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Conserved domains on  [gi|30691134|ref|NP_174292|]
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prefoldin 6 [Arabidopsis thaliana]

Protein Classification

prefoldin subunit 6( domain architecture ID 19227319)

prefoldin subunit 6 (PFDN6) is a beta subunit of prefoldin, a hexameric co-chaperone prefoldin complex that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly

Gene Ontology:  GO:0016272|GO:0061077|GO:0051082|GO:0003714
PubMed:  9630229|11106732|33137104

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 22-117 1.63e-39

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 127.98  E-value: 1.63e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134  22 KIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAILQDM 101
Cdd:cd23161   6 KLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEKQIKDL 85

                        90
                ....*....|....*.
gi 30691134 102 EEKQNNKRETIMKLQQ 117
Cdd:cd23161  86 EKKQEKKREKIAKLQQ 101
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 22-117 1.63e-39

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 127.98  E-value: 1.63e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134  22 KIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAILQDM 101
Cdd:cd23161   6 KLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEKQIKDL 85

                        90
                ....*....|....*.
gi 30691134 102 EEKQNNKRETIMKLQQ 117
Cdd:cd23161  86 EKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 18-117 3.42e-16

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 68.40  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134    18 NDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAI 97
Cdd:pfam01920   2 NKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQ 81

                          90       100
                  ....*....|....*....|
gi 30691134    98 LQDMEEKQNNKRETIMKLQQ 117
Cdd:pfam01920  82 LEKLEKELEELKEELYKKFG 101
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
12-127 5.92e-05

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 39.87  E-value: 5.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134  12 DLENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAEL 91
Cdd:COG1382   8 EVQNQLAQLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRL 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 30691134  92 KRLdailqdmeEKQNNK-RETIMKLQQRLQTIQAGKA 127
Cdd:COG1382  88 KTL--------EKQEERlQKQLEELQEKLQEALSGAG 116
gimC_beta TIGR02338
prefoldin, beta subunit, archaeal; Chaperonins are cytosolic, ATP-dependent molecular ...
 13-120 4.09e-04

prefoldin, beta subunit, archaeal; Chaperonins are cytosolic, ATP-dependent molecular chaperones, with a conserved toroidal architecture, that assist in the folding of nascent and/or denatured polypeptide chains. The group I chaperonin system consists of GroEL and GroES, and is found (usually) in bacteria and organelles of bacterial origin. The group II chaperonin system, called the thermosome in Archaea and TRiC or CCT in the Eukaryota, is structurally similar but only distantly related. Prefoldin, also called GimC, is a complex in Archaea and Eukaryota, that works with group II chaperonins. Members of this protein family are the archaeal clade of the beta class of prefoldin subunit. Closely related, but outside the scope of this family are the eukaryotic beta-class prefoldin subunits, Gim-1,3,4 and 6. The alpha class prefoldin subunits are more distantly related.


Pssm-ID: 131391 [Multi-domain]  Cd Length: 110  Bit Score: 37.33  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134    13 LENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELK 92
Cdd:TIGR02338   5 VQNQLAQLQQLQQQLQAVATQKQQVEAQLKEAEKALEELERLPDDTPVYKSVGNLLVKTDKEEAIQELKEKKETLELRVK 84

                          90       100
                  ....*....|....*....|....*...
gi 30691134    93 RLdailqdmEEKQNNKRETIMKLQQRLQ 120
Cdd:TIGR02338  85 TL-------QRQEERLREQLKELQEKIQ 105
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 13-120 1.36e-03

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 36.20  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134   13 LENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELK 92
Cdd:PRK09343   9 VQAQLAQLQQLQQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKVDKTKVEKELKERKELLELRSR 88

                         90       100
                 ....*....|....*....|....*...
gi 30691134   93 RLDAILQDMEEKQnnkRETIMKLQQRLQ 120
Cdd:PRK09343  89 TLEKQEKKLREKL---KELQAKINEMLS 113
 
Name Accession Description Interval E-value
Prefoldin_6 cd23161
Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic ...
 22-117 1.63e-39

Prefoldin subunit 6; Prefoldin subunit 6 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467477 [Multi-domain]  Cd Length: 101  Bit Score: 127.98  E-value: 1.63e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134  22 KIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAILQDM 101
Cdd:cd23161   6 KLQKELQKLVEARQQLEAQLNENEMVKKELDLLEDDAKVYKLIGPVLVKQDLDEAKSNVDKRLEFITGEIKRVEKQIKDL 85

                        90
                ....*....|....*.
gi 30691134 102 EEKQNNKRETIMKLQQ 117
Cdd:cd23161  86 EKKQEKKREKIAKLQQ 101
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 18-117 3.42e-16

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 68.40  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134    18 NDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAI 97
Cdd:pfam01920   2 NKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDEDTKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLEKQ 81

                          90       100
                  ....*....|....*....|
gi 30691134    98 LQDMEEKQNNKRETIMKLQQ 117
Cdd:pfam01920  82 LEKLEKELEELKEELYKKFG 101
Prefoldin_beta_GimC cd23162
Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric ...
 34-120 5.40e-06

Prefoldin beta subunit, archaeal; Archaeal beta subunit of prefoldin (GimC), a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467478 [Multi-domain]  Cd Length: 102  Bit Score: 42.08  E-value: 5.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134  34 RKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLdailqdmeEKQNNK-RETI 112
Cdd:cd23162  20 KQQLEAELREIERALEELEKLPDDAEVYKSVGTILVKVDKEEVIKELKERKETLELRLKTL--------EKQEERlRKQL 91


                ....*...
gi 30691134 113 MKLQQRLQ 120
Cdd:cd23162  92 EELQKKIQ 99
GimC COG1382
Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];
12-127 5.92e-05

Prefoldin, chaperonin cofactor [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440992 [Multi-domain]  Cd Length: 121  Bit Score: 39.87  E-value: 5.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134  12 DLENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAEL 91
Cdd:COG1382   8 EVQNQLAQLQQLQQQLQAVAAQKQQVESELKEAEKALEELEKLPDDAEVYKSVGNLLVKTDKEEVIKELEEKKETLELRL 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 30691134  92 KRLdailqdmeEKQNNK-RETIMKLQQRLQTIQAGKA 127
Cdd:COG1382  88 KTL--------EKQEERlQKQLEELQEKLQEALSGAG 116
gimC_beta TIGR02338
prefoldin, beta subunit, archaeal; Chaperonins are cytosolic, ATP-dependent molecular ...
 13-120 4.09e-04

prefoldin, beta subunit, archaeal; Chaperonins are cytosolic, ATP-dependent molecular chaperones, with a conserved toroidal architecture, that assist in the folding of nascent and/or denatured polypeptide chains. The group I chaperonin system consists of GroEL and GroES, and is found (usually) in bacteria and organelles of bacterial origin. The group II chaperonin system, called the thermosome in Archaea and TRiC or CCT in the Eukaryota, is structurally similar but only distantly related. Prefoldin, also called GimC, is a complex in Archaea and Eukaryota, that works with group II chaperonins. Members of this protein family are the archaeal clade of the beta class of prefoldin subunit. Closely related, but outside the scope of this family are the eukaryotic beta-class prefoldin subunits, Gim-1,3,4 and 6. The alpha class prefoldin subunits are more distantly related.


Pssm-ID: 131391 [Multi-domain]  Cd Length: 110  Bit Score: 37.33  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134    13 LENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELK 92
Cdd:TIGR02338   5 VQNQLAQLQQLQQQLQAVATQKQQVEAQLKEAEKALEELERLPDDTPVYKSVGNLLVKTDKEEAIQELKEKKETLELRVK 84

                          90       100
                  ....*....|....*....|....*...
gi 30691134    93 RLdailqdmEEKQNNKRETIMKLQQRLQ 120
Cdd:TIGR02338  85 TL-------QRQEERLREQLKELQEKIQ 105
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 40-102 8.55e-04

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 35.78  E-value: 8.55e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30691134  40 QLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELKRLDAILQDME 102
Cdd:cd00632  15 KINEQKVVLDELSNLKKNRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELEQQLKAKE 77
PRK09343 PRK09343
prefoldin subunit beta; Provisional
 13-120 1.36e-03

prefoldin subunit beta; Provisional


Pssm-ID: 181787 [Multi-domain]  Cd Length: 121  Bit Score: 36.20  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691134   13 LENKANDLGKIQKDIGKNHQLRKKYTIQLGENELVLKELDLLEEDANVYKLIGPVLVKQDLAEANANVRKRIEYISAELK 92
Cdd:PRK09343   9 VQAQLAQLQQLQQQLERLLQQKSQIDLELREINKALEELEKLPDDTPIYKIVGNLLVKVDKTKVEKELKERKELLELRSR 88

                         90       100
                 ....*....|....*....|....*...
gi 30691134   93 RLDAILQDMEEKQnnkRETIMKLQQRLQ 120
Cdd:PRK09343  89 TLEKQEKKLREKL---KELQAKINEMLS 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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