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Conserved domains on  [gi|15220057|ref|NP_173167|]
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receptor like protein 2 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 31-697 2.43e-84

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 287.13  E-value: 2.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057   31 ILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPL-NWNLSIDCCSWEGITCDDSSdsHVTVISLPSRGLSGTLASS 109
Cdd:PLN00113  11 YLIFMLFFLFLNFSMLHAEELELLLSFKSSINDPLKYLsNWNSSADVCLWQGITCNNSS--RVVSIDLSGKNISGKISSA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  110 VQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFG----------------NESNRFFSIQT 173
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNletldlsnnmlsgeipNDIGSFSSLKV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  174 LDLSSNLLEGEIlrsSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAG 253
Cdd:PLN00113 169 LDLGGNVLVGKI---PNSLTNLTSLEFLTLASNQLVGQIPRELGQMK-SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  254 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 333
Cdd:PLN00113 245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  334 PLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL 413
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  414 ESLSFMGLSDNkltNITGALSilQGCRKLSTLilakNFYDetvpskedflspdgfpklrifgVGACRLRGEIPAWLINLN 493
Cdd:PLN00113 404 RSLRRVRLQDN---SFSGELP--SEFTKLPLV----YFLD----------------------ISNNNLQGRINSRKWDMP 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  494 KVEVMDLSMNRFVGSIPGWLGTlPDLFYLDLSDNLLTGELPKELFQLRALMSQKITEnnylelpiflnpnnvttnqqynk 573
Cdd:PLN00113 453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE----------------------- 508

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  574 lysfpptiyirrNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYF 653
Cdd:PLN00113 509 ------------NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....
gi 15220057  654 NVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTR 697
Cdd:PLN00113 577 NISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTSGLPPCK 620
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 31-697 2.43e-84

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 287.13  E-value: 2.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057   31 ILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPL-NWNLSIDCCSWEGITCDDSSdsHVTVISLPSRGLSGTLASS 109
Cdd:PLN00113  11 YLIFMLFFLFLNFSMLHAEELELLLSFKSSINDPLKYLsNWNSSADVCLWQGITCNNSS--RVVSIDLSGKNISGKISSA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  110 VQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFG----------------NESNRFFSIQT 173
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNletldlsnnmlsgeipNDIGSFSSLKV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  174 LDLSSNLLEGEIlrsSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAG 253
Cdd:PLN00113 169 LDLGGNVLVGKI---PNSLTNLTSLEFLTLASNQLVGQIPRELGQMK-SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  254 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 333
Cdd:PLN00113 245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  334 PLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL 413
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  414 ESLSFMGLSDNkltNITGALSilQGCRKLSTLilakNFYDetvpskedflspdgfpklrifgVGACRLRGEIPAWLINLN 493
Cdd:PLN00113 404 RSLRRVRLQDN---SFSGELP--SEFTKLPLV----YFLD----------------------ISNNNLQGRINSRKWDMP 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  494 KVEVMDLSMNRFVGSIPGWLGTlPDLFYLDLSDNLLTGELPKELFQLRALMSQKITEnnylelpiflnpnnvttnqqynk 573
Cdd:PLN00113 453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE----------------------- 508

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  574 lysfpptiyirrNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYF 653
Cdd:PLN00113 509 ------------NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....
gi 15220057  654 NVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTR 697
Cdd:PLN00113 577 NISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTSGLPPCK 620
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-533 3.99e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 3.99e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 136 STLDQLMILNLSYNSFNGELPLEQAFGNESNRFFSIQTLDLSSNLLEGEILRSSVYLQGTINLISFNVSNNSFTGPIPSF 215
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 216 MCRSsPQLSKLDFSYNDfsghisqELGRCLRLTVLQAGFNNLSgVIPSEIYNLSELEQLFLPANQLTgKIDNNITRLRKL 295
Cdd:COG4886  92 LGDL-TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 296 TSLALYSNHLEgEIPMDIGNLSSLRSLQLHINNINgTVPLSLANCTKLVKLNLRVNQlgggLTEL--EFSQLQSLKVLDL 373
Cdd:COG4886 162 KSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQ----LTDLpePLANLTNLETLDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 374 GNNSFTgALPDkIFSCKSLTAIRFAGNKLTGeiSPQVLELESLSFMGLSDNKLTNITGALSILQGCRKLSTLILAKNFYD 453
Cdd:COG4886 236 SNNQLT-DLPE-LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 454 ETVPSKEDFLSPDGFPKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGEL 533
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-450 3.23e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 3.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 284 KIDNnITRLRKLTSLALYSNHLEgEIPmDIGNLSSLRSLQLHINNINGTVPLSlaNCTKLVKLNLRVNQLggglTELE-F 362
Cdd:cd21340  16 KIDN-LSLCKNLKVLYLYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGNRI----SVVEgL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 363 SQLQSLKVLDLGNNSftgaLPDK---IFSCKSLTAIR-------FAGNKLTgeiSPQVLE-LESLSFMGLSDNKLTNITG 431
Cdd:cd21340  87 ENLTNLEELHIENQR----LPPGeklTFDPRSLAALSnslrvlnISGNNID---SLEPLApLRNLEQLDASNNQISDLEE 159

                       170
                ....*....|....*....
gi 15220057 432 ALSILQGCRKLSTLILAKN 450
Cdd:cd21340 160 LLDLLSSWPSLRELDLTGN 178
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 47-85 1.86e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 42.28  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15220057    47 NLQDRESLIWFSGNVSSSVSPL-NWNLS-IDCCSWEGITCD 85
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALsSWNSSsSDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 31-697 2.43e-84

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 287.13  E-value: 2.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057   31 ILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPL-NWNLSIDCCSWEGITCDDSSdsHVTVISLPSRGLSGTLASS 109
Cdd:PLN00113  11 YLIFMLFFLFLNFSMLHAEELELLLSFKSSINDPLKYLsNWNSSADVCLWQGITCNNSS--RVVSIDLSGKNISGKISSA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  110 VQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFG----------------NESNRFFSIQT 173
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNletldlsnnmlsgeipNDIGSFSSLKV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  174 LDLSSNLLEGEIlrsSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAG 253
Cdd:PLN00113 169 LDLGGNVLVGKI---PNSLTNLTSLEFLTLASNQLVGQIPRELGQMK-SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  254 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 333
Cdd:PLN00113 245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  334 PLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL 413
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  414 ESLSFMGLSDNkltNITGALSilQGCRKLSTLilakNFYDetvpskedflspdgfpklrifgVGACRLRGEIPAWLINLN 493
Cdd:PLN00113 404 RSLRRVRLQDN---SFSGELP--SEFTKLPLV----YFLD----------------------ISNNNLQGRINSRKWDMP 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  494 KVEVMDLSMNRFVGSIPGWLGTlPDLFYLDLSDNLLTGELPKELFQLRALMSQKITEnnylelpiflnpnnvttnqqynk 573
Cdd:PLN00113 453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE----------------------- 508

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  574 lysfpptiyirrNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYF 653
Cdd:PLN00113 509 ------------NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576

                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....
gi 15220057  654 NVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTR 697
Cdd:PLN00113 577 NISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTSGLPPCK 620
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-533 3.99e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 3.99e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 136 STLDQLMILNLSYNSFNGELPLEQAFGNESNRFFSIQTLDLSSNLLEGEILRSSVYLQGTINLISFNVSNNSFTGPIPSF 215
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 216 MCRSsPQLSKLDFSYNDfsghisqELGRCLRLTVLQAGFNNLSgVIPSEIYNLSELEQLFLPANQLTgKIDNNITRLRKL 295
Cdd:COG4886  92 LGDL-TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 296 TSLALYSNHLEgEIPMDIGNLSSLRSLQLHINNINgTVPLSLANCTKLVKLNLRVNQlgggLTEL--EFSQLQSLKVLDL 373
Cdd:COG4886 162 KSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQ----LTDLpePLANLTNLETLDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 374 GNNSFTgALPDkIFSCKSLTAIRFAGNKLTGeiSPQVLELESLSFMGLSDNKLTNITGALSILQGCRKLSTLILAKNFYD 453
Cdd:COG4886 236 SNNQLT-DLPE-LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 454 ETVPSKEDFLSPDGFPKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGEL 533
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
247-658 5.28e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 5.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 247 LTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGeiPMDIGNLSSLRSLQLHI 326
Cdd:COG4886  28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG--LTDLGDLTNLTELDLSG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 327 NNingtvplSLANCTKLVKLNLRVNQLggglTEL--EFSQLQSLKVLDLGNNSFTgALPDKIFSCKSLTAIRFAGNKLTg 404
Cdd:COG4886 106 NE-------ELSNLTNLESLDLSGNQL----TDLpeELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT- 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 405 EISPQVLELESLSFMGLSDNKLTNITGALSilqGCRKLSTLILAKNfydeTVPSKEDFLSpdGFPKLRIFGVGACRLRgE 484
Cdd:COG4886 173 DLPEELGNLTNLKELDLSNNQITDLPEPLG---NLTNLEELDLSGN----QLTDLPEPLA--NLTNLETLDLSNNQLT-D 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 485 IPaWLINLNKVEVMDLSMNRfVGSIPGwLGTLPDLFYLDLSDNLLTGELPKELFQLRALMSQKITENNYLELPIFLNPNN 564
Cdd:COG4886 243 LP-ELGNLTNLEELDLSNNQ-LTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 565 VTTNQQYNKLYSF-PPTIYIRRNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWS 643
Cdd:COG4886 320 LTTLLLLLLLLKGlLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399

                       410
                ....*....|....*
gi 15220057 644 LTNLNFLSYFNVANN 658
Cdd:COG4886 400 VLLLTLALLDAVNTE 414
PLN03150 PLN03150
hypothetical protein; Provisional
 588-725 1.45e-15

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 80.63  E-value: 1.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  588 LTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSLEGPIPSE 667
Cdd:PLN03150 430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  668 --GQFDTFPKANFEGNPLLCGGVLLTSCKPTrakendeLNRTFLMGIAIGYFLSFVSILV 725
Cdd:PLN03150 510 lgGRLLHRASFNFTDNAGLCGIPGLRACGPH-------LSVGAKIGIAFGVSVAFLFLVI 562
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-683 1.10e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 356 GLTELEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLTNITGALSI 435
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 436 LQGCRKLSTLILAKNFYDEtvpskedflspdGFPKLRIFGVGACRLRgEIPAWLINLNKVEVMDLSMNRFvGSIPGWLGT 515
Cdd:COG4886  92 LGDLTNLTELDLSGNEELS------------NLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQL-TDLPEPLGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 516 LPDLFYLDLSDNLLTgELPKELFQLRALMSqkitennylelpiflnpnnvttnqqynklysfpptIYIRRNNLTgSIPVE 595
Cdd:COG4886 158 LTNLKSLDLSNNQLT-DLPEELGNLTNLKE-----------------------------------LDLSNNQIT-DLPEP 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 596 VGQLKVLHILELLGNNLSgSIPDELSNLTNLERLDLSNNNLSgSIPWsLTNLNFLSYFNVANNSLEGpIPSEGQFDTFPK 675
Cdd:COG4886 201 LGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLPE-LGNLTNLEELDLSNNQLTD-LPPLANLTNLKT 276


                ....*...
gi 15220057 676 ANFEGNPL 683
Cdd:COG4886 277 LDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
254-661 2.66e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 254 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 333
Cdd:COG4886   9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 334 PLSLANCTKLVKLNLRVNQlgggltelEFSQLQSLKVLDLGNNSFTgALPDKIFSCKSLTAIRFAGNKLTgEISPQVLEL 413
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 414 ESLSFMGLSDNKLTNITGALSilqGCRKLSTLILAKNFYDEtvpskedfLSPD--GFPKLRIFGVGACRLRgEIPAWLIN 491
Cdd:COG4886 159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD--------LPEPlgNLTNLEELDLSGNQLT-DLPEPLAN 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 492 LNKVEVMDLSMNRFVgSIPgWLGTLPDLFYLDLSDNLLTgELPkELFQLRALMSQKITENNYLELPI-FLNPNNVTTNQQ 570
Cdd:COG4886 227 LTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTDLKLkELELLLGLNSLL 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 571 YNKLYSFPPTIYIRRNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFL 650
Cdd:COG4886 303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382

                       410
                ....*....|.
gi 15220057 651 SYFNVANNSLE 661
Cdd:COG4886 383 ALLLLTLLLLL 393
PLN03150 PLN03150
hypothetical protein; Provisional
 279-355 3.82e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 72.93  E-value: 3.82e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15220057  279 NQ-LTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGG 355
Cdd:PLN03150 427 NQgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-447 8.99e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 8.99e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  26 LFLLCILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPLNWNLSIDCCSWEGITCDDSSDSHVTVISLPSRGLSGT 105
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 106 LASSVQNIHRLSRLDLSYNRlsgplppgFFSTLDQLMILNLSYNSFNgELPLEQAfgnesnRFFSIQTLDLSSNLLEgEI 185
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLT-DLPEELA------NLTNLKELDLSNNQLT-DL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 186 LRSsvyLQGTINLISFNVSNNSFTGpIPSFMCrSSPQLSKLDFSYNDFSgHISQELGRCLRLTVLQAGFNNLSgVIPSEI 265
Cdd:COG4886 152 PEP---LGNLTNLKSLDLSNNQLTD-LPEELG-NLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 266 YNLSELEQLFLPANQLTGKIdnNITRLRKLTSLALYSNHLEgEIPmDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVK 345
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 346 LNLRVNQLGGGLTELEFSQLQ------SLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFM 419
Cdd:COG4886 301 LLLLLLLLNLLELLILLLLLTtlllllLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380

                       410       420
                ....*....|....*....|....*...
gi 15220057 420 GLSDNKLTNITGALSILQGCRKLSTLIL 447
Cdd:COG4886 381 TLALLLLTLLLLLLTTTAGVLLLTLALL 408
PLN03150 PLN03150
hypothetical protein; Provisional
 34-213 8.81e-12

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 68.30  E-value: 8.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057   34 LSALFLTLSEAVCNLQDRESLIWFSgnvsssvSPLNWNLsiDCCS-----WEGITCD-DSSDSH--VTVISLPSRGLSGT 105
Cdd:PLN03150 363 ITAESKTLLEEVSALQTLKSSLGLP-------LRFGWNG--DPCVpqqhpWSGADCQfDSTKGKwfIDGLGLDNQGLRGF 433

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  106 LASSVQNIHRLSRLDLSYNRLSGPLPPGfFSTLDQLMILNLSYNSFNGELPleQAFGnesnRFFSIQTLDLSSNLLEGEI 185
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRGNIPPS-LGSITSLEVLDLSYNSFNGSIP--ESLG----QLTSLRILNLNGNSLSGRV 506

                        170       180       190
                 ....*....|....*....|....*....|
gi 15220057  186 LRS--SVYLQGTinliSFNVSNNSFTGPIP 213
Cdd:PLN03150 507 PAAlgGRLLHRA----SFNFTDNAGLCGIP 532
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-662 9.00e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 9.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 303 NHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGGGLTELEFSQLQSLKVLDLGNNSFTGAL 382
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 383 PDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLTNITGALSilqGCRKLSTLILAKNfydetvpskedf 462
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELA---NLTNLKELDLSNN------------ 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 463 lspdgfpKLRifgvgacrlrgEIPAWLINLNKVEVMDLSMNRfVGSIPGWLGTLPDLFYLDLSDNLLTgELPKELFQLRA 542
Cdd:COG4886 147 -------QLT-----------DLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTN 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 543 LmsqkitennylelpiflnpnnvttnqqynklysfpPTIYIRRNNLTgSIPVEVGQLKVLHILELLGNNLSgSIPdELSN 622
Cdd:COG4886 207 L-----------------------------------EELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLP-ELGN 248

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 15220057 623 LTNLERLDLSNNNLSgSIPwSLTNLNFLSYFNVANNSLEG 662
Cdd:COG4886 249 LTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTD 286
PLN03150 PLN03150
hypothetical protein; Provisional
 298-383 2.85e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 63.68  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  298 LALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNS 377
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPE-SLGQLTSLRILNLNGNS 501


                 ....*.
gi 15220057  378 FTGALP 383
Cdd:PLN03150 502 LSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 253-337 6.18e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.44  E-value: 6.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  253 GFNN--LSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNIN 330
Cdd:PLN03150 424 GLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503


                 ....*..
gi 15220057  331 GTVPLSL 337
Cdd:PLN03150 504 GRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 465-537 7.28e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 7.28e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15220057  465 PDGFPKLR---IFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGELPKEL 537
Cdd:PLN03150 435 PNDISKLRhlqSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 605-683 6.15e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.98  E-value: 6.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  605 LELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSLEGPIP-SEGQFDTFPKANFEGNPL 683
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPeSLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-450 3.23e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 3.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 284 KIDNnITRLRKLTSLALYSNHLEgEIPmDIGNLSSLRSLQLHINNINGTVPLSlaNCTKLVKLNLRVNQLggglTELE-F 362
Cdd:cd21340  16 KIDN-LSLCKNLKVLYLYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGNRI----SVVEgL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 363 SQLQSLKVLDLGNNSftgaLPDK---IFSCKSLTAIR-------FAGNKLTgeiSPQVLE-LESLSFMGLSDNKLTNITG 431
Cdd:cd21340  87 ENLTNLEELHIENQR----LPPGeklTFDPRSLAALSnslrvlnISGNNID---SLEPLApLRNLEQLDASNNQISDLEE 159

                       170
                ....*....|....*....
gi 15220057 432 ALSILQGCRKLSTLILAKN 450
Cdd:cd21340 160 LLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 160-265 9.06e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.13  E-value: 9.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  160 AFGNESNRFFsIQTLDLSSNLLEGEILRSSVYLQgtiNLISFNVSNNSFTGPIPSFMcRSSPQLSKLDFSYNDFSGHISQ 239
Cdd:PLN03150 410 QFDSTKGKWF-IDGLGLDNQGLRGFIPNDISKLR---HLQSINLSGNSIRGNIPPSL-GSITSLEVLDLSYNSFNGSIPE 484

                         90       100
                 ....*....|....*....|....*.
gi 15220057  240 ELGRCLRLTVLQAGFNNLSGVIPSEI 265
Cdd:PLN03150 485 SLGQLTSLRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 481-543 3.87e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.20  E-value: 3.87e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15220057  481 LRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGELPKELFQLRAL 543
Cdd:PLN03150 430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSL 492
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 47-85 1.86e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 42.28  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15220057    47 NLQDRESLIWFSGNVSSSVSPL-NWNLS-IDCCSWEGITCD 85
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALsSWNSSsSDPCSWTGVTCD 41
PLN03150 PLN03150
hypothetical protein; Provisional
 202-285 1.12e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  202 NVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQL 281
Cdd:PLN03150 424 GLDNQGLRGFIPNDISKLR-HLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....
gi 15220057  282 TGKI 285
Cdd:PLN03150 503 SGRV 506
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 294-427 2.17e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 294 KLTSLALYSNHLEGEIPMDIGNL----SSLRSLQLHINNING----TVPLSLANCTKLVKLNLRVNQL---GGGLTELEF 362
Cdd:cd00116 138 ALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdeGASALAETL 217

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15220057 363 SQLQSLKVLDLGNNSFTGA-----LPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL----ESLSFMGLSDNKLT 427
Cdd:cd00116 218 ASLKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFG 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-382 2.26e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 2.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  90 SHVTVISLPSRGLSgTLASSVQNIHRLSRLDLSYNRLSGpLPPgFFSTLDQLMILNLSYNSFNgELPLEqaFGNESNrff 169
Cdd:COG4886 136 TNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPE-ELGNLTNLKELDLSNNQIT-DLPEP--LGNLTN--- 206

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 170 sIQTLDLSSNLLEgEIlrsSVYLQGTINLISFNVSNNSFTgPIPSFmcRSSPQLSKLDFSYNDFSgHISqELGRCLRLTV 249
Cdd:COG4886 207 -LEELDLSGNQLT-DL---PEPLANLTNLETLDLSNNQLT-DLPEL--GNLTNLEELDLSNNQLT-DLP-PLANLTNLKT 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 250 LQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNI 329
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 15220057 330 NGTVPLSLANCTKLVKLNLRVNQLGGGLTELEFSQLQSLKVLDLGNNSFTGAL 382
Cdd:COG4886 357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR_8 pfam13855
Leucine rich repeat;
115-181 3.14e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220057   115 RLSRLDLSYNRLSGpLPPGFFSTLDQLMILNLSYNSFNGELPleQAFGNESnrffSIQTLDLSSNLL 181
Cdd:pfam13855   2 NLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSP--GAFSGLP----SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 602-658 7.03e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 7.03e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15220057 602 LHILELLGNNLSgsIPDELSNLTNLERLDLSNNNLS--GSIPWSLTNLNFLSYFNVANN 658
Cdd:cd21340 122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 363-427 7.06e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 7.06e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15220057  363 SQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLT 427
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 235-314 7.90e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 7.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057  235 GHISQELGRCLRLTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIG 314
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
602-660 1.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15220057   602 LHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSL 660
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
580-636 4.30e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057   580 TIYIRRNNLTGsipVEVGQLKVLHILELL---GNNLSGSIPDELSNLTNLERLDLSNNNL 636
Cdd:pfam13855   5 SLDLSNNRLTS---LDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
469-529 5.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 5.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15220057   469 PKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLL 529
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 290-450 9.64e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 9.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 290 TRLRKLTSLALYSNHLEGEIPMDIGNL----SSLRSLQLHINNI--NGTVPLS--LANCTKLVKLNLRVNQLGG-GLTEL 360
Cdd:COG5238 233 KGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIgaEGAIALAkaLQGNTTLTSLDLSVNRIGDeGAIAL 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220057 361 E--FSQLQSLKVLDLGNNSFTG----ALPDKIFSCKSLTAIRFAGNKLTGE----ISPQVLELESLSFMGLSDNKLTNiT 430
Cdd:COG5238 313 AegLQGNKTLHTLNLAYNGIGAqgaiALAKALQENTTLHSLDLSDNQIGDEgaiaLAKYLEGNTTLRELNLGKNNIGK-Q 391

                       170       180
                ....*....|....*....|..
gi 15220057 431 GALSILQGCR--KLSTLILAKN 450
Cdd:COG5238 392 GAEALIDALQtnRLHTLILDGN 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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