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Conserved domains on  [gi|15217917|ref|NP_173458|]
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sterol methyltransferase 2 [Arabidopsis thaliana]

Protein Classification

sterol methyltransferase( domain architecture ID 18602716)

sterol methyltransferase such as cycloartenol-C-24-methyltransferase that catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047|GO:0016126|GO:0032259
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 111-239 1.50e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 110.85  E-value: 1.50e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 111 HEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSrANVVGITINEYQVNRARLHNKKAGLDAlcEVVCGNFLQMPFDDN 190
Cdd:COG2226  10 GREALLAALGLRPGARVLDLGCGTGRLALALAERG-ARVTGVDISPEMLELARERAAEAGLNV--EFVVGDAEDLPFPDG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15217917 191 SFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSMYVSYEWVTTEKFKAED 239
Cdd:COG2226  87 SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEE 135
Sterol_MT_C pfam08498
Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a ...
 290-355 8.32e-29

Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a methyltransferase domain (pfam08241) in fungal and plant sterol methyltransferases.


:

Pssm-ID: 430034  Cd Length: 66  Bit Score: 106.37  E-value: 8.32e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217917   290 WTRLKMGRLAYWRNHIVVQILSAVGVAPKGTVDVHEMLFKTADYLTRGGETGIFSPMHMILCRKPE 355
Cdd:pfam08498   1 FTVFRMTKLGRFITHNLVGVLEKLGLAPKGTQKVAESLAKAADALVAGGKKGIFTPMYLFVARKPL 66
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 111-239 1.50e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 110.85  E-value: 1.50e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 111 HEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSrANVVGITINEYQVNRARLHNKKAGLDAlcEVVCGNFLQMPFDDN 190
Cdd:COG2226  10 GREALLAALGLRPGARVLDLGCGTGRLALALAERG-ARVTGVDISPEMLELARERAAEAGLNV--EFVVGDAEDLPFPDG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15217917 191 SFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSMYVSYEWVTTEKFKAED 239
Cdd:COG2226  87 SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEE 135
Sterol_MT_C pfam08498
Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a ...
 290-355 8.32e-29

Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a methyltransferase domain (pfam08241) in fungal and plant sterol methyltransferases.


Pssm-ID: 430034  Cd Length: 66  Bit Score: 106.37  E-value: 8.32e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217917   290 WTRLKMGRLAYWRNHIVVQILSAVGVAPKGTVDVHEMLFKTADYLTRGGETGIFSPMHMILCRKPE 355
Cdd:pfam08498   1 FTVFRMTKLGRFITHNLVGVLEKLGLAPKGTQKVAESLAKAADALVAGGKKGIFTPMYLFVARKPL 66
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 127-221 4.28e-27

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 102.64  E-value: 4.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   127 ILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDalCEVVCGNFLQMPFDDNSFDGAYSIEATCH--A 204
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVSSGVLHHlpD 78

                          90
                  ....*....|....*..
gi 15217917   205 PKLEEVYAEIYRVLKPG 221
Cdd:pfam13649  79 PDLEAALREIARVLKPG 95
PLN02244 PLN02244
tocopherol O-methyltransferase
 77-221 1.56e-23

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 99.43  E-value: 1.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   77 FYNLVTDIYEWGWGQSFH---FSPSIPGKSHKDA-TRLHEEM----AVDLIQVKPGQKILDVGCGVGGPMRAIASHSRAN 148
Cdd:PLN02244  64 FYDESSGVWEDVWGEHMHhgyYDPGASRGDHRQAqIRMIEESlawaGVPDDDEKRPKRIVDVGCGIGGSSRYLARKYGAN 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217917  149 VVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNSFDGAYSIEATCHAPKLEEVYAEIYRVLKPG 221
Cdd:PLN02244 144 VKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPG 216
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 109-282 2.87e-19

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 85.39  E-value: 2.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   109 RLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASH--SRANVVGITINEYQVNRARlhnKKAGLDALCEVVCGNFLQMP 186
Cdd:TIGR01934  25 RLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSapDRGKVTGVDFSSEMLEVAK---KKSELPLNIEFIQADAEALP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   187 FDDNSFDG---AYSIEatcHAPKLEEVYAEIYRVLKPGSMYVSYE-----WVTTEKFKAEDDEHV-EVIQGIERGDA--- 254
Cdd:TIGR01934 102 FEDNSFDAvtiAFGLR---NVTDIQKALREMYRVLKPGGRLVILEfskpaNALLKKFYKFYLKNVlPSIGGLISKNAeay 178

                         170       180       190
                  ....*....|....*....|....*....|....
gi 15217917   255 --LP-GLRAYVDIAETA---KKVGFEIVKEKDLA 282
Cdd:TIGR01934 179 tyLPeSIRAFPSQEELAamlKEAGFEEVRYRSLT 212
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 126-230 4.54e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 70.54  E-value: 4.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 126 KILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDaLCEVVCGNFLQMPFD-DNSFDGAYSIEATCHA 204
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELPPEaDESFDVIISDPPLHHL 79

                        90       100
                ....*....|....*....|....*...
gi 15217917 205 PKL-EEVYAEIYRVLKP-GSMYVSYEWV 230
Cdd:cd02440  80 VEDlARFLEEARRLLKPgGVLVLTLVLA 107
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
126-230 2.48e-06

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 47.80  E-value: 2.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917    126 KILDVGCGVGGPMRAIA-SHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNsFDGAYSIEATCHA 204
Cdd:smart00828   2 RVLDFGCGYGSDLIDLAeRHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80

                           90       100
                   ....*....|....*....|....*.
gi 15217917    205 PKLEEVYAEIYRVLKPGSMYVSYEWV 230
Cdd:smart00828  81 KDKMDLFSNISRHLKDGGHLVLADFI 106
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 111-239 1.50e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 110.85  E-value: 1.50e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 111 HEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSrANVVGITINEYQVNRARLHNKKAGLDAlcEVVCGNFLQMPFDDN 190
Cdd:COG2226  10 GREALLAALGLRPGARVLDLGCGTGRLALALAERG-ARVTGVDISPEMLELARERAAEAGLNV--EFVVGDAEDLPFPDG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15217917 191 SFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSMYVSYEWVTTEKFKAED 239
Cdd:COG2226  87 SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEE 135
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 78-221 8.29e-29

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 109.25  E-value: 8.29e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  78 YNLVTDIYEWGWGQSFHFSPSI---PGKSHKDA-TRLHEEMAvDLIQVKPGQKILDVGCGVGGPMRAIASHSRANVVGIT 153
Cdd:COG2230   3 YDLGNDFYRLFLDPTMTYSCAYfedPDDTLEEAqEAKLDLIL-RKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVT 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 154 INEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFdDNSFDGAYSIEATCHAPK--LEEVYAEIYRVLKPG 221
Cdd:COG2230  82 LSPEQLEYARERAAEAGLADRVEVRLADYRDLPA-DGQFDAIVSIGMFEHVGPenYPAYFAKVARLLKPG 150
Sterol_MT_C pfam08498
Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a ...
 290-355 8.32e-29

Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a methyltransferase domain (pfam08241) in fungal and plant sterol methyltransferases.


Pssm-ID: 430034  Cd Length: 66  Bit Score: 106.37  E-value: 8.32e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15217917   290 WTRLKMGRLAYWRNHIVVQILSAVGVAPKGTVDVHEMLFKTADYLTRGGETGIFSPMHMILCRKPE 355
Cdd:pfam08498   1 FTVFRMTKLGRFITHNLVGVLEKLGLAPKGTQKVAESLAKAADALVAGGKKGIFTPMYLFVARKPL 66
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 127-221 4.28e-27

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 102.64  E-value: 4.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   127 ILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDalCEVVCGNFLQMPFDDNSFDGAYSIEATCH--A 204
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVSSGVLHHlpD 78

                          90
                  ....*....|....*..
gi 15217917   205 PKLEEVYAEIYRVLKPG 221
Cdd:pfam13649  79 PDLEAALREIARVLKPG 95
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 128-221 1.90e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 95.42  E-value: 1.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   128 LDVGCGVGGPMRAIASHSrANVVGITINEYQVNRARLHNKKAGLdalcEVVCGNFLQMPFDDNSFDGAYSIEATCHAPKL 207
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREGL----TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....
gi 15217917   208 EEVYAEIYRVLKPG 221
Cdd:pfam08241  76 ERALREIARVLKPG 89
PLN02244 PLN02244
tocopherol O-methyltransferase
 77-221 1.56e-23

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 99.43  E-value: 1.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   77 FYNLVTDIYEWGWGQSFH---FSPSIPGKSHKDA-TRLHEEM----AVDLIQVKPGQKILDVGCGVGGPMRAIASHSRAN 148
Cdd:PLN02244  64 FYDESSGVWEDVWGEHMHhgyYDPGASRGDHRQAqIRMIEESlawaGVPDDDEKRPKRIVDVGCGIGGSSRYLARKYGAN 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217917  149 VVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNSFDGAYSIEATCHAPKLEEVYAEIYRVLKPG 221
Cdd:PLN02244 144 VKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPG 216
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 109-282 2.87e-19

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 85.39  E-value: 2.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   109 RLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASH--SRANVVGITINEYQVNRARlhnKKAGLDALCEVVCGNFLQMP 186
Cdd:TIGR01934  25 RLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSapDRGKVTGVDFSSEMLEVAK---KKSELPLNIEFIQADAEALP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   187 FDDNSFDG---AYSIEatcHAPKLEEVYAEIYRVLKPGSMYVSYE-----WVTTEKFKAEDDEHV-EVIQGIERGDA--- 254
Cdd:TIGR01934 102 FEDNSFDAvtiAFGLR---NVTDIQKALREMYRVLKPGGRLVILEfskpaNALLKKFYKFYLKNVlPSIGGLISKNAeay 178

                         170       180       190
                  ....*....|....*....|....*....|....
gi 15217917   255 --LP-GLRAYVDIAETA---KKVGFEIVKEKDLA 282
Cdd:TIGR01934 179 tyLPeSIRAFPSQEELAamlKEAGFEEVRYRSLT 212
PRK08317 PRK08317
hypothetical protein; Provisional
 113-221 6.45e-19

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 84.60  E-value: 6.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  113 EMAVDLIQVKPGQKILDVGCGVGGPMRAIA--SHSRANVVGITINEYQVNRARlhNKKAGLDALCEVVCGNFLQMPFDDN 190
Cdd:PRK08317   9 ARTFELLAVQPGDRVLDVGCGPGNDARELArrVGPEGRVVGIDRSEAMLALAK--ERAAGLGPNVEFVRGDADGLPFPDG 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15217917  191 SFDGAYSIEATCHAPKLEEVYAEIYRVLKPG 221
Cdd:PRK08317  87 SFDAVRSDRVLQHLEDPARALAEIARVLRPG 117
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 121-221 7.38e-19

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 81.60  E-value: 7.38e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 121 VKPGQKILDVGCGVGGPMRAIASHSrANVVGITINEYQVNRARLHNKKAGLDalceVVCGNFLQMPFDDNSFDGAYSIEA 200
Cdd:COG2227  22 LPAGGRVLDVGCGTGRLALALARRG-ADVTGVDISPEALEIARERAAELNVD----FVQGDLEDLPLEDGSFDLVICSEV 96

                        90       100
                ....*....|....*....|.
gi 15217917 201 TCHAPKLEEVYAEIYRVLKPG 221
Cdd:COG2227  97 LEHLPDPAALLRELARLLKPG 117
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 114-225 2.77e-18

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 82.89  E-value: 2.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  114 MAVDLIQVKPGQKILDVGCGVGGPMRAIA--SHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNS 191
Cdd:PRK00216  42 KTIKWLGVRPGDKVLDLACGTGDLAIALAkaVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNS 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15217917  192 FDgAYSIeatchA------PKLEEVYAEIYRVLKPGSMYV 225
Cdd:PRK00216 122 FD-AVTI-----AfglrnvPDIDKALREMYRVLKPGGRLV 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 126-230 4.54e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 70.54  E-value: 4.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 126 KILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDaLCEVVCGNFLQMPFD-DNSFDGAYSIEATCHA 204
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELPPEaDESFDVIISDPPLHHL 79

                        90       100
                ....*....|....*....|....*...
gi 15217917 205 PKL-EEVYAEIYRVLKP-GSMYVSYEWV 230
Cdd:cd02440  80 VEDlARFLEEARRLLKPgGVLVLTLVLA 107
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 104-221 1.20e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 71.87  E-value: 1.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 104 HKDATRLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDAlCEVVCGNFL 183
Cdd:COG0500   7 SDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGN-VEFLVADLA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15217917 184 Q-MPFDDNSFDGAYSIEATCHAP--KLEEVYAEIYRVLKPG 221
Cdd:COG0500  86 ElDPLPAESFDLVVAFGVLHHLPpeEREALLRELARALKPG 126
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 105-281 6.30e-13

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 68.12  E-value: 6.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   105 KDATRLHE------EMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDALCEVV 178
Cdd:pfam02353  37 RPDMTLEEaqqaklDLILDKLGLKPGMTLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   179 CGNFLQmpFDDNsFDGAYSIEATCHAPK--LEEVYAEIYRVLKPGSMYVSYewVTTEKFKAEDDEHVEVIQGIER----G 252
Cdd:pfam02353 117 LQDYRD--FDEP-FDRIVSVGMFEHVGHenYDTFFKKLYNLLPPGGLMLLH--TITGLHPDETSERGLPLKFIDKyifpG 191

                         170       180
                  ....*....|....*....|....*....
gi 15217917   253 DALPGLRayvDIAETAKKVGFEIVKEKDL 281
Cdd:pfam02353 192 GELPSIS---MIVESSSEAGFTVEDVESL 217
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 122-244 8.78e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 65.13  E-value: 8.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   122 KPGQKILDVGCGVGGPMRAIAS--HSRANVVGITINEYQVNRARLHNKKAGLDAlCEVVCGNFLQMP--FDDNSFDGAYS 197
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKARENAQKLGFDN-VEFEQGDIEELPelLEDDKFDVVIS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 15217917   198 IEATCHAPKLEEVYAEIYRVLKPGSMYVsyewVTTEKFKAEDDEHVE 244
Cdd:pfam13847  81 NCVLNHIPDPDKVLQEILRVLKPGGRLI----ISDPDSLAELPAHVK 123
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
109-228 1.06e-11

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 64.00  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   109 RLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASH--SRANVVGITINEYQVNRARLHNKKAGLDALcEVVCGNFLQMP 186
Cdd:pfam01209  28 RLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSagSSGKVVGLDINENMLKEGEKKAKEEGKYNI-EFLQGNAEELP 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15217917   187 FDDNSFDG---AYSIEATCHAPKleeVYAEIYRVLKPGSMYVSYE 228
Cdd:pfam01209 107 FEDDSFDIvtiSFGLRNFPDYLK---VLKEAFRVLKPGGRVVCLE 148
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
113-258 1.19e-11

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 62.71  E-value: 1.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 113 EMAVDLIQVKPGQKILDVGCG---VGGPMRAIASHsranVVGITINEYQVNRARlhnKKAGLDALcevVCGNFLQMPFDD 189
Cdd:COG4976  36 EELLARLPPGPFGRVLDLGCGtglLGEALRPRGYR----LTGVDLSEEMLAKAR---EKGVYDRL---LVADLADLAEPD 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 190 NSFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSMYV-SYEWVTTEKFKAEDDEHVEViQGIERGDALPGL 258
Cdd:COG4976 106 GRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIfSVEDADGSGRYAHSLDYVRD-LLAAAGFEVPGL 174
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 119-293 1.49e-11

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 63.84  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  119 IQVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKaglDALCEVVCGNFLQMPFDDNSFDGAYSI 198
Cdd:PTZ00098  48 IELNENSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVNIAKLRNSD---KNKIEFEANDILKKDFPENTFDMIYSR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  199 EATCHAPKLEE--VYAEIYRVLKPGSMYVSYEWVTTEKfKAEDDEHVEVIQgiERGDALPGLRAYVDIAETAKkvgFEIV 276
Cdd:PTZ00098 125 DAILHLSYADKkkLFEKCYKWLKPNGILLITDYCADKI-ENWDEEFKAYIK--KRKYTLIPIQEYGDLIKSCN---FQNV 198

                        170
                 ....*....|....*..
gi 15217917  277 KEKDLASppaepWWTRL 293
Cdd:PTZ00098 199 VAKDISD-----YWLEL 210
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 128-221 1.53e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 60.07  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   128 LDVGCGVGGPMRAIASH-SRANVVGITINEYQVNRARLHNKKAGLD--ALCEVVCGNFLQMpfDDNSFDGAYSIEATCHA 204
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlPGLEYTGLDISPAALEAARERLAALGLLnaVRVELFQLDLGEL--DPGSFDVVVASNVLHHL 78

                          90
                  ....*....|....*..
gi 15217917   205 PKLEEVYAEIYRVLKPG 221
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPG 95
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
123-221 2.16e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 57.14  E-value: 2.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 123 PGQKILDVGCGVGGPMRAIASH-SRANVVGITINEYQVNRARLHNKKagldalCEVVCGNFLQMPFDDnSFDGAYSIEAT 201
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERfPGARVTGVDLSPEMLARARARLPN------VRFVVADLRDLDPPE-PFDLVVSNAAL 73

                        90       100
                ....*....|....*....|
gi 15217917 202 CHAPKLEEVYAEIYRVLKPG 221
Cdd:COG4106  74 HWLPDHAALLARLAAALAPG 93
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 110-251 5.09e-10

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 58.04  E-value: 5.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 110 LHEEMA---VDLIQVKPGQKILDVGCGVGGpmraI---ASHSRANVVGITINEYQVNRARlHNKKAGLDALCEVVCGNFL 183
Cdd:COG1041  10 LDPRLAralVNLAGAKEGDTVLDPFCGTGT----IlieAGLLGRRVIGSDIDPKMVEGAR-ENLEHYGYEDADVIRGDAR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 184 QMPFDDNSFDGA-----YSIEATCHAPKLEEVYA----EIYRVLKPGSMYV------SYEWVTTEKFKAEDDEHVEVIQG 248
Cdd:COG1041  85 DLPLADESVDAIvtdppYGRSSKISGEELLELYEkaleEAARVLKPGGRVVivtprdIDELLEEAGFKVLERHEQRVHKS 164


                ...
gi 15217917 249 IER 251
Cdd:COG1041 165 LTR 167
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 116-280 1.56e-09

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 58.99  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  116 VDLIQVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINeyqVNRARLHNKKA-GLDALCEVVCGNFLQMPFDDNSFDG 194
Cdd:PLN02336 259 VDKLDLKPGQKVLDVGCGIGGGDFYMAENFDVHVVGIDLS---VNMISFALERAiGRKCSVEFEVADCTKKTYPDNSFDV 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  195 AYSIEATCHAPKLEEVYAEIYRVLKPGSMYVSYEWVTTEKFKAEddEHVEVIQgiERGDALPGLRAYvdiAETAKKVGFE 274
Cdd:PLN02336 336 IYSRDTILHIQDKPALFRSFFKWLKPGGKVLISDYCRSPGTPSP--EFAEYIK--QRGYDLHDVQAY---GQMLKDAGFD 408


                 ....*.
gi 15217917  275 IVKEKD 280
Cdd:PLN02336 409 DVIAED 414
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
105-172 7.52e-09

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 56.78  E-value: 7.52e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217917  105 KDATRLHE--EMAVDLI----QVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNkkAGLD 172
Cdd:PRK11705 143 KDADTLEEaqEAKLDLIcrklQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVGVTISAEQQKLAQERC--AGLP 214
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 125-223 2.03e-06

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 48.44  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   125 QKILDVGCGVGGPMRAIAS-HSRANVVGITINEYQVNRARLHNKKAgldalCEVVCGNFLQMPFDDNSFDGAYSIEAT-- 201
Cdd:TIGR02072  36 ASVLDIGCGTGYLTRALLKrFPQAEFIALDISAGMLAQAKTKLSEN-----VQFICGDAEKLPLEDSSFDLIVSNLALqw 110

                          90       100
                  ....*....|....*....|..
gi 15217917   202 CHapKLEEVYAEIYRVLKPGSM 223
Cdd:TIGR02072 111 CD--DLSQALSELARVLKPGGL 130
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
126-230 2.48e-06

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 47.80  E-value: 2.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917    126 KILDVGCGVGGPMRAIA-SHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNsFDGAYSIEATCHA 204
Cdd:smart00828   2 RVLDFGCGYGSDLIDLAeRHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80

                           90       100
                   ....*....|....*....|....*.
gi 15217917    205 PKLEEVYAEIYRVLKPGSMYVSYEWV 230
Cdd:smart00828  81 KDKMDLFSNISRHLKDGGHLVLADFI 106
PRK14968 PRK14968
putative methyltransferase; Provisional
 117-193 1.03e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 45.66  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  117 DLIQVKPGQKILDVGCGVGgpmrAIASHSRAN---VVGITINEYQVNRARLHNKKAGLDALC-EVVCGNFLQmPFDDNSF 192
Cdd:PRK14968  17 ENAVDKKGDRVLEVGTGSG----IVAIVAAKNgkkVVGVDINPYAVECAKCNAKLNNIRNNGvEVIRSDLFE-PFRGDKF 91


                 .
gi 15217917  193 D 193
Cdd:PRK14968  92 D 92
arsM PRK11873
arsenite methyltransferase;
117-226 1.15e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 46.48  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  117 DLIQVKPGQKILDVGCGvGGPMRAIASH---SRANVVGITINEYQVNRARLHNKKAGLDALcEVVCGNFLQMPFDDNSFD 193
Cdd:PRK11873  71 ALAELKPGETVLDLGSG-GGFDCFLAARrvgPTGKVIGVDMTPEMLAKARANARKAGYTNV-EFRLGEIEALPVADNSVD 148

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15217917  194 gaySIEATC---HAPKLEEVYAEIYRVLKP-GSMYVS 226
Cdd:PRK11873 149 ---VIISNCvinLSPDKERVFKEAFRVLKPgGRFAIS 182
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 122-276 1.74e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 44.34  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   122 KPGQKILDVGCGVgGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDALCEvvcgnflqmPFDDNSFDGAYSIEAT 201
Cdd:pfam13489  21 PSPGRVLDFGCGT-GIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEA---------AVPAGKFDVIVAREVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   202 CHAPKLEEVYAEIYRVLKPGS----MYVSYEWVTTEKFK-----AEDDEHVEVIQGiergdalpglrayVDIAETAKKVG 272
Cdd:pfam13489  91 EHVPDPPALLRQIAALLKPGGllllSTPLASDEADRLLLewpylRPRNGHISLFSA-------------RSLKRLLEEAG 157


                  ....
gi 15217917   273 FEIV 276
Cdd:pfam13489 158 FEVV 161
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 120-221 8.72e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.79  E-value: 8.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   120 QVKPGQKILDVGCGVGgpMRAIASH--SRANVVGITINEYQVNRARLHNKKAGLDALCEV-VCGNFLQMPFDdnsfdgay 196
Cdd:pfam06325 158 LVKPGESVLDVGCGSG--ILAIAALklGAKKVVGVDIDPVAVRAAKENAELNGVEARLEVyLPGDLPKEKAD-------- 227

                          90       100
                  ....*....|....*....|....*
gi 15217917   197 SIEATCHAPKLEEVYAEIYRVLKPG 221
Cdd:pfam06325 228 VVVANILADPLIELAPDIYALVKPG 252
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
116-221 1.68e-04

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 42.97  E-value: 1.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 116 VDLIQVKPGQKILDVGCGVGgpMRAIASHSR-----------ANVVGI-TINEYQvnrARLHNKKAGL---DAlCEVVCG 180
Cdd:COG2521 125 VKLVGVRRGDRVLDTCTGLG--YTAIEALKRgarevitvekdPNVLELaELNPWS---RELANERIKIilgDA-SEVIKT 198

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15217917 181 nflqmpFDDNSFDgaysieATCHAP-------KL--EEVYAEIYRVLKPG 221
Cdd:COG2521 199 ------FPDESFD------AIIHDPprfslagELysLEFYRELYRVLKPG 236
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 109-222 1.82e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 42.57  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  109 RLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASH--SRANVVGITINEYQVNRA--RLHNKKAGLDALCEVVCGNFLQ 184
Cdd:PLN02233  59 RIWKRMAVSWSGAKMGDRVLDLCCGSGDLAFLLSEKvgSDGKVMGLDFSSEQLAVAasRQELKAKSCYKNIEWIEGDATD 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15217917  185 MPFDDNSFDG---AYSIEATCHAPKleeVYAEIYRVLKPGS 222
Cdd:PLN02233 139 LPFDDCYFDAitmGYGLRNVVDRLK---AMQEMYRVLKPGS 176
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
186-221 2.13e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 41.39  E-value: 2.13e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15217917 186 PFDDNSFDGAYS---IEatcH--APKLEEVYAEIYRVLKPG 221
Cdd:COG4627  41 PFPDNSVDAIYSshvLE---HldYEEAPLALKECYRVLKPG 78
PRK05785 PRK05785
hypothetical protein; Provisional
 126-217 2.13e-04

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 41.98  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  126 KILDVGCGVGGPMRAIASHSRANVVGItinEYQVNRARLHNKKAgldalcEVVCGNFLQMPFDDNSFD---GAYSIEAtc 202
Cdd:PRK05785  54 KVLDVAAGKGELSYHFKKVFKYYVVAL---DYAENMLKMNLVAD------DKVVGSFEALPFRDKSFDvvmSSFALHA-- 122

                         90
                 ....*....|....*
gi 15217917  203 hAPKLEEVYAEIYRV 217
Cdd:PRK05785 123 -SDNIEKVIAEFTRV 136
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 118-226 2.17e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 41.32  E-value: 2.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 118 LIQVKPGQKILDVGCGVGGP----MRAIASHSRanVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQ-MP-FDDNS 191
Cdd:COG4122  11 LARLLGAKRILEIGTGTGYStlwlARALPDDGR--LTTIEIDPERAAIARENFARAGLADRIRLILGDALEvLPrLADGP 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15217917 192 FDGAYsIEAtcHAPKLEEVYAEIYRVLKPGSMYVS 226
Cdd:COG4122  89 FDLVF-IDA--DKSNYPDYLELALPLLRPGGLIVA 120
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 117-193 2.41e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 42.05  E-value: 2.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917 117 DLIQVKPGQKILDVGCGVGgpmraIAS------HSRANVVGITINEYQVNRARlHNKKA-GLDALCEVVCGNFLQMP--F 187
Cdd:COG4123  31 AFAPVKKGGRVLDLGTGTG-----VIAlmlaqrSPGARITGVEIQPEAAELAR-RNVALnGLEDRITVIHGDLKEFAaeL 104


                ....*.
gi 15217917 188 DDNSFD 193
Cdd:COG4123 105 PPGSFD 110
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 110-223 8.16e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 40.51  E-value: 8.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  110 LHEEMAVDLIQVKPGQK---ILDVGCGVGGPMRaiasHSRA---NVVGITINEYQVNRARLHnkkaglDALCEVVCGNFL 183
Cdd:PRK10258  26 LQRQSADALLAMLPQRKfthVLDAGCGPGWMSR----YWRErgsQVTALDLSPPMLAQARQK------DAADHYLAGDIE 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15217917  184 QMPFDDNSFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSM 223
Cdd:PRK10258  96 SLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGV 135
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 116-220 8.17e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 40.03  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917   116 VDLIQVKPGQKILDVGCGVGG------------PMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFL 183
Cdd:pfam01170  21 VNLAGWKPGDPLLDPMCGSGTilieaalmganiAPGKFDARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAA 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 15217917   184 QMPFDDNSFDGAYS----IEATCHAPKLEEVYAEIYRVLKP 220
Cdd:pfam01170 101 DLPLLEGSVDVIVTnppyGIRLGSKGALEALYPEFLREAKR 141
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 113-193 9.37e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 40.53  E-value: 9.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  113 EMAVDLIQVKPGQKILDVGCGVGgpmrAIA-----SHSRANVVGITINE--YQVnrARlHNKKAGLDALCEVVCGNFLQm 185
Cdd:PRK09328  98 EWALEALLLKEPLRVLDLGTGSG----AIAlalakERPDAEVTAVDISPeaLAV--AR-RNAKHGLGARVEFLQGDWFE- 169


                 ....*...
gi 15217917  186 PFDDNSFD 193
Cdd:PRK09328 170 PLPGGRFD 177
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 124-225 1.57e-03

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 40.10  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  124 GQKILDVGCGvGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNSFDGAYSIEATCH 203
Cdd:PLN02396 132 GLKFIDIGCG-GGLLSEPLARMGATVTGVDAVDKNVKIARLHADMDPVTSTIEYLCTTAEKLADEGRKFDAVLSLEVIEH 210

                         90       100
                 ....*....|....*....|..
gi 15217917  204 APKLEEVYAEIYRVLKPGSMYV 225
Cdd:PLN02396 211 VANPAEFCKSLSALTIPNGATV 232
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 125-225 2.55e-03

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 39.12  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217917  125 QKILDVGCGVGGPMRAIA----SHSRANVVGITINEYQVNRA--RLHNKKagldaLCevVCGNFlQMPFDDNSFDGAYSI 198
Cdd:PRK11088  87 TALLDIGCGEGYYTHALAdalpEITTMQLFGLDISKVAIKYAakRYPQVT-----FC--VASSH-RLPFADQSLDAIIRI 158

                         90       100
                 ....*....|....*....|....*..
gi 15217917  199 eatcHAPKLEEvyaEIYRVLKPGSMYV 225
Cdd:PRK11088 159 ----YAPCKAE---ELARVVKPGGIVI 178
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 121-183 3.91e-03

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 37.95  E-value: 3.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217917   121 VKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKkagldalCEVVCGNFL 183
Cdd:pfam01728  19 LKPGKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPMQLWKPRNDPG-------VTFIQGDIR 74
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 120-157 7.01e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 37.92  E-value: 7.01e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15217917 120 QVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEY 157
Cdd:COG2520 177 LVKPGERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPD 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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