wings apart-like (WAPL) family protein that may play a role in sister chromatid cohesion; similar to human wings apart-like protein homolog (WAPL) which is a regulator of sister chromatid cohesion in mitosis that destabilizes cohesin binding to chromatin
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
151-518
6.77e-47
Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
:
Pssm-ID: 462278 Cd Length: 344 Bit Score: 171.33 E-value: 6.77e-47
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
707-788
1.76e-03
Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
The actual alignment was detected with superfamily member pfam07814:
Pssm-ID: 462278 Cd Length: 344 Bit Score: 41.52 E-value: 1.76e-03
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
151-518
6.77e-47
Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Pssm-ID: 462278 Cd Length: 344 Bit Score: 171.33 E-value: 6.77e-47
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
707-788
1.76e-03
Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Pssm-ID: 462278 Cd Length: 344 Bit Score: 41.52 E-value: 1.76e-03
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
151-518
6.77e-47
Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Pssm-ID: 462278 Cd Length: 344 Bit Score: 171.33 E-value: 6.77e-47
Wings apart-like protein regulation of heterochromatin; This family contains sequences ...
707-788
1.76e-03
Wings apart-like protein regulation of heterochromatin; This family contains sequences expressed in eukaryotic organizms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Pssm-ID: 462278 Cd Length: 344 Bit Score: 41.52 E-value: 1.76e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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