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Conserved domains on  [gi|296317236|ref|NP_116565|]
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small integral membrane protein 3 [Homo sapiens]

Protein Classification

Smim3 domain-containing protein( domain architecture ID 13879670)

Smim3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smim3 pfam17307
Small integral membrane protein 3; This domain family can be found in Smim3 proteins (Small ...
 1-60 3.11e-19

Small integral membrane protein 3; This domain family can be found in Smim3 proteins (Small integral membrane protein 3) also known as NID67 (NGF-induced differentiation clone 67). It is a primary response gene, hypothesized to be involved in forming or regulating ion channels in neuronal differentiation. It is strongly induced by NGF (Nerve Growth Factor) and FGF (Fibroblast Growth Factor), both of which cause these cells to differentiate. The amino acid sequence of NID67 is strongly conserved among rat, mouse and human. This family of small membrane proteins is only 60 amino acids long and analysis of the predicted peptide sequence reveals a stretch of 29 hydrophobic and uncharged residues which very likely comprise a trans-membrane region.


:

Pssm-ID: 407417  Cd Length: 60  Bit Score: 72.53  E-value: 3.11e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 296317236   1 MDAVSQVPMEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILSGAV 60
Cdd:pfam17307  1 MDPGSQSPVEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILNGAV 60
 
Name Accession Description Interval E-value
Smim3 pfam17307
Small integral membrane protein 3; This domain family can be found in Smim3 proteins (Small ...
 1-60 3.11e-19

Small integral membrane protein 3; This domain family can be found in Smim3 proteins (Small integral membrane protein 3) also known as NID67 (NGF-induced differentiation clone 67). It is a primary response gene, hypothesized to be involved in forming or regulating ion channels in neuronal differentiation. It is strongly induced by NGF (Nerve Growth Factor) and FGF (Fibroblast Growth Factor), both of which cause these cells to differentiate. The amino acid sequence of NID67 is strongly conserved among rat, mouse and human. This family of small membrane proteins is only 60 amino acids long and analysis of the predicted peptide sequence reveals a stretch of 29 hydrophobic and uncharged residues which very likely comprise a trans-membrane region.


Pssm-ID: 407417  Cd Length: 60  Bit Score: 72.53  E-value: 3.11e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 296317236   1 MDAVSQVPMEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILSGAV 60
Cdd:pfam17307  1 MDPGSQSPVEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILNGAV 60
 
Name Accession Description Interval E-value
Smim3 pfam17307
Small integral membrane protein 3; This domain family can be found in Smim3 proteins (Small ...
 1-60 3.11e-19

Small integral membrane protein 3; This domain family can be found in Smim3 proteins (Small integral membrane protein 3) also known as NID67 (NGF-induced differentiation clone 67). It is a primary response gene, hypothesized to be involved in forming or regulating ion channels in neuronal differentiation. It is strongly induced by NGF (Nerve Growth Factor) and FGF (Fibroblast Growth Factor), both of which cause these cells to differentiate. The amino acid sequence of NID67 is strongly conserved among rat, mouse and human. This family of small membrane proteins is only 60 amino acids long and analysis of the predicted peptide sequence reveals a stretch of 29 hydrophobic and uncharged residues which very likely comprise a trans-membrane region.


Pssm-ID: 407417  Cd Length: 60  Bit Score: 72.53  E-value: 3.11e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 296317236   1 MDAVSQVPMEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILSGAV 60
Cdd:pfam17307  1 MDPGSQSPVEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATAVIIYRMRTHPILNGAV 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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