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Conserved domains on  [gi|42475970|ref|NP_149014|]
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rho GTPase-activating protein SYDE1 isoform 1 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 396-601 2.50e-106

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04379:

Pssm-ID: 470621  Cd Length: 207  Bit Score: 322.88  E-value: 2.50e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 475
Cdd:cd04379   1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 555
Cdd:cd04379  81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 42475970 556 CFGPVLLPARQAPTRPRAR-SSGPGLASAVDFKHHIEVLHYLLQSWP 601
Cdd:cd04379 161 CFGPVLMFCSQEFSRYGISpTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
 
Name Accession Description Interval E-value
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 396-601 2.50e-106

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 322.88  E-value: 2.50e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 475
Cdd:cd04379   1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 555
Cdd:cd04379  81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 42475970 556 CFGPVLLPARQAPTRPRAR-SSGPGLASAVDFKHHIEVLHYLLQSWP 601
Cdd:cd04379 161 CFGPVLMFCSQEFSRYGISpTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 411-600 1.90e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 160.12  E-value: 1.90e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970    411 GQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQP 490
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSE--YDVHDVAGLLKLFLRELPEPLITYE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970    491 LYKVVLEAMAR-DPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLparqapt 569
Cdd:smart00324  79 LYEEFIEAAKLeDETERL----RALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL------- 147

                          170       180       190
                   ....*....|....*....|....*....|.
gi 42475970    570 rpraRSSGPGLASAVDFKHHIEVLHYLLQSW 600
Cdd:smart00324 148 ----RPPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 414-566 1.23e-37

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 137.29  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970   414 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQPLYK 493
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEE--EDVHVVASLLKLFLRELPEPLLTFELYE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42475970   494 VVLEAMARDPP-NRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ 566
Cdd:pfam00620  79 EFIEAAKLPDEeERLEALRE----LLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 396-601 2.50e-106

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 322.88  E-value: 2.50e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 475
Cdd:cd04379   1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 555
Cdd:cd04379  81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 42475970 556 CFGPVLLPARQAPTRPRAR-SSGPGLASAVDFKHHIEVLHYLLQSWP 601
Cdd:cd04379 161 CFGPVLMFCSQEFSRYGISpTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 411-600 1.90e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 160.12  E-value: 1.90e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970    411 GQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQP 490
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSE--YDVHDVAGLLKLFLRELPEPLITYE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970    491 LYKVVLEAMAR-DPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLparqapt 569
Cdd:smart00324  79 LYEEFIEAAKLeDETERL----RALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL------- 147

                          170       180       190
                   ....*....|....*....|....*....|.
gi 42475970    570 rpraRSSGPGLASAVDFKHHIEVLHYLLQSW 600
Cdd:smart00324 148 ----RPPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 414-566 1.23e-37

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 137.29  E-value: 1.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970   414 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQPLYK 493
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEE--EDVHVVASLLKLFLRELPEPLLTFELYE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42475970   494 VVLEAMARDPP-NRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ 566
Cdd:pfam00620  79 EFIEAAKLPDEeERLEALRE----LLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 414-598 9.15e-37

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 135.51  E-value: 9.15e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 414 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlypDINVITGILKDYLRELPTPLITQPLYK 493
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDY---DVHDVASLLKLYLRELPEPLIPFELYD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 494 VVLEAMARDPPNRvppTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLparqaptrpra 573
Cdd:cd00159  78 EFIELAKIEDEEE---RIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL----------- 143

                       170       180
                ....*....|....*....|....*
gi 42475970 574 RSSGPGLASAVDFKHHIEVLHYLLQ 598
Cdd:cd00159 144 RPPDSDDELLEDIKKLNEIVEFLIE 168
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-564 2.20e-28

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 112.50  E-value: 2.20e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERppGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCL--SEDLYPDINVITG 473
Cdd:cd04398   1 FGVPLEDLILREG--DNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLisPEDYESDIHSVAS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 474 ILKDYLRELPTPLITQPLYKVVLEA-MARDPPNRvpptTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQN 552
Cdd:cd04398  79 LLKLFFRELPEPLLTKALSREFIEAaKIEDESRR----RDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNN 154

                       170
                ....*....|..
gi 42475970 553 LAVCFGPVLLPA 564
Cdd:cd04398 155 LAIIWGPTLMNA 166
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-598 3.65e-28

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 112.23  E-value: 3.65e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERErpPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 475
Cdd:cd04372   1 YGCDLTTLVKAH--NTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADISATVYPDINVITGAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 554
Cdd:cd04372  79 KLYFRDLPIPVITYDTYPKFIDAAKiSNPDERL----EAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLG 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 42475970 555 VCFGPVLLPARQAPTrprarssgpgLASAVDFKHHIEVLHYLLQ 598
Cdd:cd04372 155 IVFGPTLMRPPEDSA----------LTTLNDMRYQILIVQLLIT 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 396-562 8.66e-28

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 110.56  E-value: 8.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERppGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAaVCLSEDLYPDINVITGIL 475
Cdd:cd04403   1 FGCHLEALCQREN--STVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEK-LDLDDSKWEDIHVITGAL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMAR-DPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 554
Cdd:cd04403  78 KLFFRELPEPLFPYSLFNDFVAAIKLsDYEQRV----SAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLA 153


                ....*...
gi 42475970 555 VCFGPVLL 562
Cdd:cd04403 154 IVFGPTLL 161
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 396-598 2.33e-27

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 109.63  E-value: 2.33e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERppGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDS--AAVCLSEdlyPDINVITG 473
Cdd:cd04387   1 FGVKISTVTKRER--SKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNkdVSVMLSE---MDVNAIAG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 474 ILKDYLRELPTPLITQPLYKVVLEAMA-RDPPNRvpptTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQN 552
Cdd:cd04387  76 TLKLYFRELPEPLFTDELYPNFAEGIAlSDPVAK----ESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHN 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 42475970 553 LAVCFGPVLLpaRQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQ 598
Cdd:cd04387 152 LATVFGPTLL--RPSEKESKIPTNTMTDSWSLEVMSQVQVLLYFLQ 195
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 395-599 1.33e-26

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 107.49  E-value: 1.33e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 395 VFGLPLpllveRERPPGQ----VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINV 470
Cdd:cd04395   1 TFGVPL-----DDCPPSSenpyVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDVNV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 471 ITGILKDYLRELPTPLITQPLYKVVLEA-MARDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMT 549
Cdd:cd04395  76 VSSLLKSFFRKLPEPLFTNELYPDFIEAnRIEDPVERL----KELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKME 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 42475970 550 PQNLAVCFGPVLLparqaptrpraRSSGPGLASAV-DFKHHIEVLHYLLQS 599
Cdd:cd04395 152 PRNLAIVFGPTLV-----------RTSDDNMETMVtHMPDQCKIVETLIQH 191
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 396-562 1.03e-25

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 104.83  E-value: 1.03e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPpgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLsEDlYPdINVITGIL 475
Cdd:cd04377   1 FGVSLSSLTSEDRS---VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNL-ED-YP-IHVITSVL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 554
Cdd:cd04377  75 KQWLRELPEPLMTFELYENFLRAMElEEKQERV----RALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALA 150


                ....*...
gi 42475970 555 VCFGPVLL 562
Cdd:cd04377 151 IVFAPCIL 158
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 410-598 1.47e-25

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 104.81  E-value: 1.47e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 410 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdLYPdiNVITGILKDYLRELPTPLITQ 489
Cdd:cd04378  13 PDEVPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSE-LSP--HDISSVLKLFLRQLPEPLILF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 490 PLYKVVLeAMA----RDPPNRVPPTTEGT--------RGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCF 557
Cdd:cd04378  90 RLYNDFI-ALAkeiqRDTEEDKAPNTPIEvnriirklKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVF 168

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 42475970 558 GPVLLparqaptRPRARSSGPGLASAVDFKHHIEVLHYLLQ 598
Cdd:cd04378 169 GPTLI-------RPRPGDADVSLSSLVDYGYQARLVEFLIT 202
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 401-562 4.32e-25

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 102.77  E-value: 4.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 401 PLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYpDINVITGILKDYLR 480
Cdd:cd04385   3 PALEDQQLTDNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKDARSVQLREGEY-TVHDVADVLKRFLR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 481 ELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGP 559
Cdd:cd04385  82 DLPDPLLTSELHAEWIEAAElENKDERI----ARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGP 157


                ...
gi 42475970 560 VLL 562
Cdd:cd04385 158 TLF 160
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-567 3.68e-24

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 100.49  E-value: 3.68e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERdsaAVCLSEDLYPDINVITGIL 475
Cdd:cd04404   6 FGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNM---GEPVDFDQYEDVHLPAVIL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 555
Cdd:cd04404  83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQ----LLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAV 158

                       170
                ....*....|..
gi 42475970 556 CFGPVLLPARQA 567
Cdd:cd04404 159 VFGPNLLWAKDA 170
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 396-562 1.38e-22

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 95.83  E-value: 1.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPpgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdlYPdINVITGIL 475
Cdd:cd04407   1 FGVRVGSLTSNKTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLEN--YP-IHAITGLL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMardppnRVPPTTEGTRGL---LSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQN 552
Cdd:cd04407  75 KQWLRELPEPLMTFAQYNDFLRAV------ELPEKQEQLQAIyrvLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNA 148

                       170
                ....*....|
gi 42475970 553 LAVCFGPVLL 562
Cdd:cd04407 149 LAIVFAPCLL 158
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 395-561 1.66e-21

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 92.81  E-value: 1.66e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 395 VFGLPLPLLVERERPPGQ---VPLIIQKCVGQIE-RRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINV 470
Cdd:cd04400   1 IFGSPLEEAVELSSHKYNgrdLPSVVYRCIEYLDkNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 471 ITGILKDYLRELPTPLITQPLYKvVLEAMARDPPNRVPPTTEgTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTP 550
Cdd:cd04400  81 VAGLLKLYLRELPTLILGGELHN-DFKRLVEENHDRSQRALE-LKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNL 158

                       170
                ....*....|.
gi 42475970 551 QNLAVCFGPVL 561
Cdd:cd04400 159 RNVCIVFSPTL 169
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 408-597 1.18e-20

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 91.02  E-value: 1.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 408 RPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdLYPdiNVITGILKDYLRELPTPLI 487
Cdd:cd04409  11 KSPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSE-LSP--HDISNVLKLYLRQLPEPLI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 488 TQPLYKVVL----EAMARDPPNRVPPTTEG---------------TRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRM 548
Cdd:cd04409  88 LFRLYNEFIglakESQHVNETQEAKKNSDKkwpnmctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKM 167

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 42475970 549 TPQNLAVCFGPVLLparqaptRPRARSSGPGLASAVDFKHHIEVLHYLL 597
Cdd:cd04409 168 SASNLGIIFGPTLI-------RPRPTDATVSLSSLVDYPHQARLVELLI 209
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 410-562 4.81e-20

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 88.72  E-value: 4.81e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 410 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDinvITGILKDYLRELPTPLITQ 489
Cdd:cd04408  13 PEEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHD---ITSVLKHFLKELPEPVLPF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 490 PLY-------KVVLEAMARDP--PNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPV 560
Cdd:cd04408  90 QLYddfialaKELQRDSEKAAesPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPT 169


                ..
gi 42475970 561 LL 562
Cdd:cd04408 170 LL 171
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 413-561 1.68e-19

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 86.96  E-value: 1.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 413 VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdlyPDINVITGILKDYLRELPTPLITQPLY 492
Cdd:cd04382  17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSK---VDIHVICGCLKDFLRSLKEPLITFALW 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 493 KVVLEAM-ARDPPNRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAyNRMTPQNLAVCFGPVL 561
Cdd:cd04382  94 KEFMEAAeILDEDNSRAALYQ----AISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGPTI 158
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 392-565 1.97e-19

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 87.13  E-value: 1.97e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 392 EPRVFGLPLP--LLVERERppgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFerDSAAVCLSEDL-YPDI 468
Cdd:cd04386   1 EKPVFGTPLEehLKRTGRE----IALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAAL--DAGTFSLPLDEfYSDP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 469 NVITGILKDYLRELPTPLITQPLYKVVLEAMAR-DPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNR 547
Cdd:cd04386  75 HAVASALKSYLRELPDPLLTYNLYEDWVQAANKpDEDERL----QAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENK 150

                       170
                ....*....|....*...
gi 42475970 548 MTPQNLAVCFGPVLLPAR 565
Cdd:cd04386 151 MSPSNIAIVLAPNLLWAK 168
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 403-563 2.73e-19

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 86.32  E-value: 2.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 403 LVERERPPGQ-VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERdsaavclSEDLYP------DINVITGIL 475
Cdd:cd04383   7 LEEYIQDSGQaIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER-------GEDPLAddqndhDINSVAGVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLE-AMARDPPNRVPptteGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 554
Cdd:cd04383  80 KLYFRGLENPLFPKERFEDLMScVKLENPTERVH----QIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLA 155


                ....*....
gi 42475970 555 VCFGPVLLP 563
Cdd:cd04383 156 ICFGPTLMP 164
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-563 7.20e-19

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 84.81  E-value: 7.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPpgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLypDINVITGIL 475
Cdd:cd04373   1 FGVPLANVVTSEKP---IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDF--TVNAVAGAL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 554
Cdd:cd04373  76 KSFFSELPDPLIPYSMHLELVEAAKiNDREQRL----HALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLS 151


                ....*....
gi 42475970 555 VCFGPVLLP 563
Cdd:cd04373 152 ICFWPTLMR 160
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 416-566 1.54e-18

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 84.37  E-value: 1.54e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 416 IIQKCVGQIERRGLRVVGLYRLCG-SAAVKKELRDAFERDSAAvCLSEDLYP---DINVITGILKDYLRELPTPLITQPL 491
Cdd:cd04374  31 FVRKCIEAVETRGINEQGLYRVVGvNSKVQKLLSLGLDPKTST-PGDVDLDNsewEIKTITSALKTYLRNLPEPLMTYEL 109

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42475970 492 YKVVLEAMARDPPN-RVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ 566
Cdd:cd04374 110 HNDFINAAKSENLEsRV----NAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE 181
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 394-566 9.14e-18

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 82.17  E-value: 9.14e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 394 RVFGLPLPLLVERErppGQ-VPLIIQKCVGQIERRGLrVVGLYRLCGSAAVKKELRDAFerDSAAVC-LSEDLY-PDINV 470
Cdd:cd04384   1 RVFGCDLTEHLLNS---GQdVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEF--DSEQIPdLTKDVYiQDIHS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 471 ITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRvppTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTP 550
Cdd:cd04384  75 VSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEE---RLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHA 151

                       170
                ....*....|....*.
gi 42475970 551 QNLAVCFGPVLLPARQ 566
Cdd:cd04384 152 KNLAIVWAPNLLRSKQ 167
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 395-565 9.31e-17

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 79.70  E-value: 9.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 395 VFGLPLPLLVERER--PPG-QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDsaavcLSEDLYPDINV- 470
Cdd:cd04391   1 LFGVPLSTLLERDQkkVPGsKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAK-----FYEGTFLWDQVk 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 471 ---ITGILKDYLRELPTPLIT----QPLYKVvleamardppNRVPPTTEGTRGL-LSC--LPDVERATLTLLLDHLRLVS 540
Cdd:cd04391  76 qhdAASLLKLFIRELPQPLLTveylPAFYSV----------QGLPSKKDQLQALnLLVllLPEANRDTLKALLEFLQKVV 145

                       170       180
                ....*....|....*....|....*
gi 42475970 541 SFHAYNRMTPQNLAVCFGPVLLPAR 565
Cdd:cd04391 146 DHEEKNKMNLWNVAMIMAPNLFPPR 170
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 412-600 1.08e-16

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 79.41  E-value: 1.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 412 QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERdSAAVCLSEDLYPdiNVITGILKDYLRELPTPLITQPL 491
Cdd:cd04376   8 QVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR-GIDVVLDENHSV--HDVAALLKEFFRDMPDPLLPREL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 492 YKVVLEAMARDPPNR-----------VPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSfhayNRMTPQNLAVCFGPV 560
Cdd:cd04376  85 YTAFIGTALLEPDEQlealqlliyllPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSG----NKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 42475970 561 LLPArqapTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW 600
Cdd:cd04376 161 LLHK----QKSGEREFVQASLRIEESTAIINVVQTMIDNY 196
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 395-562 1.49e-16

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 78.64  E-value: 1.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 395 VFGLPLPLLVERERPPGQ--VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF---ERDSAavclseDLYPDIN 469
Cdd:cd04390   2 VFGQRLEDTVAYERKFGPrlVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFdagERPSF------DSDTDVH 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 470 VITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMT 549
Cdd:cd04390  76 TVASLLKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKGLGELMK-QVSILPKVNYNLLSYICRFLDEVQSNSSVNKMS 154

                       170
                ....*....|...
gi 42475970 550 PQNLAVCFGPVLL 562
Cdd:cd04390 155 VQNLATVFGPNIL 167
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 396-562 2.04e-16

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 78.12  E-value: 2.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERppgQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLseDLYpDINVITGIL 475
Cdd:cd04406   1 FGVELSRLTSEDR---SVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNL--DDY-NIHVIASVF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMArdppnrVPPTTEGTRGLLSCLPDVER---ATLTLLLDHLRLVSSFHAYNRMTPQN 552
Cdd:cd04406  75 KQWLRDLPNPLMTFELYEEFLRAMG------LQERRETVRGVYSVIDQLSRthlNTLERLIFHLVRIALQEETNRMSANA 148

                       170
                ....*....|
gi 42475970 553 LAVCFGPVLL 562
Cdd:cd04406 149 LAIVFAPCIL 158
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 394-559 1.40e-15

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 75.58  E-value: 1.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 394 RVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFErDSAAVCLSEDlyPDINVITG 473
Cdd:cd04393   1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLD-SGEEVDLSKE--ADVCSAAS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 474 ILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVppTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNL 553
Cdd:cd04393  78 LLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDE--FGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENL 155


                ....*.
gi 42475970 554 AVCFGP 559
Cdd:cd04393 156 AAVFGP 161
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 396-561 1.10e-13

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 69.77  E-value: 1.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERPPG--QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAaVCLSEdlYpDINVITG 473
Cdd:cd04381   1 FGASLSLAVERSRCHDgiDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRES-PNLEE--Y-EPPTVAS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 474 ILKDYLRELPTPLITQPLYKVVLEAMARdppnrvppTTEGTR-----GLLSCLPDVERATLTLLLDHLRLVSSFHAYNRM 548
Cdd:cd04381  77 LLKQYLRELPEPLLTKELMPRFEEACGR--------PTEAEReqelqRLLKELPECNRLLLAWLIVHMDHVIAQELETKM 148

                       170
                ....*....|...
gi 42475970 549 TPQNLAVCFGPVL 561
Cdd:cd04381 149 NIQNISIVLSPTV 161
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 395-580 1.84e-13

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 70.14  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 395 VFGLPLPLLVERErppGQ-VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDInviTG 473
Cdd:cd04375   4 VFGVPLLVNLQRT---GQpLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDV---AD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 474 ILKDYLRELPTPLITQPLYKVVLeAMARDPPNRVPPTTEGTRGLLscLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNL 553
Cdd:cd04375  78 MLKQYFRDLPEPLLTNKLSETFI-AIFQYVPKEQRLEAVQCAILL--LPDENREVLQTLLYFLSDVAANSQENQMTATNL 154

                       170       180       190
                ....*....|....*....|....*....|...
gi 42475970 554 AVCFGPVLLPARQ------APTRPRARSSGPGL 580
Cdd:cd04375 155 AVCLAPSLFHLNTsrrensSPARRMQRKKSLGK 187
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 395-563 7.16e-11

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 62.10  E-value: 7.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 395 VFGLPLPLLVERERPP-GQVPLIIQKCVGQIERRgLRVVGLYRLCGSAAVKKELRDAFerDSAAVCLSEDLYPDInviTG 473
Cdd:cd04394   1 VFGVPLHSLPHSTVPEyGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKL--EGGEACLSSALPCDV---AG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 474 ILKDYLRELPTPLITQPLYKVVLEAmardppNRVPPTTEGTRG--LLSC-LPDVERATLTLLLDHLRLVSSFHAYNRMTP 550
Cdd:cd04394  75 LLKQFFRELPEPLLPYDLHEALLKA------QELPTDEERKSAtlLLTClLPDEHVNTLRYFFSFLYDVAQRCSENKMDS 148

                       170
                ....*....|...
gi 42475970 551 QNLAVCFGPVLLP 563
Cdd:cd04394 149 SNLAVIFAPNLFQ 161
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-562 8.89e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 61.55  E-value: 8.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVererPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVClseDLYPdINVITGIL 475
Cdd:cd04402   2 FGQPLSNIC----EDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDL---KAEP-VLLLASVL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 476 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVpptTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 555
Cdd:cd04402  74 KDFLRNIPGSLLSSDLYEEWMSALDQENEEEK---IAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAV 150


                ....*..
gi 42475970 556 CFGPVLL 562
Cdd:cd04402 151 CIAPSLL 157
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-597 2.13e-10

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 61.23  E-value: 2.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERP-------PG--QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVclsEDLYP 466
Cdd:cd04397   1 FGVPLEILVEKFGAdstlgvgPGklRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEV---PDLSK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 467 DINV-ITGILKDYLRELPTPLITQPLYKVVLEAmardppNRVPPTTEGTRGL---LSCLPDVERATLTLLLDHLRLVSSF 542
Cdd:cd04397  78 ENPVqLAALLKKFLRELPDPLLTFKLYRLWISS------QKIEDEEERKRVLhlvYCLLPKYHRDTMEVLFSFLKWVSSF 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42475970 543 HAY-----NRMTPQNLAVCFGPVLLparqaptRPRARSSGPG----LAsavdfkhhIEVLHYLL 597
Cdd:cd04397 152 SHIdeetgSKMDIHNLATVITPNIL-------YSKTDNPNTGdeyfLA--------IEAVNYLI 200
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 400-623 4.04e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 51.03  E-value: 4.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 400 LPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRlCGSAAVKKELRDAFERDSAAVCLSEdlyPDINVITGILKDYL 479
Cdd:cd04388   2 LPDLTEQFSPPDVAPPLLIKLVEAIEKKGLESSTLYR-TQSSSSLTELRQILDCDAASVDLEQ---FDVAALADALKRYL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 480 RELPTPLITQPLYkvvlEAMARDPPNrVPPTTEGT---RGLLSC--LPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 554
Cdd:cd04388  78 LDLPNPVIPAPVY----SEMISRAQE-VQSSDEYAqllRKLIRSpnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALA 152

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42475970 555 VCFGPVLLPArQAPTRPRArssgpglasavdfKHHIEVLHYLLQSWPDPRLPrqspdvAPYLRPKrqPP 623
Cdd:cd04388 153 EIFSPLLFRF-QPASSDSP-------------EFHIRIIEVLITSEWNERQA------APALPPK--PP 199
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 429-568 5.41e-07

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 50.92  E-value: 5.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 429 LRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPdiNVITGILKDYLRELPTPLITQ---PLYKVVLEAMARDPPN 505
Cdd:cd04392  24 LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHA--HDCATVLKGFLGELPEPLLTHahyPAHLQIADLCQFDEKG 101

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42475970 506 RVPPTTEGTRG------LLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAP 568
Cdd:cd04392 102 NKTSAPDKERLlealqlLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLT 170
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 411-562 1.33e-05

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 47.02  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 411 GQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF-ERDSAAVCLSEDLYpDINVITGILKDYLRELPTPLITQ 489
Cdd:cd04396  30 GYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFsTPPDYGKSFDWDGY-TVHDAASVLRRYLNNLPEPLVPL 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 490 PLYKVVLEAMARDP---------PNRVPPTT-----EGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 555
Cdd:cd04396 109 DLYEEFRNPLRKRPrilqymkgrINEPLNTDidqaiKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAA 188


                ....*..
gi 42475970 556 CFGPVLL 562
Cdd:cd04396 189 IFQPGIL 195
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 396-572 6.12e-05

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 44.30  E-value: 6.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERER---PPGQVPLIIQKCVGQI-ERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlypdINVI 471
Cdd:cd04389   1 FGSSLEEIMDRQKekyPELKLPWILTFLSEKVlALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLED----PHVP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 472 TGILKDYLRELPTPLITQPLYKVVLEAmARDPPNRVppttegtrGLLSCLPDVERATLTL--LLDHLRLVSSFHAYNRMT 549
Cdd:cd04389  77 ASLLKLWLRELEEPLIPDALYQQCISA-SEDPDKAV--------EIVQKLPIINRLVLCYliNFLQVFAQPENVAHTKMD 147

                       170       180
                ....*....|....*....|...
gi 42475970 550 PQNLAVCFGPVLLpaRQAPTRPR 572
Cdd:cd04389 148 VSNLAMVFAPNIL--RCTSDDPR 168
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 396-528 2.12e-04

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 43.09  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42475970 396 FGLPLPLLVERERppGQVPLIIQKCVGQI-----------ERRGLRVVGLyRLCGSAAVKKELRDAFERDSAAVCLSEdl 464
Cdd:cd04399   1 FGVDLETRCRLDK--KVVPLIVSAILSYLdqlypdlindeVRRNVWTDPV-SLKETHQLRNLLNKPKKPDKEVIILKK-- 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42475970 465 yPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGL---LSCLPDVERAT 528
Cdd:cd04399  76 -FEPSTVASVLKLYLLELPDSLIPHDIYDLIRSLYSAYPPSQEDSDTARIQGLqstLSQLPKSHIAT 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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