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Conserved domains on  [gi|14318577|ref|NP_116710|]
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proteasome regulatory particle lid subunit RPN12 [Saccharomyces cerevisiae S288C]

Protein Classification

CSN8/SAC3 domain-containing protein( domain architecture ID 581622)

CSN8/SAC3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAC3_GANP super family cl24019
SAC3/GANP family; This family includes diverse proteins involved in large complexes. The ...
 122-226 8.22e-13

SAC3/GANP family; This family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localization of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.


The actual alignment was detected with superfamily member pfam10075:

Pssm-ID: 474128  Cd Length: 137  Bit Score: 64.20  E-value: 8.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318577   122 FHSELQYLDKHIKNleDDSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQNiSEFDSFTDILKSAIRDEIAKNTELSYDFLP 201
Cdd:pfam10075  23 FRLLLKRIPPDIKQ--SNPEIQQLLTLEQLLWQGDYAKFYQTLKSNDWS-EDYTPFVSGLEDTIRDEIAALVGKAYESIS 99

                          90       100
                  ....*....|....*....|....*
gi 14318577   202 LSNIKALLFFNNEKETEKFALERNW 226
Cdd:pfam10075 100 ADDLAELLGLDTPEELKKFAKARGW 124
 
Name Accession Description Interval E-value
CSN8_PSD8_EIF3K pfam10075
CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature ...
 122-226 8.22e-13

CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.


Pssm-ID: 462954  Cd Length: 137  Bit Score: 64.20  E-value: 8.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318577   122 FHSELQYLDKHIKNleDDSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQNiSEFDSFTDILKSAIRDEIAKNTELSYDFLP 201
Cdd:pfam10075  23 FRLLLKRIPPDIKQ--SNPEIQQLLTLEQLLWQGDYAKFYQTLKSNDWS-EDYTPFVSGLEDTIRDEIAALVGKAYESIS 99

                          90       100
                  ....*....|....*....|....*
gi 14318577   202 LSNIKALLFFNNEKETEKFALERNW 226
Cdd:pfam10075 100 ADDLAELLGLDTPEELKKFAKARGW 124
 
Name Accession Description Interval E-value
CSN8_PSD8_EIF3K pfam10075
CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature ...
 122-226 8.22e-13

CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.


Pssm-ID: 462954  Cd Length: 137  Bit Score: 64.20  E-value: 8.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14318577   122 FHSELQYLDKHIKNleDDSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQNiSEFDSFTDILKSAIRDEIAKNTELSYDFLP 201
Cdd:pfam10075  23 FRLLLKRIPPDIKQ--SNPEIQQLLTLEQLLWQGDYAKFYQTLKSNDWS-EDYTPFVSGLEDTIRDEIAALVGKAYESIS 99

                          90       100
                  ....*....|....*....|....*
gi 14318577   202 LSNIKALLFFNNEKETEKFALERNW 226
Cdd:pfam10075 100 ADDLAELLGLDTPEELKKFAKARGW 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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