGVLD 304
Cdd:COG2807 174 --------LAVWALLALL--ALLLWLPLLRRRPAAAAAAPAAASLRS----LWRSPLAWLLTLFFGLQSLLYYAVVAWLP 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 14249552 305 LILTPAHVSQVDAGW----IGFWSIVGGCVVGIAMARFAD 340
Cdd:COG2807 240 PILRDAGLSAATAGLllslFQLAGIPGSLLVPLLADRLGD 279
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
66-436 |
8.91e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 8.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 66 GLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIG-FLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILk 144
Cdd:cd06174 9 GLARGLISPLLPALLQSFGLSASQLGLLFALFSLGyALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLL- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 145 rrliHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLlaaessrahi 224
Cdd:cd06174 88 ----LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRA---------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 225 kdrieavLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQR-LSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSGVL 303
Cdd:cd06174 154 -------VFLIAAALALLAAILLLLVVPDPPESARAKNEEASsKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 304 -DLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLplttvtl 382
Cdd:cd06174 227 pLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL------- 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 14249552 383 yasCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVT---FLSNMFMGVLLFFLT 436
Cdd:cd06174 300 ---LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNtfgFLGGAIGPLLAGFLL 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
69-425 |
1.12e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 69 WNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFM-WLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILkrrl 147
Cdd:pfam07690 13 SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAgRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 148 iHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAaessrahikdr 227
Cdd:pfam07690 89 -LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI----------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 228 ieavlyaeFGVVCLIfSATLAYFPPRPPLPPSVAAASQRLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSGVLDLIL 307
Cdd:pfam07690 157 --------LAILSLL-AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 308 TPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFtltclnsiTHLPLTTVTLYASCI 387
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL--------LSLTLSSLWLLLALL 299
|
330 340 350
....*....|....*....|....*....|....*...
gi 14249552 388 LLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSN 425
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS 337
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
50-430 |
6.57e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 6.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 50 RRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFM-WLLDKRGLRITVLLTSFLMV 128
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAgRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 129 LGTGLrCIPISDLILkrrlIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAP 208
Cdd:COG2814 87 LGSLL-CALAPSLWL----LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 209 NGTSPLLAAessrahikdrieavlyaefGVVCLIFSATLAYFPprpplppSVAAASQRLSYRRSVCRLLSNFRFLMIALA 288
Cdd:COG2814 162 GWRWVFLVN-------------------AVLALLALLLLLRLL-------PESRPAARARLRGSLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249552 289 YAIPLGVFAGWSGVLDLILT-PAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTlt 367
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQeVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-- 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14249552 368 clnsithlpLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGV 430
Cdd:COG2814 294 ---------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| |
